Search Results - (Author, Cooperation:K. Abdi)
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1Latest Papers from Table of Contents or Articles in PressE. J. Benner ; D. Luciano ; R. Jo ; K. Abdi ; P. Paez-Gonzalez ; H. Sheng ; D. S. Warner ; C. Liu ; C. Eroglu ; C. T. Kuo
Nature Publishing Group (NPG)
Published 2013Staff ViewPublication Date: 2013-04-26Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Astrocytes/*cytology/*metabolism ; Brain Injuries/*metabolism/*pathology ; Cell Lineage ; Cell Movement ; Cerebral Cortex/cytology/metabolism/pathology ; Cerebral Ventricles/*cytology ; Cicatrix/metabolism/pathology ; Endocytosis ; Mice ; Mice, Knockout ; NFI Transcription Factors/metabolism ; Neural Stem Cells/cytology ; Neuroglia/cytology/metabolism/pathology ; Receptor, Notch1/*metabolism ; Signal Transduction ; Thrombospondins/deficiency/genetics/*metabolismPublished by: -
2Articles: DFG German National LicensesStaff View
ISSN: 1365-3083Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Interleukin (IL)-12p75 is a heterodimeric cytokine composed of the product of two different genes that specify p35 and p40 subunits. The prevailing view is that IL-12 acts as a proinflammatory cytokine that bridges the innate and adaptive immune responses and skews T-cell reactivity toward a TH1 cytokine pattern. Though the terms IL-12 and IL-12p40 are often used interchangeably, and measurements of the p40 chain are often interpreted as measurements of the intact p75 heterodimer, such interchangeable usage may be incorrect.In the following discussion, I will delineate an alternative hypothesis for the roles of the p40 and p75 proteins, suggesting specifically, that: (1) in vivo, secretion of free p40 precedes that of p75 in response to pathogens; (2) induction of p40 is a T-independent response by antigen presenting cells (APCs) to early host–pathogen interactions; and (3) IL-12p75 is a late product, whose induction requires T-dependent signals. It is made as a result, rather than as a cause, of TH1 differentiation. Thus, it is the p40 protein, either alone or paired with other polypeptides, rather than p75, that acts as an interface between the innate and adaptive immune responses.Type of Medium: Electronic ResourceURL: -
3Latest Papers from Table of Contents or Articles in PressStaff View
Publication Date: 2018-06-20Publisher: Cold Spring Harbor Laboratory PressPrint ISSN: 0890-9369Topics: BiologyKeywords: Cell Biology, NeurobiologyPublished by: -
4Latest Papers from Table of Contents or Articles in PressAbdi, K., Laky, K., Padhan, K., Petrovas, C., Skinner, J., Kabat, J., Dorward, D. W., Brzostowski, J., Long, E. O., Trinchieri, G., Varma, R.
The American Association of Immunologists (AAI)
Published 2018Staff ViewPublication Date: 2018-11-06Publisher: The American Association of Immunologists (AAI)Print ISSN: 0022-1767Electronic ISSN: 1550-6606Topics: MedicinePublished by: