Search Results - (Author, Cooperation:K. Busch)

2018-02-09

The Company of Biologists

0950-1991

1477-9129

Biology

Plant development

2014-12-04

Nature Publishing Group (NPG)

0028-0836

1476-4687

Biology

Chemistry and Pharmacology

Medicine

Natural Sciences in General

Physics

Animals ; *Cell Lineage ; Cell Proliferation ; Cell Tracking ; Erythrocytes/*cytology ; Female ; Fetus/cytology ; Granulocytes/cytology ; *Hematopoiesis ; Kupffer Cells/cytology ; Langerhans Cells/cytology ; Liver/cytology/embryology ; Macrophages/*cytology ; Macrophages, Alveolar/cytology ; Male ; Mice ; Microglia/cytology ; Monocytes/cytology ; Receptor, Macrophage Colony-Stimulating Factor/metabolism ; Receptor, TIE-2/metabolism ; Stem Cells/*cytology ; Yolk Sac/*cytology ; fms-Like Tyrosine Kinase 3/metabolism

2018-10-27

American Physical Society (APS)

1098-0121

1095-3795

Physics

Surface physics, nanoscale physics, low-dimensional systems

2015-02-18

Nature Publishing Group (NPG)

0028-0836

1476-4687

Biology

Chemistry and Pharmacology

Medicine

Natural Sciences in General

Physics

Aging ; Animals ; Animals, Newborn ; Bone Marrow Transplantation ; Cell Lineage/*physiology ; Cell Proliferation ; Cell Tracking ; Female ; Fetus/cytology/embryology ; Fluorouracil ; *Hematopoiesis ; Hematopoietic Stem Cells/*cytology/metabolism ; Male ; Mice ; Receptor, TIE-2/metabolism ; Stem Cells/*cytology/metabolism

2014-05-16

Nature Publishing Group (NPG)

0028-0836

1476-4687

Biology

Chemistry and Pharmacology

Medicine

Natural Sciences in General

Physics

Animals ; Cell Division ; Cell Movement ; *Cell Transformation, Neoplastic/genetics ; Disease Progression ; Female ; Gene Expression Regulation, Neoplastic ; HMGA Proteins/genetics ; Hematopoietic Stem Cells/*cytology/metabolism ; Humans ; Male ; Mice ; Mice, Inbred C57BL ; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/genetics/*pathology ; Receptor, Notch1/genetics ; T-Lymphocytes/cytology/metabolism/pathology ; Thymus Gland/*cytology/pathology ; Transcriptome/genetics

article

2012

Experiment ; Strukturieren ; Materialeigenschaft ; Laser ; Low-Cost-Experiment ; Physik ; Physikunterricht

American journal of physics, Bd. 80 (2012) H. 3, S. 260-265, 0002-9505

1943-2909

English

1077-3118

AIP Digital Archive

Physics

The transmissivity within the photonic band gap of two-dimensional photonic crystals of macroporous silicon is reported as a function of crystal thickness. Measurements were carried out for crystals of nominally 1, 2, 3, and 4 crystal layers using a commercial parametric source, with a wavelength tunable from 3 to 5 μm. For wavelengths well within the 3–5 μm photonic band gap, attenuation of approximately 10 dB/crystal layer is obtained, in agreement with calculations based on plane wave expansion methods. For these materials, one should be able to achieve photonic crystal functionality in many applications with very small crystal volumes. © 1999 American Institute of Physics.

Electronic Resource

1077-3118

AIP Digital Archive

Physics

We have fabricated a two-dimensional photonic band structure based on macroporous silicon with a gap common to both polarizations and centered at 5 μm. A triangular lattice of circular air rods with a lattice constant of 2.3 μm was etched 75 μm deep in an n-type silicon substrate by electrochemical pore formation in hydrofluoric acid. The porous layer was then micromechanically structured in such a way that 200 μm thick free-standing bars of porous material were left over on the silicon substrate. These bars were then used for measuring the transmission of the photonic lattice. The results showed an excellent agreement with the theoretically calculated structure. © 1996 American Institute of Physics.

Electronic Resource

0040-4020

Elsevier Journal Backfiles on ScienceDirect 1907 - 2002

Chemistry and Pharmacology

Electronic Resource

0040-4020

Elsevier Journal Backfiles on ScienceDirect 1907 - 2002

Chemistry and Pharmacology

Electronic Resource

0012-1045

Philosophy

BEMERKUNGEN UND BERICHTE

1432-1076

Key words Amlodipine ; Calcium channel blockers ; Childhood ; Cyclosporine ; Hypertension

Springer Online Journal Archives 1860-2000

Medicine

Abstract. The calcium channel blocker nifedipine is widely used in children with systemic hypertension; however, because of the short duration of action, three to four daily doses of the standard preparation are required. Amlodipine once-daily, a calcium channel blocker structurally related to nifedipine with an excellent bioavailability and a long elimination half-time, has been shown to reduce blood pressure in adults. No information is available on the use of amlodipine in childhood. The effects of amlodipine once-daily (5 to 10 mg) were therefore assessed in 28 paediatric patients with hypertension. Amlodipine was withdrawn in five patients who experienced oedema and flushing. In the remaining 23 patients blood pressure was significantly reduced 3 weeks after amlodipine (on average by 7/5 mm Hg) and further decreased at 12 weeks (by 21/12 mm Hg). Heart rate and body weight were unchanged. In eight patients concomitantly treated with cyclosporine, the blood level of this agent was stable throughout the study, thus not requiring any dose adjustment. Conclusion The study illustrates the antihypertensive properties of amlodipine once-daily in paediatric hypertension. Amlodipine appears particularly indicated in patients concomitantly treated with cyclosporine.

Electronic Resource

1435-1536

Hematite ; magnetic field ; colloid stability ; magnetohydrodynamics ; aggregation

Springer Online Journal Archives 1860-2000

Chemistry and Pharmacology

Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics

Abstract The effect of a weak magnetic field on the aggregation state and electrophoretic mobility of hematite sol was studied in flowing (dynamic) systems as a function of time and electrolyte concentration (0–60 mmol/dm3 KCl) and compared with the effect of the field in stationary (static) systems and flow in the absence of the field. During the entire treatment period, the pH remained almost constant (4.06–4.24). Conductance varied with KCl concentration, but except for minor fluctuations appeared to be unaffected by any form of treatment. While aggregation of hematite was observed during dynamic magnetic treatment (change in turbidity, scattered light intensity, and photon correlation spectroscopy), little effect on aggregation state was observed for the static systems or for the flowing systems in the absence of the field. Mobility also increased during the first 30 min of static and dynamic magnetic treatment. After longer treatment periods (90–120 min), the mobility decreased, but in almost all cases remained larger than in the case of untreated systems. Changes in both mobility and particle aggregation state also showed a significant dependence on electrolyte concentration. These effects are discussed in terms of a magnetohydrodynamic interaction between the magnetic field and the charged colloidal particles, which results only when the particles are made to pass rapidly through the field.

Electronic Resource

1435-1536

Anatase ; radiofrequency electric field ; surface charge ; hydrous titanium dioxide ; ion exchange

Springer Online Journal Archives 1860-2000

Chemistry and Pharmacology

Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics

Abstract Potentiometric titrations of TiO2 (anatase) suspensions in solutions of 10−2, 10−3, and 10−4 M NaCl prior to treatment with a radiofrequency (RF) electric field gave values of pHpzc and pHiep of 5.75±0.1 and 5.85±0.1, respectively, within the range of literature values. Surface charge plots versus pH for untreated samples gave curves with a common intersection point, indicating that NaCl acts as an indifferent electrolyte. Identical suspensions of anatase were then exposed for 30 min to an RF electric field with a peak-to-peak, no-load amplitude of 34V and a frequency of 44 MHz. Portions of the treated suspension were titrated after different time periods following removal of the field (2, 15, 30, and 45 min). At 2 min, the pHpzc had shifted to 6.50±0.1, and at 15, 30 and 45 min, the curves for the three NaCl concentrations were found to lack a common intersection point, an effect which became more pronounced with time. It is proposed that RF treatment results in the formation of a porous gel layer of hydrous titanium dioxide on the surface of the anatase particles that subsequently undergoes a slow ion-exchange reaction involving ions of the supporting electrolyte.

Electronic Resource

1435-702X

Springer Online Journal Archives 1860-2000

Medicine

Zusammenfassung An Hand von 33 Pupillotoniefällen, bei denen die Augensymptome Teil eines Adie-Syndroms sind, wird die Differentialdiagnose gegenüber der Lues des Zentralnervensystems ausführlich behandelt. Von den diagnostischen Maßnahmen wird der Cocain-Pilocarpin-Versuch hervorgehoben und statistischer Berechnung unterzogen. Nach Vorgeschichte und Klinik werden Fälle von Adie-Syndrom ohne nachweisbare Ursache von denen symptomatischer Art (nach Encephalitis, Trauma, Mangelkrankheiten, bei Hirnarteriosklerose, Encephalopathia hypertonica u. a.) unterschieden. Da bei der Pupillotonie bzw. beim Adie-Syndrom die Zeichen vegetativer Dysregulation vorherrschend sind, wird in übereinstimmung mit anderen Autoren als Sitz der Läsion das Hypothalamusgebiet mit dem subcorticalen vegetativen Zentrum angenommen. Abschließend werden therapeutische Erwägungen dargelegt, die symptomatischer Art sind und sich auf die tonische Akkommodationsstörung konzentrieren, weil sie die Patienten am stärksten behindert.

Electronic Resource

1573-0778

rat ; heart ; growth ; norepinephrine

Springer Online Journal Archives 1860-2000

Biology

Medicine

Process Engineering, Biotechnology, Nutrition Technology

Abstract An automated method for rapidly measuring surface area of individual cardiac myocytes was used as an index of myocyte growth. Hearts from 2- to 4-day-old rats were digested by overnight incubation in cold trypsin solution. Enriched suspensions of myocytes were plated at 2×105 cells/well in 12-well-culture plates. Cells were grown in M199 supplemented with 1%, 10% serum or 10% serum plus 10−7 M norepinephrine. On days 1–4 after plating, cells were fixed in Bouin's Solution and stained with Weigert's Iron Hematoxylin and Biebrich Scarlet-Acid Fuchsin. An inverted microscope, video camera and monitor were coupled to a video image processor (Image Technology Corp.). The enhanced image of stained heart cells was digitized, and perimeter, length, width and area of each selected cell were calculated. One hundred randomly selected cells were measured in each of eight wells from each treatment-day group. Areas of individual myocytes varied widely in culture dishes and the distribition was skewed toward larger cells. The standard deviation increased in proportion to an increase in mean cell area. A logarithmic transformation of the data normalized the data and yielded a more homogeneous variance. The geometric mean area of heart cells supplemented with 1% serum increased only slightly, but significantly, during four days in culture. Geometric mean area of cells supplemented with 10% serum increased nearly four-fold. Supplementing cells with norepinephrine (10−7 M) in addition to 10% serum did not induce a further increase in cell size. This technique has the potential to rapidly and objectively monitor heart cell growth following pharmacological or toxicological treatments.

Electronic Resource

1618-2650

Springer Online Journal Archives 1860-2000

Chemistry and Pharmacology

Electronic Resource

1618-2650

Springer Online Journal Archives 1860-2000

Chemistry and Pharmacology

Electronic Resource

0030-493X

Chemistry ; Analytical Chemistry and Spectroscopy

Wiley InterScience Backfile Collection 1832-2000

Chemistry and Pharmacology

3 Ill.

Electronic Resource

1052-9306

Chemistry ; Analytical Chemistry and Spectroscopy

Wiley InterScience Backfile Collection 1832-2000

Chemistry and Pharmacology

Girard's reagents were used to derivatize ketosteroids and conjugates for analysis by positive ion fast atom bombardment mass spectrometry. Spectra contain an abundant ion corresponding to the cation (C+) of the newly formed ionic derivative (C+A-) and relatively little fragmentation. With derivatization, detection of ketosteroids at a concentration of 1 μg μl-1 in glycerol was straightforward. Such derivatization schemes may prove useful in the analysis of ketosteroids in complex biological mixtures.

3 Ill.

Electronic Resource