Search Results - (Author, Cooperation:J. Whitworth)

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  1. 1
    C. Rotimi ; A. Abayomi ; A. Abimiku ; V. M. Adabayeri ; C. Adebamowo ; E. Adebiyi ; A. D. Ademola ; A. Adeyemo ; D. Adu ; D. Affolabi ; G. Agongo ; S. Ajayi ; S. Akarolo-Anthony ; R. Akinyemi ; A. Akpalu ; M. Alberts ; O. Alonso Betancourt ; A. M. Alzohairy ; G. Ameni ; O. Amodu ; G. Anabwani ; K. Andersen ; F. Arogundade ; O. Arulogun ; D. Asogun ; R. Bakare ; N. Balde ; M. L. Baniecki ; C. Beiswanger ; A. Benkahla ; L. Bethke ; M. Boehnke ; V. Boima ; J. Brandful ; A. I. Brooks ; F. C. Brosius ; C. Brown ; B. Bucheton ; D. T. Burke ; B. G. Burnett ; S. Carrington-Lawrence ; N. Carstens ; J. Chisi ; A. Christoffels ; R. Cooper ; H. Cordell ; N. Crowther ; T. Croxton ; J. de Vries ; L. Derr ; P. Donkor ; S. Doumbia ; A. Duncanson ; I. Ekem ; A. El Sayed ; M. E. Engel ; J. C. Enyaru ; D. Everett ; F. M. Fadlelmola ; E. Fakunle ; K. H. Fischbeck ; A. Fischer ; O. Folarin ; J. Gamieldien ; R. F. Garry ; S. Gaseitsiwe ; R. Gbadegesin ; A. Ghansah ; M. Giovanni ; P. Goesbeck ; F. X. Gomez-Olive ; D. S. Grant ; R. Grewal ; M. Guyer ; N. A. Hanchard ; C. T. Happi ; S. Hazelhurst ; B. J. Hennig ; C. Hertz ; Fowler ; W. Hide ; F. Hilderbrandt ; C. Hugo-Hamman ; M. E. Ibrahim ; R. James ; Y. Jaufeerally-Fakim ; C. Jenkins ; U. Jentsch ; P. P. Jiang ; M. Joloba ; V. Jongeneel ; F. Joubert ; M. Kader ; K. Kahn ; P. Kaleebu ; S. H. Kapiga ; S. K. Kassim ; I. Kasvosve ; J. Kayondo ; B. Keavney ; A. Kekitiinwa ; S. H. Khan ; P. Kimmel ; M. C. King ; R. Kleta ; M. Koffi ; J. Kopp ; M. Kretzler ; J. Kumuthini ; S. Kyobe ; C. Kyobutungi ; D. T. Lackland ; K. A. Lacourciere ; G. Landoure ; R. Lawlor ; T. Lehner ; M. Lesosky ; N. Levitt ; K. Littler ; Z. Lombard ; J. F. Loring ; S. Lyantagaye ; A. Macleod ; E. B. Madden ; C. R. Mahomva ; J. Makani ; M. Mamven ; M. Marape ; G. Mardon ; P. Marshall ; D. P. Martin ; D. Masiga ; R. Mason ; M. Mate-Kole ; E. Matovu ; M. Mayige ; B. M. Mayosi ; J. C. Mbanya ; S. A. McCurdy ; M. I. McCarthy ; H. McIlleron ; S. O. Mc'Ligeyo ; C. Merle ; A. O. Mocumbi ; C. Mondo ; J. V. Moran ; A. Motala ; M. Moxey-Mims ; W. S. Mpoloka ; C. L. Msefula ; T. Mthiyane ; N. Mulder ; G. Mulugeta ; D. Mumba ; J. Musuku ; M. Nagdee ; O. Nash ; D. Ndiaye ; A. Q. Nguyen ; M. Nicol ; O. Nkomazana ; S. Norris ; B. Nsangi ; A. Nyarko ; M. Nyirenda ; E. Obe ; R. Obiakor ; A. Oduro ; S. F. Ofori-Acquah ; O. Ogah ; S. Ogendo ; K. Ohene-Frempong ; A. Ojo ; T. Olanrewaju ; J. Oli ; C. Osafo ; O. Ouwe Missi Oukem-Boyer ; B. Ovbiagele ; A. Owen ; M. O. Owolabi ; L. Owolabi ; E. Owusu-Dabo ; G. Pare ; R. Parekh ; H. G. Patterton ; M. B. Penno ; J. Peterson ; R. Pieper ; J. Plange-Rhule ; M. Pollak ; J. Puzak ; R. S. Ramesar ; M. Ramsay ; R. Rasooly ; S. Reddy ; P. C. Sabeti ; K. Sagoe ; T. Salako ; O. Samassekou ; M. S. Sandhu ; O. Sankoh ; F. S. Sarfo ; M. Sarr ; G. Shaboodien ; I. Sidibe ; G. Simo ; M. Simuunza ; L. Smeeth ; E. Sobngwi ; H. Soodyall ; H. Sorgho ; O. Sow Bah ; S. Srinivasan ; D. J. Stein ; E. S. Susser ; C. Swanepoel ; G. Tangwa ; A. Tareila ; O. Tastan Bishop ; B. Tayo ; N. Tiffin ; H. Tinto ; E. Tobin ; S. M. Tollman ; M. Traore ; M. J. Treadwell ; J. Troyer ; M. Tsimako-Johnstone ; V. Tukei ; I. Ulasi ; N. Ulenga ; B. van Rooyen ; A. P. Wachinou ; S. P. Waddy ; A. Wade ; M. Wayengera ; J. Whitworth ; L. Wideroff ; C. A. Winkler ; S. Winnicki ; A. Wonkam ; M. Yewondwos ; T. sen ; N. Yozwiak ; H. Zar
    American Association for the Advancement of Science (AAAS)
    Published 2014
    Staff View
    Publication Date:
    2014-06-21
    Publisher:
    American Association for the Advancement of Science (AAAS)
    Print ISSN:
    0036-8075
    Electronic ISSN:
    1095-9203
    Topics:
    Biology
    Chemistry and Pharmacology
    Computer Science
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Africa ; Disease/*genetics ; England ; Genetics, Medical/trends ; Genome-Wide Association Study/*trends ; Genomics/*trends ; Health ; Humans ; National Institutes of Health (U.S.) ; United States
    Published by:
    http://www.aaas.org/

    Latest Papers from Table of Contents or Articles in Press
  2. 2
    Whitworth, J. A. ; Hewitson, T. D.

    Oxford, UK : Blackwell Publishing Ltd
    Published 1991
    Staff View
    ISSN:
    1440-1681
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Notes:
    1. Adrenocorticotrophin (ACTH) administration produces an adrenally dependent rise in blood pressure in rats.2. The haemodynamic and metabolic effects of ACTH were examined in nephrectomized, 5/6 nephrectomized and orchidectomized male Sprague-Dawley rats and sham operated controls.3. Reduction in renal mass did not increase the blood pressure rise produced by ACTH.4. Gonadectomy did not reduce the blood pressure rise produced by ACTH, which was slightly higher in castrated animals.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1111/j.1440-1681.1991.tb01397.x

    Articles: DFG German National Licenses
  3. 3
    Mason, R. T. ; Coghlan, J. P. ; Denton, D. A. ; Fei, D. W. T. ; Whitworth, J. A. ; Scoggins, B. A.

    Oxford, UK : Blackwell Publishing Ltd
    Published 1984
    Staff View
    ISSN:
    1440-1681
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Notes:
    1. The effect of prostacyclin (PGI2) infusion on plasma renin concentration (PRC) was examined before and after propranolol treatment in sheep.2. Increasing doses of prostacyclin (0.05, 0.1 or 0.3 μg/kg per min) produced dose dependent increases in PRC.3. There was a significantly lower PRC response after propranolol at 0.3 μg/kg per min only.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1111/j.1440-1681.1984.tb00869.x

    Articles: DFG German National Licenses
  4. 4
    Nelson, M. A. ; Coghlan, J. P. ; Denton, D. A. ; Mills, E. H. ; Spence, C. D. ; Whitworth, J. A. ; Scoggins, B. A.

    Oxford, UK : Blackwell Publishing Ltd
    Published 1984
    Staff View
    ISSN:
    1440-1681
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Notes:
    1. Serotonin causes a dose related (0.1–20 μg/kg i.v.) increase in mean arterial blood pressure (MAP) and heart rate in conscious sheep.2. Ketanserin (0.1 mg/kg per h i.v.) causes a decrease in blood pressure, and an increase in heart rate. In the presence of ketanserin, serotonin induced increases in MAP are attenuated, or abolished, but the increases in heart rate are enhanced.3. Ketanserin (10 mg/kg per h i.v.) attenuates or abolishes the increase in blood pressure induced by the α-adrenoceptor agonist phenylephrine in conscious sheep. When administered in the presence of the α-adrenoceptor antagonist prazosin, ketanserin (0.1 mg/kg per h i.v.) fails to induce a further hypotensive response.4. These data suggest that in the conscious sheep ketanserin exhibits predominantly α-adrenoceptor antagonism.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1111/j.1440-1681.1984.tb00872.x

    Articles: DFG German National Licenses
  5. 5
    Tresham, J. J. ; Whitworth, J. A. ; Lima, J. J. G. ; McDougall, J. G. ; Scoggins, B. A.

    Oxford, UK : Blackwell Publishing Ltd
    Published 1988
    Staff View
    ISSN:
    1440-1681
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Notes:
    b1. This study was designed to test the haemodynamic and renal effects in sheep of dihydrocyclosporin D (dCyD), an immunosuppressant agent derived from the fungus Tolypocladium inflatum Gams.2. dCyD was infused for 5 days at 12 mg/kg per day. Mean arterial pressure (MAP) was elevated after 24 h, but thereafter returned to control levels. Heart rate was significantly elevated throughout the infusion and was still high 24 h postinfusion. Cardiac output rose after 5 days, but total peripheral resistance was unchanged during the infusion.3. Glomerular filtration rate, renal blood flow and effective renal plasma flow remained unchanged, although urine sodium excretion rose for the first 48 h.4. Infusion of the castor oil-based vehicle for cyclosporin, Cremaphore EL, for 5 days in four sheep did not produce any sustained changes in any of the parameters measured.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1111/j.1440-1681.1988.tb01095.x

    Articles: DFG German National Licenses
  6. 6
    Nelson, M. ; Coghlan, J. P. ; Denton, D. A. ; Tresham, J. J. ; Whitworth, J. A. ; Scoggins, B. A.

    Oxford, UK : Blackwell Publishing Ltd
    Published 1987
    Staff View
    ISSN:
    1440-1681
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Notes:
    1. In previous studies, exogenous serotonin (5-HT), administered intravenously, caused dose-related increases in mean arterial pressure and heart rate in conscious sheep. The 5-HT2 antagonist ketanserin (0.1 mg/kg per h, i.v.) was shown to lower blood pressure in the conscious sheep primarily through antagonism of α-adrenoceptors.2. A newer 5-HT2 antagonist, ritanserin, is a more selective antagonist in vivo, as it attenuated or abolished pressor responses to exogenous 5-HT, but not to phenylephrine.3. When infused alone, ritanserin (0.1 mg/kg per h, i.v.) failed to produce a decrease in blood pressure, suggesting that 5-HT antagonistic properties are not sufficient by themselves to lower blood pressure.4. Ritanserin displayed a different metabolic profile to ketanserin, with a markedly decreased water intake. The mechanism of this effect is unresolved, but may imply a permissive role for 5-HT in the modulation of drinking responses in the sheep.5. Ritanserin did not modify ACTH-induced hypertension in sheep.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1111/j.1440-1681.1987.tb01874.x

    Articles: DFG German National Licenses
  7. 7
    Mason, R. T. ; Coghlan, J. P. ; Denton, D. A. ; Fei, D. W. T. ; Scoggins, B. A. ; Stewart, K. W. ; Whitworth, J. A.

    Oxford, UK : Blackwell Publishing Ltd
    Published 1984
    Staff View
    ISSN:
    1440-1681
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Notes:
    1. The use of a low Na, low K sorghum grain diet supplemented with intraruminal electrolyte infusions has enabled dietary manipulation of sodium status to be studied in the sheep.2. Dietary sodium restriction reduced urinary sodium excretion within 24 h with maximal retention after 3 days. There were no other substantial metabolic or haemodynamic changes.3. A more severe form of sodium deficiency produced by parotid salivary drainage resulted after only 2 days in a sodium deficit 3–4 times that seen with 14 days of sodium restriction. Extracellular fluid volume and cardiac output decreased. Blood pressure was unchanged but there was an increase in peripheral resistance and plasma renin concentration.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1111/j.1440-1681.1984.tb00861.x

    Articles: DFG German National Licenses
  8. 8
    Humphery, T. J. ; Coghlan, J. P. ; Denton, D. A. ; Fei, D. W. T. ; Graham, W. F. ; Scoggins, B. A. ; Whitworth, J. A.

    Oxford, UK : Blackwell Publishing Ltd
    Published 1984
    Staff View
    ISSN:
    1440-1681
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Notes:
    1. The short term effects of the novel diuretic MK 447 were examined in both normotensive and hypertensive (ACTH treated) conscious sheep.2. The drug had profound diuretic, natriuretic and kaliuretic effects in both groups. Plasma sodium was unchanged but plasma potassium fell and haematocrit increased. Plasma renin concentration increased with MK 447 in the normotensive but not the hypertensive sheep.3. In the normotensive sheep cardiac output fell, peripheral resistance increased and blood pressure was unchanged. In the hypertensive ACTH treated sheep cardiac output and blood pressure fell but resistance was unchanged.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1111/j.1440-1681.1984.tb00856.x

    Articles: DFG German National Licenses
  9. 9
    Mills, E. H. ; Coghlan, J. P. ; Denton, D. A. ; Scoggins, B. A. ; Spence, C. D. ; Whitworth, J. A.

    Oxford, UK : Blackwell Publishing Ltd
    Published 1983
    Staff View
    ISSN:
    1440-1681
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Notes:
    1. The effect of 5 days administration of ACTH or DOC, was examined before and after chronic potassium (K) loading in sheep.2. K loading raised plasma [K], urine volume and K excretion but had no effect on mean arterial pressure (MAP).3. On a normal K intake DOC (5 mg/day i.v.) increased MAP and plasma sodium [Na]. Plasma [K], urinary Na (day 1) and K (day 1) excretion were decreased. On a high K intake (≃800 mmol K/day), DOC lowered plasma [K] but had no effect on MAP or Na excretion.4. The hypertensive effects of ACTH were not affected by K intake.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1111/j.1440-1681.1983.tb00214.x

    Articles: DFG German National Licenses
  10. 10
    Whitworth, J. A. ; Hammond, T. G. ; Stewart, K. W. ; Mason, R. T. ; Schneider, E. G. ; Denton, D. A. ; Coghlan, J. P. ; Scoggins, B. A.

    Oxford, UK : Blackwell Publishing Ltd
    Published 1982
    Staff View
    ISSN:
    1440-1681
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Notes:
    1. The effect on renal function in sheep of inhibiting converting enzyme with captopril was examined before and after 5 days ACTH administration.2. Glomerular filtration rate, effective renal plasma flow, effective renal blood flow, mean arterial pressure and plasma sodium were all significantly incereased by ACTH treatment and plasma potassium was decreased. Captopril (20 mg i.v.) had no effect on renal function or blood pressure before or after ACTH treatment, although urinary potassium excretion decreased following captopril on day 6 of ACTH treatment.3. The increase in glomerular filtration rate and effective renal plasma flow seen with ACTH treatment in sheep does not appear to be mediated by the renin-angiotensin system.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1111/j.1440-1681.1982.tb00825.x

    Articles: DFG German National Licenses
  11. 11
    Graham, W. F. ; Allen, K. J. F. ; Coghlan, J. P. ; Denton, D. A. ; Humphery, T. J. ; Scoggins, B. A. ; Whitworth, J. A.

    Oxford, UK : Blackwell Publishing Ltd
    Published 1980
    Staff View
    ISSN:
    1440-1681
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Notes:
    1. ACTH (20 μg/kg per day) produced an elevation in blood pressure associated with an increase in cardiac output in conscious sheep, due in the first 72 h to a rise in heart rate. Stroke volume did not rise until the fourth day of ACTH treatment.2. Calculated total peripheral resistance did not change.3. Intravenous administration of acebutolol prior to and during ACTH administration did not modify the rise in blood pressure, but this was associated with a rise in total peripheral resistance.4. These studies show that while ACTH-induced hypertension is usually associated with increased cardiac output, rather than total peripheral resistance it still occurs, but is associated with a rise in total peripheral resistance if the rise in cardiac output is prevented by /J-adrenoreceptor blockade.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1111/j.1440-1681.1980.tb00113.x

    Articles: DFG German National Licenses
  12. 12
    Tresham, J. J. ; Dusting, G. J. ; Coghlan, J. P. ; Whitworth, J. A.

    Oxford, UK : Blackwell Publishing Ltd
    Published 1991
    Staff View
    ISSN:
    1440-1681
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Notes:
    1. The haemodynamic and hormonal responses to N-nitro-l-arginine (NOLA), a potent inhibitor of nitric oxide biosynthesis in endothelial cells, were investigated in conscious sheep.2. Mean arterial blood pressure (MAP), heart rate (HR) and cardiac output by thermodilution (CO) were measured in four oophrectomized ewes. Two other ewes were surgically implanted with aortic electromagnetic flow probes and an indwelling carotid arterial line for monitoring CO and MAP over 40 h.3. After a control period, NOLA (10 mg/kg) was injected intravenously and MAP, HR and CO monitored and blood samples taken at intervals over the following 24 h.4. NOLA increased blood pressure within minutes, from 76 ± 4 to a maximum of 99 ± 4 mmHg (P〈0.001) at 6 h after injection. It remained elevated 24 h after injection. CO and HR fell but these falls were not sustained longer than 6 h. Calculated total peripheral resistance increased to a maximum of 2 h, but had returned to control levels 24 h after injection. There were no significant changes in plasma concentrations of renin, atrial natriuretic factor, vasopressin, noradrenaline or endothelin during the first hour.5. NOLA may be a useful tool in understanding the role of the endothelium and nitric oxide in the control of blood pressure.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1111/j.1440-1681.1991.tb01456.x

    Articles: DFG German National Licenses
  13. 13
    Wong, K. S. ; Williamson, P. M. ; Brown, M. A. ; Zammit, V. C. ; Denton, D. A. ; Whitworth, J. A.

    Oxford, UK : Blackwell Publishing Ltd
    Published 1993
    Staff View
    ISSN:
    1440-1681
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Notes:
    1. Adrenocorticotrophic hormone (ACTH) and corticosteroids stimulate salt appetite in laboratory animals. The hypothesis tested was that cortisol administration increases salt preference in humans.2. Sodium taste studies (detection and recognition thresholds, taste intensity and preference tests) were conducted before, during and after cortisol administration (200 mg/day for 5 days) in normal men on a free diet.3. Cortisol significantly increased systolic blood pressure (SBP), 113 ± 3–130±4 mmHg, P 〈 0.05; diastolic blood pressure (DBP), 65±3–81±2 mmHg, P 〈 0.05; mean arterial pressure (MAP), 81± 2–97± 3 mmHg, P 〈 0.05; and bodyweight, 72.9±3.0–75.4±3.3 kg, P 〈 0.05.4. Salt detection and recognition thresholds, taste intensity and preference for sodium chloride were unchanged following cortisol.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1111/j.1440-1681.1993.tb00584.x

    Articles: DFG German National Licenses
  14. 14
    Scoggins, B. A. ; Allen, K. J. ; Coghlan, J. P. ; Denton, D. A. ; Tresham, J. J. ; Wang, X-M. ; Whitworth, J. A.

    Oxford, UK : Blackwell Publishing Ltd
    Published 1984
    Staff View
    ISSN:
    1440-1681
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Notes:
    1. The time of onset and dose threshold for ACTH induced hypertension was examined in conscious sheep.2. ACTH 1 μg/kg per day significantly raised blood pressure. The maximum rise occurred at 2 μg/kg per day.3. The rise in pressure was significant after 8 h of ACTH infusion.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1111/j.1440-1681.1984.tb00279.x

    Articles: DFG German National Licenses
  15. 15
    HELLIWELL, T.R. ; FLOOK, D. ; WHITWORTH, J. ; DAY, D.W.

    Oxford, UK : Blackwell Publishing Ltd
    Published 1985
    Staff View
    ISSN:
    1365-2559
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Notes:
    A case of systemic lupus erythematosus with massive haemorrhage from the colon is described. Histological examination showed ulceration of the mucosa of the ascending colon with necrotizing vasculitis of the submucosal veins. Adjacent arteries were normal apart from one which had ruptured on the surface of an ulcer. This is the first clearly documented case of colonic venulitis in systemic lupus erythematosus and the differential diagnosis of gastrointestinal haemorrhage in this disease is discussed.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1111/j.1365-2559.1985.tb02788.x

    Articles: DFG German National Licenses
  16. 16
    Whitworth, J.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    0169-4758
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Biology
    Medicine
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1016/0169-4758(92)90286-B

    Articles: DFG German National Licenses
  17. 17
    Whitworth, J. 〈Sir〉

    London : Periodicals Archive Online (PAO)
    Published 1872
    Staff View
    ISSN:
    0958-0433
    Topics:
    Art History
    URL:
    http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pao:&rft_dat=xri:pao:article:q549-1872-021-00-002434

    Articles: DFG German National Licenses
  18. 18
    Staff View
    ISSN:
    1432-1041
    Keywords:
    isoxicam ; pharmacokinetics ; renal failure
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Chemistry and Pharmacology
    Medicine
    Notes:
    Summary The accumulation and disposition of the non-steroidal antiinflammatory drug isoxicam were investigated following its oral administration to 6 subjects with normal renal function and 13 patients with diminished renal function. Isoxicam was given daily as a single oral dose for 14–15 consecutive days. Steady-state plasma levels were achieved after 13 days. The effect of differences in renal function on the kinetics of isoxicam appeared to be minimal. Accumulation of isoxicam was similar in both groups of subjects and there was no significant difference between the groups in the plasma clearance or terminal half-life of isoxicam. There were substantial differences between individuals in the apparent plasma clearance and half-life of the drug, and this is reflected in the 7-fold range of steady-state plasma isoxicam concentrations encountered in the subjects.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF00544071

    Articles: DFG German National Licenses
  19. 19
    Whitworth, J. V.
    Springer
    Published 1948
    Staff View
    ISSN:
    1618-1891
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Mathematics
    Notes:
    Sunto. Determinazione dei reticolati critici relativi alla porzione di un cubo compresa fra due piani perpendicolari ad una diagonale e simmetrici rispetto al centro.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF02415557

    Articles: DFG German National Licenses