Search Results - (Author, Cooperation:K. Drew)
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1C. Wan ; B. Borgeson ; S. Phanse ; F. Tu ; K. Drew ; G. Clark ; X. Xiong ; O. Kagan ; J. Kwan ; A. Bezginov ; K. Chessman ; S. Pal ; G. Cromar ; O. Papoulas ; Z. Ni ; D. R. Boutz ; S. Stoilova ; P. C. Havugimana ; X. Guo ; R. H. Malty ; M. Sarov ; J. Greenblatt ; M. Babu ; W. B. Derry ; E. R. Tillier ; J. B. Wallingford ; J. Parkinson ; E. M. Marcotte ; A. Emili
Nature Publishing Group (NPG)
Published 2015Staff ViewPublication Date: 2015-09-08Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Datasets as Topic ; *Evolution, Molecular ; Humans ; Multiprotein Complexes/*chemistry/*metabolism ; Protein Interaction Mapping ; *Protein Interaction Maps ; Reproducibility of Results ; Systems Biology ; Tandem Mass SpectrometryPublished by: -
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ISSN: 0018-2370Topics: HistoryNotes: Book ReviewsURL: -
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ISSN: 0018-2370Topics: HistoryDescription / Table of Contents: EURASIANotes: Book ReviewsURL: -
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ISSN: 0038-4941Topics: SociologyNotes: Book ReviewsURL: -
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ISSN: 0007-6805Topics: HistoryEconomicsNotes: BOOK REVIEWSURL: -
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ISSN: 0899-3718Topics: HistoryPolitical ScienceNotes: BOOK REVIEWSURL: -
7Smith, M. T. ; Wills, E. D. ; Drew, K. ; Maxwell, C. ; Daly, J. R. ; Reader, S. C. J. ; Robertson, W. R.
Springer
Published 1980Staff ViewISSN: 1432-119XSource: Springer Online Journal Archives 1860-2000Topics: BiologyMedicineNotes: Summary A 32 K Commodore Pet microcomputer has been interfaced with two Vickers microdensitometers. This system allows for the simultaneous logging of data from two densitometers being operated independently of each other. Software for the statistical analysis of data generated by the densitometers, and for use with the cytochemical bioassay of hormones, is described. The densitometer/Pet system is relatively cheap, reliable, and readily adaptable to other applications.Type of Medium: Electronic ResourceURL: -
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ISSN: 1432-2072Keywords: Rotational behavior ; Lateralized activity ; Amphetamine ; Classical conditioning ; Partial reinforcement ; HaloperidolSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract Amphetamine-induced lateralized activity (rotation) and nonlateralized activity (extra quarter turns) was classically conditioned in female rats using the test environment as the conditioned stimulus (CS) and 1.25 mg/kg d-amphetamine as the unconditioned stimulus. Conditioned lateralized activity extinguished more rapidly than nonlateralized activity. Also, d-amphetamine-induced nonlateralized activity was selectively decreased by a schedule of 50% partial reinforcement. These results indicate that the two d-amphetamine responses can be distinguished, that they are differentially affected by learning, and that a schedule of partial reinforcement can selectively attenuate one effect of a drug while leaving the other intact. In addition, haloperidol blocked conditioned lateralized activity; this suggests that the conditioned response may be, like the drug-induced response, mediated by dopamine.Type of Medium: Electronic ResourceURL: -
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ISSN: 1432-2072Keywords: Amphetamine ; Circling behavior ; Asymmetry ; Pavlovian conditioning ; Sensitization ; Placebo ; Latent inhibition ; Extinction ; Reverse tolerance ; RatSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract Amphetamine-induced circling behavior increases over the course of repeated administration of the drug; likewise, after repeated administration of amphetamine, an injection of saline prior to placement of the rat in the test apparatus previously associated with the pharmacologic effects of amphetamine will increase circling behavior. Experiments were designed to determine if either of these effects would respond to manipulation of the temporal contiguity between the test environment and the peak effects of amphetamine. The placebo-like response, in accordance with a Pavlovian conditioned response, was reduced by prior non-reinforced exposure to the test environment and subject to extinction. In contrast, the increase in the amphetamine-induced response was entirely dependent on the test environment but not affected by latent inhibition or extinction. These and previous findings indicate that the development and expression of the placebo-like response is the result of a Pavlovian associative process. Although amphetamine sensitization is environment dependent, it does not resemble a conditioned response in other respects.Type of Medium: Electronic ResourceURL: