Search Results - (Author, Cooperation:K. J. Tracey)
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1Latest Papers from Table of Contents or Articles in PressM. Rosas-Ballina ; P. S. Olofsson ; M. Ochani ; S. I. Valdes-Ferrer ; Y. A. Levine ; C. Reardon ; M. W. Tusche ; V. A. Pavlov ; U. Andersson ; S. Chavan ; T. W. Mak ; K. J. Tracey
American Association for the Advancement of Science (AAAS)
Published 2011Staff ViewPublication Date: 2011-09-17Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Acetylcholine/*biosynthesis ; Action Potentials ; Animals ; CD4-Positive T-Lymphocytes/*immunology/*metabolism ; Choline O-Acetyltransferase/metabolism ; Cholinergic Agents/metabolism ; Female ; *Immunity, Innate ; Immunologic Memory ; Inflammation ; Lymphocyte Activation ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; *Neuroimmunomodulation ; Norepinephrine/pharmacology ; Receptors, Nicotinic/metabolism ; Signal Transduction ; Spleen/immunology/innervation/metabolism ; T-Lymphocyte Subsets/immunology/metabolism ; Tumor Necrosis Factor-alpha/blood ; Vagus Nerve/*physiology ; Vagus Nerve Stimulation ; alpha7 Nicotinic Acetylcholine ReceptorPublished by: -
2Latest Papers from Table of Contents or Articles in PressB. Lu ; T. Nakamura ; K. Inouye ; J. Li ; Y. Tang ; P. Lundback ; S. I. Valdes-Ferrer ; P. S. Olofsson ; T. Kalb ; J. Roth ; Y. Zou ; H. Erlandsson-Harris ; H. Yang ; J. P. Ting ; H. Wang ; U. Andersson ; D. J. Antoine ; S. S. Chavan ; G. S. Hotamisligil ; K. J. Tracey
Nature Publishing Group (NPG)
Published 2012Staff ViewPublication Date: 2012-07-18Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Adaptor Proteins, Signal Transducing/metabolism ; Adenosine Triphosphate/pharmacology ; Animals ; Antigens, Bacterial/pharmacology ; Apoptosis Regulatory Proteins/metabolism ; Bacterial Toxins/pharmacology ; CARD Signaling Adaptor Proteins/metabolism ; Calcium-Binding Proteins/metabolism ; Carrier Proteins/metabolism ; Cell Line ; Cells, Cultured ; Crystallins/metabolism ; Escherichia coli/immunology/physiology ; Escherichia coli Infections/immunology/metabolism ; Female ; HMGB1 Protein/blood/*secretion ; Humans ; Inflammasomes/agonists/*metabolism ; Interleukin-18/blood ; Interleukin-1beta/blood ; Interleukin-6/analysis/blood ; Macrophages, Peritoneal/drug effects/metabolism ; Male ; Membrane Proteins/metabolism ; Mice ; Mice, Inbred C57BL ; Peritonitis/metabolism ; Phosphorylation ; RNA, Double-Stranded/immunology/pharmacology ; Rotenone/pharmacology ; Salmonella Infections/immunology/metabolism ; Salmonella typhimurium/immunology/physiology ; Transfection ; Uric Acid/pharmacology ; eIF-2 Kinase/antagonists & inhibitors/deficiency/genetics/*metabolismPublished by: -
3Latest Papers from Table of Contents or Articles in PressK. Famm ; B. Litt ; K. J. Tracey ; E. S. Boyden ; M. Slaoui
Nature Publishing Group (NPG)
Published 2013Staff ViewPublication Date: 2013-04-13Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: *Action Potentials/physiology ; Animals ; Drug Discovery ; Electric Stimulation Therapy/*methods/*trends ; Humans ; Interdisciplinary Communication ; *Neural Pathways/physiologyPublished by: -
4Latest Papers from Table of Contents or Articles in PressStaff View
Publication Date: 2011-05-10Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Action Potentials ; Afferent Pathways ; Animals ; Caenorhabditis elegans/*immunology/microbiology ; Caenorhabditis elegans Proteins/genetics/*physiology ; Cytokines/metabolism ; Humans ; *Immunity, Innate ; Pseudomonas aeruginosa/*immunology/pathogenicity ; Receptors, G-Protein-Coupled/genetics/*physiology ; Sensory Receptor Cells/*physiology ; Signal Transduction ; *Unfolded Protein ResponsePublished by: -
5Articles: DFG German National LicensesMullins, G. E. ; Sunden-Cullberg, J. ; Johansson, A.-S. ; Rouhiainen, A. ; Erlandsson-Harris, H. ; Yang, H. ; Tracey, K. J. ; Rauvala, H. ; Palmblad, J. ; Andersson, J. ; Treutiger, C. J.
Oxford, UK; Malden, USA : Blackwell Science Ltd
Published 2004Staff ViewISSN: 1365-3083Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: The nuclear protein high-mobility group box chromosomal protein 1 (HMGB1) was recently described to act as a pro-inflammatory cytokine and as a late mediator of severe sepsis and septic shock. The protein is released from monocytes in response to endotoxin and activates monocytes and endothelial cells through nuclear factor kappa B. We have previously demonstrated that the B-box of HMGB1 mediates a pro-inflammatory effect on endothelial cells including the upregulation of cell-adhesion molecules and release of interleukin (IL)-8 and granulocyte colony-stimulating factor. Here, we report that HMGB1 is released from human umbilical vein endothelial cells (HUVEC) in response to lipopolysaccharide (LPS) and tumour necrosis factor (TNF)-α. A nuclear relocation of HMGB1 to the cytoplasm was seen at 4 h. Subsequently, high amounts of HMGB1 could be seen in the supernatants from stimulated cells after 16 h. It was also observed that the pro-inflammatory activity of HMGB1 is sensitive to dexamethasone. Interestingly, the HMGB1-induced TNF-α release from monocytes could be inhibited by either the A-box of the protein or the p38 inhibitor CNI-1493, but neither had any inhibitory effects on the HMGB1-dependent upregulation of cell-adhesion molecules on HUVEC. Altogether, these results suggest that HUVEC may be an important source of HMGB1 secretion in response to systemic infection and that endothelial cells and monocytes may use different signalling pathways.Type of Medium: Electronic ResourceURL: -
6Articles: DFG German National LicensesBernhagen, J. ; Calandra, T. ; Mitchell, R. A. ; Martin, S. B. ; Tracey, K. J. ; Voelter, W. ; Manogue, K. R. ; Cerami, A. ; Bucala, R.
[s.l.] : Nature Publishing Group
Published 1993Staff ViewISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] The anterior pituitary cell line AtT-20 was cultured serum-free in the presence of increasing amounts of bacterial endotoxin Escherichia coli 0111 :B4 LPS). Conditioned media were analysed at different times for secreted proteins by SDS-polyacryla-mide gel electrophoresis. Endotoxin stimulation ...Type of Medium: Electronic ResourceURL: