Search Results - (Author, Cooperation:J. Utikal)
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1Latest Papers from Table of Contents or Articles in PressE. M. Van Allen ; D. Miao ; B. Schilling ; S. A. Shukla ; C. Blank ; L. Zimmer ; A. Sucker ; U. Hillen ; M. H. Foppen ; S. M. Goldinger ; J. Utikal ; J. C. Hassel ; B. Weide ; K. C. Kaehler ; C. Loquai ; P. Mohr ; R. Gutzmer ; R. Dummer ; S. Gabriel ; C. J. Wu ; D. Schadendorf ; L. A. Garraway
American Association for the Advancement of Science (AAAS)
Published 2015Staff ViewPublication Date: 2015-09-12Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Adult ; Aged ; Aged, 80 and over ; Antibodies, Monoclonal/*pharmacology/therapeutic use ; Antigens, Neoplasm/*genetics ; *Biomarkers, Pharmacological ; CTLA-4 Antigen/*antagonists & inhibitors ; Cell Cycle Checkpoints/genetics/immunology ; Cohort Studies ; DNA Mutational Analysis ; Drug Resistance, Neoplasm/genetics ; Exome ; Female ; Genomics ; HLA Antigens/genetics ; Humans ; Male ; Melanoma/*drug therapy/*genetics/secondary ; Middle Aged ; Mutation ; Skin Neoplasms/*drug therapy/*genetics/pathology ; Tumor Microenvironment/drug effects/immunology ; Young AdultPublished by: -
2Articles: DFG German National LicensesUtikal, J ; Beck, E ; Dippel, E ; Klemke, CD ; Goerdt, S
Oxford, UK : Blackwell Science Ltd
Published 2003Staff ViewISSN: 1468-3083Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineType of Medium: Electronic ResourceURL: -
3Articles: DFG German National LicensesGratchev, A. ; Kzhyshkowska, J. ; Utikal, J. ; Goerdt, S.
Oxford, UK; Malden, USA : Blackwell Science Ltd
Published 2005Staff ViewISSN: 1365-3083Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Alternatively activated macrophages (Mφ2) are induced by Th2 cytokines and by glucocorticoids (GC), and can be distinguished from classically activated effector macrophages (Mφ1) on the basis of their anti-inflammatory properties. In addition, Mφ2 are involved in Th2/Th1 skewing, enhance antigen uptake and processing and support tissue remodelling and healing. In order to elucidate the heterogeneity of Mφ2 population systematically, we analysed a number of genes involved in extracellular matrix (ECM) remodelling, inflammation and phagocytosis in Mφ2 populations generated with interleukin-4 (IL-4) or GC. Using real-time polymerase chain reaction, we demonstrated that the ECM component, tenascin-C, is stimulated by IL-4, whereas it is suppressed by dexamethasone. The ECM remodelling enzymes – MMP-1 and MMP-12 – and tissue transglutaminase (TG) showed a similar regulation pattern. FXIIIa, another putative Mφ2-associated TG, was synergistically regulated by IL-4 and GC. Enzyme-linked immunosorbent assay analysis revealed that the production of Mφ2-associated chemokines, AMAC-1, MCP-4 or TARC, was induced by IL-4 and was modulated by GC. Phagocytosis of opsonized and non-opsonized particles was stimulated by GC, whereas IL-4 had only a modulatory effect, what may be partially explained by the expression pattern of hMARCO, a scavenger receptor for non-opsonized particles, that was strongly and selectively induced by GC. In conclusion, stimulation of Mφ with IL-4 and GC regulate antagonistically the expression of ECM remodelling-related molecules and phagocytosis of opsonized and non-opsonized particles.Type of Medium: Electronic ResourceURL: -
4Articles: DFG German National LicensesGratchev, A. ; Kzhyshkowska, J. ; Duperrier, K. ; Utikal, J. ; Velten, F. W. ; Goerdt, S.
Oxford, UK; Malden, USA : Blackwell Science Ltd
Published 2004Staff ViewISSN: 1365-3083Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Interleukin-17E (IL-17E) (IL-25) is a recently identified cytokine capable to induce Th2-associated cytokine production (IL-5 and IL-13) and T helper 2 (Th2)-type pathologies in animal models. The IL-17E-responsive cell population in vivo was described to be a further uncharacterized non-T-, non-B-splenic accessory cell. Despite the identification of IL-17BR as the receptor for IL-17E, the cell population expressing IL-17BR has hitherto not been identified. Here, we show that human monocyte-derived Th2-skewed antigen-presenting cells (APC2) express membrane-bound and soluble forms of IL-17BR on the mRNA and protein level upon stimulation with IL-4, IL-10, IL-13 or transforming growth factor-βin vitro. These results indicate that IL-17BR-expressing APC2s may mediate the development of the IL-17E-mediated immunological reaction patterns observed in vivo.Type of Medium: Electronic ResourceURL: -
5Latest Papers from Table of Contents or Articles in PressEl-Battrawy, I., Zhao, Z., Lan, H., Li, X., Yucel, G., Lang, S., Sattler, K., Schunemann, J.-D., Zimmermann, W.-H., Cyganek, L., Utikal, J., Wieland, T., Bieback, K., Bauer, R., Ratte, A., Pribe-Wolferts, R., Rapti, K., Nowak, D., Wittig, J., Thomas, D., Most, P., Katus, H. A., Ravens, U., Schmidt, C., Borggrefe, M., Zhou, X.-B., Muller, O. J., Akin, I.
American Heart Association (AHA)
Published 2018Staff ViewPublication Date: 2018-03-16Publisher: American Heart Association (AHA)Print ISSN: 1942-325XElectronic ISSN: 1942-3268Topics: MedicineKeywords: Arrhythmias, Sudden Cardiac Death, Stem Cells, Translational Studies, CardiomyopathyPublished by: