Search Results - (Author, Cooperation:J. Weng)
-
1Staff View
Publication Date: 2018-06-09Publisher: MDPI PublishingElectronic ISSN: 1996-1944Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision MechanicsPublished by: -
2Y. Cao ; X. Jin ; H. Huang ; M. G. Derebe ; E. J. Levin ; V. Kabaleeswaran ; Y. Pan ; M. Punta ; J. Love ; J. Weng ; M. Quick ; S. Ye ; B. Kloss ; R. Bruni ; E. Martinez-Hackert ; W. A. Hendrickson ; B. Rost ; J. A. Javitch ; K. R. Rajashankar ; Y. Jiang ; M. Zhou
Nature Publishing Group (NPG)
Published 2011Staff ViewPublication Date: 2011-02-15Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: ATP-Binding Cassette Transporters/chemistry ; Amino Acid Sequence ; Crystallography, X-Ray ; Escherichia coli Proteins/chemistry ; Ion Channel Gating ; Ion Transport ; Models, Molecular ; Molecular Sequence Data ; Potassium/metabolism ; Potassium Channels/*chemistry/*metabolism ; Structure-Activity Relationship ; Substrate Specificity ; Vibrio parahaemolyticus/*chemistryPublished by: -
3Stockstill, K., Doyle, T. M., Yan, X., Chen, Z., Janes, K., Little, J. W., Braden, K., Lauro, F., Giancotti, L. A., Harada, C. M., Yadav, R., Xiao, W. H., Lionberger, J. M., Neumann, W. L., Bennett, G. J., Weng, H.-R., Spiegel, S., Salvemini, D.
Rockefeller University Press
Published 2018Staff ViewPublication Date: 2018-05-08Publisher: Rockefeller University PressPrint ISSN: 0022-1007Electronic ISSN: 1540-9538Topics: MedicineKeywords: Neuroinflammation, NeurosciencePublished by: -
4Peter J. Weng, Yang Gao, Mark T. Gregory, Pengcheng Wang, Yinsheng Wang, Wei Yang
National Academy of Sciences
Published 2018Staff ViewPublication Date: 2018-10-17Publisher: National Academy of SciencesPrint ISSN: 0027-8424Electronic ISSN: 1091-6490Topics: BiologyMedicineNatural Sciences in GeneralPublished by: -
5Y. Cao ; X. Jin ; E. J. Levin ; H. Huang ; Y. Zong ; M. Quick ; J. Weng ; Y. Pan ; J. Love ; M. Punta ; B. Rost ; W. A. Hendrickson ; J. A. Javitch ; K. R. Rajashankar ; M. Zhou
Nature Publishing Group (NPG)
Published 2011Staff ViewPublication Date: 2011-04-08Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Bacillus cereus/*enzymology ; Binding Sites ; Carbohydrate Metabolism ; Crystallization ; Membrane Transport Proteins/*chemistry ; *Models, Molecular ; Phosphorylation ; Protein Structure, Quaternary ; Protein Structure, TertiaryPublished by: -
6Alatrash, G., Perakis, A. A., Kerros, C., Peters, H. L., Sukhumalchandra, P., Zhang, M., Jakher, H., Zope, M., Patenia, R., Sergeeva, A., Yi, S., Young, K. H., Philips, A. V., Cernosek, A. M., Garber, H. R., Qiao, N., Weng, J., St John, L. S., Lu, S., Clise-Dwyer, K., Mittendorf, E. A., Ma, Q., Molldrem, J. J.
The American Association for Cancer Research (AACR)
Published 2018Staff ViewPublication Date: 2018-07-17Publisher: The American Association for Cancer Research (AACR)Print ISSN: 1078-0432Electronic ISSN: 1557-3265Topics: MedicinePublished by: -
7Staff View
ISSN: 1471-4159Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: The removal of circulating ketone bodies by the brain was investigated in 0- to 8-day-old puppies under pentobarbital anaesthesia. Of the arterial acetoacetate (AcAc) and β-hydroxybutyrate (βOHB), 24 and 30 per cent, respectively, were removed by the brain. There was a direct correlation between the arterial concentrations of either AcAc or βOHB and the A-V difference of the respective ketone body across the brain. When a continuous infusion of Na-dl-3-hydroxybutyrate [3-14T] was administered for more than 2 h, labelling of both phospholipids and free cholesterol was consistently observed in all six areas of the brain that were sampled. We conclude that the removal and utilization of ketones is of physiological importance in the brain of newborn animals.Type of Medium: Electronic ResourceURL: -
8Staff View
ISSN: 1749-6632Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: Natural Sciences in GeneralType of Medium: Electronic ResourceURL: -
9AWUAH, G.B. ; ECONOMIDES, A. ; SHAFER, B.D. ; WENG, J.
Oxford, UK and Malden, USA : Blackwell Science Inc
Published 2004Staff ViewISSN: 1745-4530Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: Process Engineering, Biotechnology, Nutrition TechnologyNotes: Experiments were conducted using Bacillus stearothermophilus spores in 0.5% w/w carboxymethylcellulose suspension to evaluate come-up contributions from the tubular heat exchanger. A lab-scale UHT/HTST simulator that allowed samples to be collected at the exit of the heat exchanger and holding tube was used with operating temperatures up to 270F. The bulk mean residence time in the heat exchanger ranged from 30 to 89 sec, while that in the holding tube ranged from 4 to 14 sec. It was observed that between 40% and 51% of the cumulative lethality ( 〈inlineGraphic alt="inline image" href="urn:x-wiley:01458876:JFPE386:JFPE_386_mu1" location="equation/JFPE_386_mu1.gif"/〉 ) at the exit of the holding tube, was contributed by come-up in the tubular heat exchanger. This come-up contribution was determined on the basis of having an 〈inlineGraphic alt="inline image" href="urn:x-wiley:01458876:JFPE386:JFPE_386_mu1" location="equation/JFPE_386_mu1.gif"/〉 of 8.5 min in the holding tube alone. It was evident that come-up lethality will depend on product initial temperature, residence time and temperature history in the heat exchanger, with higher temperatures obviously contributing more lethality. Therefore, the entire aseptic system becomes even more complex since several critical parameters need to be monitored, controlled and documented. Experimental data compared favorably with computer-simulated data using the AseptiCAL™ software, with the software package giving more conservative results. Ultimately, come-up credit (CUC) should be tested on a pilot scale or industrial setup by way of reduced residence time (i.e. increased fluid flow rate), reduced holding tube length or temperature in order to determine if CUC can be applied towards the lethality required for the product. Monitoring and control devices become critical to ensure consistency and reproducibility in product residence time and time–temperature history, in the tubular heat exchanger.Type of Medium: Electronic ResourceURL: -
10Staff View
ISSN: 0003-2670Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Chemistry and PharmacologyType of Medium: Electronic ResourceURL: -
11Staff View
ISSN: 0038-1101Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Electrical Engineering, Measurement and Control TechnologyPhysicsType of Medium: Electronic ResourceURL: -
12Staff View
ISSN: 0038-1101Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Electrical Engineering, Measurement and Control TechnologyPhysicsType of Medium: Electronic ResourceURL: -
13Staff View
ISSN: 0038-1101Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Electrical Engineering, Measurement and Control TechnologyPhysicsType of Medium: Electronic ResourceURL: -
14Staff View
ISSN: 0167-9317Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Electrical Engineering, Measurement and Control TechnologyType of Medium: Electronic ResourceURL: -
15Staff View
ISSN: 0168-9452Keywords: Cytoplasmic low molecular weight heat shock proteins ; Heat shock response ; Triticum aestivum ; cDNAsSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyType of Medium: Electronic ResourceURL: -
16Staff View
ISSN: 1432-0541Keywords: Key words. Steiner tree, Linear-time algorithm.Source: Springer Online Journal Archives 1860-2000Topics: Computer ScienceMathematicsNotes: Abstract. A Steiner tree T on a given set of points A is called linear if all Steiner points, including those collapsing into their adjacent given points, lie on one path referred to as its trunk. Suppose A is a simple polygonal line. Roughly speaking, T is similar to A if its trunk turns right or left when A does. In this paper we prove that A can be expanded to another polygonal line, and T can be constructed in linear time using this expansion method.Type of Medium: Electronic ResourceURL: -
17Staff View
ISSN: 1432-0541Keywords: Steiner minimal tree ; Zigzag lineSource: Springer Online Journal Archives 1860-2000Topics: Computer ScienceMathematicsNotes: Abstract Sets of points for which the Steiner minimal tree is known, are available only for some very special cases. This paper describes the Steiner minimal tree for a set of points forming the vertices of special zigzag lines.Type of Medium: Electronic ResourceURL: -
18Staff View
ISSN: 1432-0444Source: Springer Online Journal Archives 1860-2000Topics: Computer ScienceMathematicsNotes: Abstract Fifty years ago Jarnik and Kössler showed that a Steiner minimal tree for the vertices of a regularn-gon contains Steiner points for 3 ≤n≤5 and contains no Steiner point forn=6 andn≥13. We complete the story by showing that the case for 7≤n≤12 is the same asn≥13. We also show that the set ofn equally spaced points yields the longest Steiner minimal tree among all sets ofn cocircular points on a given circle.Type of Medium: Electronic ResourceURL: -
19Lehto, M. ; Wipemo, C. ; Ivarsson, S.-A. ; Lindgren, C. ; Lipsanen-Nyman, M. ; Weng, J. ; Wibell, L. ; Widén, E. ; Tuomi, T. ; Groop, L.
Springer
Published 1999Staff ViewISSN: 1432-0428Keywords: Keywords Glucokinase ; HNF-1 ; HNF-4 ; MODY ; MIDD ; genetics.Source: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract Aims/hypothesis. To investigate the contribution of mutations in maturity-onset diabetes of the young (MODY) and mitochondrial genes to early-onset diabetes with a strong family history of diabetes in a cohort with a high prevalence of Type I (insulin-dependent) diabetes mellitus. Methods. Screening for sequence variants in the hepatocyte nuclear factor (HNF)–4 α (MODY1), glucokinase (MODY2), HNF-1 α (MODY3) genes and mitochondrial DNA was carried out in 115 Finnish and Swedish patients with early-onset ( ≤ 40 years) diabetes using the single strand conformation polymorphism (SSCP) technique and direct sequencing. Allele frequencies were compared with 118 patients with onset of diabetes Type II (non-insulin-dependent) diabetes mellitus after the age of 40 and 92 non–diabetic control subjects without a family history of diabetes. Results. In total 52 sequence variants were found in the HNF-1α, HNF-4α and glucokinase genes, 12 of which were considered as MODY mutations. Three families had the A3243G mutation in the mitochondrial tRNA Leu gene, which resulted in an overall prevalence of these mutations of 13 %. Conclusion/interpretation. Among 115 Scandinavian families, mutations in the HNF-1α gene represented the most common cause of familial early-onset ( ≤ 40 years) diabetes: MODY3 (5.2 %) more than MODY2 (3.5 %) more than MIDD (2.6 %) more than MODY1 (1.7 %). [Diabetologia (1999) 42: 1131–1137]Type of Medium: Electronic ResourceURL: -
20Staff View
ISSN: 1573-4811Source: Springer Online Journal Archives 1860-2000Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision MechanicsType of Medium: Electronic ResourceURL: