Search Results - (Author, Cooperation:K. Hogan)
-
1Latest Papers from Table of Contents or Articles in PressE. Tran ; S. Turcotte ; A. Gros ; P. F. Robbins ; Y. C. Lu ; M. E. Dudley ; J. R. Wunderlich ; R. P. Somerville ; K. Hogan ; C. S. Hinrichs ; M. R. Parkhurst ; J. C. Yang ; S. A. Rosenberg
American Association for the Advancement of Science (AAAS)
Published 2014Staff ViewPublication Date: 2014-05-09Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Adaptor Proteins, Signal Transducing/*genetics ; Adoptive Transfer/*methods ; Adult ; Bile Duct Neoplasms/genetics/*therapy ; *Bile Ducts, Intrahepatic ; CD4-Positive T-Lymphocytes/*immunology ; Cholangiocarcinoma/genetics/*therapy ; Clinical Trials, Phase II as Topic ; Exome ; Female ; Humans ; Lymphocytes, Tumor-Infiltrating/*transplantation ; Mutation ; Receptor, ErbB-2/metabolism ; Th1 Cells/*transplantationPublished by: -
2Latest Papers from Table of Contents or Articles in PressA. Viros ; B. Sanchez-Laorden ; M. Pedersen ; S. J. Furney ; J. Rae ; K. Hogan ; S. Ejiama ; M. R. Girotti ; M. Cook ; N. Dhomen ; R. Marais
Nature Publishing Group (NPG)
Published 2014Staff ViewPublication Date: 2014-06-12Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Base Sequence ; Cell Transformation, Neoplastic/*genetics/*radiation effects ; DNA Damage/genetics ; Disease Models, Animal ; Female ; Humans ; Melanocytes/metabolism/pathology/radiation effects ; Melanoma/etiology/*genetics/metabolism/*pathology ; Mice ; Mice, Inbred C57BL ; Mutagenesis/genetics/*radiation effects ; Mutation/genetics/radiation effects ; Nevus/etiology/genetics/metabolism/pathology ; Proto-Oncogene Proteins B-raf/*genetics/metabolism ; Skin Neoplasms/etiology/genetics/metabolism/pathology ; Sunburn/complications/etiology/genetics ; Sunscreening Agents/pharmacology ; Tumor Suppressor Protein p53/*genetics/metabolism ; Ultraviolet Rays/*adverse effectsPublished by: -
3Articles: DFG German National LicensesWHITEHEAD, D. ; LIVINGSTON, N. J. ; KELLIHER, P.M. ; HOGAN, K. P. ; PEPIN, S. ; MCSEVENY, T.M. ; BYERS, J.N.
Oxford, UK : Blackwell Publishing Ltd
Published 1996Staff ViewISSN: 1365-3040Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: BiologyNotes: Sudden but transient changes in the fraction or illuminated foliage area in a well-watered 7-year-old Pinus radiata D. Don tree were imposed by completely covering either the upper 22% or the lower 78% of the foliage for periods of up to 36 h. Measurements of transpiration flux density (E), tree conductance (gt), stomatal conductance (gs) and net photosynthesis (A) were made to test the hypothesis that compensatory responses would occur in the remaining illuminated foliage when the cover was installed. When the lower foliage was covered there was an immediate decrease in gt. However, when tree conductance was normalized with respect to the illuminated leaf area (gt'), it increased between 50 and 75%, depending on the value of air saturation deficit (D). The effect was also apparent from concurrent measurements of increases in gs and A up to 59 and 24%, respectively, for needles in the top third of (he crown. When the cover was removed these effects were reversed. The changes in the lower foliage when the upper foliage was covered were much smaller. Changes in bulk needle water potential were small. It is suggested that the observed responses occurred because of a perturbation to the hydraulic pathway in the xylem that could have triggered the action of a chemical signal to regulate stomatal conductance and photosynthesis.Type of Medium: Electronic ResourceURL: -
4Articles: DFG German National LicensesStaff View
ISSN: 1365-3040Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: BiologyNotes: According to the theory of optimal nitrogen partitioning within a leaf, the chlorophyll (Chl) a/b ratio is expected to increase when leaf N content decreases. Here, we report the first empirical support for this prediction. The Chl a/b ratio increased while Chl content decreased in response to N limitation in photosynthetic cotyledons and leaves of seedlings of four tropical woody species in the Bignoniaceae. The responses of all four species were in the same direction, but differed in magnitude. For Tabebuia rosea, the species that exhibited the greatest increase in Chl a/b ratios (up to values of 5.9), detailed photosynthetic characteristics were also examined. Light and N availability were positively correlated with the light- and CO2-saturated photosynthetic O2 evolution rate, as well as with leaf carboxylation capacity (Vcmax) and electron transport rate (Vj). Severe N limitation and high light did not cause chronic photo-inhibition (i.e. no change in quantum yield or in dark-acclimated Fv/Fm). The observed change in the ratio of Vcmax to leaf N in response to N availability was consistent with likely functional reasons for change in the Chl a/b ratio. Adjustment of the Chl a/b ratio was apparently an integral feature of acclimation to high light conditions and low N availability.Type of Medium: Electronic ResourceURL: -
5Articles: DFG German National LicensesStaff View
ISSN: 1365-3040Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: BiologyNotes: Abstract. Very little attention has been directed at the responses of tropical plants to increases in global atmospheric CO2 concentrations and the potential climatic changes. The available data, from greenhouse and laboratory studies, indicate that the photosynthesis, growth and water use efficiency of tropical plants can increase at higher CO2 concentrations. However, under field conditions abiotic (light, water or nutrients) or biotic (competition or herbivory) factors might limit these responses. In general, elevated atmospheric CO2 concentrations seem to increase plant tolerance to stress, including low water availability, high or low temperature, and photoinhibition. Thus, some species may be able to extend their ranges into physically less favourable sites, and biological interactions may become relatively more important in determining the distribution and abundance of species. Tropical plants may be more narrowly adapted to prevailing temperature regimes than are temperate plants, so expected changes in temperature might be relatively more important in the tropics. Reduced transpiration due to decreased stomatal conductance could modify the effects of water stress as a cue for vegetative or reproductive phenology of plants of seasonal tropical areas. The available information suggests that changes in atmospheric CO2 concentrations could affect processes as varied as plant/herbivore interactions, decomposition and nutrient cycling, local and geographic distributions of species and community types, and ecosystem productivity. However, data on tropical plants are few, and there seem to be no published tropical studies carried out in the field. Immediate steps should be undertaken to reduce our ignorance of this critical area.Type of Medium: Electronic ResourceURL: -
6Articles: DFG German National LicensesStaff View
ISSN: 0006-291XSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyPhysicsType of Medium: Electronic ResourceURL: -
7Articles: DFG German National LicensesStaff View
ISSN: 0005-2787Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyType of Medium: Electronic ResourceURL: -
8Articles: DFG German National LicensesStaff View
ISSN: 0888-7543Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyMedicineType of Medium: Electronic ResourceURL: -
9Articles: DFG German National LicensesStaff View
ISSN: 0888-7543Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyMedicineType of Medium: Electronic ResourceURL: -
10Articles: DFG German National LicensesStaff View
ISSN: 0888-7543Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyMedicineType of Medium: Electronic ResourceURL: -
11Articles: DFG German National LicensesStaff View
ISSN: 0888-7543Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyMedicineType of Medium: Electronic ResourceURL: -
12Articles: DFG German National LicensesStaff View
ISSN: 0888-7543Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyMedicineType of Medium: Electronic ResourceURL: -
13Articles: DFG German National LicensesStaff View
ISSN: 0888-7543Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyMedicineType of Medium: Electronic ResourceURL: -
14Articles: DFG German National LicensesStaff View
ISSN: 0888-7543Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyMedicineType of Medium: Electronic ResourceURL: -
15Articles: DFG German National LicensesStaff View
ISSN: 0888-7543Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyMedicineType of Medium: Electronic ResourceURL: -
16Articles: DFG German National LicensesStaff View
ISSN: 0261-5606Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: EconomicsType of Medium: Electronic ResourceURL: -
17Articles: DFG German National LicensesStaff View
ISSN: 1432-1939Keywords: A/Ci ; C3 ; CAM ; Pi regeneration ; RuBP carboxylaseSource: Springer Online Journal Archives 1860-2000Topics: BiologyNotes: Summary Seedlings of nine tropical species varying in growth and carbon metabolism were exposed to twice the current atmospheric level of CO2 for a 3 month period on Barro Colorado Island, Panama. A doubling of the CO2 concentration resulted in increases in photosynthesis and greater water use efficiency (WUE) for all species possessing C3 metabolism, when compared to the ambient condition. No desensitization of photosynthesis to increased CO2 was observed during the 3 month period. Significant increases in total plant dry weight were also noted for 4 out of the 5 C3 species tested and in one CAM species, Aechmea magdalenae at high CO2. In contrast, no significant increases in either photosynthesis or total plant dry weight were noted for the C4 grass, Paspallum conjugatum. Increases in the apparent quantum efficiency (AQE) for all C3 species suggest that elevated CO2 may increase photosynthetic rate relative to ambient CO2 over a wide range of light conditions. The response of CO2 assimilation to internal Ci suggested a reduction in either the RuBP and/or Pi regeneration limitation with long term exposure to elevated CO2. This experiment suggests that: (1) a global rise in CO2 may have significant effects on photosynthesis and productivity in a wide variety of tropical species, and (2) increases in productivity and photosynthesis may be related to physiological adaptation(s) to increased CO2.Type of Medium: Electronic ResourceURL: -
18Articles: DFG German National LicensesVan Calcar, S. C. ; Harding, C. O. ; Lyne, P. ; Hogan, K. ; Banerjee, R. ; Sollinger, H. ; Rieselbach, R. E. ; Wolff, J. A.
Springer
Published 1998Staff ViewISSN: 1573-2665Source: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract Renal insufficiency is frequently reported in mutase-deficient methylmalonic acidaemia. We present a case report of a patient with mut– methylmalonic acidaemia who developed chronic tubulointerstitial nephropathy during adolescence. At 24 years of age, she developed end-stage renal failure and underwent renal transplantation. Both plasma and urine methylmalonic acid levels decreased significantly with improved renal function following transplantation. Complications included cyclosporin toxicity and development of diabetes. Renal, metabolic, and clinical status remained improved at 3 years after the kidney transplant.Type of Medium: Electronic ResourceURL: