Search Results - (Author, Cooperation:K. Asano)
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1Latest Papers from Table of Contents or Articles in PressMurakami, R., Singh, C. R., Morris, J., Tang, L., Harmon, I., Takasu, A., Miyoshi, T., Ito, K., Asano, K., Uchiumi, T.
The American Society for Microbiology (ASM)
Published 2018Staff ViewPublication Date: 2018-07-31Publisher: The American Society for Microbiology (ASM)Print ISSN: 0270-7306Electronic ISSN: 1098-5549Topics: BiologyMedicinePublished by: -
2Latest Papers from Table of Contents or Articles in PressMurata, K., Asano, M., Matsumoto, A., Sugiyama, M., Nishida, N., Tanaka, E., Inoue, T., Sakamoto, M., Enomoto, N., Shirasaki, T., Honda, M., Kaneko, S., Gatanaga, H., Oka, S., Kawamura, Y. I., Dohi, T., Shuno, Y., Yano, H., Mizokami, M.
BMJ Publishing Group
Published 2018Staff ViewPublication Date: 2018-01-10Publisher: BMJ Publishing GroupPrint ISSN: 0017-5749Electronic ISSN: 1468-3288Topics: MedicineKeywords: Open accessPublished by: -
3Latest Papers from Table of Contents or Articles in PressStaff View
Publication Date: 2018-05-23Publisher: Institute of Physics Publishing (IOP)Electronic ISSN: 1748-0221Topics: PhysicsPublished by: -
4Latest Papers from Table of Contents or Articles in PressM. Ackermann ; M. Ajello ; K. Asano ; W. B. Atwood ; M. Axelsson ; L. Baldini ; J. Ballet ; G. Barbiellini ; M. G. Baring ; D. Bastieri ; K. Bechtol ; R. Bellazzini ; E. Bissaldi ; E. Bonamente ; J. Bregeon ; M. Brigida ; P. Bruel ; R. Buehler ; J. M. Burgess ; S. Buson ; G. A. Caliandro ; R. A. Cameron ; P. A. Caraveo ; C. Cecchi ; V. Chaplin ; E. Charles ; A. Chekhtman ; C. C. Cheung ; J. Chiang ; G. Chiaro ; S. Ciprini ; R. Claus ; W. Cleveland ; J. Cohen-Tanugi ; A. Collazzi ; L. R. Cominsky ; V. Connaughton ; J. Conrad ; S. Cutini ; F. D'Ammando ; A. de Angelis ; M. DeKlotz ; F. de Palma ; C. D. Dermer ; R. Desiante ; A. Diekmann ; L. Di Venere ; P. S. Drell ; A. Drlica-Wagner ; C. Favuzzi ; S. J. Fegan ; E. C. Ferrara ; J. Finke ; G. Fitzpatrick ; W. B. Focke ; A. Franckowiak ; Y. Fukazawa ; S. Funk ; P. Fusco ; F. Gargano ; N. Gehrels ; S. Germani ; M. Gibby ; N. Giglietto ; M. Giles ; F. Giordano ; M. Giroletti ; G. Godfrey ; J. Granot ; I. A. Grenier ; J. E. Grove ; D. Gruber ; S. Guiriec ; D. Hadasch ; Y. Hanabata ; A. K. Harding ; M. Hayashida ; E. Hays ; D. Horan ; R. E. Hughes ; Y. Inoue ; T. Jogler ; G. Johannesson ; W. N. Johnson ; T. Kawano ; J. Knodlseder ; D. Kocevski ; M. Kuss ; J. Lande ; S. Larsson ; L. Latronico ; F. Longo ; F. Loparco ; M. N. Lovellette ; P. Lubrano ; M. Mayer ; M. N. Mazziotta ; J. E. McEnery ; P. F. Michelson ; T. Mizuno ; A. A. Moiseev ; M. E. Monzani ; E. Moretti ; A. Morselli ; I. V. Moskalenko ; S. Murgia ; R. Nemmen ; E. Nuss ; M. Ohno ; T. Ohsugi ; A. Okumura ; N. Omodei ; M. Orienti ; D. Paneque ; V. Pelassa ; J. S. Perkins ; M. Pesce-Rollins ; V. Petrosian ; F. Piron ; G. Pivato ; T. A. Porter ; J. L. Racusin ; S. Raino ; R. Rando ; M. Razzano ; S. Razzaque ; A. Reimer ; O. Reimer ; S. Ritz ; M. Roth ; F. Ryde ; A. Sartori ; P. M. Parkinson ; J. D. Scargle ; A. Schulz ; C. Sgro ; E. J. Siskind ; E. Sonbas ; G. Spandre ; P. Spinelli ; H. Tajima ; H. Takahashi ; J. G. Thayer ; J. B. Thayer ; D. J. Thompson ; L. Tibaldo ; M. Tinivella ; D. F. Torres ; G. Tosti ; E. Troja ; T. L. Usher ; J. Vandenbroucke ; V. Vasileiou ; G. Vianello ; V. Vitale ; B. L. Winer ; K. S. Wood ; R. Yamazaki ; G. Younes ; H. F. Yu ; S. J. Zhu ; P. N. Bhat ; M. S. Briggs ; D. Byrne ; S. Foley ; A. Goldstein ; P. Jenke ; R. M. Kippen ; C. Kouveliotou ; S. McBreen ; C. Meegan ; W. S. Paciesas ; R. Preece ; A. Rau ; D. Tierney ; A. J. van der Horst ; A. von Kienlin ; C. Wilson-Hodge ; S. Xiong ; G. Cusumano ; V. La Parola ; J. R. Cummings
American Association for the Advancement of Science (AAAS)
Published 2013Staff ViewPublication Date: 2013-11-23Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsPublished by: -
5Latest Papers from Table of Contents or Articles in PressStaff View
Publication Date: 2018-03-06Publisher: Oxford University PressPrint ISSN: 0305-1048Electronic ISSN: 1362-4962Topics: BiologyPublished by: -
6Latest Papers from Table of Contents or Articles in PressKikuchi, K., Iida, M., Ikeda, N., Moriyama, S., Hamada, M., Takahashi, S., Kitamura, H., Watanabe, T., Hasegawa, Y., Hase, K., Fukuhara, T., Sato, H., Kobayashi, E. H., Suzuki, T., Yamamoto, M., Tanaka, M., Asano, K.
The American Association of Immunologists (AAI)
Published 2018Staff ViewPublication Date: 2018-07-10Publisher: The American Association of Immunologists (AAI)Print ISSN: 0022-1767Electronic ISSN: 1550-6606Topics: MedicinePublished by: -
7Articles: DFG German National LicensesIshida-Yamamoto, A. ; Kelsell, D. ; Common, J. ; Houseman, M.J. ; Hashimoto, M. ; Shibaki, H. ; Asano, K. ; Takahashi, H. ; Hashimoto, Y. ; Senshu, T. ; Leigh, I.M. ; Iizuka, H.
Oxford, UK : Blackwell Science Ltd
Published 2000Staff ViewISSN: 1365-2133Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Erythrokeratoderma (EK) variabilis is a heterogeneous group of diseases characterized by migratory erythematous patches and hyperkeratotic plaques. Mutations in connexin 31 have recently been found to underlie several cases of EK variabilis. We describe a Japanese girl with extensive lesions that appeared to be a form of EK variabilis, clinically resembling genodermatose en cocardes (Degos). Our patient had characteristic migratory rosette or target-like erythematous keratotic plaques with peripheral scaling in addition to relatively fixed keratotic plaques. Sequencing of the connexin 31 gene did not detect mutations. Skin biopsy showed parakeratotic hyperkeratosis with hypergranulosis. Immunohistochemically, suprabasal keratins, involucrin and profilaggrin were unequivocally expressed, while loricrin expression was greatly diminished and deiminated K1 was undetectable. Our results confirm aetiological heterogeneity in EK. The histological features suggest disruption of keratinocyte terminal differentiation at a very late stage.Type of Medium: Electronic ResourceURL: -
8Articles: DFG German National LicensesFowler, M. T. ; Suzuki, M. ; Engel, A. K. ; Asano, K. ; Itoh, T.
[S.l.] : American Institute of Physics (AIP)
Published 1987Staff ViewISSN: 1089-7550Source: AIP Digital ArchiveTopics: PhysicsNotes: In order to fabricate metal-insulator-semiconductor (MIS) devices on III-V semiconductors it is often necessary to use deposited insulators, since these semiconductors do not form native oxides of the quality found with the Si/SiO2 system. Langmuir–Blodgett (LB) organic thin films have previously been investigated as such insulators. Unfortunately, conventional LB films have too low a melting point (about 70 °C) for practical applications. We have studied films which are spread as a monomer, then polymerize on the water surface to form poly [1,4-phenylene-5,5'(6,6')-bibenzimidazole-2,2'-diyl] (PBI). We show that deposited films of PBI have the repeatable and finely controllable thickness of conventional LB films, but remain fairly stable when subjected to temperatures up to 400 °C. Using PBI LB films as a gate insulator we have fabricated working depletion mode MISFET structures on n-type indium phosphide with gate lengths down to 1.2 μm.Type of Medium: Electronic ResourceURL: -
9Articles: DFG German National LicensesStaff View
ISSN: 1365-2222Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Background Allergic rhinitis (AR) is an inflammatory disease characterized by nasal wall remodelling with intense infiltration of eosinophils and mast cells/basophils. Matrix metalloproteinases (MMPs), MMP-2 and MMP-9, are the major proteolytic enzymes that induce airway remodelling. These enzymes are also important in the migration of inflammatory cells through basement membrane components.Objective We evaluated whether fexofenadine hydrochloride (FEX), the carboxylic acid metabolite of terfenadine with selective H1-receptor antagonist activity, could inhibit MMP production from nasal fibroblasts (NFs) in response to TNF-α stimulation in vitro.Methods NFs were established from nasal polyp-derived fibroblasts (PFs) taken from patients with AR. Nasal mucosal fibroblasts (MFs) were also induced from nasal mucosal tissues from septal deformity patients without allergy. PF and MF (2 × 105 cells/mL, each) were stimulated with TNF-α in the presence of various concentrations of FEX. After 24 h, culture supernatants were obtained and assayed for MMP-2, MMP-9, tissue inhibitor of metalloproteinase (TIMP)-1 and TIMP-2 levels by ELISA. The influence of FEX on mRNA expression of MMPs and TIMPs in 4 h-cultured cells was also evaluated by real-time RT-PCR. Furthermore, nuclear factor-κB (NF-κB) activation in fibroblasts treated with FEX for 4 h was examined by ELISA.Results FEX at more than 350 ng/mL inhibited the production of MMP-2 and MMP-9 from both PF and MF in response to TNF-α stimulation, whereas TIMP-1 and TIMP-2 production was scarcely affected by FEX. FEX also inhibited MMP mRNA expression and NF-κB activation in PF and MF after TNF-α stimulation.Conclusion The present data suggest that the attenuating effect of FEX on MMP-2 and -9 production from NFs induced by inflammatory stimulation may underlie the therapeutic mode of action of the agent on allergic diseases, including AR.Type of Medium: Electronic ResourceURL: -
10Articles: DFG German National LicensesHosaka, M. ; Takai, Y. ; Mukasu, N. ; Asano, K. ; Mori, M.
Oxford, UK : Blackwell Publishing Ltd
Published 1984Staff ViewISSN: 1600-0714Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Peroxidase-conjugated lectins were used for the histochemical detection of carbohydrates in experimental carcinomas of mouse submandibular glands. Induced carcinomas, 43 lesions from 25 cases, were examined histoehemically with galactose-binding leetins (PNA and RCA-I), N-acetyl-galactosamine-binding leetins (DBA and SBA), a fucosc-binding lectin(UEA-l), and a N-acetyl-glucosamine-binding lectin (WGA). In non- or slightly keratinized squamous-cell carcinomas, the lectin binding of PNA, RCA-1, DBA, SBA. and WGA was weak in tumor epithelia, and UEA-1 binding was slight. In highly keratinized squamous-cell carcinomas, lectin binding was increased in tumor epithelia, but no reaction was noted in completely keratinized regions. Desquamated materials in lumens of tumors gave an intense stain with leetins. Stromal connective tissue, including collagen fibers and basement membranes stained intensely. Lectin binding to submandibular carcinomas was different from binding to granular convoluted tubules and the striated ducts of the normal submandibular gland.Type of Medium: Electronic ResourceURL: -
11Articles: DFG German National LicensesTakai, Y. ; Asano, K. ; Clemente, R. P. ; Mori, M.
Oxford, UK : Blackwell Publishing Ltd
Published 1985Staff ViewISSN: 1600-0714Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Lectin binding patterns of Con A. PNA, SHA, DBA, WGA, RCA-1 and UEA-1 were tarried out in duct-ligated submandibular glands (SMGs) of rats that diplayed acute degenerating changes Lectin staining was also related to histologic changes. Proliferating epithelial cells which were probably derived from intercalated duet cells showed a strong SBA and WGA staining on the 3rd day. Duct-like and cystic structures appeared on the 7th day and staining by PNA, SBA. WGA. RCA-1 and Con A was described In mice. lectin binding after duct ligation appeared similar to the rat In the long-term observation of mice SMGs. acinar cell regeneration occurred between the 2lsl and 42nd days and they stained strongly for DBA.Type of Medium: Electronic ResourceURL: -
12Articles: DFG German National LicensesTakai, Y. ; Sumitomo, S. ; Noda, Y. ; Asano, K. ; Mori, M.
Oxford, UK : Blackwell Publishing Ltd
Published 1985Staff ViewISSN: 1600-0714Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Immunohistochemical defection of epidermal growth factor (EGF) and nerve growth factor (NGF) was carried out in duct-ligated submandibular glands (SMG) of mice with or without testosterone treatement. High levels of EGF and NGF were limited to granular convoluted tubule (GCT) cells in normal adult male mice, and reduced levels were evident in the female. After duet ligation, EGF and NGF stainings began to decrease on the 2nd or 3rd day, and by the 10th day, no staining was detectable. Decreasing levels of EGF and NGF following duct ligation, were more pronounced in the male SMG than in the female. Testosterone administration before ligation resulted in decreased EGF and NGF levels of staining; however, staining of sections on the 1st and 3rd day was a little stronger than comparable stained sections of untreated mice. In contrast, testosterone administration after duet ligation showed GCT cells of normal size with some degranulation at 10 days and irregular staining of growth factors with varying degrees of degranulation at 14 days. Histochemical staining for EGF and NGF in this group was marked, as in the normal, until the 10th day with decreasing reactions by the 14th day.Type of Medium: Electronic ResourceURL: -
13Articles: DFG German National LicensesMurase, N. ; Takai, Y. ; Hosaka, M. ; Asano, K. ; Mori, M.
Oxford, UK : Blackwell Publishing Ltd
Published 1984Staff ViewISSN: 1600-0714Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Complex carbohydrates in premalignant lesions of mouse submandibular gland tumors were examined by the lectin-peroxidase conjugate method. Peroxidase-conjugated lectins of PNA, RCA-1, DBA, SBA, UEA-1 and WGA were used to detect specific sugar residues of complex carbohydrates in premalignant lesions during experimental carcinogenesis. Marked reduction of PNA and SBA bindings occurred in duct-like structures and cystic lesions which were transformed from granular convoluted tubule cells. Premalignant lesions bound slightly to PNA, RCA-1, DBA, SBA and WGA and manifested increased UEA-1 binding. Squamous metaplastic epithelia of premalignant lesions manifested increased binding to PNA, RCA-1 and SBA as compared to those of duct-like structure and cystic epithelia.Type of Medium: Electronic ResourceURL: -
14Articles: DFG German National LicensesStaff View
ISSN: 0167-4781Keywords: (Rabbit reticulocytes) ; Elongation cycle ; Elongation factor ; Protein synthesis ; Translation inhibitorSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyMedicinePhysicsType of Medium: Electronic ResourceURL: -
15Articles: DFG German National LicensesStaff View
ISSN: 0008-6215Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Chemistry and PharmacologyType of Medium: Electronic ResourceURL: -
16Articles: DFG German National LicensesStaff View
ISSN: 0005-2760Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyMedicinePhysicsType of Medium: Electronic ResourceURL: -
17Articles: DFG German National LicensesStaff View
ISSN: 0003-9861Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyPhysicsType of Medium: Electronic ResourceURL: -
18Articles: DFG German National LicensesStaff View
ISSN: 0922-338XSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Process Engineering, Biotechnology, Nutrition TechnologyType of Medium: Electronic ResourceURL: -
19Articles: DFG German National LicensesStaff View
ISSN: 0922-338XSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Process Engineering, Biotechnology, Nutrition TechnologyType of Medium: Electronic ResourceURL: -
20Articles: DFG German National LicensesStaff View
ISSN: 0922-338XSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Process Engineering, Biotechnology, Nutrition TechnologyType of Medium: Electronic ResourceURL: