Search Results - (Author, Cooperation:J. Shimada)
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1Latest Papers from Table of Contents or Articles in PressMima, S., Kakinuma, C., Higuchi, T., Saeki, K., Yamada, T., Uematsu, R., Ishino, M., Kito, N., Nishikawa, H., Kuniyoshi, H., Matsumoto, T., Fujiwara, H., Paradiso, L. J., Shimada, Y., Iwamura, H.
The American Society for Pharmacology and Experimental Therapeutics
Published 2018Staff ViewPublication Date: 2018-06-05Publisher: The American Society for Pharmacology and Experimental TherapeuticsPrint ISSN: 0022-3565Electronic ISSN: 1521-0103Topics: MedicinePublished by: -
2Latest Papers from Table of Contents or Articles in PressD. Nepstad ; D. McGrath ; C. Stickler ; A. Alencar ; A. Azevedo ; B. Swette ; T. Bezerra ; M. DiGiano ; J. Shimada ; R. Seroa da Motta ; E. Armijo ; L. Castello ; P. Brando ; M. C. Hansen ; M. McGrath-Horn ; O. Carvalho ; L. Hess
American Association for the Advancement of Science (AAAS)
Published 2014Staff ViewPublication Date: 2014-06-07Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Brazil ; Cattle ; Conservation of Natural Resources/*trends ; Humans ; Meat/*supply & distribution ; *Public Policy ; Soybeans/*supply & distributionPublished by: -
3Articles: DFG German National LicensesMayer, K. M. ; Makita, Y. ; Yamada, A. ; Shibata, H. ; Beye, A. C. ; Shimada, J.
[S.l.] : American Institute of Physics (AIP)
Published 1992Staff ViewISSN: 1089-7550Source: AIP Digital ArchiveTopics: PhysicsNotes: Low-temperature photoluminescence experiments were performed on high-purity InP substrates as a function of heat treatment, flat-profile ion implantation and subsequent annealing procedures. Whereas the well resolved near band edge luminescence proved the superior substrate quality, up to 6 sharp luminescence lines (some of them not reported so far) and one shallow broad-band emission were observed after Si3N4 deposition and various annealing procedures. From the temperature dependence of the luminescence peak intensities the activation energies of the novel lines were determined and discussed in terms of excitons bound to processing-induced complex defects. These assignments are supported by the observation of a strong enhancement of the luminescence after low dose Ar+ ion implantation.Type of Medium: Electronic ResourceURL: -
4Articles: DFG German National LicensesStaff View
ISSN: 0030-4018Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: PhysicsType of Medium: Electronic ResourceURL: -
5Articles: DFG German National LicensesStaff View
ISSN: 0006-291XSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyPhysicsType of Medium: Electronic ResourceURL: -
6Articles: DFG German National LicensesStaff View
ISSN: 0040-4039Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Chemistry and PharmacologyType of Medium: Electronic ResourceURL: -
7Articles: DFG German National LicensesStaff View
ISSN: 0040-4039Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Chemistry and PharmacologyType of Medium: Electronic ResourceURL: -
8Articles: DFG German National LicensesHiroi-Furuya, E. ; Kameda, T. ; Hiura, K. ; Mano, H. ; Miyazawa, K. ; Nakamaru, Y. ; Watanabe-Mano, M. ; Okuda, N. ; Shimada, J. ; Yamamoto, Y. ; Hakeda, Y. ; Kumegawa, M.
Springer
Published 1999Staff ViewISSN: 1432-0827Keywords: Key words: EHDP — Osteoclast — Apoptosis — Actin rings.Source: Springer Online Journal Archives 1860-2000Topics: BiologyMedicinePhysicsNotes: Abstract. Bisphosphonates, therapeutic reagents against tumoral bone diseases (Paget's disease or osteoporosis), are potent inhibitors of bone resorption. The mechanisms by which they directly act on mature osteoclasts remain unclear. Using a recently developed technique for isolation of highly purified mammalian mature osteoclasts, we demonstrated that etidronate [ethane-1-hydroxy-1,1-diphosphonate (EHDP), 1-hydroxy-1,1-ethylidenebisphosphonate], inhibited directly osteoclastic bone-resorbing activity by pit assay. In addition, EHDP also directly induced apoptosis and disrupted actin rings in osteoclasts. The data support previous data on non-purified osteoclasts and results in vivo.Type of Medium: Electronic ResourceURL: -
9Articles: DFG German National LicensesStaff View
ISSN: 0030-4018Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: PhysicsType of Medium: Electronic ResourceURL: -
10Articles: DFG German National LicensesStaff View
ISSN: 0030-4018Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: PhysicsType of Medium: Electronic ResourceURL: -
11Articles: DFG German National LicensesStaff View
ISSN: 0030-4018Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: PhysicsType of Medium: Electronic ResourceURL: -
12Articles: DFG German National LicensesShimada, J. ; Hayashi, Izumi ; Inamatsu, Takashi ; Ishida, Masashi ; Iwai, Shigetomi ; Kamidono, Sadao ; Kurosawa, Hiromi ; Masaoka, Tohru ; Matsumoto, Fumio ; Monden, Morito ; Morii, Hirotoshi ; Nakashio, Satoshi ; Narita, Nobuhiro ; Sakai, Osamu ; Toda, Gotaro ; Shimizu, Kihachiro ; Ueda, Yasushi ; Ohno, Tsuneya
Springer
Published 1999Staff ViewISSN: 1437-7780Keywords: Key words SIRS ; Sepsis ; Bacteremia ; Neutrophils ; In-situ hybridization ; Blood cultureSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract We evaluated the utility of in-situ hybridization (ISH) for the rapid diagnosis of sepsis. We applied this approach to polymorphonuclear neutrophil (PMN)-rich smears from patients with suspected bacterial infection. Positive results by ISH were obtained in the smears of 123 of 292 patients (42%), while only 32 of the 292 (11%) were positive by blood culture. These findings indicate that ISH is almost four times more sensitive than the culture method for the detection of sepsis. ISH results are obtained within 1 day, while 1 day to 2 weeks is required for the results of blood culture. Blood culture and ISH methods detected the same bacteria in two patients. ISH also successfully identified the same bacteria in blood and PMN-rich body fluid (bronchoalveolar lavage samples) in 6 patients. In 19 patients, ISH of blood detected the same bacteria as those found in subcultures from other sources (e.g., stool, sputum, nasal cavity). We discuss these results in comparison with blood culture results in terms of evaluating a rapid approach to the management of patients with sepsis.Type of Medium: Electronic ResourceURL: -
13Articles: DFG German National LicensesStaff View
ISSN: 1437-7780Keywords: Key wordsMycoplasma pneumoniae ; Grepafloxacin (GPFX) ; MICSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract We made a comparative study of the in-vitro activities of grepafloxacin (GPFX), ofloxacin (OFLX), erythromycin (EM), clarithromycin (CAM), roxithro-mycin (RXM), and minocycline (MINO) against 20 strains of Mycoplasma pneumoniae (17 clinical isolates and 3 standard strains). The minimum inhibitory concentration (MIC)90-to-minimum bactericidal concentration (MBC)90 ratio showed that the new quinolones have bactericidal effects on M. pneumoniae. Thus, it is expected that the new quinolones, especially grepafloxacin, will be clinically useful antimicrobial agents for the treatment of M. pneumoniae infection because of their good pharmacokinetic properties and bactericidal action.Type of Medium: Electronic ResourceURL: -
14Articles: DFG German National LicensesStaff View
ISSN: 1437-7780Keywords: Key words Intracellular uptake ; Grepafloxacin ; Ciprofloxacin ; THP-1 monocyte ; Fluoroquinolone ; Macrophage-like cellSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract The present study was designed to compare the uptake of grepafloxacin by a human monocytic cell line, THP-1, with that of ciprofloxacin. THP-1 cells were incubated with 20 μg/ml of either drug, and the entry of the drugs into the cells was determined using a velocity gradient centrifugation technique and HPLC assay. Antibiotic uptake by the cells was expressed as the ratio of the intracellular to the extracellular drug concentration (IC/EC). Grepafloxacin entered THP-1 cells readily within 5 min, and at steady-state (37°C; 60 min), the IC/EC ratio of grepafloxacin (11.9 ± 1.7; n = 13) was about 2.4-fold higher than that of ciprofloxacin (5.0 ± 1.3; n = 13). The ratios decreased at low incubation temperature (4°C), in paraformaldehyde-treated dead cells, and at low extracellular pH (pH 6.0), but were not influenced by high extracellular pH (pH, 9.0). Characterization of fluoroquinolone uptake suggests that these drugs penetrate the THP-1 membrane by passive diffusion, and also, in part, via an active transport system. We also examined the uptake of the two fluoroquinolones in phorbol 12 myristate 13-acetate (PMA)-stimulated adherent THP-1 cells (THP-1 macrophages). The IC/EC ratios for both fluoroquinolones in the THP-1 macrophages were significantly higher than those in the THP-1 monocytes. Further the uptake of three other fluoroquinolones, levofloxacin, tosufloxacin, and sparfloxacin, by THP-1 monocytes was examined in comparative studies. The IC/EC ratio of grepafloxacin was comparable to that of sparfloxacin and significantly higher than that of the other fluoroquinolones. Our results indicate that grepafloxacin exhibits better intracellular accumulation than ciprofloxacin and other fluoroquinolones in human monocytic and macrophage-like cells.Type of Medium: Electronic ResourceURL: -
15Articles: DFG German National LicensesStaff View
ISSN: 1437-7780Keywords: Key wordsLegionella pneumophila ; Intracellular activity ; A549 ; Alveolar epithelial cell ; THP-1 ; MacrophageSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract The intracellular activity of three antimicrobial agents, erythromycin, clarithromycin, and ciprofloxacin, against Legionella pneumophila was examined in the human monocyte-derived cell line, THP-1, and the human alveolar epithelial cell line, A549. L. pneumophila multiplied by three- to four-log in THP-1 and by two- to three-log in A549 after 48-h incubation. The activity of the two macrolides was markedly greater in A549 than in THP-1, while ciprofloxacin exhibited similar activity in both cell lines. The intracellular concentrations of the two macrolides were markedly higher in A549 than in THP-1, while those of ciprofloxacin were almost equal in both types of cell lines. The intracellular activity of antimicrobial agents and the intracellular growth of L. pneumophila vary with different types of host cells.Type of Medium: Electronic ResourceURL: -
16Articles: DFG German National LicensesStaff View
ISSN: 1432-0495Keywords: Key words Water cycle ; Groundwater flow ; Water quality ; Isotopic composition ; Evolution of groundwater qualitySource: Springer Online Journal Archives 1860-2000Topics: GeosciencesNotes: Abstract The evolution of groundwater quality at a wet zone in Sri Lanka was made clear using field investigation, chemical and isotopic analyses methods. In the wet zone, the concentrations of major ions and electrical conductivity (EC) in the groundwater are low with small seasonal change. Except for sodium, silica and chloride, the EC and other major ion concentrations increase along the groundwater flow direction. The contributions of bicarbonate and calcium ions to the increase in EC are the largest among the major ions. The groundwater quality shows calcium-bicarbonate type, the initial stage of the Chebotarev series. There is a seasonal change in isotopic composition. The isotopically lighter groundwater was found at the valley bottom in the rainy season. Under the very heavy precipitation conditions, the slope of the regression line between δD and δ18O and deuterium excess for groundwater are close to 8 and 10, respectively. In other cases, the slopes of the regression lines and deuterium excess are, less than 8 and 10, respectively.Type of Medium: Electronic ResourceURL: -
17Articles: DFG German National LicensesStaff View
ISSN: 0098-1273Keywords: Physics ; Polymer and Materials ScienceSource: Wiley InterScience Backfile Collection 1832-2000Topics: Chemistry and PharmacologyPhysicsType of Medium: Electronic ResourceURL:
