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Publication Date: 2018-10-06Publisher: American Physical Society (APS)Print ISSN: 1539-3755Electronic ISSN: 1550-2376Topics: PhysicsKeywords: Computational PhysicsPublished by: -
2S. Sawcer ; G. Hellenthal ; M. Pirinen ; C. C. Spencer ; N. A. Patsopoulos ; L. Moutsianas ; A. Dilthey ; Z. Su ; C. Freeman ; S. E. Hunt ; S. Edkins ; E. Gray ; D. R. Booth ; S. C. Potter ; A. Goris ; G. Band ; A. B. Oturai ; A. Strange ; J. Saarela ; C. Bellenguez ; B. Fontaine ; M. Gillman ; B. Hemmer ; R. Gwilliam ; F. Zipp ; A. Jayakumar ; R. Martin ; S. Leslie ; S. Hawkins ; E. Giannoulatou ; S. D'Alfonso ; H. Blackburn ; F. Martinelli Boneschi ; J. Liddle ; H. F. Harbo ; M. L. Perez ; A. Spurkland ; M. J. Waller ; M. P. Mycko ; M. Ricketts ; M. Comabella ; N. Hammond ; I. Kockum ; O. T. McCann ; M. Ban ; P. Whittaker ; A. Kemppinen ; P. Weston ; C. Hawkins ; S. Widaa ; J. Zajicek ; S. Dronov ; N. Robertson ; S. J. Bumpstead ; L. F. Barcellos ; R. Ravindrarajah ; R. Abraham ; L. Alfredsson ; K. Ardlie ; C. Aubin ; A. Baker ; K. Baker ; S. E. Baranzini ; L. Bergamaschi ; R. Bergamaschi ; A. Bernstein ; A. Berthele ; M. Boggild ; J. P. Bradfield ; D. Brassat ; S. A. Broadley ; D. Buck ; H. Butzkueven ; R. Capra ; W. M. Carroll ; P. Cavalla ; E. G. Celius ; S. Cepok ; R. Chiavacci ; F. Clerget-Darpoux ; K. Clysters ; G. Comi ; M. Cossburn ; I. Cournu-Rebeix ; M. B. Cox ; W. Cozen ; B. A. Cree ; A. H. Cross ; D. Cusi ; M. J. Daly ; E. Davis ; P. I. de Bakker ; M. Debouverie ; B. D'Hooghe M ; K. Dixon ; R. Dobosi ; B. Dubois ; D. Ellinghaus ; I. Elovaara ; F. Esposito ; C. Fontenille ; S. Foote ; A. Franke ; D. Galimberti ; A. Ghezzi ; J. Glessner ; R. Gomez ; O. Gout ; C. Graham ; S. F. Grant ; F. R. Guerini ; H. Hakonarson ; P. Hall ; A. Hamsten ; H. P. Hartung ; R. N. Heard ; S. Heath ; J. Hobart ; M. Hoshi ; C. Infante-Duarte ; G. Ingram ; W. Ingram ; T. Islam ; M. Jagodic ; M. Kabesch ; A. G. Kermode ; T. J. Kilpatrick ; C. Kim ; N. Klopp ; K. Koivisto ; M. Larsson ; M. Lathrop ; J. S. Lechner-Scott ; M. A. Leone ; V. Leppa ; U. Liljedahl ; I. L. Bomfim ; R. R. Lincoln ; J. Link ; J. Liu ; A. R. Lorentzen ; S. Lupoli ; F. Macciardi ; T. Mack ; M. Marriott ; V. Martinelli ; D. Mason ; J. L. McCauley ; F. Mentch ; I. L. Mero ; T. Mihalova ; X. Montalban ; J. Mottershead ; K. M. Myhr ; P. Naldi ; W. Ollier ; A. Page ; A. Palotie ; J. Pelletier ; L. Piccio ; T. Pickersgill ; F. Piehl ; S. Pobywajlo ; H. L. Quach ; P. P. Ramsay ; M. Reunanen ; R. Reynolds ; J. D. Rioux ; M. Rodegher ; S. Roesner ; J. P. Rubio ; I. M. Ruckert ; M. Salvetti ; E. Salvi ; A. Santaniello ; C. A. Schaefer ; S. Schreiber ; C. Schulze ; R. J. Scott ; F. Sellebjerg ; K. W. Selmaj ; D. Sexton ; L. Shen ; B. Simms-Acuna ; S. Skidmore ; P. M. Sleiman ; C. Smestad ; P. S. Sorensen ; H. B. Sondergaard ; J. Stankovich ; R. C. Strange ; A. M. Sulonen ; E. Sundqvist ; A. C. Syvanen ; F. Taddeo ; B. Taylor ; J. M. Blackwell ; P. Tienari ; E. Bramon ; A. Tourbah ; M. A. Brown ; E. Tronczynska ; J. P. Casas ; N. Tubridy ; A. Corvin ; J. Vickery ; J. Jankowski ; P. Villoslada ; H. S. Markus ; K. Wang ; C. G. Mathew ; J. Wason ; C. N. Palmer ; H. E. Wichmann ; R. Plomin ; E. Willoughby ; A. Rautanen ; J. Winkelmann ; M. Wittig ; R. C. Trembath ; J. Yaouanq ; A. C. Viswanathan ; H. Zhang ; N. W. Wood ; R. Zuvich ; P. Deloukas ; C. Langford ; A. Duncanson ; J. R. Oksenberg ; M. A. Pericak-Vance ; J. L. Haines ; T. Olsson ; J. Hillert ; A. J. Ivinson ; P. L. De Jager ; L. Peltonen ; G. J. Stewart ; D. A. Hafler ; S. L. Hauser ; G. McVean ; P. Donnelly ; A. Compston
Nature Publishing Group (NPG)
Published 2011Staff ViewPublication Date: 2011-08-13Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Alleles ; Cell Differentiation/immunology ; Europe/ethnology ; Genetic Predisposition to Disease/*genetics ; Genome, Human/genetics ; Genome-Wide Association Study ; HLA-A Antigens/genetics ; HLA-DR Antigens/genetics ; HLA-DRB1 Chains ; Humans ; Immunity, Cellular/genetics/*immunology ; Major Histocompatibility Complex/genetics ; Multiple Sclerosis/*genetics/*immunology ; Polymorphism, Single Nucleotide/genetics ; Sample Size ; T-Lymphocytes, Helper-Inducer/cytology/immunologyPublished by: -
3L. Jostins ; S. Ripke ; R. K. Weersma ; R. H. Duerr ; D. P. McGovern ; K. Y. Hui ; J. C. Lee ; L. P. Schumm ; Y. Sharma ; C. A. Anderson ; J. Essers ; M. Mitrovic ; K. Ning ; I. Cleynen ; E. Theatre ; S. L. Spain ; S. Raychaudhuri ; P. Goyette ; Z. Wei ; C. Abraham ; J. P. Achkar ; T. Ahmad ; L. Amininejad ; A. N. Ananthakrishnan ; V. Andersen ; J. M. Andrews ; L. Baidoo ; T. Balschun ; P. A. Bampton ; A. Bitton ; G. Boucher ; S. Brand ; C. Buning ; A. Cohain ; S. Cichon ; M. D'Amato ; D. De Jong ; K. L. Devaney ; M. Dubinsky ; C. Edwards ; D. Ellinghaus ; L. R. Ferguson ; D. Franchimont ; K. Fransen ; R. Gearry ; M. Georges ; C. Gieger ; J. Glas ; T. Haritunians ; A. Hart ; C. Hawkey ; M. Hedl ; X. Hu ; T. H. Karlsen ; L. Kupcinskas ; S. Kugathasan ; A. Latiano ; D. Laukens ; I. C. Lawrance ; C. W. Lees ; E. Louis ; G. Mahy ; J. Mansfield ; A. R. Morgan ; C. Mowat ; W. Newman ; O. Palmieri ; C. Y. Ponsioen ; U. Potocnik ; N. J. Prescott ; M. Regueiro ; J. I. Rotter ; R. K. Russell ; J. D. Sanderson ; M. Sans ; J. Satsangi ; S. Schreiber ; L. A. Simms ; J. Sventoraityte ; S. R. Targan ; K. D. Taylor ; M. Tremelling ; H. W. Verspaget ; M. De Vos ; C. Wijmenga ; D. C. Wilson ; J. Winkelmann ; R. J. Xavier ; S. Zeissig ; B. Zhang ; C. K. Zhang ; H. Zhao ; M. S. Silverberg ; V. Annese ; H. Hakonarson ; S. R. Brant ; G. Radford-Smith ; C. G. Mathew ; J. D. Rioux ; E. E. Schadt ; M. J. Daly ; A. Franke ; M. Parkes ; S. Vermeire ; J. C. Barrett ; J. H. Cho
Nature Publishing Group (NPG)
Published 2012Staff ViewPublication Date: 2012-11-07Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Colitis, Ulcerative/genetics/immunology/microbiology/physiopathology ; Crohn Disease/genetics/immunology/microbiology/physiopathology ; Genetic Predisposition to Disease/*genetics ; Genome, Human/genetics ; *Genome-Wide Association Study ; Haplotypes/genetics ; *Host-Pathogen Interactions/genetics/immunology ; Humans ; Inflammatory Bowel Diseases/*genetics/immunology/*microbiology/physiopathology ; Mycobacterium/*immunology/pathogenicity ; Mycobacterium Infections/genetics/microbiology ; Mycobacterium tuberculosis/immunology/pathogenicity ; Phenotype ; Polymorphism, Single Nucleotide/genetics ; Reproducibility of ResultsPublished by: -
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Type of Medium: OnlinePublication Date: 2014Keywords: Schüler ; Lernerfolg ; Demonstrationsexperiment ; Unterricht ; Optik ; PhysikunterrichtIn: Bernholt, Sascha (Hrsg.), Naturwissenschaftliche Bildung zwischen Science- und Fachunterricht., Kiel: IPN (2014), S. 249-251, 978-3-89088-361-8Language: German -
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Type of Medium: OnlinePublication Date: 2014Keywords: Kompetenz ; Kognitiver Prozess ; Testaufgabe ; Schüler ; Chemie ; Physik ; Modell ; ExperteIn: Bernholt, Sascha (Hrsg.), Naturwissenschaftliche Bildung zwischen Science- und Fachunterricht., Kiel: IPN (2014), S. 519-521, 978-3-89088-361-8Language: German -
6Wadewitz, T. ; Winkelmann, J.
College Park, Md. : American Institute of Physics (AIP)
Published 2000Staff ViewISSN: 1089-7690Source: AIP Digital ArchiveTopics: PhysicsChemistry and PharmacologyNotes: Common density functional theories often use the so-called mean-field approximation to the attractive term of the free energy, which is not accurate when compared with molecular dynamics simulations. We applied a modification of this attractive free energy term of a local density functional approach where an analytical representation of the radial distribution function is taken into account. A cutoff Lennard-Jones-12-6 potential, divided according to the Weeks–Chandler–Andersen prescription, is used as the intermolecular interaction force model. This density functional perturbation approach gives the correct phase quilibrium and predicts a surface tension in excellent agreement with recent molecular dynamics simulations. The surface tension of some pure simple fluids is predicted from an intrinsic contribution, obtained by the modified density functional perturbation theory, plus contributions due to capillary wave roughening of the surface. The respective Lennard-Jones potential parameters were obtained from fitting to saturated liquid densities of the pure fluids. © 2000 American Institute of Physics.Type of Medium: Electronic ResourceURL: -
7Staff View
ISSN: 0378-4371Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: PhysicsType of Medium: Electronic ResourceURL: -
8Staff View
ISSN: 1531-586XSource: Springer Online Journal Archives 1860-2000Topics: MathematicsNotes: Abstract We investigate holomorphic self-maps of complex manifolds of the formG/Γ whereG is a complex Lie group and Γ a lattice. We show that they are induced by automorphisms ofG and that a surjective holomorphic self-map can be nonbijective only in the directions of the nilradical ofG.Type of Medium: Electronic ResourceURL: -
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ISSN: 1432-1807Keywords: 14K20 ; 22E40 ; 32M10Source: Springer Online Journal Archives 1860-2000Topics: MathematicsType of Medium: Electronic ResourceURL: -
10Staff View
ISSN: 1420-908XSource: Springer Online Journal Archives 1860-2000Topics: MedicineType of Medium: Electronic ResourceURL: -
11Staff View
ISSN: 1420-908XSource: Springer Online Journal Archives 1860-2000Topics: MedicineType of Medium: Electronic ResourceURL: -
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ISSN: 1432-1750Source: Springer Online Journal Archives 1860-2000Topics: MedicineType of Medium: Electronic ResourceURL: -
13Hartung, H. P. ; Bitter-Suermann, D. ; Hadding, U. ; Maillet, F. ; Lambré, C. ; Kazatchkine, M. ; Kalter, E. S. ; Dijk, W. C. ; Timmermans, A. ; Verhoef, J. ; Bouma, B. N. ; Doekes, G. ; Daha, M. R. ; Es, L. A. ; Drummond, L. ; Gemmell, D. K. ; Rampart, M. ; Bult, H. ; Herman, A. G. ; Gemsa, D. ; Fischer, E. ; Jouvin, M. H. ; Hartwig, H. P. ; Parnham, M. J. ; Winkelmann, J.
Springer
Published 1982Staff ViewISSN: 1434-9949Source: Springer Online Journal Archives 1860-2000Topics: MedicineType of Medium: Electronic ResourceURL: -
14Lutz, Walburga ; Mayr, A. ; Mahnel, H. ; Winkelmann, J. ; Rieß, P. ; Lammers, H. J.
Springer
Published 1990Staff ViewISSN: 1439-0574Source: Springer Online Journal Archives 1860-2000Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, NutritionDescription / Table of Contents: Summary Since the mid 1950's the populations of rabbits have been reduced by myxomatosis. After 1979, however, a marked recovery was evident. An analysis of the hunting quotients in all hunting districts and cities in the state of Northrhine-Westfalia showed evidence of three similar epidemics but clear differences among the reactions of the various rabbit populations to the disease. For example, the highly populated district Kleve showed mortality rates of less than 30 % to more than 90 % (Tabs. 7 and 8) during the hunting year 1988/89. From July 1988 to April 1989 104 rabbits were investigated from 4 different areas (Tab. 2). From 80 wild rabbits 124 organ samples and 27 serum samples were tested for the presence of the myxomatosis virus. No virus of any kind could be isolated from any of the organ samples. Two of the serum samples neutralized the myxomatosis virus. Hence the decline of the rabbit populations can not solely be ascribed to myxomatosis. The bacteriological (Tab. 3), histological (Tab. 4), and parasitological (Tab. 5) results provided no evidence for an unusual disease level among the animals. The detailed investigations of the ovaries and testes of 32 rabbits, as well as the analysis of the levels of lead and cadmium in the livers and kidneys of 29 rabbits (Tab. 6) could not definitely prove the possibility of diminished fertility. Other possible causes of the decline in rabbit populations such as weather conditions, food supply, and predator pressure are discussed.Abstract: Résumé Depuis la moitié des années cinquante, les effectifs du Lapin de garenne enregistrent une réduction due à la Myxomatose. Après 1979, on ne put faire état d'un net rétablissement de la situation. Une analyse des tableaux de chasse dans tous les districts du Land de Rhénanie-Westphalie montre, pour trois grandes vagues d'épidémie, un parallélisme mais aussi des différences marquantes dans l'évolution des effectifs après l'apparition de l'épidémie. En prenant l'exemple du District de Clèves, trés vif en lapins, on indique qu'au cours de la saison de chasse 1988/89 la Myxomatose a entraîné des taux de mortalité estimés à moins de 30 % jusqu'à plus de 90 % (Tableaux 7 et 8). De juillet 1988 à avril 1989, dans 4 territoires, 104 lapins ont été prélevés pour examen (Tableau 2). Sur 80 lapins ont été recueillis 124 échantillons d'organes en vue de tester la présence du virus de la Myxomatose et 27 échantillons de sérum en vue de tester la présence d'anticorps de la Myxomatose. Aucun échantillon d'organe ne permit d'isoler le virus de la Myxomatose ni un virus d'une autre espèce. Deux échantillons de sérum permirent de neutraliser le virus de la Myxomatose. La régression du Lapin ne peut résulter de la seule Myxomatose. Les examens bactériologiques (Tableau 3), biologiques (Tableau 4) et parasitologiques (Tableau 5) ne révélèrent aucune charge pathologique inhabituelle des animaux. L'exament détaillé des ovaires et des testicules de 32 lapins et l'analyse de la teneur en Plomb et Cadmium dans les foies et reins de 29 animaux (Tableau 6) ne purent conforter la possibilité d'une fécondité réduite. Comme autres causes possibles de la régression du Lapin sont avancés les influences météorologiques, les ressources alimentaires et l'effet de la prédation.Notes: Zusammenfassung Seit Mitte der 50er Jahre werden die Kaninchenbesätze durch die Myxomatose reduziert. Nach 1979 setzte eine deutliche Erholung nicht mehr ein. Eine Analyse der Jagdstrecken in allen Kreisen und kreisfreien Städten des Landes Nordrhein-Westfalen zeigt für drei große Seuchenzüge Parallelen, aber deutliche Unterschiede in der Entwicklung der Besätze nach dem Auftreten der Seuche. Am Beispiel des kaninchenreichen Kreises Kleve wird für das Jagdjahr 1988/89 das Auftreten der Myxomatose mit geschätzten Mortalitätsraten unter 30 % bis über 90 % dokumentiert (Tabelle 7 und 8). Aus vier Räumen wurden von Juli 1988 bis April 1989 104 Kaninchen für eine Untersuchung entnommen (Tabelle 2). Von 80 Wildkaninchen wurden 124 Organproben auf Myxomatosevirus und 27 Serumproben auf Myxomatose-Antikörper geprüft. Aus keiner Organprobe konnte Myxomatosevirus oder ein Virus anderer Art isoliert werden. Zwei Serumproben neutralisierten das Myxomatosevirus. Der Rückgang der Kaninchen kann durch die Myxomatose allein nicht begründet werden. Die bakteriologischen (Tabelle 3), histologischen (Tabelle 4) und parasitologischen (Tabelle 5) Befunde erbrachten keine Nachweise für eine ungewöhnliche Belastung der Tiere durch Krankheiten. Die detaillierte Untersuchung der Ovarien und Hoden von 32 Kaninchen und die Analyse von Blei und Cadmium in den Lebern und Nieren von 28 Tieren (Tabelle 6) konnten die Möglichkeit einer verringerten Fruchtbarkeit nicht erhärten. Als weitere mögliche Ursachen für den Rückgang der Kaninchen werden Witterungseinflüsse, Nahrungsangebot und Feinddruck diskutiert.Type of Medium: Electronic ResourceURL: -
15Mecke, M. ; Müller, A. ; Winkelmann, J. ; Vrabec, J. ; Fischer, J. ; Span, R. ; Wagner, W.
Springer
Published 1996Staff ViewISSN: 1572-9567Keywords: coexistence curve ; equation of state ; Lennard Jones fluid ; thermodynamic propertiesSource: Springer Online Journal Archives 1860-2000Topics: PhysicsNotes: Abstract A new equation of state (EOS) is proposed for the Helmholtz energyF of the Lennard Jones fluid which represents the thermodynamic properties over a wide range of temperatures and densities. The EOS is written in the form of a generalized van der Waals equation.F =F u +F v. WhereF u is a hard body contribution andF A an anttractive dispersion force contribution. The expression forF H is closely related to the hybrid Barker Henderson pertubation theory. The construction ofF A is accomplished with the Setzmann Wagner optimization procedure on the basis of virial coefficients and critically assessed computer simulation data. A comparison with the EOS of Johnson et al. shows improvement in the description of the vapor liquid coexistence properties, thepvT data. and in peculiar, of the calorie properties. A comparison with the EOS of Kolafa and Nezbeda which appeared after the bulk of this work was finished shows still by about 30%.Type of Medium: Electronic ResourceURL: -
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ISSN: 1572-9567Keywords: Lennard Jones two-center potential model ; molecular dynamics simulations ; nitrogen ; thermodynamic propertiesSource: Springer Online Journal Archives 1860-2000Topics: PhysicsNotes: Abstract Molecular dynamics simulation results in the isochoric isothermal ensemble are reported for a two-center Lennard Jones model of fluid nitrogen characterized by the fixed molecular elongationL = 1σ = 0.3292, New values ofε andσ were determined by fitting the vapor pressure and the saturated liquid density of the model to experimental data at 94,67 K. The required vapor liquid equilibrium data of the model were taken from a study using the NpT + test particle method. The resulting values areε k = 36.32013 K (36.673 K) andσ = 0.32973 nm (0.33073 nm), with values in parentheses being those obtained previously from a Weeks Chandler Andersen-type perturbation theory. Then pressures and internal energies were calculated by molecular simulations for 110 state points in the temperature range from 72 to 330 K and for densities up to 35 mol · L1. Comparison of the predictions based on the new parameters with the empirical equation of state of Jacobsen et al. shows good to excellent agreement except in the near-critical region. Moreover. for almost all state points the new parameters yield an improvement over old ones from perturbation theory.Type of Medium: Electronic ResourceURL: -
17Staff View
ISSN: 0021-8383Keywords: Chemistry ; Organic ChemistrySource: Wiley InterScience Backfile Collection 1832-2000Topics: Chemistry and PharmacologyType of Medium: Electronic ResourceURL: -
18Schleicher, A. ; Blacet, Fr. E. ; Mac Donald, G. D. ; Pierce, H. F. ; Friedenwald, J. S. ; Freeman, D. ; Kofler, L. ; Fischer, R. ; Kofler, Adelheid ; Winkelmann, J. ; Salvioni, E. ; Friedrich, A. ; Manley, J. J. ; Dede, L. ; Donau, J. ; Damianovich, H. ; Sussmann, S.
Springer
Published 1936Staff ViewISSN: 1618-2650Source: Springer Online Journal Archives 1860-2000Topics: Chemistry and PharmacologyType of Medium: Electronic ResourceURL: