Search Results - (Author, Cooperation:K. Gardner)
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1Latest Papers from Table of Contents or Articles in PressA. P. Boyle ; C. L. Araya ; C. Brdlik ; P. Cayting ; C. Cheng ; Y. Cheng ; K. Gardner ; L. W. Hillier ; J. Janette ; L. Jiang ; D. Kasper ; T. Kawli ; P. Kheradpour ; A. Kundaje ; J. J. Li ; L. Ma ; W. Niu ; E. J. Rehm ; J. Rozowsky ; M. Slattery ; R. Spokony ; R. Terrell ; D. Vafeados ; D. Wang ; P. Weisdepp ; Y. C. Wu ; D. Xie ; K. K. Yan ; E. A. Feingold ; P. J. Good ; M. J. Pazin ; H. Huang ; P. J. Bickel ; S. E. Brenner ; V. Reinke ; R. H. Waterston ; M. Gerstein ; K. P. White ; M. Kellis ; M. Snyder
Nature Publishing Group (NPG)
Published 2014Staff ViewPublication Date: 2014-08-29Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Binding Sites ; Caenorhabditis elegans/*genetics/growth & development ; Chromatin Immunoprecipitation ; Conserved Sequence/genetics ; Drosophila melanogaster/*genetics/growth & development ; *Evolution, Molecular ; Gene Expression Regulation/*genetics ; Gene Expression Regulation, Developmental/genetics ; Gene Regulatory Networks/*genetics ; Genome/genetics ; Humans ; Molecular Sequence Annotation ; Nucleotide Motifs/genetics ; Organ Specificity/genetics ; Transcription Factors/genetics/*metabolismPublished by: -
2Articles: DFG German National LicensesStaff View
ISSN: 0003-2670Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Chemistry and PharmacologyType of Medium: Electronic ResourceURL: -
3Articles: DFG German National LicensesStaff View
ISSN: 0003-2670Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Chemistry and PharmacologyType of Medium: Electronic ResourceURL: -
4Articles: DFG German National LicensesStaff View
ISSN: 0003-2670Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Chemistry and PharmacologyType of Medium: Electronic ResourceURL: -
5Articles: DFG German National LicensesStaff View
ISSN: 0003-2670Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Chemistry and PharmacologyType of Medium: Electronic ResourceURL: -
6Articles: DFG German National LicensesStaff View
ISSN: 0003-2670Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Chemistry and PharmacologyType of Medium: Electronic ResourceURL: -
7Articles: DFG German National LicensesStaff View
ISSN: 0003-2670Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Chemistry and PharmacologyType of Medium: Electronic ResourceURL: -
8Articles: DFG German National LicensesStaff View
ISSN: 0003-2670Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Chemistry and PharmacologyType of Medium: Electronic ResourceURL: -
9Articles: DFG German National LicensesStaff View
ISSN: 1572-9435Keywords: coordination ; infrastructure ; road pricing ; transport policySource: Springer Online Journal Archives 1860-2000Topics: Architecture, Civil Engineering, SurveyingNotes: Abstract The paper reports the results of a series of studies conducted to enable the London Planning Advisory Committee to provide advice on strategic transport policy for London. The analytical approach combined the use of an area-based, multi-modal strategic model (LAM) and professional judgment. The performance of LAM as a basis for providing rapid advice on complex issues in transport policy is assessed. The resulting policy advice advocated a coherent approach, involving new infrastructure, particularly for rail; improved management of the road and public transport networks; the use of subsidy to enhance public transport service levels; and road user charges to reduce the impact of private vehicles on congestion and the environment. Road user charges emerged as the pivotal issue in the policy; the paper discusses their role, and the questions which still need to be resolved before they can be implemented. The main message of the study is that no one element of transport policy can tackle London's problems alone; an integrated policy in which infrastructure provision, management and pricing are used to complement one another is shown to be far more effective.Type of Medium: Electronic ResourceURL: -
10Articles: DFG German National LicensesStaff View
ISSN: 1420-9071Source: Springer Online Journal Archives 1860-2000Topics: BiologyMedicineNotes: Zusammenfassung Chromatographisch (Ionenaustausch, Papierchromatographie, Dünnschichtchromatographie und Hochspannungselektrophorese) wird nach enzymatischer Hydrolyse von nativem und denaturiertem Wolle-Keratin ε(γ-Glutamyl)-lysin und ε(β-Aspartyl)-lysin identifiziert und so die in Proteinen postulierte anomale Peptidverknüpfung nachgewiesen.Type of Medium: Electronic ResourceURL: -
11Articles: DFG German National LicensesStaff View
ISSN: 0162-0134Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyType of Medium: Electronic ResourceURL: -
12Articles: DFG German National LicensesStaff View
ISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] In the method described here, the sugars are separated by circular chromatography and are then shown up by an acid-base indicator. The latter does not destroy the sugars, which can then be cut out, eluted from the paper and estimated. The solution under test is applied to the centre of a Whatman ...Type of Medium: Electronic ResourceURL: -
13Articles: DFG German National LicensesLi, Q. ; Zhang, L. ; Tsang, B. ; Gardner, K. ; Bostick-Bruton, F. ; Reed, E.
Springer
Published 1999Staff ViewISSN: 1420-9071Keywords: Key words. AP-1; ERCC-1 mRNA; ERCC-1 gene transcription; nucleotide excision repair; ovarian cancer; phorbol ester.Source: Springer Online Journal Archives 1860-2000Topics: BiologyMedicineNotes: Abstract. ERCC-1 is an essential gene in the nucleotide excision repair pathway, and may be essential for life. However, the mechanism of transcriptional activation and regulation of ERCC-1 gene expression is unclear. We therefore investigated the effect of the phorbol ester 12-O-tetradecanoyl-phorbol-13-acetate (TPA) on the expression of the ERCC-1 gene in A2780/CP70 human ovarian carcinoma cells. TPA induced a four- to sixfold increase in steady-state ERCC-1 messenger RNA (mRNA) levels that was time- and concentration-dependent. Nuclear run-on experiments demonstrated that the rate of transcription of ERCC-1 was approximately 2.8-fold higher in TPA-treated cells than in the controls. TPA stimulation of A2780/CP70 cells also resulted in a rapid but transient induction of c-jun and c-fos as determined by Northern and Western blot analyses, which peaked about 2 h before the peak in ERCC-1 expression. Electrophoretic mobility shift assays of nuclear extracts from TPA-treated cells revealed an increase in DNA-binding activity specific for the AP-1-like binding site in the 5′-flanking region of ERCC-1. c-Jun and c-Fos proteins were confirmed to be the components of the activated AP-1 complex by supershift analysis. The increase in AP-1 activity occurs immediately before the increase in ERCC-1 transcription. The increase in AP-1 DNA-binding activity and the increase in ERCC-1 mRNA expression were prevented by pretreatment with cycloheximide. These data suggest that AP-1 may contribute to the upregulation of ERCC-1 in response to TPA in human ovarian cancer cells.Type of Medium: Electronic ResourceURL: -
14Articles: DFG German National LicensesStarkweather, H. W. ; Avakian, P. ; Gardner, K. H. ; Hsiao, B. S. ; Keating, M. Y. ; Ng, H.
Springer
Published 2000Staff ViewISSN: 1572-8943Keywords: branched diamine ; crystal structures ; dielectric properties ; dodecanedioic acid ; mechanic properties ; 2-methylpentamethylenediamine ; modulated DSC ; polyamides ; polymorphism ; SAXS ; Synchrotron X-ray ; WAXDSource: Springer Online Journal Archives 1860-2000Topics: Chemistry and PharmacologyNotes: Abstract The polyamide from 2-methylpentamethylenediamine and dodecanedioic acid (MPMD-12) has been studied by differential scanning calorimetry, dynamic mechanical analysis, dielectric analysis, X-ray crystallography, and simultaneous small and wide-angle X-ray scattering using synchrotron radiation. The polymer exhibits polymorphism which is shown to be associated with the incorporation of the branched diamine. At relatively low temperatures, the crystal structure is similar to the gamma form which has been found in many other polyamides. At higher temperatures, a new delta form appears in which the diamine moiety adopts a bent conformation. In this form, the chains follow a zig-zag pattern with two chemical repeats units per crystallographic repeat with a shortening of about 10% along the c-axis.Type of Medium: Electronic ResourceURL: -
15Articles: DFG German National LicensesKeating, M. Y. ; Gardner, K. H. ; Ng, H. ; Marks, D. N. ; Yung, W. S. ; Avakian, P. ; Starkweather, H. W.
Springer
Published 1999Staff ViewISSN: 1572-8943Keywords: branched diamine ; melting ; polyamides ; polymorphism ; transformation ; WXRDSource: Springer Online Journal Archives 1860-2000Topics: Chemistry and PharmacologyNotes: Abstract Our X-ray work of Dytek®-A, 2-methyl-pentamethylenediamine, containing polyamides shows polymorphism, whereas the polyamides with linear diamines do not. The polyamide of Dytek®-A and dodecanedioic acid, MPMD-12, is singled out for discussion and compared with the unbranched analogs of polyamides 6,12 and 5,12. Due to the presence of the -CH3 side group in the 2-position of the diamine, the polyamide MPMD-12 exhibits two stable crystal conformations. The new δ polymorph is not seen in linear polyamides 6,12 and 5,12. Studies by DSC polyamide MPMD-12 clearly illustrates at least two crystal forms, γ and δ, coexisting over a wide temperature range, and the isolation of each phase is possible by controlling temperature and time. The DMA modulus in the temperature region between the glass transition (or alpha relaxation) and melting transition shows strong dependence on the thermal history as demonstrated in a study of crystallization kinetics.Type of Medium: Electronic ResourceURL: -
16Articles: DFG German National LicensesPepose, J. S. ; Nestor, M. S. ; Gardner, K. M. ; Foos, R. Y. ; Pettit, T. H.
Springer
Published 1985Staff ViewISSN: 1435-702XSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract We utilized the leu series of monoclonal antibodies and an indirect immunoperoxidase technique to quantitate the cellular infiltrates in seven rejected human corneal allografts and compared them to nine identically processed corneas from patients with chronic herpetic stromal keratitis and to three control corneas. The cellular infiltrates in the rejected allografts were of mixed composition, comprised predominantly of leu-1 positive T-lymphocytes and leu-M3 positive macrophages. Both helper and cytotoxic-suppressor T-cells were identified in the stromal lesions. Statistically significant differences were noted in the absolute number of mononuclear cells and macrophages seen infiltrating the rejected corneal allografts compared to the herpetic corneas. We discuss the implications of these findings with regard to possible mechanisms underlying corneal allograft rejection in man.Type of Medium: Electronic ResourceURL: -
17Articles: DFG German National LicensesKoch, H. -R. ; Beitzen, R. ; Kremer, F. ; Chioralia, G. ; Baurmann, H. ; Megaw, J. ; Gardner, K. ; Lerman, S.
Springer
Published 1982Staff ViewISSN: 1435-702XSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract The effect of systemic 8-methoxypsoralen (8-MOP; 100 mg/kg daily) and subsequent long ultraviolet irradiation (UVA; 300 mJ/cm2; peak: 365 nm) on albino and pigmented rat eyes was studied in a 3-dimensional experimental set-up. While 8-MOP and UVA did not cause any ocular pathology when administered alone, a combined application of the two factors caused reversible corneal opacities, and irreversible iris devascularisation and cataracts. The irreversible changes were seen only in the albinos and accompanied by a significant decrease in lens wet weight. Phosphorescence and EPR spectroscopy demonstrated the formation of an 8-MOP-protein photoadduct in the animals treated with both 8-MOP and UVA. The results of this study emphasize the necessity of shielding the eyes of patients on photochemotherapy with protective spectacles.Type of Medium: Electronic ResourceURL: -
18Articles: DFG German National LicensesStaff View
ISSN: 1573-4811Source: Springer Online Journal Archives 1860-2000Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision MechanicsType of Medium: Electronic ResourceURL: -
19Articles: DFG German National LicensesStaff View
ISSN: 0006-3525Keywords: Chemistry ; Polymer and Materials ScienceSource: Wiley InterScience Backfile Collection 1832-2000Topics: Chemistry and PharmacologyNotes: The structure of β-chitin has been refined by rigid-body least-squares methods, based on the intensity data for highly crystalline specimens from the pogonophore Oligobrachia ivanovi. The structure consists of an array of poly-N-acetyl-D-glucosamine chains all having the same sense, which are linked together in sheets by N—H … O=C hydrogen bonding of the amide groups. In addition to the O-3′—H … O-5 intramolecular hydrogen bond, analogous to that in cellulose, the CH2OH side chain forms an intrasheet hydrogen bond to the carbonyl oxygen on the next chain. This structure shows considerably better agreement between observed and calculated intensities than that possessing an intersheet hydrogen bond, as had been proposed previously. The structure is consistent with the swelling properties of β-chitin and can also be seen to be analogous to that of native cellulose.Additional Material: 4 Ill.Type of Medium: Electronic ResourceURL: -
20Articles: DFG German National LicensesAsquith, R. S. ; Gardner, K. L. ; McGarel, W. S. ; Otterburn, M. S.
New York, NY [u.a.] : Wiley-Blackwell
Published 1978Staff ViewISSN: 0021-8995Keywords: Chemistry ; Polymer and Materials ScienceSource: Wiley InterScience Backfile Collection 1832-2000Topics: Chemistry and PharmacologyMechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision MechanicsPhysicsNotes: A study has been made of the uptake of a commercial polyaminoamide resin (Hercosett-57) by wool fibers. The effect of various chemical pretreatments on the uptake of the resin was monitored in order to investigate the mechanism of bonding of the polymer with the wool. From the results obtained it would appear that the deposition of the resin is not controlled by simple chemical reaction with the fiber. Surface treatments to the wool fibers and adhesion play a more important part in the resin-bonding process. Insoluble chlorinating agents such as DCCA and Chloramine T proved more effective in bringing about resin deposition than did the more widely used acid chlorination treatments, which use free chlorine in solution.Additional Material: 4 Ill.Type of Medium: Electronic ResourceURL: