Search Results - (Author, Cooperation:K. Goto)

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  1. 1
    Staff View
    Publication Date:
    2013-07-12
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Animals ; Antiviral Agents/pharmacology ; Cells, Cultured ; Chickens/virology ; DNA-Directed RNA Polymerases/antagonists & inhibitors ; Dogs ; Enzyme Inhibitors/pharmacology ; Female ; Ferrets/virology ; Humans ; Influenza A Virus, H1N1 Subtype/drug effects/enzymology ; *Influenza A virus/chemistry/drug effects/isolation & purification/pathogenicity ; Influenza, Human/drug therapy/*virology ; Macaca fascicularis/virology ; Madin Darby Canine Kidney Cells ; Male ; Mice ; Mice, Inbred BALB C ; Models, Molecular ; Monkey Diseases/pathology/virology ; Neuraminidase/antagonists & inhibitors ; Orthomyxoviridae Infections/pathology/transmission/*virology ; Quail/virology ; Swine/virology ; Swine, Miniature/virology ; *Virus Replication/drug effects
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  2. 2
    Staff View
    Publication Date:
    2018-02-17
    Publisher:
    Institute of Physics Publishing (IOP)
    Electronic ISSN:
    1748-0221
    Topics:
    Physics
    Published by:
    http://www.iop.org/

    Latest Papers from Table of Contents or Articles in Press
  3. 3
    Ogawa-Goto, K. ; Funamoto, N. ; Ohta, Y. ; Abe, T. ; Nagashima, K.

    Oxford, UK : Blackwell Publishing Ltd
    Published 1992
    Staff View
    ISSN:
    1471-4159
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Notes:
    Abstract: Myelins of the PNS were isolated from human motor and sensory nerves of cauda equina, and their ganglioside compositions were compared. The predominant ganglioside in the human PNS myelins, both from motor and sensory nerves, was LM1 (sialosylneolactotetraosylceramide). Sialosyl-nLc6Cer and disialosyl-nLc4Cer, GD3, GM3, and GDlb were detected as common components of the two nerve myelins. Furthermore, it was revealed that the motor nerve myelin contained GM1 (about 15% of total gangliosides), whereas sensory nerve myelin contained only a trace amount of GM1 (less than 5%), by TLC analyses together with TLC immunostaining using anti-GM 1 antibody. As for the disialoganglioside fraction, the content of GD1 a, as well as that of GM1, differed in motor and sensory nerves. Thus, the different contents of the ganglioseries gangliosides in human motor and sensory nerve myelins were demonstrated.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1111/j.1471-4159.1992.tb11018.x

    Articles: DFG German National Licenses
  4. 4
    Ogawa-Goto, K. ; Ohta, Y. ; Kubota, K. ; Funamoto, N. ; Abe, T. ; Taki, T. ; Nagashima, K.

    Oxford, UK : Blackwell Publishing Ltd
    Published 1993
    Staff View
    ISSN:
    1471-4159
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Notes:
    Abstract: Compositions of neutral and sulfated glucuronyl glycosphingolipids purified from human motor and sensory nerves and myelins were studied. Higher neutral glycosphingolipids (fraction B), which were separated from GazlCer (fraction A), were analyzed by TLC and TLC-immunostaining. Both nerve myelins contained paragloboside (nLc4Cer) and nLc6Cer dominantly as major higher glycosphingolipids and very little globoside (Gb4Cer), whereas both nerves contained Gb4Cer and nLc4Cer. Besides these major glycosphingolipids, a neutral glycolipid containing asialoGMI (Gg4Cer) epitope and other minor components such as ceramide trihexoside and ceramide dihexoside were detected in both nerves and their myelins. Furthermore, sulfated glucuronyl nLc4Cer and n Lc6Cer, which were monoclonal antibody HNK-1 reactive glycolipids, were detected in both nerves and myelins.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1111/j.1471-4159.1993.tb13633.x

    Articles: DFG German National Licenses
  5. 5
    Ogawa-Goto, K. ; Funamoto, N. ; Abe, T. ; Nagashima, K.

