Search Results - (Author, Cooperation:J. Wade)
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1FIS Bildung LiteraturdatenbankGoldberg, Alfred L. [Verfasser] ; Elledge, Stephen J. [Verfasser] ; Harper, J. Wade [Verfasser]
Published 2001Staff ViewType of Medium: articlePublication Date: 2001Keywords: Sachinformation ; Biologie ; Protein ; Zytologie ; Humanmedizin ; Medizin ; Stoffwechsel ; Naturwissenschaften ; EntsorgungIn: Spektrum der Wissenschaft, (2001) H. 5, S. 5459, 0170-2971Language: GermanNote: Literaturangaben -
2Latest Papers from Table of Contents or Articles in PressSimone Kuhnle, Gustavo Martinez–Noel, Flavien Leclere, Sebastian D. Hayes, J. Wade Harper, Peter M. Howley
The American Society for Biochemistry and Molecular Biology (ASBMB)
Published 2018Staff ViewPublication Date: 2018-11-24Publisher: The American Society for Biochemistry and Molecular Biology (ASBMB)Print ISSN: 0021-9258Electronic ISSN: 1083-351XTopics: BiologyChemistry and PharmacologyPublished by: -
3Latest Papers from Table of Contents or Articles in PressThurber, K. A., Joshy, G., Korda, R., Eades, S. J., Wade, V., Bambrick, H., Liu, B., Banks, E.
BMJ Publishing Group
Published 2018Staff ViewPublication Date: 2018-05-11Publisher: BMJ Publishing GroupPrint ISSN: 0143-005XElectronic ISSN: 1470-2738Topics: MedicineKeywords: Open access, EpidemiologyPublished by: -
4Latest Papers from Table of Contents or Articles in PressStaff View
Publication Date: 2013-06-21Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsPublished by: -
5Latest Papers from Table of Contents or Articles in PressC. W. Dale ; K. W. Burton ; R. C. Greenwood ; A. Gannoun ; J. Wade ; B. J. Wood ; D. G. Pearson
American Association for the Advancement of Science (AAAS)
Published 2012Staff ViewPublication Date: 2012-04-12Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsPublished by: -
6Latest Papers from Table of Contents or Articles in PressStaff View
Publication Date: 2012-11-10Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Antelopes/*physiology ; Female ; Male ; *Mating Preference, Animal ; *Predatory Behavior ; *Sexual Behavior, AnimalPublished by: -
7Latest Papers from Table of Contents or Articles in PressJ. Alfoldi ; F. Di Palma ; M. Grabherr ; C. Williams ; L. Kong ; E. Mauceli ; P. Russell ; C. B. Lowe ; R. E. Glor ; J. D. Jaffe ; D. A. Ray ; S. Boissinot ; A. M. Shedlock ; C. Botka ; T. A. Castoe ; J. K. Colbourne ; M. K. Fujita ; R. G. Moreno ; B. F. ten Hallers ; D. Haussler ; A. Heger ; D. Heiman ; D. E. Janes ; J. Johnson ; P. J. de Jong ; M. Y. Koriabine ; M. Lara ; P. A. Novick ; C. L. Organ ; S. E. Peach ; S. Poe ; D. D. Pollock ; K. de Queiroz ; T. Sanger ; S. Searle ; J. D. Smith ; Z. Smith ; R. Swofford ; J. Turner-Maier ; J. Wade ; S. Young ; A. Zadissa ; S. V. Edwards ; T. C. Glenn ; C. J. Schneider ; J. B. Losos ; E. S. Lander ; M. Breen ; C. P. Ponting ; K. Lindblad-Toh
Nature Publishing Group (NPG)
Published 2011Staff ViewPublication Date: 2011-09-02Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Birds/*genetics ; Chickens/genetics ; *Evolution, Molecular ; GC Rich Sequence/genetics ; Genome/*genetics ; Genomics ; Humans ; Lizards/*genetics ; Mammals/*genetics ; Molecular Sequence Data ; Phylogeny ; Synteny/genetics ; X Chromosome/geneticsPublished by: -
8Articles: DFG German National LicensesStaff View
ISSN: 1546-170XSource: Nature Archives 1869 - 2009Topics: BiologyMedicineNotes: [Auszug] Aberrant regulation of the cell-division cycle, the process by which cells replicate their genetic material and precisely divide it into two daughter cells, is the major hallmark of cancer. Neoplastic cells tend to escape physiological mechanisms controlling cell division and continue to ...Type of Medium: Electronic ResourceURL: -
9Articles: DFG German National LicensesStegmeier, Frank ; Rape, Michael ; Draviam, Viji M. ; Nalepa, Grzegorz ; Sowa, Mathew E. ; Ang, Xiaolu L. ; McDonald III, E. Robert ; Li, Mamie Z. ; Hannon, Gregory J. ; Sorger, Peter K. ; Kirschner, Marc W. ; Harper, J. Wade ; Elledge, Stephen J.
[s.l.] : Nature Publishing Group
Published 2007Staff ViewISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] The spindle checkpoint prevents chromosome mis-segregation by delaying sister chromatid separation until all chromosomes have achieved bipolar attachment to the mitotic spindle. Its operation is essential for accurate chromosome segregation, whereas its dysregulation can contribute to birth defects ...Type of Medium: Electronic ResourceURL: -
10Articles: DFG German National LicensesStaff View
ISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] Dioxins are some of the most prevalent and dangerous pollutants in the environment. They are generated as by-products of, among other things, rubbish incineration and industrial processes, and act by disrupting the endocrine system. Because dioxins are fat-soluble, they tend to accumulate in the ...Type of Medium: Electronic ResourceURL: -
11Articles: DFG German National LicensesXu, Lai ; Wei, Yue ; Reboul, Jerome ; Vaglio, Philippe ; Shin, Tae-Ho ; Vidal, Marc ; Elledge, Stephen J. ; Harper, J. Wade
[s.l.] : Macmillian Magazines Ltd.
Published 2003Staff ViewISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] Programmed destruction of regulatory proteins through the ubiquitin–proteasome system is a widely used mechanism for controlling signalling pathways. Cullins are proteins that function as scaffolds for modular ubiquitin ligases typified by the SCF (Skp1–Cul1–F-box) complex. ...Type of Medium: Electronic ResourceURL: -
12Articles: DFG German National LicensesSchulman, Brenda A. ; Carrano, Andrea C. ; Jeffrey, Philip D. ; Bowen, Zachary ; Kinnucan, Elspeth R. E. ; Finnin, Michael S. ; Elledge, Stephen J. ; Harper, J. Wade ; Pagano, Michele ; Pavletich, Nikola P.
[s.l.] : Macmillian Magazines Ltd.
Published 2000Staff ViewISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] F-box proteins are members of a large family that regulates the cell cycle, the immune response, signalling cascades and developmental programmes by targeting proteins, such as cyclins, cyclin-dependent kinase inhibitors, IκBα and β-catenin, for ubiquitination ...Type of Medium: Electronic ResourceURL: -
13Articles: DFG German National LicensesZheng, Ning ; Schulman, Brenda A. ; Song, Langzhou ; Miller, Julie J. ; Jeffrey, Philip D. ; Wang, Ping ; Chu, Claire ; Koepp, Deanna M. ; Elledge, Stephen J. ; Pagano, Michele ; Conaway, Ronald C. ; Conaway, Joan W. ; Harper, J. Wade ; Pavletich, Nikola P.
[s.l.] : Macmillian Magazines Ltd.
Published 2002Staff ViewISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] SCF complexes are the largest family of E3 ubiquitin–protein ligases and mediate the ubiquitination of diverse regulatory and signalling proteins. Here we present the crystal structure of the Cul1–Rbx1–Skp1–F boxSkp2 SCF complex, which shows that Cul1 is an ...Type of Medium: Electronic ResourceURL: -
14Articles: DFG German National LicensesZhang, Pumin ; Liégeois, Nanette J. ; Wong, Calvin ; Finegold, Milton ; Hou, Harry ; Thompson, Janet C. ; Silverman, Adam ; Harper, J. Wade ; DePinho, Ronald A. ; Elledge, Stephen J.
[s.l.] : Nature Publishing Group
Published 1997Staff ViewISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] Mice lacking the imprinted Cdk inhibitor p57KIP2 have altered cell proliferation and differentiation, leading to abdominal muscle defects; cleft palate; endochondral bone ossification defects with incomplete differentiation of hypertrophic chondrocytes; renal medullary dysplasia; ...Type of Medium: Electronic ResourceURL: -
15Articles: DFG German National LicensesStaff View
ISSN: 0032-1966Topics: English, American StudiesNotes: ELOQUENCE IN SILENCEURL: -
16Articles: DFG German National LicensesJin, Jianping ; Li, Xue ; Gygi, Steven P. ; Harper, J. Wade
[s.l.] : Nature Publishing Group
Published 2007Staff ViewISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] Modification of proteins with ubiquitin or ubiquitin-like proteins (UBLs) by means of an E1–E2–E3 cascade controls many signalling networks. Ubiquitin conjugation involves adenylation and thioesterification of the carboxy-terminal carboxylate of ubiquitin by the E1-activating ...Type of Medium: Electronic ResourceURL: -
17Articles: DFG German National LicensesStaff View
ISSN: 0028-4866Topics: English, American StudiesNotes: MEMORANDA AND DOCUMENTSURL: -
18Articles: DFG German National LicensesStaff View
ISSN: 1573-4943Keywords: human angiogenin ; bovine ribonuclease ; protein homology ; limited proteolysisSource: Springer Online Journal Archives 1860-2000Topics: Chemistry and PharmacologyNotes: Abstract The primary structure of angiogenin is 33% identical to that of bovine pancreatic ribonuclease (RNase), but the enzymatic activities of the two proteins differ markedly. Similarly, their susceptibilities to limited proteolysis differ as well. In contrast to RNase, angiogenin totally resists proteolysis by subtilisin. Indeed, among 16 proteases examined, only endoprotease Lys-C, trypsin, and pepsin are able to cleave angiogenin. Even with prolonged incubation, endoprotease Lys-C selectively cleaves the Lys-60-Asn-61 bond; the product retains full ribonucleolytic activity. Initially, trypsin also cleaves this same bond, but with time it causes extensive degradation. Pepsin, atpH 2, cleaves the Phe-9-Leu-10 bond, to give angiogenin (10–123), which displays ∼15% of the native activity toward ribosomal RNA (rRNA). The susceptibility to proteolysis and/or the sites of cleavage of angiogenin and bovine RNase differ markedly despite their structural homology. These differences are considered in terms of the amino acid sequences of the two proteins.Type of Medium: Electronic ResourceURL: -
19Articles: DFG German National LicensesGillespie, H. J. ; Wade, J. K. ; Crook, G. E. ; Matyi, R. J.
[S.l.] : American Institute of Physics (AIP)
Published 1993Staff ViewISSN: 1089-7550Source: AIP Digital ArchiveTopics: PhysicsNotes: High-resolution x-ray diffraction has been used to characterize Si/GaAs superlattices grown on GaAs substrates by molecular beam epitaxy. A typical superlattice structure consisted of ten periods of thin (〈5 A(ring)) layers of pseudomorphic silicon alternating with thick GaAs layers; typical GaAs thicknesses range from approximately 100 to 1850 A(ring). X-ray rocking curves showed sharp and intense satellite peaks (out to 22 orders in one case), indicating a high level of structural quality. Excellent agreement has been obtained between the observed diffraction patterns and those calculated via dynamical simulation. Structural models in which the silicon exists as 2.7 A(ring) bilayers with interfacial Si/GaAs alloy transition layers of either monolayer or bilayer thickness fully describes the observed diffraction patterns.Type of Medium: Electronic ResourceURL: -
20Articles: DFG German National LicensesWade, J. V. ; Olson, J. P. ; Samson, F. E. ; Nelson, S. R. ; Pazdernik, T. L.
Oxford, UK : Blackwell Publishing Ltd
Published 1988Staff ViewISSN: 1471-4159Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Abstract: Intracranial microdialysis was used to measure changes in extracellular amino acids within the rat brain during local osmotic alteration of the extracellular micro-environment or during systemic water intoxication. Increased cellular hydration produced by either of these methods was accompanied by a marked increase in extracellular taurine levels without affecting the other amino acids measured. With local osmotic alteration, this increase was osmolarity dependent and reversible. The specificity, sensitivity, and reversibility of the increase in extracellular taurine strongly suggest a functional role in osmoregulation in the brain under normal as well as pathological conditions.Type of Medium: Electronic ResourceURL: