Search Results - (Author, Cooperation:K. C. Anderson)
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1Latest Papers from Table of Contents or Articles in PressT. Ni Chonghaile ; K. A. Sarosiek ; T. T. Vo ; J. A. Ryan ; A. Tammareddi ; G. Moore Vdel ; J. Deng ; K. C. Anderson ; P. Richardson ; Y. T. Tai ; C. S. Mitsiades ; U. A. Matulonis ; R. Drapkin ; R. Stone ; D. J. Deangelo ; D. J. McConkey ; S. E. Sallan ; L. Silverman ; M. S. Hirsch ; D. R. Carrasco ; A. Letai
American Association for the Advancement of Science (AAAS)
Published 2011Staff ViewPublication Date: 2011-10-29Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Adult ; Aged ; Animals ; Antineoplastic Agents/*therapeutic use ; *Apoptosis ; Cell Line, Tumor ; Cell Proliferation ; Child ; Disease-Free Survival ; Drug Resistance, Neoplasm ; Female ; Humans ; Leukemia, Myeloid, Acute/drug therapy/physiopathology ; Male ; Membrane Potential, Mitochondrial ; Mice ; Mice, Inbred C57BL ; Middle Aged ; Mitochondria/*physiology ; Multiple Myeloma/drug therapy/physiopathology ; Neoplasms/*drug therapy/*physiopathology ; Ovarian Neoplasms/drug therapy/physiopathology ; Peptide Fragments/metabolism ; Permeability ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/drug therapy/physiopathology ; Proto-Oncogene Proteins c-bcl-2/chemistry/metabolism ; Remission Induction ; Signal TransductionPublished by: -
2Latest Papers from Table of Contents or Articles in PressM. A. Chapman ; M. S. Lawrence ; J. J. Keats ; K. Cibulskis ; C. Sougnez ; A. C. Schinzel ; C. L. Harview ; J. P. Brunet ; G. J. Ahmann ; M. Adli ; K. C. Anderson ; K. G. Ardlie ; D. Auclair ; A. Baker ; P. L. Bergsagel ; B. E. Bernstein ; Y. Drier ; R. Fonseca ; S. B. Gabriel ; C. C. Hofmeister ; S. Jagannath ; A. J. Jakubowiak ; A. Krishnan ; J. Levy ; T. Liefeld ; S. Lonial ; S. Mahan ; B. Mfuko ; S. Monti ; L. M. Perkins ; R. Onofrio ; T. J. Pugh ; S. V. Rajkumar ; A. H. Ramos ; D. S. Siegel ; A. Sivachenko ; A. K. Stewart ; S. Trudel ; R. Vij ; D. Voet ; W. Winckler ; T. Zimmerman ; J. Carpten ; J. Trent ; W. C. Hahn ; L. A. Garraway ; M. Meyerson ; E. S. Lander ; G. Getz ; T. R. Golub
Nature Publishing Group (NPG)
Published 2011Staff ViewPublication Date: 2011-03-25Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Amino Acid Sequence ; Blood Coagulation/genetics ; CpG Islands/genetics ; DNA Mutational Analysis ; DNA Repair/genetics ; Exons/genetics ; Exosome Multienzyme Ribonuclease Complex ; Genome, Human/*genetics ; Genomics ; Histones/metabolism ; Homeodomain Proteins/genetics ; Homeostasis/genetics ; Humans ; Methylation ; Models, Molecular ; Molecular Sequence Data ; Multiple Myeloma/drug therapy/enzymology/*genetics/metabolism ; Mutation/*genetics ; NF-kappa B/metabolism ; Oncogenes/genetics ; Open Reading Frames/genetics ; Protein Biosynthesis/genetics ; Protein Conformation ; Proto-Oncogene Proteins B-raf/antagonists & inhibitors/genetics/metabolism ; RNA Processing, Post-Transcriptional/genetics ; Ribonucleases/chemistry/genetics ; Signal Transduction/genetics ; Transcription, Genetic/geneticsPublished by: -
3Latest Papers from Table of Contents or Articles in PressStaff View
Publication Date: 2018-01-19Publisher: American Society of Hematology (ASH)Print ISSN: 0006-4971Electronic ISSN: 1528-0020Topics: BiologyMedicineKeywords: Multiple Myeloma, Free Research Articles, Lymphoid Neoplasia, Clinical Trials and ObservationsPublished by: -
4Latest Papers from Table of Contents or Articles in PressStaff View
Publication Date: 2018-08-10Publisher: American Society of Hematology (ASH)Print ISSN: 0006-4971Electronic ISSN: 1528-0020Topics: BiologyMedicineKeywords: Lymphoid NeoplasiaPublished by: -
5Latest Papers from Table of Contents or Articles in PressStaff View
Publication Date: 2018-12-07Publisher: American Society of Hematology (ASH)Print ISSN: 0006-4971Electronic ISSN: 1528-0020Topics: BiologyMedicineKeywords: Multiple Myeloma, Lymphoid Neoplasia, Clinical Trials and ObservationsPublished by: -
6Latest Papers from Table of Contents or Articles in PressKinneer, K., Meekin, J., Tiberghien, A. C., Tai, Y.-T., Phipps, S., Kiefer, C. M., Rebelatto, M. C., Dimasi, N., Moriarty, A., Papadopoulos, K. P., Sridhar, S., Gregson, S. J., Wick, M. J., Masterson, L., Anderson, K. C., Herbst, R., Howard, P. W., Tice, D. A.
The American Association for Cancer Research (AACR)
Published 2018Staff ViewPublication Date: 2018-12-15Publisher: The American Association for Cancer Research (AACR)Print ISSN: 1078-0432Electronic ISSN: 1557-3265Topics: MedicinePublished by: -
7Articles: DFG German National LicensesAnderson, K. C. ; Simpson, W. G. ; Ballou, R. J. ; Harty, J. I. ; Tseng, M. T.
Springer
Published 1986Staff ViewISSN: 1434-0879Keywords: Bladder cancer ; In vitro chemosensitivity ; J-82 ; Stem cellsSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Summary While chemotherapy offers a valuable adjunct to surgery in the management of intravesical bladder cancer, an accurate in vitro predictive test for chemosensitivity has yet to be developed. Drug sensitivity of the human bladder cancer cell line J-82 was assessed using monolayer, stem cell and [3H]thymidine incorporation assays. The 72-h monolayer assay provided a rapid reflection of in vitro drug sensitivity and when combined with the labeling index the results generally paralleled those obtained with the soft agar stem cell assay without the associated large commitment of time and labor. It is suggested that 72-h monolayer assay alone or in combination with [3H]thymidine labeling index may offer valuable insight into the chemotherapeutic response of bladder tumors.Type of Medium: Electronic ResourceURL: -
8Articles: DFG German National LicensesTreon, S. P. ; Shima, Y. ; Grossbard, M. L. ; Preffer, F. I. ; Belch, A. R. ; Pilarski, L. M. ; Anderson, K. C.
Springer
Published 2000Staff ViewISSN: 1569-8041Keywords: B cells ; CD20 ; core protein ; dexamethasone ; immunotherapy ; interferon-gamma ; Muc-1 ; multiple myeloma ; plasma cells ; RituximabSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract Background:In view of the successful use of serotherapy in manyB-cell malignancies, we and others have sought to identify tumor selectiveantigens for the serotherapy of plasma cell dyscrasias (PCD) includingmultiple myeloma (MM), and Waldenstrom's macroglobulinemia (WM). We recentlyidentified Muc-1 core protein as a MM selective antigen. Though Muc-1 coreprotein is abundantly expressed on most MM plasma cells, expression of thisantigen can be absent, or weak on some plasma cells which could potentiallyresult in the selection of Muc-1 core protein negative clones followingserotherapy of PCD. In addition to Muc-1 core protein, we have also beenexamining the use of CD20 directed serotherapy for PCD. Design:As part of these efforts, we recently initiated a phaseII clinical trial examining the use of Rituximab (Rituxan, MabThera) as asingle agent in MM patients; as well several WM patients have been treatedwith Rituximab at our Institutions. Results:In previous studies, we have shown that CD20 isabundantly expressed on the plasma cells of most WM patients; in contrast,CD20 is expressed on plasma cells from a minority of MM patients, and in thesepatients expression of CD20 can be weak or heterogeneous with both CD20+ andCD20− plasma cells present. As such, we have sought out clinicallyuseful inducers of Muc-1 core protein, and of CD20 on malignant plasma cells. Conclusions:These efforts resulted in the identification ofdexamethasone (Dex) as a potent inducer of Muc-1 core protein on MM plasmacells, and interferon-γ (IFN-γ) as a potent inducer of CD20 on MMplasma cells and B-cells. Importantly, these agents induced their respectiveantigens at pharmacologically achievable doses.Type of Medium: Electronic ResourceURL: