Search Results - (Author, Cooperation:K. Kidd)
-
1Latest Papers from Table of Contents or Articles in PressD. Reich ; N. Patterson ; D. Campbell ; A. Tandon ; S. Mazieres ; N. Ray ; M. V. Parra ; W. Rojas ; C. Duque ; N. Mesa ; L. F. Garcia ; O. Triana ; S. Blair ; A. Maestre ; J. C. Dib ; C. M. Bravi ; G. Bailliet ; D. Corach ; T. Hunemeier ; M. C. Bortolini ; F. M. Salzano ; M. L. Petzl-Erler ; V. Acuna-Alonzo ; C. Aguilar-Salinas ; S. Canizales-Quinteros ; T. Tusie-Luna ; L. Riba ; M. Rodriguez-Cruz ; M. Lopez-Alarcon ; R. Coral-Vazquez ; T. Canto-Cetina ; I. Silva-Zolezzi ; J. C. Fernandez-Lopez ; A. V. Contreras ; G. Jimenez-Sanchez ; M. J. Gomez-Vazquez ; J. Molina ; A. Carracedo ; A. Salas ; C. Gallo ; G. Poletti ; D. B. Witonsky ; G. Alkorta-Aranburu ; R. I. Sukernik ; L. Osipova ; S. A. Fedorova ; R. Vasquez ; M. Villena ; C. Moreau ; R. Barrantes ; D. Pauls ; L. Excoffier ; G. Bedoya ; F. Rothhammer ; J. M. Dugoujon ; G. Larrouy ; W. Klitz ; D. Labuda ; J. Kidd ; K. Kidd ; A. Di Rienzo ; N. B. Freimer ; A. L. Price ; A. Ruiz-Linares
Nature Publishing Group (NPG)
Published 2012Staff ViewPublication Date: 2012-07-18Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Americas ; Asia ; Cluster Analysis ; Emigration and Immigration/*history/statistics & numerical data ; Gene Flow ; Genetics, Population ; History, Ancient ; Humans ; Indians, North American/*genetics/*history ; Models, Genetic ; *Phylogeny ; Polymorphism, Single Nucleotide/genetics ; SiberiaPublished by: -
2Articles: DFG German National LicensesKidd, J. R. ; Black, F. L. ; Weiss, K. M. ; Balazs, I. ; Kidd, K. K.
Baltimore : Periodicals Archive Online (PAO)
Published 1991Staff ViewISSN: 0018-7143Topics: BiologyNotes: Symposium Articles: Organized and edited by Carlos E.A. Coimbra, Jr.URL: -
3Articles: DFG German National LicensesAsplund, A. ; Gustafsson, A.C. ; Wikonkal, N.M. ; Sela, A. ; Leffell, D.J. ; Kidd, K. ; Lundeberg, J. ; Brash, D.E. ; Pontén, F.
Oxford, UK : Blackwell Science Ltd
Published 2005Staff ViewISSN: 1365-2133Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Background The PTCH tumour suppressor gene is involved in the development of nearly all basal cell carcinomas (BCCs) of the skin and a fraction of squamous cell carcinomas (SCCs). A nonconservative Pro/Leu nucleotide polymorphism within PTCH exon 23 at codon 1315 was recently reported to be potentially important for the development of breast epithelial cell cancers.Objectives Accordingly, the status of PTCH codon 1315 was analysed for a possible association with the development of nonmelanoma skin cancers (NMSCs) in a pilot study. Because skin cancer risk is affected by specific population-dependent phenotypes such as skin and hair colour, codon 1315 was also analysed for normal allele frequency variation in human populations having differing extents of eumelanin vs. phaeomelanin.Methods The single nucleotide polymorphism in codon 1315 of the human PTCH gene was analysed in genomic DNA from six different populations comprising 472 blood samples and from 170 patients in four different categories with NMSC. Polymerase chain reaction and pyrosequencing were used to determine the allele frequencies. Allelic loss was furthermore determined in tumours following microdissection.Results The Pro/Pro genotype frequency ranged from 30% to 65% between populations, with a significant trend for a reduced frequency of the Pro/Pro genotype in populations having lighter pigmentation (P = 0·020). Pro/Pro frequency showed an increasing trend with increasing tumour case severity (P = 0·027). In 260 samples from 180 Swedish patients with NMSC and a control group of 96 healthy ethnically matched volunteers, no statistically significant pairwise differences between groups were detected in the PTCH codon 1315 allelic distribution, neither was a difference seen for multiple or early onset cases of BCC in the Swedish population. In Swedish patients with single tumours, allelic loss (loss of heterozygosity) was observed in 20 of 30 (67%) patients with BCC and four of 22 (18%) patients with SCC, with no preference in the allele lost. In contrast, the Pro/Pro genotype was frequent in seven U.S. patients having multiple independent BCCs. One of these patients was heterozygous, enabling allelic loss studies. Of 20 independent tumours, 11 had lost an allele; 10 of the 11 had lost Leu, suggesting nonrandom loss that favoured retention of Pro (P = 0·0059).Conclusions Our results indicate an association between the eumelanin-to-phaeomelanin shift and a shift from the Pro/Pro genotype to Leu-containing genotypes. Failure to lose Pro during the shift to phaeomelanin may be associated with an increased population risk for BCC and increased individual risk for multiple BCC. During development of a tumour, the effect of Pro may be magnified by loss of the Leu allele.Type of Medium: Electronic ResourceURL: -
4Articles: DFG German National LicensesSimpson, N. E. ; Kidd, K. K. ; Goodfellow, P. J. ; McDermid, H. ; Myers, S. ; Kidd, J. R. ; Jackson, C. E. ; Duncan, A. M. V. ; Farrer, L. A. ; Brasch, K. ; Castiglione, C. ; Genel, M. ; Gertner, J. ; Greenberg, C. R. ; Gusella, J. F. ; Holden, J. J. A. ; White, B. N.
[s.l.] : Nature Publishing Group
Published 1987Staff ViewISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] The MEN2A syndrome is characterized by one or more of three types of tumours: medullary thyroid cancer (MTC), phaeo-chromocytomas (PHEOs) and parathyroid adenomas, of which MTC is both the most frequent and most aggressive. MTC and its presumed precursor, C-cell hyperplasia, are commonly detec- ...Type of Medium: Electronic ResourceURL: -
5Articles: DFG German National LicensesStaff View
ISSN: 1432-1203Source: Springer Online Journal Archives 1860-2000Topics: BiologyMedicineNotes: Abstract Abnormalities in monoamine metabolism, including serotonin metabolism, have been implicated in the pathophysiology of affective disorders, schizophrenia, suicide, and other psychiatric disorders. Serotonin transporter protein (SERT) allows neurons to retrieve serotonin that has been released into a synapse. SERT is a site of action for several drugs with CMS effects, including both therapeutic agents (e.g., antidepressants) and drugs of abuse (e.g., cocaine). This gene had previously been physically mapped to chromosome 17. We used a PCR product corresponding to the 3′ untranslated region of the gene as a probe to identify restriction fragment length polymorphism (RFLP), which we then used to establish that the SLC6A4, genetic locus for SERT, is near 17q12 and probably flanked by D17S58 and D17S73 (a location consistent with observed crossovers). These data should be useful for linkage studies of neuropsychiatric disorders. (Joyce et al. 1993). Neurotransmitter reuptake sites (including also the norepinephrine transporter protein and the dopamine transporter protein) are logical candidate genes for susceptibility to psychiatric illness. We have previously (Gelernter et al. 1993) mapped the norepinephrine transporter protein to chromosome 16q21. We describe here linkage mapping of the serotonin transporter protein gene (gene symbol SLC6A4, for “solute carrier family 6 (neurotransporter, serotonin), member 4”), which was cloned in 1991 (Blakely et al. 1991; Hoffman et al. 1991) and previously assigned to chromosome 17, most likely to band 17q11.2, by in situ hybridization (Ramamoorthy et al. 1993). Our linkage results confirm the initial mapping of SLC6A4 and place it in the linkage map of proximal 17q.Type of Medium: Electronic ResourceURL: -
6Articles: DFG German National LicensesStaff View
ISSN: 1432-1203Source: Springer Online Journal Archives 1860-2000Topics: BiologyMedicineNotes: Abstract We have investigated the frequency distribution, across a broad range of geographically dispersed populations, of alleles of the polymorphicAlu insertion that occurs within the 8th intron of the tissue plasminogen activator gene (PLAT). ThisAlu is a member of a recently derived subfamily ofAlu elements that has been expanding during human evolution and continues to be transpositionally active. We used a “population tube” approach to screen 10 chromosomes from each of 19 human populations for presence or absence of thisAlu in the PLAT locus and found that all tested populations are dimorphic for presence/absence of this insertion. We show that the previously publishedEcoRI,HincII,PstI,TaqI, andXmnI polymorphisms at the PLAT locus all result from insertion of thisAlu and we use both restriction fragment length polymorphism and polymerase chain reaction analysis to examine the frequency ofAlu(+) andAlu(−) alleles in a sample of 1003 individuals from 27 human populations and in 38 nonhuman primates. Nonhuman primates are monomorphic for theAlu(−) allele. Human populations differ substantially in allele frequency, and in several populations both alleles are common. Our results date the insertion event prior to the spread and diversification of modern humans.Type of Medium: Electronic ResourceURL: -
7Articles: DFG German National LicensesChang, Fong-Ming ; Kidd, Judith R. ; Livak, Kenneth J. ; Pakstis, Andrew J. ; Kidd, K. K.
Springer
Published 1996Staff ViewISSN: 1432-1203Source: Springer Online Journal Archives 1860-2000Topics: BiologyMedicineNotes: Abstract The dopamine D4 receptor gene (DRD4) has an expressed polymorphism in the third exon that may have functional relevance. The polymorphism exists at two levels. At the higher level there is an imperfect tandem repeat of 48 base pairs (bp) coding for 16 amino acids; alleles have been identified with 2 (32 amino acids) to 10 (160 amino acids) repeats. The imperfect nature of the repeats is responsible for a more subtle level of variation since alleles with the same number of repeats can differ in the exact sequences or in the order of the variants of the 48-bp unit. We have undertaken a global survey of this expressed polymorphism as one approach to understanding the evolutionary significance and origins of the polymorphism as well as understanding what selective forces, if any, may be operating at this locus. As the first step, we have determined the repeat number genotype of the DRD4 repeat polymorphism in 1,327 individuals from 36 different populations. The allele frequencies differ considerably among the different populations. The 4-repeat allele was the most prevalent (global mean allele frequency = 64.3%) and appeared in every population with a frequency ranging from 0.16 to 0.96. The 7-repeat allele was the second most common (global mean = 20.6%), appearing quite frequently in the Americas (mean frequency = 48.3%) but only occasionally in East and South Asia (mean frequency = 1.9%). The 2-repeat allele was the third most common (global mean frequency = 8.2%) and was quite frequent in East and South Asia (mean frequency = 18.1%) while uncommon in the Americas (mean frequency = 2.9%) and Africa (mean frequency = 1.7%). The universality of the polymorphism with only three common repeat-number alleles (4, 7, and 2) indicates that the polymorphism is ancient and arose before the global dispersion of modern humans. The diversity of actual allele frequencies for this expressed polymorphism among different populations emphasizes the importance of population considerations in the design and interpretation of any association studies carried out with this polymorphism.Type of Medium: Electronic ResourceURL: -
8Articles: DFG German National LicensesStaff View
ISSN: 1432-1203Source: Springer Online Journal Archives 1860-2000Topics: BiologyMedicineNotes: Abstract We have investigated the frequency distribution, across a broad range of geographically dispersed populations, of alleles of the polymorphic Alu insertion that occurs within the 8th intron of the tissue plasminogen activator gene (PLAT). This Alu is a member of a recently derived subfamily of Alu elements that has been expanding during human evolution and continues to be transpositionally active. We used a “population tube” approach to screen 10 chromosomes from each of 19 human populations for presence or absence of this Alu in the PLAT locus and found that all tested populations are dimorphic for presence/absence of this insertion. We show that the previously published EcoRI, HincII, PstI, TaqI, and XmnI polymorphisms at the PLAT locus all result from insertion of this Alu and we use both restriction fragment length polymorphism and polymerase chain reaction analysis to examine the frequency of Alu(+) and Alu(–) alleles in a sample of 1003 individuals from 27 human populations and in 38 nonhuman primates. Nonhuman primates are monomorphic for the Alu(–) allele. Human populations differ substantially in allele frequency, and in several populations both alleles are common. Our results date the insertion event prior to the spread and diversification of modern humans.Type of Medium: Electronic ResourceURL: -
9Articles: DFG German National LicensesStaff View
ISSN: 1573-3297Keywords: Macaca radiata ; macaques ; bonnett monkeys ; laterality ; handedness ; degree of handedness ; genetics of handednessSource: Springer Online Journal Archives 1860-2000Topics: BiologyPsychologyNotes: Abstract Handedness and its possible inheritance have been studied in a colony of 69Macaca radiata by observation of hand usage during daily feeding and foraging activities. Each animal was observed for the number of right- and left-handed actions made during two tasks: feeding and searching. Individual animals fell into one of three classes: significantly right-handed, significantly left-handed, and no significant preference. For analysis, handedness was considered as both a directional phenomenon (percentage right-handed usage) and a degree phenomenon (absolute deviation from 50∶50 hand usage). Feeding and searching were significantly correlated for both direction and degree. Therefore, laterality for handedness does exist in this primate species. A developmental aspect to laterality was suggested by the positive correlation of degree with age. No mother-offspring correlations were found for either direction or degree and half-sibships were not more similar for either. Thus, there is no evidence for a genetic component to either direction or degree of handedness.Type of Medium: Electronic ResourceURL: -
10Articles: DFG German National LicensesThe influence of trophic level as measured by δ15N on mercury concentrations in freshwater organismsStaff View
ISSN: 1573-2932Source: Springer Online Journal Archives 1860-2000Topics: Energy, Environment Protection, Nuclear Power EngineeringNotes: Abstract The relationship between mercury (Hg) concentrations in freshwater biota and trophic position, as defined by stable nitrogen isotope ratios (δ15N), was examined in 6 lakes in northwestern Ontario. The heavier isotope of nitrogen (15N) increases an average of 3 parts per thousand (‰) from prey to predator and is used as a measure of an organism's trophic position. Dorsal muscle from lake trout, burbot, walleye, northern pike, white sucker, lake cisco, lake whitefish, and yellow perch was analyzed for Hg and δ15N using flameless atomic absorption and mass spectrometry respectively. Within each lake, log Hg was significantly related to δ15N (r 2 ranged from 0.47 to 0.91,P〈0.01). For four species, yellow perch, northern pike, lake cisco, and lake trout, log Hg was positively related to δ15N (r 2 ranged from 0.37 to 0.47,P≤0.09) across all lakes. We also used δ15N measurements (assuming a 3‰ shift between an organism and its diet) and the developed within-lake regression equations to calculate a prey Hg for each individual fish. These food Hg values were then used to predict predator Hg using Norstromet al's bioenergetics model. Predicted results were strongly correlated to measured Hg concentrations (r=0.91,P〈0.001), indicating that δ15N has potential to be used in modeling.Type of Medium: Electronic ResourceURL: