Search Results - (Author, Cooperation:K. Ishihara)

2018-04-04

The American Society for Pharmacology and Experimental Therapeutics

0022-3565

1521-0103

Medicine

2018-08-17

Institute of Physics (IOP)

1757-8981

1757-899X

Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics

2018-07-14

American Physical Society (APS)

1098-0121

1095-3795

Physics

Superfluidity and superconductivity

2014-10-11

American Association for the Advancement of Science (AAAS)

0036-8075

1095-9203

Biology

Chemistry and Pharmacology

Computer Science

Medicine

Natural Sciences in General

Physics

Animals ; Cell Membrane/chemistry/*physiology ; *Cell-Free System ; Centrosome/physiology ; *Cytokinesis ; DNA-Binding Proteins/genetics/metabolism ; Guanosine Triphosphate/metabolism ; Kinesin/genetics/metabolism ; Lipid Bilayers ; Microtubules/physiology ; Models, Biological ; Nuclear Proteins/genetics/metabolism ; *Signal Transduction ; Xenopus laevis ; rhoA GTP-Binding Protein/metabolism

2014-07-19

American Association for the Advancement of Science (AAAS)

0036-8075

1095-9203

Biology

Chemistry and Pharmacology

Computer Science

Medicine

Natural Sciences in General

Physics

Catalysis ; Catalytic Domain ; Chromans/*chemistry ; Cyclization ; Iodine Compounds/*chemistry ; Ketones/*chemistry ; Oxidation-Reduction ; Quaternary Ammonium Compounds/chemistry ; Tocopherols/*chemical synthesis/chemistry ; tert-Butylhydroperoxide/chemistry

2018-08-17

Institute of Physics (IOP)

1757-8981

1757-899X

Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics

2018-08-17

Institute of Physics (IOP)

1757-8981

1757-899X

Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics

1365-2230

Blackwell Publishing Journal Backfiles 1879-2005

Medicine

Summary The effects of a newly synthesized phospholipid polymer, poly(2-methacryloyloxyethyl phosphorylcholine-co-n-butyl methacrylate) [poly(MPC-co-BMA)], on the water barrier function and water-holding capacity of the stratum corneum were examined by measuring transepidermal water loss (TEWL) and electrical conductance of the skin surface. On the backs of four NC mice, the epidermal permeability barrier was abrogated by cellophane tape stripping 30 times. The skin was then treated with 0.1% poly(MPC-co-BMA) or distilled water twice daily for the following 3 days. Poly(MPC-co-BMA) reduced TEWL significantly compared with the control after the first treatment (P = 0.044) and this effect was observed for 3 days. In human skin, water-holding capacity was measured at 5, 10, 15, 30 min and 1, 2, and 4 h after the application of poly(MPC-co-BMA) or distilled water to both volar forearms of 21 healthy volunteers. Skin treated with poly(MPC-co-BMA) showed significantly greater ability to retain water at all time points. Poly(MPC-co-BMA) is the first synthetic material that can enhance both the water barrier function and water-holding capacity of the stratum corneum. Our results indicate that this substance may be useful clinically in the treatment of dry skin.

Electronic Resource

1089-7550

AIP Digital Archive

Physics

Bulk Fe/Ag multilayers with layer thickness of about 10 nm have been successfully fabricated by repeated press-rolling directly from a macroscopic stack of metal sheets. The press-rolled multilayers exhibited giant magnetoresistance of 13% in the current perpendicular to the plane geometry and 4% in the current in the plane geometry at 5 K. © 1997 American Institute of Physics.

Electronic Resource

1600-0560

Blackwell Publishing Journal Backfiles 1879-2005

Medicine

Forty-nine cases of cutaneous malignant lymphoma were reviewed in order to analyze the clinicopathological features of these neoplasms. Excluding 13 cases of mycosis fungoides and 4 cases of cutaneous involvement of proven adult T-cell lymphoma/leukemia, the remaining 32 cases were further classified according to their pathological and clinical features. There were 12 primary cutaneous lymphomas, 15 cases of secondary cutaneous involvement of systemic lymphoma, and 5 cases of concurrent skin and lymph node involvement. Histologically, large cell lymphoma predominated in both primary and secondary cutaneous lymphomas. Immunohistochemical study using monoclonal antibodies reactive with B- and T-cells in paraffin sections revealed the cellular lineage in 30 cases. Nineteen cases were of T-cell origin and 11 cases were of B-cell derivation. The prognosis of these patients was rather poor; 25 patients died within 5 years. The predominance of T-cell lymphoma contrasts with a higher frequency of cutaneous B-cell lymphoma in Western countries. As the clinicopathological features of cutaneous lymphomas are diverse, it is suggested that cutaneous lymphomas should be classified and studied in a similar way to their nodal counterparts.

Electronic Resource

1365-3040

Blackwell Publishing Journal Backfiles 1879-2005

Biology

The hydrotropic bending of roots of an ageotropic pea mutant, ageotropum, was studied in humid air in a chamber with a steady humidity gradient. We examined the effects of atmospheric humidity around the root on the water status of root tissues, as well as the wall growth and the hydraulic properties of the elongating tissues. Atmospheric humidity at the surface of the root was clearly lower on the side orientated towards the air with lower humidity than on the side orientated towards the air with higher humidity. However, there were no differences in water potential and osmotic potential between the tissues that faced air with higher and lower humidities in the elongating and mature regions. Plastic extensibility was higher in the tissues that faced the air with lower humidity than in the tissues that faced the air with higher humidity. No differences in turgor pressure and yield threshold were observed between the tissues that faced air with higher and lower humidities. Therefore, the extensibility of the cell wall appeared to be responsible for the different growth rates of tissues in root hydrotropism. A further probable cause of the hydrotropical bending of roots is changes in the hydraulic conductance in the elongating tissues. Since the hydrotropic bending of roots occurred only when a root tip was exposed to a humidity gradient, hydrotropism might occur after perception of a difference in humidity by the root tip, with accompanying changes in cell wall extensibility and hydraulic conductance.

Electronic Resource

1600-0765

Blackwell Publishing Journal Backfiles 1879-2005

Medicine

This study was undertaken to determine the immunodominant antigens from Porphyromonas gingivalis which reacted with sera from patients of pubertal and adult gingivitis. The patients with cultivable P. gingivalis and the patients without cultivable P. gingivalis were compared by immunoblots. Fifty subjects participated in this study: 20 with gingivitis, 20 periodontally healthy, and 10 with adult periodontitis. The groups with gingivitis and healthy periodontium each contained 10 pubescent subjects and 10 adult subjects. P. gingivalis was isolated from 9 of 20 patients with gingivitis and from all of 10 with periodontitis by culture study. Approximate molecular weight 43 KDa fimbriae antigen, 57, 53, 46, 28 KDa antigens from outer membrane, and 57, 44, 40, 18.5 KDa antigens from sonicated extracts of P. gingivalis reacted significantly more frequently with sera from the P. gingivalis culture-positive gingivitis patients than with sera from the culture-negative patients by Fisher's exact test. A molecular weight 75, 31 KDa antigen from outer membrane and a 46 KDa antigen from sonicated extract were immunodominant in sera from adult patients with periodontitis. These findings indicate that the specific antigens which reacted with sera from P. gingivalis culture-positive patients are markers of infection with P. gingivalis. Additionally, reactivity to antigens were slightly different between sera from patients with gingivitis and those from patients with periodontitis.

Electronic Resource

1600-0765

Blackwell Publishing Journal Backfiles 1879-2005

Medicine

Localization of Porphyromonas gingivalis and Treponema denticola in different areas of subgingival plaque from advanced adult periodontitis patients was studied immunohistochemically using sensitive immunogold-silver staining and immunoelectron microscopy. Fourteen periodontally diseased teeth were extracted without damaging the subgingival plaque, fixed, and embedded. The subgingival plaque samples were sectioned according to four different pocket depths (0–2 mm, 2–4 mm, 4–6 mm and ≤6 mm). Serial thin sections were stained using specific antisera to P. gingivalis or T. denticola and then with secondary antibody labelled with colloidal-gold. Cells of both P. gingivalis and T. denticola were predominantly found in subgingival plaque located at depths of more than 4 mm in periodontal pockets. T. denticola cells were found in the surface layers of subgingival plaque, and P. gingivalis were predominant beneath them. However, in the deeper subgingival plaque, the coexistence of P. gingivalis and T. denticola was observed. The present findings suggest that P. gingivalis and T. denticola play important roles in the pathogenicity of periodontal disease and provide the useful information for elucidating the pattern of colonization of microorganisms in the periodontal pocket.

Electronic Resource

0011-2240

Elsevier Journal Backfiles on ScienceDirect 1907 - 2002

Biology

Medicine

Electronic Resource

1365-2559

Blackwell Publishing Journal Backfiles 1879-2005

Medicine

AimsTo investigate the histogenetic relationship between gastric epithelial neoplasms we studied differences in expression of mucin carbohydrate antigens and mucin core protein, in normal and metaplastic gastric mucosa, and in gastric adenomas and superficial adenocarcinomas.Methods and resultsWe generated four monoclonal antibodies, including HGM72/75 against human gastric mucin and HCM14/21 against human colonic mucin, and investigated immunoreactivities of these antibodies and MUC2 protein expression in normal and metaplastic gastric mucosa, adenomas (15 samples) and superficial adenocarcinomas (intestinal-type, 77; diffuse-type, 59 samples). HGM72 reacted with mucous neck cells of the fundic glands and with pyloric glandular cells whereas HGM75 stained foveolar cells and metaplastic goblet cells. Weak binding of HCM14/21 and strong staining with MUC2 were found in metaplastic goblet cells. Binding of HGM75, HCM14, MUC2, but not HGM72 was high in adenomas. An equivalent staining with HGM72 and HGM75 with low expression of MUC2 and HCM14 was shown in intestinal-type carcinomas while the diffuse-type demonstrated more strong reactivity with HGM75 than with HGM72, MUC2 and HCM14. Little binding of HCM21 was observed in any specimens.ConclusionsThis study demonstrates that adenomas predominantly have a intestinal phenotype, but both types of adenocarcinomas retain some cells with a gastric phenotype during the early steps of neoplastic development.

Electronic Resource

1365-2133

Blackwell Publishing Journal Backfiles 1879-2005

Medicine

Summary We report the successful treatment of a patient with plaque-stage mycosis fungoides with long-term and intravenous administration of recombinant human interferon-γ (IFN-γ) and discuss the possible mechanisms of this therapy.A 55-year-old female patient had been resistant to existing treatments and had suffered repeated exacerbations over a 5-year period. Four weeks after initiation of 2 × 106U/day of IFN-γ. a 〉 10% decrease in the affected surface area was noted. Twenty-two weeks after the administration of 228 × 106U of IFN-γ, complete remission (CR) was obtained. The CR continued for 13 weeks, but this was followed by an exacerbation. The second CR was obtained after the IFN-γ dosage was increased to 16 × 106U/week. The dosage was then gradually reduced by 2–4 × 106U every 2 or 3 months. She was treated with a total dose of 2814 × 106 of IFN-γ. She has been followed up for more than 6 years, and there has been no recurrence of mycotic skin lesions nor any visceral involvement. During therapy, no serious side-effects were noted.Long-term administration of IFN-γ is useful for the treatment of patients with intractable mycosis fungoides. A gradual decrease in the dose of IFN-γ is important for maintaining remission.

Electronic Resource

1365-2133

Blackwell Publishing Journal Backfiles 1879-2005

Medicine

Electronic Resource

0006-291X

Elsevier Journal Backfiles on ScienceDirect 1907 - 2002

Biology

Chemistry and Pharmacology

Physics

Electronic Resource

0020-1693

Elsevier Journal Backfiles on ScienceDirect 1907 - 2002

Chemistry and Pharmacology

Electronic Resource

0020-1693

Elsevier Journal Backfiles on ScienceDirect 1907 - 2002

Chemistry and Pharmacology

Electronic Resource