    Oxford, UK : Blackwell Publishing Ltd
    Published 1990
    Staff View
    ISSN:
    1471-4159
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Notes:
    Abstract: Ganglioside analysis of human motor and sensory nerves revealed that ceramide compositions of sensory nerve GD1a, GD1b, and GMl differed apparently from those in the motor nerve. These gangliosides from sensory nerve contained a large amount of long-chain fatty acids and d18:1 as a major long chain base. On the contrary, the motor nerve gangliosides contained C16–18 fatty acids and a large amount of d20:1 besides d 18:1. Furthermore, these gangliosides were enriched more in the axon fraction than in the myelin fraction. LM1, which was a major ganglioside in myelin from human peripheral nerve, was composed of similar ceramide compositions in the two nerves. The present findings suggest that the characteristic ceramide species of nerve gangliosides may reflect in part properties of their own neurons.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1111/j.1471-4159.1990.tb04930.x

    Articles: DFG German National Licenses
  6. 6
    Ding, Z.-J. ; Shimizu, R. ; Goto, K.

    [S.l.] : American Institute of Physics (AIP)
    Published 1994
    Staff View
    ISSN:
    1089-7550
    Source:
    AIP Digital Archive
    Topics:
    Physics
    Notes:
    Monte Carlo simulations of cascade processes of secondary electron generation in Si, Cu, and Au have been performed to study the energy distribution of backscattered electrons in the low-energy region. Calculation results show that the characteristic hump appearing in the energy distribution above Si-LVV Auger peak in the EN(E) spectrum can be well described by those electrons ejected from the L shell followed by the cascade process. The shape of EN(E) spectra in the low-energy region is dominated by the directly produced secondary electrons and, hence, strongly correlated with the excitation spectrum Im[−1/ε(ω)] for electron generation.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1063/1.357844

    Articles: DFG German National Licenses
  7. 7
    Watanabe, K. ; Katagiri, K. ; Noto, K. ; Awaji, S. ; Goto, K. ; Sadakata, N. ; Saito, T. ; Kohno, O.

    [S.l.] : American Institute of Physics (AIP)
    Published 1994
    Staff View
    ISSN:
    1089-7550
    Source:
    AIP Digital Archive
    Topics:
    Physics
    Notes:
    For bronze-processed multifilamentary pure Nb3Sn and 2.3 at. % Ti added (Nb,Ti)3Sn wires, which were prepared under the condition of the same wire parameters such as the filament size, filament number, and bronze ratio, the strain effects on the critical current density were measured. The large difference of the residual strain between Nb3Sn and (Nb,Ti)3Sn wires was obtained. It was found that the martensitic transformation for Nb3Sn compound largely contributes to the residual strain through the variation of the elastic modulus in bronze-processed multifilamentary Nb3Sn wires. It was verified that the ternary element addition of Ti surely suppresses the martensitic transformation in the bronze processed multifilamentary Nb3Sn wire.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1063/1.357033

    Articles: DFG German National Licenses
  8. 8
    Iramina, K. ; Hong, B. ; Uchida, S. ; Goto, K. ; Ueno, S.

    [S.l.] : American Institute of Physics (AIP)
    Published 1998
    Staff View
    ISSN:
    1089-7550
    Source:
    AIP Digital Archive
    Topics:
    Physics
    Notes:
    We have developed a multichannel high-resolution superconducting quantum interference device magnetometer for measuring biomagnetic fields produced by small animals. We measured the magnetocardiogram produced by a rat. Topographies of the P wave, QRS wave, and T wave of the rat magnetocardiogram were obtained. We also measured the magnetoretinogram, visually evoked magnetic fields, and auditory evoked magnetic fields of the rat. The signals of the magnetoretinogram appeared at 60 ms latency and the field intensities were about 0.6 pT. It was not possible to obtain the clear visually evoked fields because those signals were hidden behind the magnetoretinogram. It was possible to obtain auditory evoked magnetic fields of the rat. The significant differences of the wave forms were observed in both sides of the right ear, which are separated by 15 mm. Our system has adequate spatial resolution for measurement of the magnetocardiogram and auditory evoked magnetic fields produced by small animals. © 1998 American Institute of Physics.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1063/1.367739

    Articles: DFG German National Licenses
  9. 9
    Uchida, S. ; Iramina, K. ; Goto, K. ; Ueno, S.

    [S.l.] : American Institute of Physics (AIP)
    Published 2000
    Staff View
    ISSN:
    1089-7550
    Source:
    AIP Digital Archive
    Topics:
    Physics
    Notes:
    The purpose of our study was to identify the current source produced by acute ischemia and infarction. We measured magnetocardiograms (MCG) and electrocardiograms (ECG) of five male rats using a high-resolution dc superconducting quantum interference device gradiometer in a magnetically shielded room after performing coronary artery occlusion. The spatial resolution of the detecting magnetic field of our system is higher than the typical system, thus permitting the measurement of magnetic fields in small animals. Distribution of the magnetic fields B(t) and distribution of |rot B(t)|, which corresponded to the distribution of the current source, were imaged by 12-channel MCGs. As a result, the distribution of current source changes in the affected area of the myocardium during the ST segment, and amplitude of the peak significantly increased after occlusion. Our system can be used to help clarify the mechanism of the ST shift related to severe heart disease. © 2000 American Institute of Physics.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1063/1.372655

    Articles: DFG German National Licenses
  10. 10
    Ichimura, S. ; Goto, K. ; Kokubun, K. ; Shimizu, H. ; Hashizume, H.

    [S.l.] : American Institute of Physics (AIP)
    Published 1990
    Staff View
    ISSN:
    1089-7623
    Source:
    AIP Digital Archive
    Topics:
    Physics
    Electrical Engineering, Measurement and Control Technology
    Notes:
    A new counting system for charged particles, which is suitable for the counting of pulse trains arriving in a short time, was constructed. The system is composed of a microchannel-plate intensifier, a CCD camera, a frame buffer, a particle counter, and a personal computer. Ion (or electron) pulses incident on the microchannel plate are amplified and then converted to photoradiating spots on a fluorescent screen. The image of the bright spots on the screen is taken by the camera and stored in the frame buffer. The computer processes the stored data and counts the number of bright spots. The performance of the system was examined by applying it to the detection of ions generated by a pulse laser. More than 300 photoions generated by one laser pulse (pulse width: 30 ns) were successfully counted, indicating that the peak counting rate of the system exceeds 1010 cps.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1063/1.1141210

    Articles: DFG German National Licenses
  11. 11
    Watanabe, J. ; Goto, K. ; Nakamura, T.

    Woodbury, NY : American Institute of Physics (AIP)
    Published 1997
    Staff View
    ISSN:
    1077-3118
    Source:
    AIP Digital Archive
    Topics:
    Physics
    Notes:
    We have observed visible light emission from Co-silicided junctions by emission microscopy. It was found that leakage current across the junction was accompanied by weak emission of light arising from spots distributed spatially on the electrode. In addition, the emission characteristics depended on the annealing temperature of the metallization process. It can be concluded that a plausible leakage origin is anomalous diffusion of Co, resulting in a locally high electric field. We also measured the energy dependence of the emission intensity and found that the emission intensity increases with decreasing photon energy. © 1997 American Institute of Physics.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1063/1.118420

    Articles: DFG German National Licenses
  12. 12
    Miyazaki, H. ; Hanada, N. ; Andoh, M. I. ; Yamashita, Y. ; Saito, T. ; Sogame, A. ; Goto, K. ; Shirahama, R. ; Takehara, T.

    Oxford, UK : Blackwell Publishing Ltd
    Published 1989
    Staff View
    ISSN:
    1600-0528
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Notes:
    Abstract A CPITN survey was conducted involving 12832 Japanese subjects from 7 to 64 years of age. Subjects under 18 were schoolchildren, and 18-year-old and older subjects represented various social backgrounds, having been randomly selected from both urban and rural Japan. Fifty percent of the 7-yr-old children had signs of periodontal disease, and this percentage increased with increasing age. In those under 14, this increase in periodontal disease was mainly due to an increase in the proportion of children developing dental calculus. Subjects with 6 mm or deeper pockets were observed starting from the 20-29-yr-old age group. In subjects over this age, the prevalence of periodontal disease was higher in men than in women. The percentages of subjects having pathologic pockets had increased remarkably in the 30-44-yr-olds. In the 45–64-yr-old group, almost all subjects had some sign of periodontal disease, and the percentage of those with 4 or 5 mm pockets and 6 mm or deeper pockets were 37% and 21%, respectively
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1111/j.1600-0528.1989.tb00591.x

    Articles: DFG German National Licenses
  13. 13
    ANSAI, S. ; GOTO, K. ; AOKI, T. ; HOZUMI, Y. ; ASO, K.

    Oxford, UK : Blackwell Publishing Ltd
    Published 1993
    Staff View
    ISSN:
    1365-2230
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Notes:
    A case of malignant haemangioendothelioma of the scalp in an 82-year-old female treated with intralesional, intra-arterial and intravenous recombinant interleukin-2 (rIL-2) is reported. The scalp lesions disappeared after injection of 35 350 000 Japan reference units of rIL-2 and excision of the residual tumour. Immunohistochemical characterization of the cells infiltrating the lesion after rIL-2 administration revealed 30–40% CD4+ and CD8+ T lymphocytes, 20–30% macrophages and 5–10% natural killer cells. These findings are similar to those in other human cancers. Almost all of the cells in the intersticies of the lesion after rIL-2 injection expressed leucocyte function-associated antigen-1, and some of the tumour cells and the infiltrating cells around them expressed intercellular adhesion molecule-1. HLA-DR-positive cells markedly increased in number after rIL-2 administration. This report suggests that rIL-2 administration is the most effective therapy for malignant haemangioendothelioma.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1111/j.1365-2230.1993.tb02255.x

    Articles: DFG German National Licenses
  14. 14
    Staff View
    ISSN:
    0006-291X
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Biology
    Chemistry and Pharmacology
    Physics
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1016/S0006-291X(05)80813-7

    Articles: DFG German National Licenses
  15. 15
    Staff View
    ISSN:
    0006-291X
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Biology
    Chemistry and Pharmacology
    Physics
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1016/S0006-291X(05)80849-6

    Articles: DFG German National Licenses
  16. 16
    Staff View
    ISSN:
    0006-291X
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Biology
    Chemistry and Pharmacology
    Physics
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1016/S0006-291X(05)80813-7

    Articles: DFG German National Licenses
  17. 17
    Hama, H. ; Sakurai, T. ; Kasuya, Y. ; Fujiki, M. ; Masaki, T. ; Goto, K.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    0006-291X
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Biology
    Chemistry and Pharmacology
    Physics
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1016/S0006-291X(05)80815-0

    Articles: DFG German National Licenses
  18. 18
    Staff View
    ISSN:
    0006-291X
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Biology
    Chemistry and Pharmacology
    Physics
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1016/S0006-291X(05)81197-0

    Articles: DFG German National Licenses
  19. 19
    Staff View
    ISSN:
    0006-291X
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Biology
    Chemistry and Pharmacology
    Physics
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1006/bbrc.1993.1267

    Articles: DFG German National Licenses
  20. 20
    Staff View
    ISSN:
    0006-291X
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Biology
    Chemistry and Pharmacology
    Physics
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1016/S0006-291X(88)80757-5

    Articles: DFG German National Licenses