Search Results - (Author, Cooperation:J. Walters)
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1Latest Papers from Table of Contents or Articles in PressStaff View
Publication Date: 2018-06-22Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyGeosciencesComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Genetics, Medicine, Diseases, Online OnlyPublished by: -
2Latest Papers from Table of Contents or Articles in PressKeen, C., Skilbeck, J., Ross, H., Smith, L., Collins, K., Dixey, J., Walters, S., Greenfield, D. M., Snowden, J. A., Mawson, S.
BMJ Publishing
Published 2018Staff ViewPublication Date: 2018-03-12Publisher: BMJ PublishingElectronic ISSN: 2044-6055Topics: MedicineKeywords: Rehabilitation medicine, Open access, Haematology (incl blood transfusion)Published by: -
3Latest Papers from Table of Contents or Articles in PressStaff View
Publication Date: 2018-06-09Publisher: American Physical Society (APS)Print ISSN: 1050-2947Electronic ISSN: 1094-1622Topics: PhysicsKeywords: Atomic and molecular collisions and interactionsPublished by: -
4Latest Papers from Table of Contents or Articles in PressGregory G. Kenning, Daniel M. Tennant, Christina M. Rost, Fagner Garrote da Silva, Brian J. Walters, Qiang Zhai, David C. Harrison, E. Dan Dalhberg, and Raymond L. Orbach
American Physical Society (APS)
Published 2018Staff ViewPublication Date: 2018-09-29Publisher: American Physical Society (APS)Print ISSN: 1098-0121Electronic ISSN: 1095-3795Topics: PhysicsKeywords: MagnetismPublished by: -
5Latest Papers from Table of Contents or Articles in PressC. Zhang ; W. Spevak ; Y. Zhang ; E. A. Burton ; Y. Ma ; G. Habets ; J. Zhang ; J. Lin ; T. Ewing ; B. Matusow ; G. Tsang ; A. Marimuthu ; H. Cho ; G. Wu ; W. Wang ; D. Fong ; H. Nguyen ; S. Shi ; P. Womack ; M. Nespi ; R. Shellooe ; H. Carias ; B. Powell ; E. Light ; L. Sanftner ; J. Walters ; J. Tsai ; B. L. West ; G. Visor ; H. Rezaei ; P. S. Lin ; K. Nolop ; P. N. Ibrahim ; P. Hirth ; G. Bollag
Nature Publishing Group (NPG)
Published 2015Staff ViewPublication Date: 2015-10-16Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Cell Line, Tumor ; Enzyme Activation/drug effects ; Female ; Genes, ras/genetics ; Heterocyclic Compounds, 2-Ring/adverse effects/pharmacology ; Humans ; Indoles/adverse effects/pharmacology ; MAP Kinase Signaling System/*drug effects/genetics ; Mice ; Mitogen-Activated Protein Kinases/*metabolism ; Models, Biological ; Mutation/genetics ; Protein Kinase Inhibitors/adverse effects/*pharmacology ; Proto-Oncogene Proteins B-raf/*antagonists & inhibitors/genetics ; Sulfonamides/adverse effects/pharmacologyPublished by: -
6Latest Papers from Table of Contents or Articles in PressPye, C., Chatters, R., Cohen, J., Brian, K., Cheong, Y. C., Laird, S., Mohiyiddeen, L., Skull, J., Walters, S., Young, T., Metwally, M.
BMJ Publishing
Published 2018Staff ViewPublication Date: 2018-05-22Publisher: BMJ PublishingElectronic ISSN: 2044-6055Topics: MedicineKeywords: Open access, Reproductive medicinePublished by: -
7Latest Papers from Table of Contents or Articles in PressY. Shi ; X. Chen ; S. Elsasser ; B. B. Stocks ; G. Tian ; B. H. Lee ; N. Zhang ; S. A. de Poot ; F. Tuebing ; S. Sun ; J. Vannoy ; S. G. Tarasov ; J. R. Engen ; D. Finley ; K. J. Walters
American Association for the Advancement of Science (AAAS)
Published 2016Staff ViewPublication Date: 2016-02-26Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: DNA-Binding Proteins/metabolism ; Endopeptidases/metabolism ; Metabolic Networks and Pathways ; Models, Molecular ; Mutation ; Proteasome Endopeptidase Complex/chemistry/genetics/*metabolism ; Saccharomyces cerevisiae/*metabolism ; Saccharomyces cerevisiae Proteins/*chemistry/genetics/*metabolism ; Ubiquitin-Specific Proteases/metabolism ; UbiquitinationPublished by: -
8FIS Bildung LiteraturdatenbankStaff View
Type of Medium: bookPublication Date: 1986Keywords: ErziehungLanguage: English -
9Latest Papers from Table of Contents or Articles in PressStaff View
Publication Date: 2018-12-14Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyGeosciencesComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Neuroscience, Online OnlyPublished by: -
10Articles: DFG German National LicensesStaff View
ISSN: 1089-7550Source: AIP Digital ArchiveTopics: PhysicsNotes: The effects of nitrogen incorporation on the atomic-scale structure of amorphous CNx samples have been studied for 0, 5, 20, and 30 at. % N concentration, by x-ray diffraction. Significant differences in the structure are observed on the incorporation of only 5 at. % N, and the changes in structure continue as further N is added. From the experimental data, we are able to obtain directly the average bond distances and then calculate the average bond angles for each of the samples. The average first neighbor distance shows a gradual decrease from 1.55 Å for 0 at. % N, to 1.44 Å for 30 at. % N, and a similar trend is observed in the position of the second neighbor peak. This gives a corresponding increase in the average bond angle from 108° to 114°. The results show an increase in the fraction of sp2 bonded carbon atoms with increasing N concentration, and there is evidence for the presence of significant numbers of C(Triple Bond)N and C(Double Bond)N bonds. These results are also consistent with stress, hardness, and optical gap measurements for these samples. © 1998 American Institute of Physics.Type of Medium: Electronic ResourceURL: -
11Articles: DFG German National LicensesWalters, J. R. ; Eng, N. ; Peričić, D. ; Miller, L. P.
Oxford, UK : Blackwell Publishing Ltd
Published 1978Staff ViewISSN: 1471-4159Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Abstract— Aminooxyacetic acid (AOAA) administration produced an increase in γ-aminobutyric acid (GABA) levels in regions of cerebral cortex, subcortex and cerebellum. In some cortical areas studied, the maximal effect was observed with 25 mg/kg AOAA; in other regions GABA levels were increased further with 50 and 75 mg/kg AOAA. Pretreatment with 25 mg/kg AOAA effectively inhibited GABA:2-oxoglutarate aminotransferase (GABA-T) and partially inhibited glutamic acid decarboxylase (GAD) activity in regions of cerebral cortex. However, this dose did not affect GAD activity in substantia nigra while GABA-T in the nigra and in the cerebellum was only partially inhibited. In both cortical and subcortical areas, the increase in GABA produced by 25 mg/kg of AOAA was linear. In contrast, l-glutamic acid-hydrazide (GAH) had no effect in the pyriform and cingulate cortex for the first 60 min after injection, and produced a biphasic GABA increase in caudate and substantia nigra over a 4 h period. Results suggest that GAH and AOAA affect regional GABA metabolism differentially and that there are several problems associated with estimating absolute GABA synthesis rates by measuring the rate or GABA accumulation after inhibition of GABA catabolism with these agents. This approach, however, may provide an easily obtainable indication of whether drugs or other manipulations are altering GABA synthesis in a given region.Type of Medium: Electronic ResourceURL: -
12Articles: DFG German National LicensesMiller, L. P. ; Martin, D. L. ; Mazumder, A. ; Walters, J. R.
Oxford, UK : Blackwell Publishing Ltd
Published 1978Staff ViewISSN: 1471-4159Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: The association between glutamate decarboxylase (GAD) and its cofactor, pyridoxal-5′-phos-phate (pyridoxal-P), was studied using 20,0000 supernatant of rat brain. In this preparation GAD required added pyridoxal-P to maintain a linear reaction rate beyond 5 min of incubation. Following exhaustive dialysis the enzyme was more than 83% saturated with cofactor indicating that the cofactor was tightly bound to the enzyme. When incubations were performed in the presence of glutamate and without added pyridoxal-P there was a progressive inactivation of the enzyme which was dependent on the glutamate concentration. This lost activity was almost completely recovered by addition of pyridoxal-P to the dialyzed glutamate-inactivated enzyme. The results suggest that glutamate inactivates GAD by promoting the dissociation of pyridoxal-P from the enzyme thereby producing inactive apoen-zyme which can be reactivated by combining with available pyridoxal-P. This interpretation is supported by the finding that progress curves for the reaction were accurately described over a 30 min incubation period and 10-fold glutamate concentration range by an integrated rate equation which takes the glutamate-promoted dissociation of cofactor into account. The progressive inactivation could not be attributed to denaturation of the enzyme, impurities in the substrate, effects of pH, depletion of substrate, protein concentration, sulfhydryl reagents or product inhibition. The results presented here also show that certain precautions must be adopted to accurately measure GAD activity in the absence of added pyridoxal-P as has been widely done in studies of drug action. Specifically, measurements must be made at short times of incubation and low concentrations of glutamate to minimize the glutamate-promoted inactivation of the enzyme.Type of Medium: Electronic ResourceURL: -
13Articles: DFG German National LicensesStaff View
ISSN: 1471-4159Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Abstract— The effect of diazepam and pentobarbital on γ-aminobutyric acid (GABA) levels, the aminooxyacetic acid (AOAA)-induced accumulation of GABA, and the in vitro activity of l-glutamate 1-carboxyl-lyase (EC 4.1.1.15) [GAD] were studied in various regions of rat brain. Diazepam increased GABA levels in the substantia nigra, diminished the AOAA-induced accumulation of GABA in the caudate nucleus, cingulate, parietal and entorhinal cortex and had no effect on GABA accumulation in the pyriform and cerebellar cortex. After pentobarbital, GABA levels were elevated in the caudate nucleus but decreased in the parietal and pyriform cortex; the AOAA-induced accumulation of GABA also diminished in all cortical regions studied. No correlation was found between the apparent changes in GABA synthesis, as estimated by accumulation after inhibition of 4-aminobutyrate-2-oxoglu-tarate (EC 2.6.1.19) [GABA-T] with AOAA, and the changes in GABA levels induced by these drugs. The reduction in AOAA-induced GABA accumulation after diazepam and pentobarbital treatment was most pronounced in regions which showed the greatest accumulation of GABA after AOAA administration. Neither diazepam nor pentobarbital administration affected the activity of GAD in homogenates of cingulate cortex. Chlorpromazine, at a dose which decreased spontaneous activity, enhanced the AOAA-induced GABA accumulation in the cingulate cortex, suggesting that drug-induced sedation is not necessarily associated with decreased GABA synthesis. While regional differences were observed in the effects of diazepam and pentobarbital on GABA synthesis, both agents appear to inhibit GABA synthesis in vivo and both do so, in at least some brain areas, at subsedative doses.Type of Medium: Electronic ResourceURL: -
14Articles: DFG German National LicensesStaff View
ISSN: 1471-4159Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Abstract— The effects of γ-butyrolactone (GBL) and picrotoxin on both the post-mortem and amino-oxyacetic acid (AOAA) induced accumulations of γ-aminobutyric acid (GABA) were examined in rats. GBL produced a marked dose-dependent decrease in AOAA-induced GABA accumulation in caudate. globus pallidus, cerebellar and cerebral cortices. The cingulate cortex showed the greatest response to GBL treatment; subanesthetic doses completely blocked the effect of AOAA. Picrotoxin increased the AOAA-induced accumulation of GABA in parietal, entorhinal and cerebellar cortices, and had no significant effect in pyriform or cingulate cortices. Neither drug significantly altered the post-mortem accumulation of GABA. Results suggest that picrotoxin, a GABA antagonist and convulsant drug, causes an increase in GABA synthesis in vivo. The apparent decrease in GABA synthesis following GBL treatment was greater than that observed with anesthetic doses of chloral hydrate and was not blocked by picrotoxin. Alterations in the activity of GABA neurons, cerebral glucose metabolism and GAD activity may contribute to the apparent decrease in in vivo GABA synthesis caused by GBL.Type of Medium: Electronic ResourceURL: -
15Articles: DFG German National LicensesWinstead, C. B. ; Paukstis, S. J. ; Walters, J. L. ; Gole, J. L.
College Park, Md. : American Institute of Physics (AIP)
Published 1995Staff ViewISSN: 1089-7690Source: AIP Digital ArchiveTopics: PhysicsChemistry and PharmacologyNotes: A previously unknown excited electronic state of Ag2 has been observed using mass selected resonant two photon ionization. The initial rovibrational level of this state observed via a forbidden transition near 46 870 cm−1 lies in near perfect double resonance with the lower energy A 1Σ+u(v'=3)←X 1Σ+g(v'=0) transition. The double resonance leads to an anomalously large single color ionization signal near the A(v'=3)←X(v‘=0) transition wavelength (426.7 nm). Symmetry selection rules allow an identification of the new state symmetry as 1g or 0+g [Hund's case (c)]. The presence of this state is demonstrated to have a significant impact on previous measurements of the ionization potential of Ag2. Two color resonant two photon ionization spectroscopy of the Ag2 A1Σ+u state is implemented using both excimer laser and Nd:YAG laser fourth harmonic ionization. The results of these experiments yield a new measurement of the ionization potential of Ag2, while demonstrating the importance of field ionization effects. © 1995 American Institute of Physics.Type of Medium: Electronic ResourceURL: -
16Articles: DFG German National LicensesWalters, J. K. ; Fox, D. M. ; Burke, T. M. ; Weedon, O. D. ; Newport, R. J. ; Howells, W. S.
College Park, Md. : American Institute of Physics (AIP)
Published 1994Staff ViewISSN: 1089-7690Source: AIP Digital ArchiveTopics: PhysicsChemistry and PharmacologyNotes: The results of a neutron diffraction study on the structure of amorphous hydrogenated carbon a-C:H are presented up to a maximum temperature of 1000 °C. The data show clearly the effect on atomic correlations of elevated temperatures, with the initial room-temperature amorphous network (a mixture of single bonds and olefinic double bonds) becoming progressively aromatic, then graphitic as hydrogen is evolved. Complementary x-ray diffraction and infrared spectroscopy data are also presented, the infrared data enabling a more detailed discussion of the temperature-dependent hydrogen environment, and the x-ray data are used to highlight the change in the carbon network. Comparisons have been made with previous work on similar systems and a brief summary of these results is given.Type of Medium: Electronic ResourceURL: -
17Articles: DFG German National LicensesStaff View
ISSN: 1467-971XSource: Blackwell Publishing Journal Backfiles 1879-2005Topics: English, American StudiesNotes: The topic of this paper is ‘Welsh English’. Firstly, a brief historical account is given of the growth of English in Wales, because it has only recently supplanted Welsh as the dominant language and the topic of ‘Welsh English’ can scarcely be approached without some understanding of the interaction between the two languages. Then, a short description is given of an accent in the industrialized ‘Valleys’ area of South Wales, where less than 10 per cent of the population can now speak Welsh. Its phonology is examined to see what are its defining characteristics and also ‘how Welsh it is’, i.e. the extent of influence of the Welsh language upon it. It appears that the strongest and most enduring Welsh language influence on the accent is found in its prosodics–its rhythm, the way that stress is realized and intonation.Type of Medium: Electronic ResourceURL: -
18Articles: DFG German National LicensesO'SHEA, P. ; WALTERS, J. ; RIDGE, I. ; WAINRIGHT, M. ; TRINCI, A. P. J.
Oxford, UK : Blackwell Publishing Ltd
Published 1990Staff ViewISSN: 1365-3040Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: BiologyNotes: Abstract. Cell wall particles were prepared from the semi-aquatic plants Regnellidium diphyllum and Nymphoides peltata with minimum disruption to the integrity of the cell wall. The behaviour of freshly-prepared and frozen-thawed particles in a D.C. electric field was monitored with a microscope attached to video recording apparatus. From the respective particles mobility in a well-defined electric field. it was possible to determine their electrostatic potential and consequently estimate the corresponding surface charge density. Experiments were performed in media of different pH and cation concentration (ie, K+ Ca2+). A significant electronegative potential was found in cell wall preparations of both plants. Freezing and thawing further reduced the electrostatic potential for both plant species in all the media utilized for electrophoresis. A reduction of pH or an increase of the cation concentration was found to neutralize the electrostatic potential in a sigmoidal fashion. Ca2+ was more than 10 times more effective than K+ at neutralizing the apparent electrostatic potential of the cell wall preparations. Regnellidium was found to have a lower electrostatic potential than Nymphoides, although both responded in a similar manner to the various treatments. The possible relevance of the cell wall electrostatic potential, pH and [Ca2+] and particularly their inter-relationship is discussed for the two species of plants in terms of their differing growth responses to the ionic environment of the plant.Type of Medium: Electronic ResourceURL: -
19Articles: DFG German National LicensesStaff View
ISSN: 0022-2429Topics: EconomicsURL: -
20Articles: DFG German National LicensesStaff View
ISSN: 0006-291XSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyPhysicsType of Medium: Electronic ResourceURL: