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Schwenzer ; E. Sebastian Martinez ; A. Sengstacken ; R. Shterts ; K. Siebach ; T. Siili ; J. Simmonds ; J. B. Sirven ; S. Slavney ; R. Sletten ; M. Smith ; P. Sobron Sanchez ; N. Spanovich ; J. Spray ; S. Squyres ; K. Stack ; F. Stalport ; T. Stein ; N. Stewart ; S. L. Stipp ; K. Stoiber ; E. Stolper ; B. Sucharski ; R. Sullivan ; R. Summons ; D. Sumner ; V. Sun ; K. Supulver ; B. Sutter ; C. Szopa ; F. Tan ; C. Tate ; S. Teinturier ; I. ten Kate ; P. Thomas ; L. Thompson ; R. Tokar ; M. Toplis ; J. Torres Redondo ; M. Trainer ; A. Treiman ; V. Tretyakov ; R. Urqui-O'Callaghan ; J. Van Beek ; T. Van Beek ; S. VanBommel ; D. Vaniman ; A. Varenikov ; A. Vasavada ; P. Vasconcelos ; E. Vicenzi ; A. Vostrukhin ; M. Voytek ; M. Wadhwa ; J. Ward ; E. Weigle ; D. Wellington ; F. Westall ; R. C. Wiens ; M. B. Wilhelm ; A. Williams ; J. Williams ; R. Williams ; R. B. Williams ; M. Wilson ; R. Wimmer-Schweingruber ; M. Wolff ; M. Wong ; J. Wray ; M. Wu ; C. Yana ; A. Yen ; A. Yingst ; C. Zeitlin ; R. Zimdar ; M. P. Zorzano Mier
    American Association for the Advancement of Science (AAAS)
    Published 2013
    Staff View
    Publication Date:
    2013-07-23
    Publisher:
    American Association for the Advancement of Science (AAAS)
    Print ISSN:
    0036-8075
    Electronic ISSN:
    1095-9203
    Topics:
    Biology
    Chemistry and Pharmacology
    Computer Science
    Medicine
    Natural Sciences in General
    Physics
    Published by:
    Latest Papers from Table of Contents or Articles in Press
  2. 2
    Staff View
    Publication Date:
    2013-05-24
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Autoimmune Diseases/*genetics ; European Continental Ancestry Group/genetics ; Exons/genetics ; Gene Frequency ; Genetic Predisposition to Disease/*genetics ; Genetic Variation/*genetics ; Genome-Wide Association Study ; Great Britain ; Humans ; Models, Genetic ; Mutation/genetics ; Open Reading Frames/*genetics ; Phenotype ; Sample Size
    Published by:
    Latest Papers from Table of Contents or Articles in Press
  3. 3
  4. 4
    Sabour, M. ; Simmonds, J. ; Setterfield, G.

    Oxford, UK : Blackwell Publishing Ltd
    Published 1986
    Staff View
    ISSN:
    1439-0523
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes:
    Several Nicotiana species, their intergeneric sexual and somatic hybrids were compared for their in vitro growth rate and nicotine content. Cell yield on a dry weight basis and HPLC analysis of their nicotine content revealed a very high variation within each cell line from parental, sexual and somatic hybrids for the two traits analyzed. The trigeneríc sexual hybrids (N. rustica × N. debneyi) × N. tabacum and only two of the N. rustica × N. tabacum somatic hybrid lines show a positive heterosis in nicotine content in vitro The in vitro growth rate and nicotine content did not demonstrate a statistically significant correlation.
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  5. 5
  6. 6
    Simmonds, J.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    0304-4238
    Keywords:
    in vitro propagation ; plant establishment ; rooting
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  7. 7
    Simmonds, J. G. ; Nicholson, J. W.
    Springer
    Published 1981
    Staff View
    ISSN:
    1432-0673
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Mathematics
    Physics
    Notes:
    Abstract Sanders showed in 1960, within the framework of two-dimensional elasticity, that in any body a certain integral I around a closed curve containing a crack is path-independent. I is equal to the rate of release of potential energy of the body with respect to crack length. Here we first derive, in a simple way, Sanders' integral I for a loaded elastic body undergoing finite deformations and containing an arbitrary void. The strain energy density need not be homogeneous nor isotropic and there may be body forces. In the absence of body forces, for flat continua, and for special forms of the strain energy density, it is shown that I reduces to the well-known vector and scalar path-independent integrals often denoted by J, L, and M.
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  8. 8
    Simmonds, J.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    0168-9452
    Keywords:
    Triticum aestivum ; anther culture ; donor plant ; haploidy ; temperature
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Biology
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  9. 9
    Simmonds, J. ; Robinson, G. K.
    Springer
    Published 1998
    Staff View
    ISSN:
    1432-0614
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Biology
    Process Engineering, Biotechnology, Nutrition Technology
    Notes:
    Abstract Aromatic and heterocyclic aldehydes may be produced by the mandelate pathway of Pseudomonas putida ATCC 12633 via the biotransformation of benzoyl formate and substrate analogues. Under optimised biotransformation conditions (37 °C, pH 5.4) and with benzoyl formate as a substrate, benzaldehyde may be accumulated with yields above 85%. Benzaldehyde is toxic to P. putida ATCC 12633; levels above 0.5 g/l (5 mM) reduce the biotransformation activity. Total activity loss occurs at an aldehyde concentration of 2.1 g/l (20 mM). To overcome this limitation, the rapid removal of the aldehyde is desirable via in situ product removal. The biotransformation of benzoyl formate (working volume 1 l) without in situ product removal accumulates 2.1 g/l benzaldehyde. Benzaldehyde removal by gas stripping produces a total of 3.5 g/l before inhibition. However, the most efficient method is solid-phase adsorption using activated charcoal as the sorbant, this allows the production of over 4.1 g/l benzaldehyde. Addition of bisulphite as a complexing agent causes inhibition of the biotransformation and bisulphite is therefore is not suitable for in situ product removal.
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  10. 10
    Simmonds, J. G. ; Libai, A.
    Springer
    Published 1987
    Staff View
    ISSN:
    1432-0924
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes:
    Abstract The static equations of the first-approximation theory of thin shells of revolution suffering small strains but arbitrarily large rotations are reduced, to within errors inherent in the assumption of a quadratic strain-energy density without transverse shear strains, to a coupled pair of equations for the meridional angle of rotation and a stress function. These equations are simpler than both Reissner's equations as well as a simpler version of Reissner's equations proposed by Koiter whose equations, like ours, are virtually free of Poisson's ratio.
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  11. 11
    Simmonds, J. G. ; Libai, A.
    Springer
    Published 1987
    Staff View
    ISSN:
    1432-0924
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes:
    Abstract A new, simplified version of Reissner's equations for the torsionless, axisymmetric deformation of elastically isotropic shells of revolution suffering small strains but large angles of rotation is specialized to clamped spherical caps under uniform outward pressure. The non-dimensional equations contain a thickness parameter, a shallowness parameter, and a load parameter. The latter two are written as powers of the former and the dependent variables scaled so that as the thickness parameter goes to zero, meaningful limit equations emerge. Seventeen distinct sets of simplified equations are found. In thirteen cases these are linear and the solutions are listed. These results should provide a useful set of benchmarks for testing the efficacy of numerical codes which often have difficulties with very thin shells.
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  12. 12
    Staff View
    ISSN:
    1573-7373
    Keywords:
    brain edema ; brain tumor ; 9L glioma ; cat ; magnetic resonance imaging
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Summary An in vivo model for correlative imaging studies of intracerebral glial tumors and peritumor brain edema has been developed. Adult male and female cats implanted with 1 × 106 or 5 × 105 9L glioma cells had parietal tumors of 4 mm or greater in diameter and showed signs of increased intracranial pressure 13.7±1.9 days or 19.2±1.3 days after implantation. No immunosuppression was required and the success rate for tumor growth after implantation was 88%. Histologically, the tumor resembles a malignant astrocytoma. The tumor contained the highest water content (85.94%); peritumor white matter was more edematous (73.01%) than white matter in the contralateral hemisphere (69.04%), sham-operated (69.41%) and control brain (68.76%). There was no correlation between the size of the tumor and water content in tumor or white matter. Increased tissue albumin in peritumor white matter indicated blood-brain barrier dysfunction within the tumor and confirmed the vasogenic origin of the edema. Proton magnetic resonance imaging provided good spatial and contrast resolution with increased signal intensity in edematous white matter, decreasing with distance from the tumor. The large brain of this animal model allows the use of serial imaging and regional correlative biochemical measurements in a single animal. Other advantages of this model are its predictability and the short time required to produce tumors with marked peritumor edema.
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  13. 13
    Simmonds, J.
    Springer
    Published 1984
    Staff View
    ISSN:
    1573-5044
    Keywords:
    Tissue culture ; micropropagation ; organogenesis
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Biology
    Notes:
    Abstract The efficiency of commercial micropropagation programs for Begonia x hiemalis depends on the production of large adventitious shoots for easy handling and on effective rooting and acclimatization procedures. Maximum induction of adventitious buds on petiole segments occurred in response to NAA (0.1 mg, l-1) and BA (0.5 mg l-1), but continued shoot growth was limited. With a lower concentration of BA (0.1 mg l-1) fewer shoots were produced but shoot growth was enhanced. With a combined agar/liquid culture program the low BA (0.1 mg l-1) medium produced 50 percent more shoots larger than 1 cm than did the high BA (0.5 mg l-1) medium. In vitro rooted explants developed weak root systems and acclimatization losses occurred during adaptation to greenhouse conditions. Adventitious shoots treated with commercial rooting powder and placed directly in mist frames produced much stronger root systems and could be adapted to greenhouse conditions without loss. The elimination of the in vitro rooting stage also simplifies the micropropagation program.
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  14. 14
    Simmonds, J. G. ; Warne, P. G.
    Springer
    Published 1995
    Staff View
    ISSN:
    1573-2681
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Physics
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  15. 15
    Simmonds, J. G.
    Springer
    Published 1990
    Staff View
    ISSN:
    1573-2681
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Physics
    Notes:
    Abstract An infinite, horizontal, elastically isotropic plate is subjected to a distributed vertical, axisymmetric load, part of which is a body force and part of which is a surface traction. The resulting 3-dimensional stresses and displacements are found with the aid of Love's stress function and Hankel transforms. From these, the sum of the principal stress couples, the average rotation of radial fibers, and the average vertical deflection are computed and compared against the predictions of classical and Reissner's shear-deformation plate theory. Remarkably, the elasticity and plate theory predictions for the stress couples and the rotation agree if Poisson's ratio is zero. In general, for smoothly varying loads, the predictions of Reissner's theory are closer than those of classical theory to the predictions of elasticity theory. However, if a part of the load is (nearly) concentrated, then it is shown that the singularities in the sum of the principal stress couples and in the rotation predicted by Reissner's theory are too strong (because his theory accounts for normal stress effects based on smoothly varying loads). Moreover, if the concentrated part of the external load is a uniformly distributed line load through the thickness, then classical theory predicts the correct singularity in these variables, although with an erroneous strength. On the other hand, Reissner's theory correctly predicts the logarithmic singularity in the average vertical deflection (for any type of concentrated load), although with an erroneous strength.
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  16. 16
    Simmonds, J. G. ; Horn, M. A.
    Springer
    Published 1990
    Staff View
    ISSN:
    1573-2681
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Physics
    Notes:
    Abstract An infinite slab of incompressible Rivlin-Saunders material of constant thickness 2H is subject to an equilibrated, radially varying, vertical body force, comprising a concentrated, downward line load and a smooth, upward, exponentially distributed load with a characteristic decay length R. The deformation is axisymmetric and described by three stretches and a shear strain (or, equivalently, four strains) and a rotation which satisfy three relatively simple compatibility conditions. Force equilibrium is satisfied identically by the introduction of three stress functions. The incompressibility constraint is used to eliminate the normal stretch. With the introduction of stress-strain relations, the field equations are reduced to a set of seven, first-order, quasilinear partial differential equations. The loads, the radial distance, and the unknowns are scaled by the small parameter ɛ=H/R. As ɛ→0, 11 possible sets of field equations are found, including linear plate theory, von Kármán plate theory, Föppl membrane theory, large-strain membrane theory, and Wu's large-stretch (asymptotic) membrane theory. Notably absent as limiting cases are thick plate theories.
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  17. 17
    Simmonds, J. G. ; Warne, P. G.
    Springer
    Published 1994
    Staff View
    ISSN:
    1573-2681
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Physics
    Notes:
    Abstract The nonlinearly elastic Boussinesq problem is to find the deformation produced in a homogeneous, isotropic, elastic half space by a point force normal to the undeformed boundary, using the exact equations of elasticity for an incompressible or compressible material. First we derive the governing equations from the Principle of Stationary Potential Energy and then we examine some of the implications of the conservation laws of elastostatics when applied to the entire half space, assuming that the well-known linear Boussinesq solution is valid at large distances from the point load. Next, we hypothesize asymptotic forms for the solutions near the point load and, finally, we seek solutions for two specific materials: an incompressible, generalized neo-Hookean (power-law) material introduced by Knowles and a compressible Blatz-Ko material. We find that the former, if sufficiently stiffer than the conventional neo-Hookean material, can support a finite deflection under the point load, but that the latter cannot.
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses