Search Results - (Author, Cooperation:K. Jahn)
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1Latest Papers from Table of Contents or Articles in PressF. Denoeud ; L. Carretero-Paulet ; A. Dereeper ; G. Droc ; R. Guyot ; M. Pietrella ; C. Zheng ; A. Alberti ; F. Anthony ; G. Aprea ; J. M. Aury ; P. Bento ; M. Bernard ; S. Bocs ; C. Campa ; A. Cenci ; M. C. Combes ; D. Crouzillat ; C. Da Silva ; L. Daddiego ; F. De Bellis ; S. Dussert ; O. Garsmeur ; T. Gayraud ; V. Guignon ; K. Jahn ; V. Jamilloux ; T. Joet ; K. Labadie ; T. Lan ; J. Leclercq ; M. Lepelley ; T. Leroy ; L. T. Li ; P. Librado ; L. Lopez ; A. Munoz ; B. Noel ; A. Pallavicini ; G. Perrotta ; V. Poncet ; D. Pot ; Priyono ; M. Rigoreau ; M. Rouard ; J. Rozas ; C. Tranchant-Dubreuil ; R. VanBuren ; Q. Zhang ; A. C. Andrade ; X. Argout ; B. Bertrand ; A. de Kochko ; G. Graziosi ; R. J. Henry ; Jayarama ; R. Ming ; C. Nagai ; S. Rounsley ; D. Sankoff ; G. Giuliano ; V. A. Albert ; P. Wincker ; P. Lashermes
American Association for the Advancement of Science (AAAS)
Published 2014Staff ViewPublication Date: 2014-09-06Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Caffeine/biosynthesis/*genetics ; Coffea/classification/*genetics ; *Evolution, Molecular ; *Genome, Plant ; Methyltransferases/genetics/*physiology ; Phylogeny ; Plant Proteins/genetics/*physiologyPublished by: -
2Articles: DFG German National LicensesStaff View
ISSN: 1539-6924Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: Energy, Environment Protection, Nuclear Power EngineeringNotes: Political context may play a large role in influencing the efficiency of environmental and health regulations. This case study uses data from a 1989 update of the Occupational Safety and Health Administration (OSHA) Permissible Exposure Limits (PELS) program to determine the relative effects of legislative mandates, costly acquisition of information by the agency, and pressure applied by special interest groups upon exposure standards. The empirical analysis suggests that federal agencies successfully thwart legislative attempts to limit agency discretion, and that agencies exercise bounded rationality by placing greater emphasis on more easily obtained information. The 1989 PEL were less significantly related to more costly information, contained “safety factors” for chemicals presenting relatively more ambiguous risks, and the proposed standard stringencies showed evidence of beinginfluenced by vying industry and labor interests.Type of Medium: Electronic ResourceURL: -
3Articles: DFG German National LicensesKrampfl, K. ; Jahn, K. ; Cordes, A.-L. ; Dengler, R. ; Bufler, J.
Oxford, UK : Blackwell Science Ltd
Published 2002Staff ViewISSN: 1460-9568Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: A characteristic feature of the kinetics of nicotinic acetylcholine receptor (nAChR) channels is fast and nearly complete desensitization with a time course between 10 and 100 ms and recovery from desensitization in the range of some hundred ms. In the present study we used a piezo-driven system for ultra-fast solution exchange, analysed the recovery from the fast desensitized state of mouse recombinant adult-type nAChR channels and found no difference to that of embryonic-type channels. By double pulse experiments with application of pulses with a saturating concentration of 1 mm acetylcholine (ACh) with increasing duration of the first pulse and a constant interval between pulses we detected a second slow desensitized state which was entered with a time constant of 2835 ms. Recovery from the slow desensitized state proceeded with a single exponential with a time constant of 16134 ms. The experimental data were interpreted by the addition of a transition from the desensitized state with two bound ACh molecules to a slow desensitized state to the well known circular kinetic scheme of activation and desensitization of nAChR channels. This slow desensitized state might play a role in muscle fatigue or in pathological states like myasthenic syndromes.Type of Medium: Electronic ResourceURL: -
4Articles: DFG German National LicensesStaff View
ISSN: 1460-9568Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptor channels of rat caudate-putamen neurones were studied by ultrafast application of agonists to outside-out vesicles taken from medium-sized spiny neurones in thin slices. Upon application of 10 m m glutamate for 50 ms, fast rising and desensitizing currents were activated. Ten to 90% rise time values were ≈ 0.5 ms. Dose–response studies revealed an EC50 of 0.63 mm glutamate. In double logarithmic coordinates, the curve had a maximal slope between 1.33 and 1.85 at low concentrations, indicating at least two binding sites for glutamate. Rise time increased with low agonist concentrations, whereas desensitization kinetics showed only a weak dependence on concentration. The time constant of desensitization was fitted with one exponential and ranged between 2 and 11 ms, with a mean of 6.19 ± 2.31 ms (n = 239). Following brief glutamate pulses (1 ms) currents decayed with time constants of 2.7 ± 0.23 ms (n = 12). Recovery from desensitization was investigated by double-pulse experiments. Recovery time constants fell in two subgroups with respective mean values of 110.6 ± 14.2 ms (n = 8) and 288.6 ± 33.2 ms (n = 8). By adding low glutamate concentrations to the bath solution, predesensitization of AMPA-type receptors without channel opening could be shown. A 50% reduction in control amplitude was achieved with 5.2 ± 2.1 μm (n = 22) glutamate in the background. We hypothesize a circular reaction scheme with at least two binding sites for glutamate to describe activation, desensitization and recovery from desensitization in rat caudate-putamen neurones.Type of Medium: Electronic ResourceURL: -
5Articles: DFG German National LicensesSeifert, J ; Peters, E ; Jahn, K ; Metzner, C ; Ohlmeier, M ; Wildt, B ; Emrich, HM ; Schneider, U
Oxford, UK : Blackwell Publishing Ltd
Published 2004Staff ViewISSN: 1369-1600Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Although relatively little attention has been paid to the question how acute alcohol withdrawal might affect cognitive functions, this factor remains of particular interest because it influences psychotherapeutic treatment during detoxification. The clinical outcome and neuropsychological state of 37 inpatients with alcohol withdrawal was investigated in a randomized single-blind approach. Two different medical strategies [chlormethiazole (CMZ) vs. carbamazepine (CBZ)] in the treatment of inpatients with alcohol withdrawal syndrome were compared. Among comparable groups (related to gender, age, initial alcohol level, severity of abuses, severity of initial withdrawal symptoms such as tremor, perspiration, psychomotor agitation, hallucinations, orientation, intelligence, patient demographics), CBZ is just as potent as CMZ in therapy of withdrawal symptoms (circulatory function, vegetative function, psychomotor activity). Patients in both groups showed initial impairments in some neuropsychological tests (d2, Zahlen-Verbundings test, Beck Depression Inventory, Anxiety Sensitivity Index) with significant improvement during detoxification. Additionally, CBZ-treated patients showed significantly better verbal memory performance during the first days of treatment. Without any addictive potential, CBZ therapy could be very supportive in alcohol detoxification. In addition a higher verbal memory performance state could be favourable for a psychotherapeutic approach.Type of Medium: Electronic ResourceURL: -
6Articles: DFG German National LicensesWohlrab, J. ; Jahn, K. ; Plaetzer, M. ; Neubert, R. ; Marsch, W.C.
Oxford, UK : Blackwell Science Ltd
Published 2001Staff ViewISSN: 1365-2133Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineType of Medium: Electronic ResourceURL: -
7Articles: DFG German National LicensesStaff View
ISSN: 0022-2313Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Chemistry and PharmacologyPhysicsType of Medium: Electronic ResourceURL: -
8Articles: DFG German National LicensesStaff View
ISSN: 0040-6031Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Chemistry and PharmacologyType of Medium: Electronic ResourceURL: -
9Articles: DFG German National LicensesStaff View
ISSN: 1539-6924Keywords: OSHA ; environmental health regulation ; risk ambiguity ; indoor/workplace air qualitySource: Springer Online Journal Archives 1860-2000Topics: Energy, Environment Protection, Nuclear Power EngineeringNotes: Abstract Political context may play a large role in influencing the efficiency of environmental and health regulations. This case study uses data from a 1989 update of the Occupational Safety and Health Administration (OSHA) Permissible Exposure Limits (PELs) program to determine the relative effects of legislative mandates, costly acquisition of information by the agency, and pressure applied by special interest groups upon exposure standards. The empirical analysis suggests that federal agencies successfully thwart legislative attempts to limit agency discretion, and that agencies exercise bounded rationality by placing greater emphasis on more easily obtained information. The 1989 PELs were less significantly related to more costly information, contained “safety factors” for chemicals presenting relatively more ambiguous risks, and the proposed standard stringencies showed evidence of being influenced by vying industry and labor interests.Type of Medium: Electronic ResourceURL: -
10Articles: DFG German National LicensesStaff View
ISSN: 1436-5057Keywords: 65G10 ; Interval mathematics ; Hausdorff distancesSource: Springer Online Journal Archives 1860-2000Topics: Computer ScienceDescription / Table of Contents: Zusammenfassung In der vorliegenden Arbeit werden für eine Klasse von Metriken in ℝ n , darunter die Hölder-Metriken, explizite Ausdrücke zur Berechnung der Werte der zugehörigen Hausdorff-Metriken entwickelt.Notes: Abstract In the present paper for a class of metrices in ℝ n including the Hölder metrices explicit expressions will be developed for evaluating the values of the corresponding Hausdorff metrices.Type of Medium: Electronic ResourceURL: -
11Articles: DFG German National LicensesStaff View
ISSN: 1436-5057Keywords: Primary: 93B05 ; Secondary: 65G10 ; Controllability set ; interval mathematicsSource: Springer Online Journal Archives 1860-2000Topics: Computer ScienceDescription / Table of Contents: Zusammenfassung Es wird eine Intervallmethode vorgeschlagen, mit deren Hilfe der Null-Steuerbarkeitsbereich von autonomen nichtlinearen Systemen approximiert werden kann.Notes: Abstract An interval computational method is proposed by means of which the null-controllability set of autonomous nonlinear systems can be approximated.Type of Medium: Electronic ResourceURL: -
12Articles: DFG German National LicensesStaff View
ISSN: 1432-1912Keywords: Brain slice ; Patch-clamp ; Rabbit ; Cyclic AMP ; Potassium current ; Histamine receptors Olfactory bulbSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract Effects of histamine, histamine agonists and antagonists on steady state current in principal neurons and interneurons were investigated in thin slices from the olfactory bulb of newborn rabbits with the nystatin perforated patch-clamp technique and local pipette application. No change in steady state current was observed in mitral cells. In most of the periglomerular, juxtaglomerular and granular cells, however, H1-receptor activation caused an outward current; a similar effect, but mostly not on the same neurons was elicited by 8-bromo-cyclic-AMP. These currents were reversed at the potassium equilibrium potential and blocked by apamin and therefore probably represent calcium sensitive potassium currents. H2-receptor activation caused an inward current which also reversed at the potassium equilibrium potential, indicating block of a potassium current. Specific H3-receptor activation and cyclic GMP were ineffective. Histamine usually caused a combined effect beginning with an inward current. Histaminergic neurons fire with changes in behavioural state and can, by the described mechanisms, markedly influence signal processing in the olfactory bulb.Type of Medium: Electronic ResourceURL: -
13Articles: DFG German National LicensesStaff View
ISSN: 1432-1912Keywords: Key words Brain slice ; Patch-clamp ; Rabbit ; Cyclic AMP ; Potassium current ; Histamine receptors ; Olfactory bulbSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract Effects of histamine, histamine agonists and antagonists on steady state current in principal neurons and interneurons were investigated in thin slices from the olfactory bulb of newborn rabbits with the nystatin perforated patch-clamp technique and local pipette application. No change in steady state current was observed in mitral cells. In most of the periglomerular, juxtaglomerular and granular cells, however, H1-receptor activation caused an outward current; a similar effect, but mostly not on the same neurons was elicited by 8-bromo-cyclic-AMP. These currents were reversed at the potassium equilibrium potential and blocked by apamin and therefore probably represent calcium sensitive potassium currents. H2-receptor activation caused an inward current which also reversed at the potassium equilibrium potential, indicating block of a potassium current. Specific H3-receptor activation and cyclic GMP were ineffective. Histamine usually caused a combined effect beginning with an inward current. Histaminergic neurons fire with changes in behavioural state and can, by the described mechanisms, markedly influence signal processing in the olfactory bulb.Type of Medium: Electronic ResourceURL: -
14Articles: DFG German National LicensesStaff View
ISSN: 1432-0711Source: Springer Online Journal Archives 1860-2000Topics: MedicineDescription / Table of Contents: Zusammenfassung Fallberichte und epidemiologische Untersuchungen zeigen deutlich, daß HIV von Männer auf Frauen, von Frauen auf Kinder in utero und von Frauen auf Männer übertragen werden kann. Studien über die heterosexuelle Übertragung belegen, daß das jeweilige Ausmaß der Übertragung verschieden sein kann: weibliche Partner von Männern mit HIV-Infektionen weisen die höchste Quote auf. Die Übertragung von infizierten Frauen auf ihre Kinder wird mit 65% angegeben. Im Rahmen einer multizentrischen Studie mit mehreren Frauenkliniken, die bereits Erfahrungen mit dem Krankheitsbild und der Betreuung von HIV-positiven Patienten haben, werden Fragestellungen nachgegangen, die in der Beratung und Behandlung zu Verbesserungen führen können.Notes: Summary Case studies and epidemic surveys clearly show that HIV can be transmitted from males to females, from females to children in utero, and from females to males, as well as from males to males. Studies of heterosexual transmission prove that the extent of transmission varies: female partners of HIV-infected men have the highest incidence; transmission from infected women to their children is approximately 25%–50%. The unsolved questions in gynecology and obstetrics are presented and examined on the basis of a multicenter study of the experience with AIDS and in consultation with HIV-infected patients, so that a better understanding of AIDS might lead to improved treatment and counselling.Type of Medium: Electronic ResourceURL: -
15Articles: DFG German National LicensesStaff View
ISSN: 1432-1351Keywords: Area postrema ; Rabbit ; Patch clamp ; Glutamate-receptor ; GABA-receptorSource: Springer Online Journal Archives 1860-2000Topics: BiologyMedicineNotes: Abstract Using the patch-clamp technique in combination with sliced tissue preparation the membrane properties of newborn rabbit area postrema neurons were investigated. The neurons responded upon depolarization with a fast Na +-current followed by an inactivating and non-inactivating K +-current. GABA-activated currents were investigated resulting in a large Cl--conductance, indicating the expression of GABAA-receptors. The expression of glutamate receptor mRNA was studied by in situ hybridization and electrophysiological measurements of these receptors by means of the patch-clamp technique. As a main result it was found that ionotropic glutamate receptors in the area postrema are composed of “flop” variants of the GluA-, GluB- and GluC-subunits.Type of Medium: Electronic ResourceURL: -
16Articles: DFG German National LicensesStaff View
ISSN: 1433-0407Keywords: Schlüsselwörter Schlaganfall ; Paraneoplastische Hämostasestörung ; Trousseau-Syndrom ; Ovarialtumor ; Atypische Endosalpingiose ; Key words Stroke ; Paraneoplastic hemostasis ; Trousseau’s syndrom ; Ovarian tumor ; Atypical endosalpingiosisSource: Springer Online Journal Archives 1860-2000Topics: MedicineDescription / Table of Contents: Summary Thrombembolic events as paraneoplastic complications in malignant disease account for severe morbidity and mortality in these patients. In some cases disturbance in hemostasis is the first manifestation of a neoplastic process. We report the cases of two patients with cerebral and extracerebral vessel occlusions, in whom epithelial tumors of low malignant potential (borderline-tumors) of ovar and peritoneum were diagnosed later on. In one case the removal of the tumor stopped the coagulation problems. The second patient died a few days after the first symptoms with devastating multiple vessel occlusion. In stroke of unknown aetiology a paraneoplastic process should be kept in mind. The diagnosis is more probable with recurrent thrombembolism in different body regions and when warfarin therapie was ineffective. Thoughtful coagulation studies and a tumor search program is recommended in these cases.Notes: Zusammenfassung Thrombembolische Komplikationen treten paraneoplastisch bei malignen Erkrankungen auf und tragen zu Morbidität und Mortalität bei. In einigen Fällen sind Hämostasestörungen die erste Manifestation eines neoplastischen Prozesses. Wir beschreiben die Fälle von zwei Patientinnen mit zerebralen und extrazerebralen Gefäßverschlüssen, bei denen nach der Gefäßmanifestation epitheliale Tumoren mit niedrigem Malignitätspotential (Borderline-Tumoren) an Ovar und Peritoneum diagnostiziert wurden. Paraneoplastische Hämostasestörungen sind bei diesen Tumoren mit per se guter Prognose bisher nicht beschrieben worden. In einem Fall führte die Tumorentfernung zum Sistieren der Gerinnungsstörung. Die zweite Patientin starb wenige Tage nach den ersten Symptomen an den Folgen multipler Gefäßverschlüsse. Bei Schlaganfällen unklarer Ätiologie sollte auch an eine paraneoplastische Genese gedacht werden. Besonders wahrscheinlich ist die Diagnose bei rezidivierenden venösen und arteriellen Gefäßverschlüssen in verschiedenen Körperregionen und bei der Resistenz auf die Therapie mit Vitamin-K-Antagonisten. Eine sorgfältige Gerinnungsdiagnostik und ein Tumorsuchprogramm sind in diesen Fällen zu empfehlen.Type of Medium: Electronic ResourceURL: -
17Articles: DFG German National LicensesStaff View
ISSN: 1436-5057Keywords: 65G05 ; 65G10 ; 68Q60 ; Floating-point algorithm ; directed rounding ; loop invariant ; result verificationSource: Springer Online Journal Archives 1860-2000Topics: Computer ScienceDescription / Table of Contents: Zusammenfassung Es wird gezeigt, daß unter Benutzung von gerichteten Rundungen bzw. Einschließungsmengen für die jeweils exakten Werte Schleifen-Bedingungen und Schleifen-Invarianten aus den für das exakte Rechnen aufgestellten numerischen Algorithmen auf naheliegende Weise für das Rechnen in Gleitpunktrastern verallgemeinert werden können. Dadurch ist trotz des Auftretens von Rundungsfehlern eine Verifikation der erhaltenen Ergebnisse möglich. Verwendet werden dazu nur dem Algorithmus innewohnende Eigenschaften, die gleichzeitig ein Terminieren der Schleifen bewirken.Notes: Abstract It will be shown that by using directed roundings resp. enclosure sets for the exact values, the loop conditions and loop invariants of numerical algorithms can be generalized for computing in a discrete screen. On this way, in spite of rounding errors, it is possible to verify the received results. Thereby only inherent properties of the algorithms are used, which moreover guarantee that the loops terminate.Type of Medium: Electronic ResourceURL: -
18Articles: DFG German National LicensesStaff View
ISSN: 1436-5057Keywords: Primary: 65G10 ; Secondary: 65J15 ; Interval mathematics ; fixed point theoremsSource: Springer Online Journal Archives 1860-2000Topics: Computer ScienceDescription / Table of Contents: Abstract The main result of this paper is a fixed point theorem for interval functions. This theorem and two additional fixed point theorems will be applied to linear and nonlinear algebraic equations and to nonlinear integral equations.Notes: Zusammenfassung Das Hauptresultat dieser Arbeit ist ein Fixpunktsatz für Intervallfunktionen. Dieser Satz und zwei weitere Fixpunktsätze werden angewandt auf lineare und nichtlineare algebraische Gleichungen sowie auf nichtlineare Integralgleichungen.Type of Medium: Electronic ResourceURL: -
19Articles: DFG German National LicensesStaff View
ISSN: 1420-8989Source: Springer Online Journal Archives 1860-2000Topics: MathematicsType of Medium: Electronic ResourceURL: -
20Articles: DFG German National LicensesSchmitt, H. J. ; Wirsing von König, C. H. ; Zepp, F. ; Huff, J. ; Jahn, K. ; Schmidtke, P. ; Meyer, C. ; Habermehl, P. ; Uhlenbusch, R. ; Angersbach, P.
Springer
Published 1997Staff ViewISSN: 1439-0973Source: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Summary To evaluate the reactogenicity and immunogenicity of aHaemophilus influenzae type b conjugate vaccine (HbOC) and of a tricomponent acellular pertussis vaccine (DTaP) when injected simultaneously into either contralateral arms or into contralateral thighs, 110 infants were enrolled to receive three doses of DTaP at 3, 4, and 5 months and two HbOC doses at 3 and 5 months of age. Administration of either of the two vaccines into arms was associated with significantly more local side effects than administration into thighs. There was no difference in geometric mean concentration (GMC) values for any of the four vaccine antigens between subjects who had been vaccinated into arms or thighs. After immunization, all children had protective antibody titers to diphtheria toxin. While post vaccination the mean anti-tetanus toxoid GMC was ≥ 1.25 IU/ml, there was no significant rise as compared to the GMC before vaccination. GMCs of antibodies against the various pertussis antigens were similar to those observed before with the same DTaP vaccine. The simultaneous administration of DTaP and HbOC was safe and immunogenic irrespective of the site of vaccine administration, but significantly more local reactions occurred when vaccines were injected into arms.Type of Medium: Electronic ResourceURL: