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1Latest Papers from Table of Contents or Articles in PressM. E. Allentoft ; M. Sikora ; K. G. Sjogren ; S. Rasmussen ; M. Rasmussen ; J. Stenderup ; P. B. Damgaard ; H. Schroeder ; T. Ahlstrom ; L. Vinner ; A. S. Malaspinas ; A. Margaryan ; T. Higham ; D. Chivall ; N. Lynnerup ; L. Harvig ; J. Baron ; P. Della Casa ; P. Dabrowski ; P. R. Duffy ; A. V. Ebel ; A. Epimakhov ; K. Frei ; M. Furmanek ; T. Gralak ; A. Gromov ; S. Gronkiewicz ; G. Grupe ; T. Hajdu ; R. Jarysz ; V. Khartanovich ; A. Khokhlov ; V. Kiss ; J. Kolar ; A. Kriiska ; I. Lasak ; C. Longhi ; G. McGlynn ; A. Merkevicius ; I. Merkyte ; M. Metspalu ; R. Mkrtchyan ; V. Moiseyev ; L. Paja ; G. Palfi ; D. Pokutta ; L. Pospieszny ; T. D. Price ; L. Saag ; M. Sablin ; N. Shishlina ; V. Smrcka ; V. I. Soenov ; V. Szeverenyi ; G. Toth ; S. V. Trifanova ; L. Varul ; M. Vicze ; L. Yepiskoposyan ; V. Zhitenev ; L. Orlando ; T. Sicheritz-Ponten ; S. Brunak ; R. Nielsen ; K. Kristiansen ; E. Willerslev
Nature Publishing Group (NPG)
Published 2015Staff ViewPublication Date: 2015-06-13Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Archaeology/methods ; Asia/ethnology ; Asian Continental Ancestry Group/*genetics ; Cultural Evolution/*history ; DNA/genetics/isolation & purification ; Europe/ethnology ; European Continental Ancestry Group/*genetics ; *Fossils ; Gene Frequency/genetics ; Genetics, Population ; Genome, Human/*genetics ; *Genomics ; History, Ancient ; Human Migration/history ; Humans ; Lactose Intolerance/genetics ; Language/*history ; Polymorphism, Single Nucleotide/genetics ; Skin Pigmentation/geneticsPublished by: -
2Articles: DFG German National LicensesAllen, M. ; Pratscher, B. ; Krepler, C. ; Frei, K. ; Schöfer, C. ; Pehamberger, H. ; Müller, M. ; Lucas, T.
Oxford, UK : Blackwell Science Ltd
Published 2005Staff ViewISSN: 1744-313XSource: Blackwell Publishing Journal Backfiles 1879-2005Topics: BiologyMedicineNotes: Two novel interleukin-24 (IL-24) splice variants were identified in normal human melanocytes by sequencing cloned polymerase chain reaction (PCR) products that are not expressed in metastatic melanoma. These gene products have been generated by differential skipping of exons 3 (IL-24 delE3) and 5 (IL-24 delE5). IL-24 delE3 has limited sequence identity to the IL-24-interacting protein mda-7s, and IL-24 delE5 is homologous to IL-24.Type of Medium: Electronic ResourceURL: -
3Articles: DFG German National LicensesCONSTANTINESCU, C. S. ; FREI, K. ; WYSOCKA, M. ; TRINCHIERI, G. ; MALIPIERO, U. ; ROSTAMI, A. ; FONTANA, A.
Oxford, UK : Blackwell Publishing Ltd
Published 1996Staff ViewISSN: 1749-6632Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: Natural Sciences in GeneralType of Medium: Electronic ResourceURL: -
4Articles: DFG German National LicensesSIEPL, C. ; BODMER, S. ; HOFER, E. ; WRANN, M. ; FREI, K. ; FONTANA, A.
Oxford, UK : Blackwell Publishing Ltd
Published 1988Staff ViewISSN: 1749-6632Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: Natural Sciences in GeneralType of Medium: Electronic ResourceURL: -
5Articles: DFG German National LicensesStaff View
ISSN: 0014-5793Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyPhysicsType of Medium: Electronic ResourceURL: -
6Articles: DFG German National LicensesStaff View
ISSN: 0014-5793Keywords: APP gene expression ; Astrocyte ; Microglial cell ; Neuron ; OligodendrocyteSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyPhysicsType of Medium: Electronic ResourceURL: -
7Articles: DFG German National LicensesStaff View
ISSN: 0022-2852Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Chemistry and PharmacologyPhysicsType of Medium: Electronic ResourceURL: -
8Articles: DFG German National LicensesKorenkov, A. I. ; Pahnke, J. ; Frei, K. ; Warzok, R. ; Schroeder, H. W. S. ; Frick, R. ; Muljana, L. ; Piek, J. ; Yonekawa, Y. ; Gaab, M. R.
Springer
Published 2000Staff ViewISSN: 1437-2320Keywords: Key words Focal cerebral ischemia ; Programmed neuronal death ; Nimodipine ; Mannitol ; CerebroprotectionSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract The present study was conducted to evaluate the effects of nimodipine and mannitol on infarct size and on the amount of apoptosis after transient focal cerebral ischemia. Focal cerebral ischemia was induced in male Sprague-Dawley rats (weight 300–380 g) by transient occlusion of the right middle cerebral artery (MCAO) using an intraluminal thread model. All animals underwent ischemia for 2 h, followed by 24 h of reperfusion. Group I (n=16) was untreated. Group II (n=16) received 15% mannitol (1 g/kg as bolus) and group III (n=9) received 15 µg/kg/h nimodipine intravenously beginning 15 min prior to MCAO. Twenty-four hours after reperfusion, the brain was taken and sectioned in coronal slices. The slices were stained with H&E and with the transferase dUTP nick-end labeling (TUNEL) technique. Histopathological analysis revealed a significant (P〈0.05) decrease in infarct size in the striatum with both drugs: mannitol (group II) 25.4±5.9% and nimodipine (group III) 21.5±11.0% versus control (group I) 34.9±7.0% and in the cortex 2.7±2.0% (group II) and 6.3±2.4% (group III) versus control 14.4±9.0% (group I). The number of apoptotic cells was statistically lower in the therapy groups (group III 9.6, group II 25.8) versus control (group I 57.9) (Mann-Whitney-Wilcoxon U-test Z〉1.96, P〈0.05). This study indicates that mannitol and nimodipine provide neuroprotection by preventing both the necrotic and apoptotic components of cell death after transient focal cerebral ischemia and may be effective as neuroprotective drugs for cerebrovascular surgery.Type of Medium: Electronic ResourceURL: -
9Articles: DFG German National LicensesStaff View
ISSN: 0165-1161Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyMedicineType of Medium: Electronic ResourceURL: -
10Articles: DFG German National LicensesStaff View
ISSN: 1420-908XSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract Prenatal exposure to diazepam and other benzodiazepines (BDZ) has been found to result in a marked reduction of T-lymphocyte proliferation during postnatal development of rats. In search for pathogenic changes underlying this effect, we investigated the mitogen lipopolysaccharide (LPS) and concanavalin A (ConA) stimulated release of tumour necrosis factor (TNF)-α by mixed splenocytes of male offspring from Long Evans rats treated with 1.25 mg/kg per day diazepam from gestational day 14 to 20. In response to LPS, TNF-α release was found to be significantly lower in mixed splenocytes of two- and four-week-old treated than in control offspring. However, at eight weeks of age, prenatally diazepam-treated animals showed a significantly higher LPS-induced TNF-α release than control rats. Since monocytes/macrophages represent a major source of TNF-α, additional experiments were performed on purified spleen macrophages and lymphocytes stimulated with LPS. TNF-α release was only detectable in supernatants of adherent spleen macrophages and not in supernatants of lymphocytes. Thus, our data indicate that a disturbance in TNF-α release from macrophages is involved in the deficient immune response of prenatally diazepam-exposed rats.Type of Medium: Electronic ResourceURL: -
11Articles: DFG German National LicensesStaff View
ISSN: 1420-908XSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract Prenatal exposure to diazepam leads to a suppression of mitogen or allogen-induced lymphocyte proliferation as well as to a reduced production of tumour necrosis factor (TNF)-α from rat splenocytes during postnatal development of rats. We analysed the secretion of interleukin (IL)-6 which occurs at a later stage of the cytokine cascade. Splenocytes of male offspring from Long Evans rats, treated with a daily dose of diazepam (1.25 mg/kg) from gestational day 14 to 20, were stimulated with lipopolysaccaride (LPS) and concanavalin A (Con A). In response to LPS, IL-6 liberation was significantly lower in mixed splenocytes and spleen macrophages of 2 and 8 week old prenatally diazepam-treated rats than in controls. Spleen lymphocyte preparations of prenatally treated animals exhibited a reduction of IL-6 release at 12 h and an increase at 24 h of incubation. At 2 weeks of age, Con A-induced IL-6 production could only be detected in mixed splenocytes; prenatally treated rats were releasing significantly less IL-6 than controls. In 8 week old rats, IL-6 liberation from mixed splenocytes and spleen macrophages was significantly lower in prenatally treated animals than in controls. Spleen lymphocytes presented a complex response picture depending upon incubation conditions. Our data indicate that in prenatally diazepam-exposed rats, the disturbance of cytokine release also extends to cytokines which play an important role in the later phases of immune responses.Type of Medium: Electronic ResourceURL: -
12Articles: DFG German National LicensesStaff View
ISSN: 1432-1831Source: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract The effects of sheep anti-murine recombinant tumor necrosis factor-alpha (TNF-α) on resistance to Listeria monocytogenes infection were studied in T cell-deficient nu/nu mice. The sheep anti-TNF-α antibody preparation was specific for TNF since it neutralized 300 U of recombinant murine TNF-α in vitro at a dilution of up to 1/1,000 but did not neutralize 32 U of interferon (IFN)-α, -β or 32 U of IFN-γ in vitro at a 1/20 dilution. When tested in vivo in sublethally Listeria-infected nu/nu or T cell-competent C57BL/6 or ICR mice, a single treatment of 0.2 ml anti-TNF-α given intraperitoneally on either day -1,0 or +1 resulted in the death of mice by day 5–7 due to the uncontrolled growth of Listeria; bacterial counts in spleen and liver were increased on days 3–5 by a factor of 10–1,000 in these organs. When examined histologically, organs from mice with the anti-TNF-α treatment contained more, and considerably bigger, lesions that exhibited central necrosis. The enhancing effect of anti-TNF-α on Listeria infection seemed greater early during Listeria infection on days 1–6 when compared to later phases of the infection around days 6–10. From the data presented we conclude that in addition to other lymphokines, such as IFN-γ, TNF-α is of importance during the entire course of a Listeria infection in nu/nu mice.Type of Medium: Electronic ResourceURL: -
13Articles: DFG German National LicensesStaff View
ISSN: 0018-019XKeywords: Chemistry ; Organic ChemistrySource: Wiley InterScience Backfile Collection 1832-2000Topics: Chemistry and PharmacologyNotes: For the usual range of temperatures the thermodynamic functions of cyclobutanone and α,α,α′,α′-d4-cyclobutanone have been calculated statistically assuming an assignment reported elsewhere1. The unknown ring frequency v27 was put into the calculations as a parameter with values v27 = 50, 100, 135, 150, 200 cm-1.Additional Material: 1 Ill.Type of Medium: Electronic ResourceURL: -
14Articles: DFG German National LicensesStaff View
ISSN: 0018-019XKeywords: Chemistry ; Organic ChemistrySource: Wiley InterScience Backfile Collection 1832-2000Topics: Chemistry and PharmacologyNotes: For the SN1, SN2, E1, E2, AND E1cb mechanisms exact solutions of the kinetic equations are compared with solutions obtained under the hypothesis of stationarity. Exact integrals are calculated numerically for a set of the essential reaction rate constants. Comparison with the stationary state solution demonstrates that both types of solutions are approximately equal in many cases if the transient particle concentration remains low, whereas the conventional requirement | \documentclass{article}\pagestyle{empty}\begin{document}$ \mathop x\limits^. $\end{document} | = 0 is unimportant. For approximation of exact kinetics by stationary kinetics, however, neither condition is sufficient nor necessary. Practical criterions for recognition of deviations from stationary kinetics are given.Additional Material: 4 Ill.Type of Medium: Electronic ResourceURL: -
15Articles: DFG German National LicensesStaff View
ISSN: 0018-019XKeywords: Chemistry ; Organic ChemistrySource: Wiley InterScience Backfile Collection 1832-2000Topics: Chemistry and PharmacologyNotes: The autocorrelation function of photographic granularity has been assumed to be described by an isotropic function RN(x) = R0(sin(π x/x0))/(π x/x0), cf. (2-3). Formulas for the distortion of the corresponding power spectrum due to the effect of slit function (rectangular slit 21·2 ϱ s) and of recording by a simple RC network (transfer function (1 + iωτ)1, time constant τ, scanning speed v1, recording speed v2) have been derived. The results are expressed as the ratio defined by the variance of noise after passing the photometer divided by the variance without distortion by the photometer, 2σ′/σN. The discussion of numerical application shows that there exists a certain region - slit variable x 〈 0,5, recording parameter p ≥ 0,5-1,0-, where this ratio cannot be influenced by increasing μ.Additional Material: 2 Ill.Type of Medium: Electronic ResourceURL: -
16Articles: DFG German National LicensesStaff View
ISSN: 0018-019XKeywords: Chemistry ; Organic ChemistrySource: Wiley InterScience Backfile Collection 1832-2000Topics: Chemistry and PharmacologyNotes: The information content of a photoplate is assumed to consist of GAUSSian cornnoise and a periodic signal, expressed as a POISSON sum of single signals. Its power spectrum after passing through the photometer is calculated as a function of the dimensions of the rectangular slit, plate speed, recording speed and the time constant of the amplifier. Means and variance of noise and signal are derived for use in a deflection criterion, expressing the detectability of signals in noise.Type of Medium: Electronic ResourceURL: