Search Results - (Author, Cooperation:K. Iqbal)

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  1. 1
    T. P. Gu ; F. Guo ; H. Yang ; H. P. Wu ; G. F. Xu ; W. Liu ; Z. G. Xie ; L. Shi ; X. He ; S. G. Jin ; K. Iqbal ; Y. G. Shi ; Z. Deng ; P. E. Szabo ; G. P. Pfeifer ; J. Li ; G. L. Xu
    Nature Publishing Group (NPG)
    Published 2011
    Staff View
    Publication Date:
    2011-09-06
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    5-Methylcytosine/metabolism ; Alleles ; Animals ; *Cellular Reprogramming ; Cytosine/analogs & derivatives/metabolism ; DNA/chemistry/genetics/metabolism ; DNA Methylation/genetics ; DNA-Binding Proteins/deficiency/genetics/*metabolism ; Dioxygenases/genetics/*metabolism ; Embryo, Mammalian/embryology/metabolism ; Embryonic Development ; *Epigenesis, Genetic ; Female ; Fertility/genetics ; Gene Expression Regulation, Developmental ; Germ Cells/metabolism ; Male ; Mice ; Octamer Transcription Factor-3/genetics ; Oocytes/cytology/*enzymology/*metabolism ; Oxidation-Reduction ; Proto-Oncogene Proteins/deficiency/genetics/*metabolism ; Zygote/cytology/metabolism
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  2. 2
    McDermott, J. R. ; Iqbal, K. ; Wisniewski, H. M.

    Oxford, UK : Blackwell Publishing Ltd
    Published 1977
    Staff View
    ISSN:
    1471-4159
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Notes:
    Abstract— Oligodendroglia isolated from frozen human brain induced EAE in the guinea pig when injected with Freund's complete adjuvant. An acid extract of the isolated cells was highly encephalitogenic. The disease was clinically and histologically similar to EAE induced with CNS white matter or myelin basic protein(MBP). The isolated cells were essentially myelin-free but contained a large amount of myelin basic protein as determined by polyacrylamide gel electrophoresis. It was shown that the cells can absorb 125I-MBP during isolation and the possibility that contamination from extra cellular MBP is responsible for the encephalitogenic activity is considered.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1111/j.1471-4159.1977.tb10672.x

    Articles: DFG German National Licenses
  3. 3
    Iqbal, K. ; Grundke-Iqbal, I. ; Wisniewski, H. M. ; Terry, R. D.

    Oxford, UK : Blackwell Publishing Ltd
    Published 1977
    Staff View
    ISSN:
    1471-4159
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Notes:
    Abstract— Neurofilaments and neurotubules are the principal fibers of the mature normal neuron. In this study the protein subunits of these neurofibrils were isolated from human autopsy tissue, and compared by sodium dodecyl sulfate-polyacrylamide gel electrophoresis, and by two dimensional peptide maps of the tryptic digest of these proteins labelled with 125I. The α and the β monomers of neurotubule are related but distinct in their peptide maps, while the major neurofilament protein subunit (molecular weight, 50,000) is remarkably similar to β tubulin. The neurofilament fraction binds colchicine, but the specificity is not yet determined. Neurotubule and neurofilament are also similar in having minor proteins which coelectrophorese on the gels. These results suggest that neurofilament and neurotubule may share one or more protein subunits.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1111/j.1471-4159.1977.tb10689.x

    Articles: DFG German National Licenses
  4. 4
    Ritchie, K. ; Bradbury, I. ; Slattery, J. ; Wright, D. ; Iqbal, K. ; Penney, G.

    Oxford, UK and Malden, USA : Blackwell Science Ltd
    Published 2005
    Staff View
    ISSN:
    1471-0528
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Notes:
    Objective  Within the framework of a health technology assessment and using an economic model, to determine the most clinically and cost effective policy of scanning and screening for fetal abnormalities in early pregnancy.Design  A discrete event simulation model of 50,000 singleton pregnancies.Setting  Maternity services in Scotland.Population  Women during the first 24 weeks of their pregnancy.Methods  The mathematical model was populated with data on uptake of screening, prevalence, detection and false positive rates for eight fetal abnormalities and with costs for ultrasound scanning and serum screening. Inclusion of abnormalities was based on the relative prevalence and clinical importance of conditions and the availability of data. Six strategies for the identification of abnormalities prenatally including combinations of first and second trimester ultrasound scanning and first and second trimester screening for chromosomal abnormalities were compared.Main outcome measures  The number of abnormalities detected and missed, the number of iatrogenic losses resulting from invasive tests, the total cost of strategies and the cost per abnormality detected were compared between strategies.Results  First trimester screening for chromosomal abnormalities costs more than second trimester screening but results in fewer iatrogenic losses. Strategies which include a second trimester ultrasound scan result in more abnormalities being detected and have lower costs per anomaly detected.Conclusions  The preferred strategy includes both first and second trimester ultrasound scans and a first trimester screening test for chromosomal abnormalities. It has been recommended that this policy is offered to all women in Scotland.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1111/j.1471-0528.2005.00560.x

    Articles: DFG German National Licenses
  5. 5
    Staff View
    ISSN:
    0006-291X
    Keywords:
    [abr] ALS; amyotrophic lateral sclerosis ; [abr] ND2; NADH dehydrogenase (EC 1.6.99.3) subunit 2 ; [abr] ND4; NADH dehydrogenase (EC 1.6.99.3) subunit 4 ; [abr] NFT; neurofibrillary tangles ; [abr] PCR; polymerase chain reaction ; [abr] PHF; paired helical filaments ; [abr] SNuPE; single nucleotide primer extension ; [abr] pfu; plaques forming unit
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Biology
    Chemistry and Pharmacology
    Physics
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1016/S0006-291X(05)80136-6

    Articles: DFG German National Licenses
  6. 6
    Staff View
    ISSN:
    0003-9861
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Biology
    Chemistry and Pharmacology
    Physics
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1006/abbi.1993.1112

    Articles: DFG German National Licenses
  7. 7
    Staff View
    ISSN:
    0006-291X
    Keywords:
    [abr] ALS; amyotrophic lateral sclerosis ; [abr] ND2; NADH dehydrogenase (EC 1.6.99.3) subunit 2 ; [abr] ND4; NADH dehydrogenase (EC 1.6.99.3) subunit 4 ; [abr] NFT; neurofibrillary tangles ; [abr] PCR; polymerase chain reaction ; [abr] PHF; paired helical filaments ; [abr] SNuPE; single nucleotide primer extension ; [abr] pfu; plaques forming unit
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Biology
    Chemistry and Pharmacology
    Physics
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1016/S0006-291X(05)80136-6

    Articles: DFG German National Licenses
  8. 8
    Murthy, L.R. ; Iqbal, K.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    0003-2697
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Biology
    Chemistry and Pharmacology
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1016/0003-2697(91)90025-O

    Articles: DFG German National Licenses
  9. 9
    Iqbal, K. ; Smith, A.J. ; Zaidi, T. ; Grundke-Iqbal, I.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    0014-5793
    Keywords:
    Amino acid sequencing ; Cyanogen bromide cleavage ; Microtubule ; Protein phosphorylation ; Protein, tau
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Biology
    Chemistry and Pharmacology
    Physics
    Type of Medium:
    Electronic Resource
    URL:
    http://linkinghub.elsevier.com/retrieve/pii/0014-5793(89)80437-5

    Articles: DFG German National Licenses
  10. 10
    Khatoon, S. ; Grundke-Iqbal, I. ; Iqbal, K.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    0014-5793
    Keywords:
    Abnormally phosphorylated tau ; Alzheimer disease ; Microtubule associated protein tau ; Neurofibrillary degeneration ; Radioimmunoslot-blot assay
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Biology
    Chemistry and Pharmacology
    Physics
    Type of Medium:
    Electronic Resource
    URL:
    http://linkinghub.elsevier.com/retrieve/pii/0014-5793(94)00829-9

    Articles: DFG German National Licenses
  11. 11
    Iqbal, K. ; Zaidi, T. ; Bancher, C. ; Grundke-Iqbal, I.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    0014-5793
    Keywords:
    Alzheimer disease ; Microtubule assembly ; Microtubule associated protein tau ; Paired helical filament ; Protein dephosphorylation
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Biology
    Chemistry and Pharmacology
    Physics
    Type of Medium:
    Electronic Resource
    URL:
    http://linkinghub.elsevier.com/retrieve/pii/0014-5793(94)00650-4

    Articles: DFG German National Licenses
  12. 12
    Staff View
    ISSN:
    0021-9673
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Chemistry and Pharmacology
    Type of Medium:
    Electronic Resource
    URL:
    http://linkinghub.elsevier.com/retrieve/pii/0021-9673(92)87124-Q

    Articles: DFG German National Licenses
  13. 13
    Guzman, N.A. ; Ali, H. ; Moschera, J. ; Iqbal, K. ; Malick, A.W.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    0021-9673
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Chemistry and Pharmacology
    Type of Medium:
    Electronic Resource
    URL:
    http://linkinghub.elsevier.com/retrieve/pii/0021-9673(91)80080-Z

    Articles: DFG German National Licenses
  14. 14
    Staff View
    ISSN:
    0021-9673
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Chemistry and Pharmacology
    Type of Medium:
    Electronic Resource
    URL:
    http://linkinghub.elsevier.com/retrieve/pii/0021-9673(92)85122-A

    Articles: DFG German National Licenses
  15. 15
    Saska, M. ; Clarke, S.J. ; Di Wu, M. ; Iqbal, K.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    0021-9673
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Chemistry and Pharmacology
    Type of Medium:
    Electronic Resource
    URL:
    http://linkinghub.elsevier.com/retrieve/pii/0021-9673(92)87016-2

    Articles: DFG German National Licenses
  16. 16
    Dahiya, J.N. ; Iqbal, K. ; Kraft, H.G. ; Eue, W.C. ; Bevan, J.W.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    0020-0891
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Physics
    Type of Medium:
    Electronic Resource
    URL:
    http://linkinghub.elsevier.com/retrieve/pii/0020-0891(82)90021-5

    Articles: DFG German National Licenses
  17. 17
    Iqbal, K. ; Owen, N.L. ; Sheridan, J.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    0022-2860
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Chemistry and Pharmacology
    Physics
    Type of Medium:
    Electronic Resource
    URL:
    http://linkinghub.elsevier.com/retrieve/pii/0022-2860(80)80123-2

    Articles: DFG German National Licenses
  18. 18
    Kumar, A. ; Iqbal, K. ; Owen, N.L. ; Sheridan, J.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    0022-2860
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Chemistry and Pharmacology
    Physics
    Type of Medium:
    Electronic Resource
    URL:
    http://linkinghub.elsevier.com/retrieve/pii/0022-2860(80)80124-4

    Articles: DFG German National Licenses
  19. 19
    Iqbal, K. ; Owen, N.L.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    0022-2860
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Chemistry and Pharmacology
    Physics
    Type of Medium:
    Electronic Resource
    URL:
    http://linkinghub.elsevier.com/retrieve/pii/0022-2860(81)85106-X

    Articles: DFG German National Licenses
  20. 20
    Gong, C.-X. ; Grundke-Iqbal, I. ; Damuni, Z. ; Iqbal, K.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    0014-5793
    Keywords:
    Alzheimer disease ; Dephosphorylation ; Protein phosphatase ; Tau
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Biology
    Chemistry and Pharmacology
    Physics
    Type of Medium:
    Electronic Resource
    URL:
    http://linkinghub.elsevier.com/retrieve/pii/0014-5793(94)80247-5

    Articles: DFG German National Licenses