Search Results - (Author, Cooperation:J. Webster)

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  1. 1
    Staff View
    Publication Date:
    2018-02-22
    Publisher:
    Wiley-Blackwell
    Print ISSN:
    1051-0761
    Electronic ISSN:
    1939-5582
    Topics:
    Biology
    Published by:
    Latest Papers from Table of Contents or Articles in Press
  2. 2
    Staff View
    Publication Date:
    2014-12-04
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Animals ; Enzyme Stability ; Female ; Inflammation/genetics/pathology ; Interleukin-17/*biosynthesis ; Intestine, Small/metabolism/pathology ; Lymphocyte Activation ; Mice ; Mice, Inbred C57BL ; Nuclear Receptor Subfamily 1, Group F, Member 3/metabolism ; Proteasome Endopeptidase Complex/metabolism ; Protein Binding ; *Protein Biosynthesis ; Signal Transduction ; Substrate Specificity ; Th17 Cells/*metabolism ; Transforming Growth Factor beta/metabolism ; Ubiquitin-Protein Ligases/metabolism ; Ubiquitin-Specific Proteases/biosynthesis/deficiency/genetics/*metabolism ; Ubiquitination
    Published by:
    Latest Papers from Table of Contents or Articles in Press
  3. 3
    Staff View
    Publication Date:
    2018-05-22
    Publisher:
    BMJ Publishing
    Electronic ISSN:
    2044-6055
    Topics:
    Medicine
    Keywords:
    Open access, Public health
    Published by:
    Latest Papers from Table of Contents or Articles in Press
  4. 4
    P. J. Webster
    Nature Publishing Group (NPG)
    Published 2013
    Staff View
    Publication Date:
    2013-01-04
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Bangladesh/epidemiology ; Cyclonic Storms/mortality ; *Developing Countries/economics/statistics & numerical data ; Disasters/economics/prevention & control/*statistics & numerical data ; Droughts/mortality ; Floods/mortality ; Forecasting/*methods ; Humans ; Meteorology/*methods/standards ; Starvation/epidemiology ; Time Factors ; *Weather
    Published by:
    Latest Papers from Table of Contents or Articles in Press
  5. 5
    K. Newton ; D. L. Dugger ; K. E. Wickliffe ; N. Kapoor ; M. C. de Almagro ; D. Vucic ; L. Komuves ; R. E. Ferrando ; D. M. French ; J. Webster ; M. Roose-Girma ; S. Warming ; V. M. Dixit
    American Association for the Advancement of Science (AAAS)
    Published 2014
    Staff View
    Publication Date:
    2014-02-22
    Publisher:
    American Association for the Advancement of Science (AAAS)
    Print ISSN:
    0036-8075
    Electronic ISSN:
    1095-9203
    Topics:
    Biology
    Chemistry and Pharmacology
    Computer Science
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Animals ; *Apoptosis ; Caspase 8/genetics/metabolism ; Cell Survival ; Embryo Loss ; Embryonic Development ; Enteritis/pathology ; Fas-Associated Death Domain Protein/metabolism ; Gene Knock-In Techniques ; Intestine, Large/pathology ; Intestine, Small/pathology ; Mice ; *Necrosis ; Receptor-Interacting Protein Serine-Threonine Kinases/antagonists & ; inhibitors/genetics/*metabolism ; Tumor Necrosis Factor-alpha/pharmacology
    Published by:
    Latest Papers from Table of Contents or Articles in Press
  6. 6
  7. 7
    Latest Papers from Table of Contents or Articles in Press
  8. 8
    WEBSTER, J. CLARENCE

    Oxford, UK : Blackwell Publishing Ltd
    Published 1902
    Staff View
    ISSN:
    1471-0528
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  9. 9
    WEBSTER, J. M.

    Oxford, UK : Blackwell Publishing Ltd
    Published 1960
    Staff View
    ISSN:
    1550-7408
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Biology
    Notes:
    Stages in the life-cycle of the coccidium Eimeria neosciuri Prasad(12), from the epithelial lining of the small intestine of Sciurus carolinensis Gmelin are described, with particular reference to the endogenous phases. The pathology, sporulation and rate of oocyst production are determined, and a discussion on known coccidia from related Sciurus spec: included.
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  10. 10
    Staff View
    ISSN:
    1471-4159
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Notes:
    Abstract : Human nicotinic acetylcholine (ACh) receptor subtypes expressed in Xenopus oocytes were characterized in terms of their activation by the experimental agonist RJR-2403. Responses to RJR-2403 were compared with those evoked by ACh and nicotine. These agonists were also characterized in terms of whether application of the drugs had the effect of producing a residual inhibition that was manifest as a decrease in subsequent control responses to ACh measured 5 min after the washout of the drug. For the activation of α4β2 receptors, RJR-2403 had an efficacy equivalent to that of ACh and was more potent than ACh. RJR-2403 was less efficacious than ACh for other human receptor subtypes, suggesting that it is a partial agonist for all these receptors. Nicotine activated peak currents in human α4β2 and α3β2 receptors that were 85 and 50% of the respective ACh maximum responses. Nicotine was an efficacious activator of human α7 receptors, with a potency similar to ACh, whereas RJR-2403 had very low potency and efficacy for these receptors. At concentrations of 〈1 mM, RJR-2403 did not produce any residual inhibition of subsequent ACh responses for any receptor subtype. In contrast, nicotine produced profound residual inhibition of human α4β2, α3β2, and α7 receptors with IC50 values of 150, 200, and 150 μM, respectively. Co-expression of the human α5 subunit with α3 and β2 subunits had the effect of producing protracted responses to ACh and increasing residual inhibition by ACh and nicotine but not RJR-2403. In conclusion, our results, presented in the context of the complex pharmacology of nicotine for both activating and inhibiting neuronal nicotinic receptor subtypes, suggest that RJR-2403 will be a potent and relatively selective activator of human α4β2 receptors.
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  11. 11
    WEBSTER, J. CLARENCE

    Oxford, UK : Blackwell Publishing Ltd
    Published 1903
    Staff View
    ISSN:
    1471-0528
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  12. 12
    McIntosh, R. A. ; Porter, D. R. ; Baker, C. A. ; Webster, J. A.

    Oxford, UK : Blackwell Publishing Ltd
    Published 1998
    Staff View
    ISSN:
    1439-0523
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes:
    The Russian wheat aphid (RWA), Diuraphis noxia (Mordvilko), has become a serious, perennial pest of wheat (Triticum aestivum L.) in many areas of the world. This study was initiated to determine the inheritance of RWA resistance in PI 140207 (a RWA-resistant spring wheat) and to determine its allelic relationship with a previously reported RWA resistance gene. Crosses were made between PI 140207 and ‘Pavon’ (a RWA-susceptible spring wheat). Genetic analysis was performed on the parents, F1, F2, backcross (BC) population and F2-derived F3 families. Analyses of segregation patterns of plants in the F1, F2, and BC populations, and F2-derived F3 families indicated single dominant gene control of RWA resistance in PI 140207. Results of the allelism test indicated that the resistance gene in PI 140207, while conferring distinctly different seedling reactions to RWA feeding, is the same as Dn 1, the resistance gene in PI 137739.
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  13. 13
    ROSEN, M. ; WEBSTER, J. A.

    Oxford, UK : Blackwell Publishing Ltd
    Published 1985
    Staff View
    ISSN:
    1365-2044
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Notes:
    In a randomised double-blind trial in postoperative ambulant day case dental patients suprofen 200 mg (29 patients) was compared with dextropropoxyphene hydrochloride 65 mg and paracetamol 650 mg (Cosalgesic, 28 patients) both available four times daily for 3 days. Suprofen was better than cosalgesic in the patients' opinion of initial (p = 0.01) and overall pain relief (p = 0.08) compared to Cosalgesic and the second night's sleep was better (p = 0.01). Side effects were reported in six suprofen patients and 10 cosalgesic patients (two suffering from vomiting withdrew). Suprofen, a non-steroidal anti-inflammatory drug is as good as, or better than, a widely used opioiparacetamol mixture for ambulant patients with postoperative dental pain.
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  14. 14
    BENFIELD, E. F. ; WEBSTER, J. R.

    Oxford, UK : Blackwell Publishing Ltd
    Published 1985
    Staff View
    ISSN:
    1365-2427
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Biology
    Notes:
    SUMMARY. 〈list xml:id="l1" style="custom"〉1Breakdown rates of dogwood (Cornus florida L.), red maple (Acer rubrum L.) and white oak (Quercus alba L.) leaves were investigated at two first-order and two second-order sites in an Appalachian Mountain stream.2Leaves exposed in mesh bags were sampled on eight occasions over a 207 day period and breakdown rates were compared using an exponential decay model.3There was a consistent ranking in leaf breakdown rate within each site, i.e. dogwood 〉 red maple 〉 white oak, and all species broke down faster at second-than at first-order sites.4Our data suggest that differences in species-specific leaf breakdown rates were largely a function of shredder abundance on the leaves.
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  15. 15
    PETERS, G. T. ; WEBSTER, J. R. ; BENFIELD, E. F.

    Oxford, UK : Blackwell Publishing Ltd
    Published 1987
    Staff View
    ISSN:
    1365-2427
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Biology
    Notes:
    SUMMARY 1. The influences of temperature and dissolved nitrates and phosphates on microbial activity associated with suspended fine particulate organic matter (seston) were evaluated in four headwater streams in the southern Appalachian Mountains.2. Temperature manipulations of ± 5°C always induced significant changes in [14C] glucose mineralization (ANOVA; P〈0.05) and [3H]thymidine incorporation (ANOVA; P〈0.05).3. Nutrient amendments of 1.0 mg NO3 I−1 and 0.05 mg PO4I−1 induced no significant alterations in bacterial mineralization of [14C]glucose (ANOVA; P〉0.05) or incorporation of [3H]thymidine (ANOVA; P〉0.05) in short-term (i.e. 3 h) experiments.4. Microorganisms attached to refractory particulate organic matter do not appear to be limited by nitrogen or phosphorus even in streams with ambient nutrient concentrations as low as 0.06 mg NO3 I−1 and 〈0.03 mg PO4 I−1.5. Our results indicate that variations in water temperature resulting from diurnal and seasonal temperature fluctuations, forest clear-cutting, and catchment elevation and aspect can have marked effects upon microbial activity and production, while short-term alterations in nutrient regime appear to have no significant effect on microbial activity associated with seston.
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  16. 16
    SCHOFIELD, J. B. ; LINDLEY, R. P. ; HARCOURT-WEBSTER, J. N.

    Oxford, UK : Blackwell Publishing Ltd
    Published 1989
    Staff View
    ISSN:
    1365-2559
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Notes:
    In a 3 year period from the beginning of January 1985 to the end of December 1987, 474 biopsies obtained from 266 patients with serological evidence of human immunodeficiency virus infection were examined. Most frequent were skin biopsies of which 52% showed Kaposi's sarcoma, and transbronchial lung biopsies of which 40% showed Pneumocystis carinii pneumonia. Other opportunistic infections were much less common; Mycobacterium avium intracellulare was found in six biopsies and Cytomegalovirus in three. Non-Hodgkin's lymphoma was diagnosed in six patients.
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  17. 17
    Tonelli, L. ; Kramer, P. ; Webster, J. I. ; Wray, S. ; Listwak, S. ; Sternberg, E.

    Oxford, UK : Blackwell Science, Ltd
    Published 2002
    Staff View
    ISSN:
    1365-2826
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Notes:
    Oestrogen receptor (ER) regulation of gene transcription in neurosecretory and pituitary cells has been proposed as an important mechanism for increased hypothalamic-pituitary-adrenal (HPA) axis responses in females of several mammalian species, including humans. Inbred female Fischer (F344/N) and Lewis (LEW/N) rats have similar oestrogen levels, although Fischer rats exhibit hyper- and Lewis rats hypo-HPA axis responses. The blunted HPA axis response of Lewis rats has been associated with their blunted hypothalamic corticotropin releasing hormone (CRH) expression. To determine if the female CRH expression deficiency in Lewis rats is associated with defective ER expression and regulation, hypothalamic paraventricular nucleus (PVN) transcript levels of CRH and ER were determined under basal conditions and after immune challenge. Microdissected PVN were obtained from control and lipopolysaccharide (LPS) treated Lewis and Fischer rats and CRH, ERα and β mRNA levels were determined by semiquantitative reverse-transcriptase-polymerase chain reaction. In addition, ERα and β protein levels were determined by semiquantitative Western blots. ERα and β mRNA and protein levels in the PVN of control Fischer rats were significantly higher than in control Lewis rats. ERα and β mRNA and protein levels in Fischer rats were reduced by LPS administration at the time of maximal CRH mRNA levels but did not change in Lewis rats, an effect independent of oestrogen levels. These data indicate that defective neuroendocrine HPA axis responses are associated with defective ER expression and regulation in Lewis PVN despite oestrogen concentrations.
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  18. 18
    Webster, J. M.

    Oxford, UK : Blackwell Publishing Ltd
    Published 1967
    Staff View
    ISSN:
    1365-3059
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes:
    After spraying an aqueous solution of 2,4-dichlorophenoxyacetic acid, 2,4-D (140 mg/100 ml/sq. yd) onto nematode susceptible (cv. Sun II) and resistant (cv. Manod) oats infested with Ditylenchus dipsaci the final number of nematodes per plant after eight weeks in both resistant and susceptible cultivars was greater in the sprayed than in the unsprayed plants. Seedlings (18 days old) sprayed two weeks after nematode inoculation tended to contain the largest number of nematodes. Spraying of Shell D50, a commercial 2,4-D herbicide (10 ml of concentrate /250ml/4 sq. yd) on nematode-infested oats resulted in a larger number of nematodes per plant than in the unsprayed plants but the difference was insignificant. The 2,4-D spray, which decreased the resistance of oats, but not of barley, to nematodes, caused plant cell hypertrophy and proliferation, which is a necessary response for favourable nematode development.
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  19. 19
    Staff View
    ISSN:
    1365-2427
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Biology
    Notes:
    1. We studied whole-ecosystem metabolism in eight streams from several biomes in North America to identify controls on the rate of stream metabolism over a large geographic range. The streams studied had climates ranging from tropical to cool-temperate and from humid to arid and were all relatively uninfluenced by human disturbances.2. Rates of gross primary production (GPP), ecosystem respiration (R) and net ecosystem production (NEP) were determined using the open-system, two-station diurnal oxygen change method.3. Three general patterns in metabolism were evident among streams: (1) relatively high GPP with positive NEP (i.e. net oxygen production) in early afternoon, (2) moderate primary production with a distinct peak in GPP during daylight but negative NEP at all times and (3) little or no evidence of GPP during daylight and a relatively constant and negative NEP over the entire day.4. Gross primary production was most strongly correlated with photosynthetically active radiation (PAR). A multiple regression model that included log PAR and stream water soluble reactive phosphorus (SRP) concentration explained 90% of the variation in log GPP.5. Ecosystem respiration was significantly correlated with SRP concentration and size of the transient storage zone and, together, these factors explained 73% of the variation in R. The rate of R was poorly correlated with the rate of GPP.6. Net ecosystem production was significantly correlated only with PAR, with 53% of the variation in log NEP explained by log PAR. Only Sycamore Creek, a desert stream in Arizona, had positive NEP (GPP: R 〉 1), supporting the idea that streams are generally net sinks rather than net sources of organic matter.7. Our results suggest that light, phosphorus concentration and channel hydraulics are important controls on the rate of ecosystem metabolism in streams over very extensive geographic areas.
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  20. 20
    Webster, J. R. ; Benfield, E. F. ; Ehrman, T. P. ; Schaeffer, M. A. ; Tank, J. L. ; Hutchens, J. J. ; D’Angelo, D. J.

    Oxford, UK : Blackwell Science, Ltd
    Published 1999
    Staff View
    ISSN:
    1365-2427
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Biology
    Notes:
    1. ,One of two things can happen to allochthonous material once it enters a stream: it can be broken down or it can be transported downstream. The efficiency with which allochthonous material is used is the result of these two opposing factors: breakdown and transport.2. ,The present synthesis of new and published studies at Coweeta Hydrologic Laboratory compares biological use versus transport for four categories of particulate organic material: (1) large wood (logs); (2) small wood (sticks); (3) leaves; and (4) fine particulate organic matter (FPOM).3. ,Over 8_years, logs showed no breakdown or movement.4. ,The breakdown rate of sticks (≤3_cm diameter) ranged from 0.00017 to 0.00103_day−1, while their rate of transport, although varying considerably with discharge, ranged from 0 to 0.1_m_day−1.5. ,Based on 40 published measurements, the average rate of leaf breakdown was 0.0098_day−1. The leaf transport rate depended on stream size and discharge.6. ,The average respiration rate of FPOM was 1.4_mg_O2_g_AFDM−1_day−1 over a temperature range of 6–22_°C, which implies a decomposition rate of 0.00104_day−1. Transport distances of both corn pollen and glass beads, surrogates of natural FPOM, were short (〈_10_m) except during high discharge.7. , Estimates of transport rate were substantially larger than the breakdown rates for sticks, leaves and FPOM. Thus, an organic particle on the stream bottom is more likely to be transported than broken down by biological processes, although estimates of turnover length suggest that sticks and leaves do not travel far. However, once these larger particles are converted to refractory FPOM, either by physical or biological processes, they may be transported long distances before being metabolized.
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses