Search Results - (Author, Cooperation:K. Gotoh)

2018-12-11

The American Society for Pharmacology and Experimental Therapeutics (ASPET)

0090-9556

1521-009X

Chemistry and Pharmacology

Medicine

2011-05-14

American Association for the Advancement of Science (AAAS)

0036-8075

1095-9203

Biology

Chemistry and Pharmacology

Computer Science

Medicine

Natural Sciences in General

Physics

Animals ; Argonaute Proteins ; *DNA Methylation ; *Genomic Imprinting ; Male ; Mice ; Mice, Inbred C57BL ; Mitochondrial Proteins/genetics/metabolism ; Models, Genetic ; Mutation ; Phospholipase D/genetics/metabolism ; Proteins/genetics/metabolism ; RNA, Small Interfering/*genetics/metabolism ; RNA, Untranslated/*genetics/metabolism ; Repetitive Sequences, Nucleic Acid ; Retroelements ; Spermatogonia/metabolism ; Testis/embryology/metabolism ; Transcription, Genetic ; ras-GRF1/*genetics

2016-03-31

Nature Publishing Group (NPG)

0028-0836

1476-4687

Biology

Chemistry and Pharmacology

Medicine

Natural Sciences in General

Physics

Animals ; Bacterial Adhesion ; Caco-2 Cells ; Cell Line ; Colitis/chemically induced/drug therapy/genetics ; Colon/*microbiology ; Dextran Sulfate ; Epithelium/*microbiology ; Female ; *Flagella ; GPI-Linked Proteins/deficiency/genetics/*metabolism/secretion ; Gram-Negative Bacteria/drug effects/metabolism/pathogenicity/*physiology ; Homeostasis ; Humans ; Inflammation/chemically induced/drug therapy/genetics ; Intestinal Mucosa/cytology/metabolism/*microbiology/secretion ; Male ; Mice ; Proteus mirabilis/drug effects/metabolism/pathogenicity ; Symbiosis

1089-7550

AIP Digital Archive

Physics

The single-chip superconducting quantum interference device (SQUID) we made using niobium Josephson junctions integrates a two-junction SQUID and a superconducting feedback circuit. The switching probability, its derivative to input flux, and the flux spectral density measured by varying the sinusoidal bias frequency and amplitude agree well with thermal noise theory. The best sensitivity and cutoff frequency were 6.2×10−6 Φ0(large-closed-square)(square root of)Hz and 1.1 kHz for a bias frequency at 10 MHz. The dynamic range was 2.5×105. These data show the SQUID to be suited to practical biomagnetic application.

Electronic Resource

1089-7550

AIP Digital Archive

Physics

Electrical properties of Au/ and YBa2Cu3O7−x/SrTi1−yNbyO3 heterojunctions were studied by measuring their capacitance-voltage, current-voltage, and conductance-voltage characteristics. The heterostructures were made by depositing Au or YBa2Cu3O7−x films on SrTi1−yNbyO3 substrates. The results of the capacitance-voltage measurement indicated that there was an interfacial layer having a dielectric constant lower than that of bulk SrTiO3 at the Au/SrTiO3 and YBa2Cu3O7−x/SrTiO3 interfaces. The current-voltage characteristics of the Au/SrTi1−yNbyO3 diodes with substrate Nb concentrations of 0.05 and 0.005 wt. % matched characteristics normally associated Schottky junctions and had a large ideality factor, n, consistent with the low-dielectric-constant interfacial layers. When the carrier concentration of the n-SrTiO3 substrate was 2×1019 cm−3, the Au and YBa2Cu3O7−x junctions showed interfacial-layer tunneling characteristics. The YBa2Cu3O7−x junctions exhibited two peaks in their conductance-voltage relations whose peak structures relies on the superconducting state density in YBa2Cu3O7−x films.

Electronic Resource

1365-2494

Blackwell Publishing Journal Backfiles 1879-2005

Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition

Canopy structure, productivity and their relationships were examined in 2-year-old swards of fourteen tall fescue (Festuca arundinacea Schreb.) strains during the vegetative and reproductive growth stages. During the vegetative growth stage morphological characters, particularly tiller size, were closely associated with productivity. Swards with large tillers showed an effective distribution of the incoming light energy within the canopy and hence low extinction coefficient (K) value and high productivity at complete light interception. On the other hand, although there was no apparent correlation between K and the productivity or the whole crop during the reproductive growth stage, the productivities of the reproductive and vegetative tillers were positively and negatively related to K respectively. Leaf area index of the reproductive tillers and their position in the canopy had marked effects on the distribution of the incoming light energy within the canopy and on the productivity of both types of tillers. The productivity of the vegetative and the reproductive tillers is discussed in terms of the effect of the competition for incoming light energy between both types of tillers.

Electronic Resource

1365-3059

Blackwell Publishing Journal Backfiles 1879-2005

Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition

A total of 401 isolates of Phytophthora infestans were collected from eight Asian regions (Korea, India, Taiwan, Indonesia, Thailand, Nepal, China and Japan) between 1992 and 2000 – 318 from potato and 83 from tomato. The isolates were analysed for mating type, metalaxyl resistance, RG57 fingerprinting, mitochondrial DNA (mtDNA) haplotype and the polymorphism of three allozyme loci, i.e. glucose-6-phosphate isomerase (Gpi), peptidase (Pep) and malic enzyme (Me). The isolates were multilocus-genotyped based on RFLP (RG57) fingerprint, dilocus allozyme genotype, mtDNA haplotype and mating type. Twenty multilocus genotypes were identified among 125 isolates. Of these genotypes, 14 had not been previously reported. Some of the multilocus genotypes were common to isolates from several geographical regions, suggesting migration. The metalaxyl-resistant isolates belonged to the multilocus genotypes JP-1, JP-2, and JP-3. Multilocus genotypes coexisting in a single field were found in following regions: Thailand (1994), central China (1996), Nepal (1997) and Japan (1998 and 2000). The possible origins of certain genotypes are discussed, including the possibility of sexual recombination within the P. infestans populations in Nepal and perhaps Thailand.

Electronic Resource

1476-4687

Nature Archives 1869 - 2009

Biology

Chemistry and Pharmacology

Medicine

Natural Sciences in General

Physics

[Auszug] GOTOH AND FINNEY REPLY-We are aware of the numerical closeness of 2/n and 0.6366, but until now had no good nonnumerological reason for asserting its significance. We are grateful to Gamba for pointing out the possible use of integral geometry, and will follow up the The average volume of the ...

Electronic Resource

0011-2240

Elsevier Journal Backfiles on ScienceDirect 1907 - 2002

Biology

Medicine

Electronic Resource

1359-0197

Elsevier Journal Backfiles on ScienceDirect 1907 - 2002

Chemistry and Pharmacology

Energy, Environment Protection, Nuclear Power Engineering

Physics

Electronic Resource

0014-5793

(Rat granulomatous tissue) ; Acid proteinase ; Met-T-kinin ; T-Kinin

Elsevier Journal Backfiles on ScienceDirect 1907 - 2002

Biology

Chemistry and Pharmacology

Physics

Electronic Resource

0031-9422

6-methoxybenzoxazolinone. ; Scoparia dulcis ; Scrophulariacea ; callus ; hairy root ; multiple shoot ; plant growth regulator

Elsevier Journal Backfiles on ScienceDirect 1907 - 2002

Biology

Chemistry and Pharmacology

Electronic Resource

0031-9422

6-methoxybenzoxazolinone. ; Scoparia dulcis ; Scrophulariacea ; callus ; hairy root ; multiple shoot ; plant growth regulator

Elsevier Journal Backfiles on ScienceDirect 1907 - 2002

Biology

Chemistry and Pharmacology

Electronic Resource

0921-4526

Elsevier Journal Backfiles on ScienceDirect 1907 - 2002

Physics

Electronic Resource

0921-4526

Elsevier Journal Backfiles on ScienceDirect 1907 - 2002

Physics

Electronic Resource

0040-6031

Elsevier Journal Backfiles on ScienceDirect 1907 - 2002

Chemistry and Pharmacology

Electronic Resource

0040-6031

Elsevier Journal Backfiles on ScienceDirect 1907 - 2002

Chemistry and Pharmacology

Electronic Resource

1435-1536

Detergency ; electro-osmosis ; iron (III) oxide ; electrokinetic phenomena ; heterocoagulation

Springer Online Journal Archives 1860-2000

Chemistry and Pharmacology

Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics

Abstract The detachment of submicron particles of iron (III) oxide from a quartz plate in aqueous solutions was investigated by using a well-defined flow of electro-osmosis in comparison with the ordinary flow of water without electrokinetic effect. A rectangular quartz cell was used for removal experiments. Zeta potentials of the particles and the plate were determined by electrophoresis and electro-osmosis, respectively. When the iron (III) oxide particles adhering to the quartz plate were removed by the electro-osmotic flow or the ordinary (Poiseuille) flow, the removal efficiency increased with increasing hydrodynamic force. The removal efficiency by electro-osmotic flow was almost the same as that by ordinary flow under the condition of the same magnitude of applied hydrodynamic force. The values of volume flow rate for the removal efficiency of 0.5 for the electro-osmotic flow was extremely small compared with that for the ordinary flow, showing the effectiveness of particle removal by electrokinetic effect of electro-osmosis. The kinetic analysis of the particle removal process showed that it was characterized by two different rate constants, the rate constant of the rapid process and that of the slow process. The rate constant of slow process increased with increasing electro-osmotic velocity. This shows that the electro-osmotic flow acts as a mechanical force to overcome the energy barrier in the removal process. The rate constant increased with increasing surfactant concentration and this trend became more noticeable as electro-osmotic velocity increased. It is concluded from this result that the effect of surfactant on particle removal is enhanced by the mechanical force in removal processes.

Electronic Resource

1435-1536

Electro-osmotic washing ; electro-osmosis ; electrokinetic phenomena ; detergency

Springer Online Journal Archives 1860-2000

Chemistry and Pharmacology

Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics

Abstract The direct application of electrokinetic phenomena to detergency was investigated. Experiments were carried out to remove particles from substrate by electro-osmosis. A model system which consisted of spherical nylon particles of 5Μm in mean diameter, a quartz plate, and wash liquid were used in analyzing the kinetic process of particle removal from substrate. When an electric field was applied to the system, electro-osmotic flow took place, and hence the particles were removed from the quartz surface. The ζ-potentials of nylon particles and quartz plate were measured by electrophoresis. The rate constants of removal,κ, were obtained from the changes with time in the ratio of particle residue by applying the first-order reaction scheme. The value ofκ increased with increasing electric field and with increasing concentration of surfactant. The total force of interaction between particle and plate was calculated on the basis of heterocoagulation theory of colloid stability. It was found from results thus obtained that the hydrodynamic force due to the electro-osmotic flow worked effectively as a mechanical force on the removal process and the adhesion force of particle to substrate reduced by adding surfactant.

Electronic Resource

1432-0827

Transforming growth factor β1 ; Age difference ; Chondrogenesis ; Parietal bone ; Mesenchymal cell differentiation

Springer Online Journal Archives 1860-2000

Biology

Medicine

Physics

Summary We examined the osteogenesis process in transforming growth factor β1 (TGF-β1)-treated neonatal and adult rats, aiming to investigate the age difference in the effect of TGF-β1 on mesenchymal cell differentiation. Recombinant human (rh) TGF-β1 (20 and 200 ng) was injected onto the outer periostea of the right side of the parietal bone of each rat once a day for 1–12 days starting at the age of either 1 day or 12 weeks. On the day after the final injection, the calvaria was excised and evaluated histologically. In the neonates, the 12-day treatment with rhTGF-β1 increased the number of osteoprogenitor cells, resulting in intramembranous ossification. In the adult rats, rhTGF-β1 induced differentiation of chondrocytes. Cartilage masses were surrounded by mesenchymal cells, which would differentiate into chondrocytes. The cartilage matrix was partially calcified, with chondrocytes buried therein. In the calcified matrix, marrow cavities containing some multinuclear osteoclasts were formed. These findings indicate that rhTGF-β1 stimulated the differentiation of mesenchymal cells into chondrocytes and produced the cartilaginous matrix. rhTGF-β1 induced intramembranous ossification of the parietal bone in neonatal rats, and it induced enchondral ossification in adults. This result suggests that the different responses of mesenchymal cells in the periosteum to rhTGF-β1 may depend on the age of the animals used: namely, they may reflect the respective osteogenic stages of modeling and remodeling.

Electronic Resource