Search Results - (Author, Cooperation:J. Turton)
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1Latest Papers from Table of Contents or Articles in PressC. Cruchaga ; C. M. Karch ; S. C. Jin ; B. A. Benitez ; Y. Cai ; R. Guerreiro ; O. Harari ; J. Norton ; J. Budde ; S. Bertelsen ; A. T. Jeng ; B. Cooper ; T. Skorupa ; D. Carrell ; D. Levitch ; S. Hsu ; J. Choi ; M. Ryten ; J. Hardy ; D. Trabzuni ; M. E. Weale ; A. Ramasamy ; C. Smith ; C. Sassi ; J. Bras ; J. R. Gibbs ; D. G. Hernandez ; M. K. Lupton ; J. Powell ; P. Forabosco ; P. G. Ridge ; C. D. Corcoran ; J. T. Tschanz ; M. C. Norton ; R. G. Munger ; C. Schmutz ; M. Leary ; F. Y. Demirci ; M. N. Bamne ; X. Wang ; O. L. Lopez ; M. Ganguli ; C. Medway ; J. Turton ; J. Lord ; A. Braae ; I. Barber ; K. Brown ; P. Passmore ; D. Craig ; J. Johnston ; B. McGuinness ; S. Todd ; R. Heun ; H. Kolsch ; P. G. Kehoe ; N. M. Hooper ; E. R. Vardy ; D. M. Mann ; S. Pickering-Brown ; N. Kalsheker ; J. Lowe ; K. Morgan ; A. David Smith ; G. Wilcock ; D. Warden ; C. Holmes ; P. Pastor ; O. Lorenzo-Betancor ; Z. Brkanac ; E. Scott ; E. Topol ; E. Rogaeva ; A. B. Singleton ; M. I. Kamboh ; P. St George-Hyslop ; N. Cairns ; J. C. Morris ; J. S. Kauwe ; A. M. Goate
Nature Publishing Group (NPG)
Published 2013Staff ViewPublication Date: 2013-12-18Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: African Americans/genetics ; Age of Onset ; Aged ; Aged, 80 and over ; Alzheimer Disease/*genetics/metabolism ; Amyloid beta-Peptides/metabolism ; Amyloid beta-Protein Precursor/metabolism ; Brain/metabolism ; Case-Control Studies ; Europe/ethnology ; Exome/genetics ; Female ; Genetic Predisposition to Disease/*genetics ; Genetic Variation/*genetics ; Humans ; Male ; Peptide Fragments/metabolism ; Phospholipase D/deficiency/*genetics/metabolism ; Protein Processing, Post-Translational/genetics ; ProteolysisPublished by: -
2Latest Papers from Table of Contents or Articles in PressK. D. Ersche ; P. S. Jones ; G. B. Williams ; A. J. Turton ; T. W. Robbins ; E. T. Bullmore
American Association for the Advancement of Science (AAAS)
Published 2012Staff ViewPublication Date: 2012-02-04Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Adolescent ; Adult ; Amphetamine-Related Disorders/*pathology/physiopathology/*psychology ; Anisotropy ; Behavior, Addictive/*pathology/physiopathology/*psychology ; Brain/*abnormalities/pathology/physiology/physiopathology ; Brain Mapping ; Cocaine-Related Disorders/*pathology/physiopathology/*psychology ; Corpus Striatum/abnormalities/pathology/physiopathology ; Disease Susceptibility ; Endophenotypes ; Female ; Frontal Lobe/abnormalities/pathology/physiopathology ; Humans ; Inhibition (Psychology) ; Male ; Middle Aged ; Neural Pathways ; Reaction Time ; Siblings ; Young AdultPublished by: -
3Articles: DFG German National LicensesStaff View
ISSN: 1089-7623Source: AIP Digital ArchiveTopics: PhysicsElectrical Engineering, Measurement and Control TechnologyNotes: A method based on standard four-point probe geometry is described for measuring the resistivity and temperature coefficient of resistivity of conducting samples under UHV conditions. The device has been designed to be combined with in situ sample preparation and synchrotron induced photoemission, and as such it is fully compatible with a wide range of surface science experiments. The equipment has been used to measure the electrical properties of the reactive alloys CaAl and CaMg over a temperature range of −70 °C to room temperature and has been tested over a range of −100–600 °C. The results have shown that it can be used to provide immediate characterization of the amorphicity of samples for photoemission studies. The observed resistivity ranges of 14–400 μΩ cm for CaAl and 9–30 μΩ cm for CaMg are entirely comparable with previous measurements. © 1995 American Institute of Physics.Type of Medium: Electronic ResourceURL: -
4Articles: DFG German National LicensesWalker, C.G.H. ; Hucknall, P.K. ; Matthew, J.A.D. ; Norman, D. ; Greig, D. ; Walker, M.J. ; Turton, J.
Amsterdam : ElsevierStaff ViewISSN: 0039-6028Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: PhysicsType of Medium: Electronic ResourceURL: -
5Articles: DFG German National LicensesWalker, C.G.H. ; Hucknall, P.K. ; Greig, D. ; Walker, M.J. ; Turton, J. ; Matthew, J.A.D. ; Norman, D.
Amsterdam : ElsevierStaff ViewISSN: 0038-1098Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: PhysicsType of Medium: Electronic ResourceURL: -
6Articles: DFG German National LicensesStaff View
ISSN: 0378-4347Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Chemistry and PharmacologyType of Medium: Electronic ResourceURL: -
7Articles: DFG German National LicensesStaff View
ISSN: 1433-2981Keywords: Bone marrow ; Busulphan ; Cell counting ; Haematopoiesis ; Mouse ; ToxicitySource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract Three experiments were carried out to investigate the myelotoxicity of busulphan in female B6C3F1 mice using the Technicon H*1 and the Sysmex R-1000 flow cytometers, instruments which produce a full blood count and a differential leucocyte count, and an automated reticulocyte count, respectively. In Experiment 1, a single dose of busulphan was administered at levels from 0 to 60 mg/kg and blood parameters measured at day 14. In Experiment 2, four doses of busulphan, from 0 to 40 mg/kg, were given at fortnightly intervals, and blood samples taken at days 14 and 42. In the third experiment, a single dose of busulphan was given at 0, 35 or 45 mg/kg and sequential blood, marrow and spleen samples examined up to day 10. In the first experiment there was a dose-related depression in the numbers of all leucocyte types. Values for Hb, RBC and HCT were not affected, whereas MCV and percentage macrocytic erythrocytes were increased, and MCHC was decreased, at high dose levels. Platelet numbers showed marked dose-related decreases. There were dose-related decreases in the numbers of all leucocyte types in Experiment 2 at days 14 and 42. Large unstained cell (LUC) numbers were reduced, and the mean neutrophil peroxidase index (MPXI) was increased, at high busulphan levels. Hb, RBC and HCT were reduced, whereas MCV, MCH and percentage macrocytic and percentage hypochromic erythrocytes were increased, in a dose-related fashion. Reticulocyte numbers showed a dose-related upward trend, but platelet counts illustrated a dose-related decrease, at days 14 and 42. In Experiment 3, busulphan caused a depression with a ‘U’-shaped curve, in the numbers of monocytes, eosinophils, lymphocytes and neutrophils. Decreased values and ‘U’-shaped curves were also seen for Hb, RBC, HCT and reticulocyte counts. Reticulocyte fluorescence ratio analysis showed that the high fluorescence ratio (HFR) was affected first and most profoundly. Calculation of the reticulocyte maturation index also demonstrated a dose-related effect on the earliest reticulocytes, and a ‘rebound’ effect. Total nucleated cell counts of the spleen and femur showed decreasing cell numbers and ‘U’-shaped responses with 45 mg/kg busulphan. This series of three experiments has established the use of a 6 week dosing regimen, with busulphan administered at fortnightly intervals, to induce myelotoxicity in a range of haematological parameters in female B6C3F1 mice. We consider the use of the newly-developed flow cytometers and associated software, and the measurement of ‘non-standard parameters’ such as LUC, HFR and MPXI, to be particularly effective in the charcterisation of these busulphan-induced haematological changes.Type of Medium: Electronic ResourceURL: -
8Articles: DFG German National LicensesStaff View
ISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] Eighty-five female Sprague-Dawley SPF rats (200-250 g) were infected by stomach tube under light ether anaesthesia with five or twenty-five cysticercoids of H. diminuta dissected from the flour beetle Tribolium confusum. Groups of four rats taken at weekly intervals, together with uninfected ...Type of Medium: Electronic ResourceURL: -
9Articles: DFG German National LicensesStaff View
ISSN: 1432-1955Source: Springer Online Journal Archives 1860-2000Topics: BiologyMedicineNotes: Summary A mitochondrial fraction from the cestodeHymenolepis diminuta was prepared, and the respiration of the preparation followed polarographically. Of the substrates tested, glycerol-3-phosphate was the most rapidly oxidised, but the highest respiratory control ratio (1.7) was obtained using isocitrate. With isocitrate as substrate, the fasciolicide oxyclozanide, at low concentration (161 nM), stimulated oxygen uptake and relieved oligomycin inhibition of ADP-stimulated respiration. At higher concentrations (above 2 μM) progressive inhibition of oxygen uptake was observed. The effects of 6 other fasciolicidal or anti-cestode agents (rafoxanide, niclosamide, 3,4,5-tribromosalicylanilide, nitroxynil, resorantel, and dichlorophen) and 2,4-dinitrophenol on the respiration of the mitochondrial preparation were examined. The compounds exhibited effects similar to those of oxyclozanide on the respiration of the preparation; their relative potencies are compared. The possible mode of action of the compounds is discussed.Type of Medium: Electronic ResourceURL: -
10Articles: DFG German National LicensesHucknall, P. K. ; Walker, C. G. H. ; Greig, D. ; Matthew, J. A. D. ; Norman, D. ; Turton, J.
Chichester [u.a.] : Wiley-Blackwell
Published 1992Staff ViewISSN: 0142-2421Keywords: Chemistry ; Polymer and Materials ScienceSource: Wiley InterScience Backfile Collection 1832-2000Topics: PhysicsNotes: Films of amorphous NbSi prepared by magnetron sputtering were found to have a higher concentration of silicon at the surface than in the bulk material. In this paper we report on measurements of both ultraviolet photoemission spectroscopy and Auger electron spectroscopy carried out on samples prepared in situ at the UK Synchrotron Radiation Source, Daresbury. Spectr taken immediately after sputter deposition show that the surface is rich in silicon, while following argon ion bombardment the bulk composition is slowly revealed with a much greater concentration of niobium. This is observed by a comparison of the relative heights of peaks in the Auger spectra and by resonance effects and the sharpening of the Fermi edge in the UP spectra. Of particular interest are changes around the metal-insulator transition that occur at approximately 11 at.% niobium.Additional Material: 4 Ill.Type of Medium: Electronic ResourceURL: