Search Results - (Author, Cooperation:K. Britton)
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1Latest Papers from Table of Contents or Articles in PressMc; Carter, K., Britton, B., Baker, A. L., Halpin, S. A., Beck, A. K., Carter, G., Wratten, C., Bauer, J., Forbes, E., Booth, D., Wolfenden, L.
BMJ Publishing
Published 2018Staff ViewPublication Date: 2018-01-07Publisher: BMJ PublishingElectronic ISSN: 2044-6055Topics: MedicineKeywords: Open access, Oncology, Screening (epidemiology)Published by: -
2Latest Papers from Table of Contents or Articles in PressM. Raghavan ; M. DeGiorgio ; A. Albrechtsen ; I. Moltke ; P. Skoglund ; T. S. Korneliussen ; B. Gronnow ; M. Appelt ; H. C. Gullov ; T. M. Friesen ; W. Fitzhugh ; H. Malmstrom ; S. Rasmussen ; J. Olsen ; L. Melchior ; B. T. Fuller ; S. M. Fahrni ; T. Stafford, Jr. ; V. Grimes ; M. A. Renouf ; J. Cybulski ; N. Lynnerup ; M. M. Lahr ; K. Britton ; R. Knecht ; J. Arneborg ; M. Metspalu ; O. E. Cornejo ; A. S. Malaspinas ; Y. Wang ; M. Rasmussen ; V. Raghavan ; T. V. Hansen ; E. Khusnutdinova ; T. Pierre ; K. Dneprovsky ; C. Andreasen ; H. Lange ; M. G. Hayes ; J. Coltrain ; V. A. Spitsyn ; A. Gotherstrom ; L. Orlando ; T. Kivisild ; R. Villems ; M. H. Crawford ; F. C. Nielsen ; J. Dissing ; J. Heinemeier ; M. Meldgaard ; C. Bustamante ; D. H. O'Rourke ; M. Jakobsson ; M. T. Gilbert ; R. Nielsen ; E. Willerslev
American Association for the Advancement of Science (AAAS)
Published 2014Staff ViewPublication Date: 2014-08-30Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Alaska/ethnology ; Arctic Regions/ethnology ; Base Sequence ; Bone and Bones ; Canada/ethnology ; DNA, Mitochondrial/genetics ; Genome, Human/*genetics ; Greenland/ethnology ; Hair ; History, Ancient ; *Human Migration ; Humans ; Inuits/ethnology/*genetics/history ; Molecular Sequence Data ; Siberia/ethnology ; Survivors/history ; ToothPublished by: -
3Latest Papers from Table of Contents or Articles in PressStaff View
Publication Date: 2018-03-15Publisher: BMJ PublishingElectronic ISSN: 2044-6055Topics: MedicineKeywords: Health policy, Open access, Smoking and tobacco, EpidemiologyPublished by: -
4Articles: DFG German National LicensesSHEPHERD, JOHN H. ; GRANOWSKA, M. ; BRITTON, K. E. ; MATHER, S. ; SLEVTN, MAURICE ; EPENETOS, A. A. ; WARD, E.G.
Oxford, UK : Blackwell Publishing Ltd
Published 1987Staff ViewISSN: 1471-0528Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Summary. A tumour-associated radiolabelled monoclonal antibody (HMFG 2) was used to investigate 51 patients who were referred with a pelvic mass and suspected ovarian cancer or recurrent disease. The day before operation the 123I-labelled antibody was injected and the patients then underwent radioimmunoscintigraphy immediately and again 4 and 22 h after the injection. An exploratory laparotomy with appropriate surgery was then performed and the tumours were staged. Tumours were positively imaged 3 min-22 h after injection in all the patients with ovarian cancer, with a mean 0.6% of the injected antibody taken up by the tumour. The presence of HMFG antigen on the tumour was confirmed by immunoperoxidase staining of the surgically-removed tissues. Of the 51 patients, 39 proved to have ovarian cancer. The accuracy of diagnosis and detection of primary and metastatic malignant disease was 95% when correlating pre-operative radioimmune scan findings and laparotomy findings. The procedure is minimally invasive, apparently without side-effects and offers information for tumour detection as an adjunct or alternative to existing methods.Type of Medium: Electronic ResourceURL: -
5Articles: DFG German National LicensesCROWTHER, M. E. ; BRITTON, K. E. ; GRANOWSKA, M. ; SHEPHERD, J. H.
Oxford, UK : Blackwell Publishing Ltd
Published 1989Staff ViewISSN: 1471-0528Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineType of Medium: Electronic ResourceURL: -
6Articles: DFG German National LicensesSUN, J H ; LI, Z-C ; JEWETT, D K ; BRITTON, K O ; YE, W H ; GE, X-J
Oxford, UK : Blackwell Science Ltd
Published 2005Staff ViewISSN: 1365-3180Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, NutritionNotes: Kudzu (Pueraria lobata) is a noxious weed infesting some areas of the USA. Knowledge of its genetic variation in both native and invasive areas can lead to effective biological control measures. Inter-simple sequence repeat (ISSR) variations were studied in P. lobata and its four closely related congeneric species (P. edulis, P. montana, P. phaseoloides and P. thomsoni). ISSR results allowed a clear separation of these five species. For P. lobata, 108 plants from China and USA were analysed. The samples from the US were genetically closer to Chinese P. lobata populations than to other congeneric populations. High genetic differentiation was found for P. lobata, P. montana and P. thomsoni in Chinese samples. High genetic diversity and low population differentiation was found in P. lobata samples of the US. This supports the hypothesis of multiple introductions into the USA from different sources in Japan or China, followed by subsequent gene exchange and recombination.Type of Medium: Electronic ResourceURL: -
7Articles: DFG German National LicensesStaff View
ISSN: 0022-1325Topics: PsychologyURL: -
8Articles: DFG German National LicensesStaff View
ISSN: 0026-7937Topics: Linguistics and Literary StudiesNotes: REVIEWSURL: -
9Articles: DFG German National LicensesTHOMAS, D. J. ; KIRBY, J. D. T. ; BRITTON, K. E. ; GALTON, D. J.
Oxford, UK : Blackwell Publishing Ltd
Published 1982Staff ViewISSN: 1365-2133Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Two patients with extensive livedo reticularis have developed multiple severe neurological lesions over a 6-year period. The possible pathogenesis is discussed.The presence of livedo reticularis has been described in conjunction with many diseases (Rook, Wilkinson & Ebling, 1979). A rare association between this condition and neurological syndromes has also been reported (Sneddon, 1965; Quimby & Perry, 1980). We report two cases which add further support to this association.Type of Medium: Electronic ResourceURL: -
10Articles: DFG German National LicensesStaff View
ISSN: 0022-2836Keywords: glutamate dehydrogenase ; leucine dehydrogenase ; phenylalanine dehydrogenase ; quaternary structure ; substrate specificitySource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyType of Medium: Electronic ResourceURL: -
11Articles: DFG German National LicensesStaff View
ISSN: 0196-9781Keywords: Corticotropin releasing factor ; Growth hormone pituitary ; Hypophysectomy ; LocomotionSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Chemistry and PharmacologyType of Medium: Electronic ResourceURL: -
12Articles: DFG German National LicensesStaff View
ISSN: 1467-6494Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: PsychologyType of Medium: Electronic ResourceURL: -
13Articles: DFG German National LicensesLilley, K.S. ; Baker, P.J. ; Linda Britton, K. ; Stillman, T.J. ; Brown, P.E. ; Moir, A.J.G. ; Engel, P.C. ; Rice, D.W. ; Bell, E. ; Ellis Bell, J.
Amsterdam : ElsevierStaff ViewISSN: 0167-4838Keywords: Coenzyme specificity ; Enzyme evolution ; Glutamate dehydrogenase ; Primary sequence ; Sequence comparisonSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyMedicineType of Medium: Electronic ResourceURL: -
14Articles: DFG German National LicensesStaff View
ISSN: 0167-0115Keywords: alcohol ; conflict ; corticotropin-releasing factorSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: MedicineType of Medium: Electronic ResourceURL: -
15Articles: DFG German National LicensesStaff View
ISSN: 0026-7937Topics: Linguistics and Literary StudiesNotes: REVIEWSURL: -
16Articles: DFG German National LicensesStaff View
ISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] WE have been much intrigued of late by the actions of a cock house sparrow which has apparently become permanently attracted by its own reflexion in a glass window. The window forms a transom over a door and we first noticed the bird flying at the glass and pecking it violently. When this was ...Type of Medium: Electronic ResourceURL: -
17Articles: DFG German National LicensesStaff View
ISSN: 1432-1262Source: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract This prospective study of radioimmunoscintigraphy using111 In-labelled, C46, a monoclonal antibody against carcino embryonic antigen, CEA, was undertaken in 23 patients with colorectal cancer, 18 with primary carcinomas, 3 with recurrences and 2 with metastases. A sensitivity of 95% and an accuracy of 91% was found. New observations through the use of two administered doses of antibody and the analysis of surgical specimens showed that for the low dose of antibody (average 0.76 mg) tumour uptake was 1.14×10−2% of the injected dose per gram, whereas on the higher dose (average 4.67 mg) the average tumour uptake was 6.77% (same units)p〈0.01. Thus a six-fold increase of antibody caused a sixfold increase in tumour uptake, but no change was seen in the tumour to mucosa ratio 4.8±0.5 (low dose) and 4.0±1.0 (high dose). A further observation was that well and moderately differentiated tumours took up about four times more than poorly differentiated tumours (p〈0.05). It was also found that tumour free lymph nodes had a six-fold greater uptake than tumour involved nodes (p〈0.05) confirming other work with anti-CEA monoclonal antibody. In conclusion, although biological factors influence its efficacy,111In labelled C46 anti-CEA is a suitable radiopharmaceutical for the radioimmunoscintigraphy of colorectal cancer.Type of Medium: Electronic ResourceURL: -
18Articles: DFG German National LicensesStaff View
ISSN: 1432-2072Keywords: Conflict ; Ethanol ; Chlordiazepoxide ; FG 7142 ; RO 15-1788Source: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract Previous results in our laboratory have shown that both chlordiazepoxide and ethanol will release punished responding in a rat operant conflict test using incremental shock. In the present study, a benzodiazepine antagonist and a benzodiazepine inverse agonist were used to explore the neurochemical basis for this behavioral action. N-methyl-β-carboline-3-carboxamide (FG 7142) at high doses (20 and 40 mg/kg) produced suppression of both punished and unpunished responding, and reversed the release of punished responding produced by both chlordiazepoxide and ethanol, but only at doses that produced an effect on its own. FG 7142 thus acted to oppose the actions of both ethanol and benzodiazepines but in an additive, not interactive, manner. In contrast, RO 15-1788 produced no changes when injected by itself in doses as high as 12 mg/kg and reversed chlordiazepoxide-induced but not ethanol-induced release of punished responding. RO 15-1788 also reversed the decrease in punished responding produced by FG 7142. Results suggest that ethanol does not interact directly with the benzodiazepine binding sites on the GABA/benzodiazepine ionophore complex to produce its anxiolytic action.Type of Medium: Electronic ResourceURL: -
19Articles: DFG German National LicensesBritton, K. T. ; Southerland, S. ; Uden, E. Van ; Kirby, D. ; Rivier, J. ; Koob, G.
Springer
Published 1997Staff ViewISSN: 1432-2072Keywords: Key words Neuropeptide Y ; Conflict test ; GABAa receptor ; AnxietySource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract This investigation examined receptor subtype specificity and possible modulation by GABAa receptor ligands of NPY-induced behavioral responses to stressful stimuli. First, a series of NPY receptor agonists were examined for their potential effects on punished responding in a conflict test modified for incremental shock. NPY, peptide YY (PYY) and NPY Y1 receptor agonists [Leu31,Pro34]-NPY and [Gly6, Glu26,Lys29,Pro34]-NPY produced increases in punished responding in the conflict test. No significant effects on unpunished responding were noted. The pattern of responding was similar to that observed with the benzodiazepine agonist chlordiazepoxide. Neither pancreatic peptide (PP) nor the Y2 agonists NPY13–36 or [Glu2,32,Ala6,Dpr27,Lys28]-NPY significantly altered punished or unpunished responding. Of significance, the atypical Y1 agonist [Cys7,21,Pro34]-NPY produced negligible effects on punished responding, consistent with the presence of a subclass of Y1 receptors. Second, the anxiolytic effects of NPY were subjected to treatments that block actions at the GABAa receptor complex. The increase in punished responding produced by NPY was not altered by administration of the benzodiazepine antagonist flumazenil and only partially blocked by the picrotoxinin receptor ligand isopropylbicyclophosphate (10 and 15 μg/kg). These findings further support the hypothesis that the pharmacologic substrates for the anxiolytic-like actions of NPY may be mediated by the Y1 receptor subtype and suggest that these actions are independent of either the benzodiazepine or picrotoxinin binding sites of the GABA/benzodiazepine receptor complex.Type of Medium: Electronic ResourceURL: -
20Articles: DFG German National LicensesGranowska, M. ; Britton, K. E. ; Mather, S. J. ; Morris, G. ; Ellison, D. ; Soobramoney, S. ; Talbot, I. C. ; Northover, J. M. A.
Springer
Published 1993Staff ViewISSN: 1619-7089Keywords: Colorectal cancer ; Radioimmunoscintigraphy ; Technetium-99m labelled 1A3 monoclonal antibodvSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract This study of radioimmunoscintigraphy (RIS) was primarily undertaken to determine how the imaging results related to surgical findings. Technetium-99m radiolabelled 1A3, a monoclonal antibody against a columnar cell surface antigen, was used. No adverse effects or thyroid uptake was observed in 127 studies. The 85 primary colorectal cancers were all image positive. In the assessment of recurrent tumour in the abdomen or pelvis, the accuracy was 33/35 (94%), including true-positive findings in some whose serum carcinoembryonic antigen was normal. There was a positive predictive value for abdominal or pelvic recurrence of 92% and a negative predictive value of 100%, at a prevalence of 66%. In those patients whose liver was able to be evaluated, the accuracy was 72/79 (91%). There was a positive predictive value for liver metastases of 88% and a negative predictive value of 93%, at a prevalence of 32%. The simple procedure for labelling antibody with 99mTc and its ready availability allow a completed report to be given within 24 h of the request.Type of Medium: Electronic ResourceURL: