Search Results - (Author, Cooperation:J. S. Cox)
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1Latest Papers from Table of Contents or Articles in PressC. McGregor, M. S. Al-Abdul-Wahid, V. Robertson, J. S. Cox, P. R. Tremaine
American Chemical Society (ACS)
Published 2018Staff ViewPublication Date: 2018-09-18Publisher: American Chemical Society (ACS)Electronic ISSN: 1520-5207Topics: Chemistry and PharmacologyPhysicsPublished by: -
2Latest Papers from Table of Contents or Articles in PressP. S. Manzanillo ; J. S. Ayres ; R. O. Watson ; A. C. Collins ; G. Souza ; C. S. Rae ; D. S. Schneider ; K. Nakamura ; M. U. Shiloh ; J. S. Cox
Nature Publishing Group (NPG)
Published 2013Staff ViewPublication Date: 2013-09-06Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Autophagy/immunology ; Bone Marrow Cells/microbiology ; Drosophila melanogaster/genetics/*immunology/metabolism/*microbiology ; Female ; Immunity, Innate/*immunology ; Lysine/metabolism ; Macrophages/microbiology ; Male ; Mice ; Mice, Inbred C57BL ; Mitochondria/metabolism/pathology ; Mitochondrial Degradation ; Models, Immunological ; Mycobacterium marinum/*immunology ; Mycobacterium tuberculosis/growth & development/*immunology/metabolism ; Polyubiquitin/chemistry/metabolism ; Salmonella typhimurium/*immunology ; Symbiosis/immunology ; Tuberculosis/enzymology/immunology/microbiology/pathology ; Ubiquitin/analysis/chemistry/metabolism ; Ubiquitin-Protein Ligases/chemistry/deficiency/*immunology/metabolismPublished by: -
3Latest Papers from Table of Contents or Articles in PressK. D. Nguyen ; S. J. Fentress ; Y. Qiu ; K. Yun ; J. S. Cox ; A. Chawla
American Association for the Advancement of Science (AAAS)
Published 2013Staff ViewPublication Date: 2013-08-24Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: ARNTL Transcription Factors/genetics/*metabolism ; Animals ; Antigens, Ly/immunology ; Chemokines/genetics ; Chemotaxis/genetics/immunology ; Circadian Clocks/genetics/*immunology ; Circadian Rhythm/genetics/*immunology ; Gene Expression Regulation ; Inflammation/genetics/*immunology ; Listeria monocytogenes/immunology/pathogenicity ; Listeriosis/genetics/immunology ; Metabolic Diseases/metabolism ; Mice ; Mice, Knockout ; Monocytes/*immunology ; Myeloid Cells/metabolismPublished by: -
4Latest Papers from Table of Contents or Articles in PressStaff View
Publication Date: 2016-04-07Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; *Endoplasmic Reticulum Stress ; Female ; Humans ; Inflammation/*metabolism ; Male ; Nod1 Signaling Adaptor Protein/*metabolism ; Nod2 Signaling Adaptor Protein/*metabolism ; *Signal TransductionPublished by: -
5Latest Papers from Table of Contents or Articles in PressStaff View
Publication Date: 2018-08-15Publisher: American Physical Society (APS)Print ISSN: 1539-3755Electronic ISSN: 1550-2376Topics: PhysicsKeywords: Films and InterfacesPublished by: -
6Articles: DFG German National LicensesStaff View
ISSN: 1467-9310Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: EconomicsNotes: Abstract. Information retrieval systems in R & D laboratories are normally used to provide information about the state of the art in fields of corporate interest and to help to solve day-to-day problems. The authors show that such systems can also be used as a tool for planning by R & D managers, corporate planners and others involved in evaluating and setting strategic objectives for the firm. Their approach is to use the Science Citation Index to ascertain the specific institutional setting and geographical locations of researchers in whom material published by the subject firm excited a ‘resonance’.In their study they used the publications lists covering a five-year period provided by two West German companies. They point out that it is possible not only to assess the scientific standing of the R & D laboratory but also to get early warning of spin-offs into hitherto unrecognized fields, to identify ‘markets’ for the profitable exchange of information and to locate complementary sources of expertise.Type of Medium: Electronic ResourceURL: -
7Articles: DFG German National LicensesStaff View
ISSN: 1467-9310Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: EconomicsNotes: The process of turning a promising chemical compound into a safe and effective drug is both expensive and risky. Effective strategic planning is vital to ensure that investment in staff and equipment is used productively and that an acceptable output of products can be maintained. But methods of planning in common use do not deal satisfactorily with the uncertainties. This paper sets out an analysis of the process and describes the use of a simple model to establish a strategic plan. The model allows the output, resource efficiency and robustness of a plan to be examined. Important conclusions about the relative distribution of resources between different activities are drawn and the effects of possible changes in regulatory requirements are explored.Type of Medium: Electronic ResourceURL: -
8Articles: DFG German National LicensesOsbaldeston, M. D. ; Cox, J. S. G. ; Loveday, D. E. E.
Oxford, UK : Blackwell Publishing Ltd
Published 1978Staff ViewISSN: 1467-9310Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: EconomicsNotes: This paper reviews the results of a study carried out in conjunction with the Chemical and Allied Products Industry Training Board to link internal environmental factors of an organization to measures of creativity in R & D in the pharmaceutical industry. The methods adopted have been described and the preliminary results of the pilot study carried out in one organization in order to develop, refine and test methodology. It is hoped in the future that the techniques developed will be extended to provide comparisons in other organizations in the pharmaceutical industry in order to draw firm conclusions. The paper also sets the study in the context of a brief historical review of other studies in this field. It is concluded that the investigation has evolved a methodology capable of identifying and measuring some facilitatory and inhibitory influences on creativity in an R & D environment, allowing comparisons to be drawn between environmental influences in different parts of the same organization.Type of Medium: Electronic ResourceURL: -
9Articles: DFG German National LicensesStaff View
ISSN: 1467-9310Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: EconomicsNotes: Within the financial and technical objectives of pharmaceutical R & D, an important sub-goal is the maintenance of a long-term balance between the different activities of research. Such a balance provides stability and, by ensuring a high utilization of research man-power, offers a higher output from a given level of investment. This paper describes the development and use of a simple technique to assist in attaining this balance. The performance of a strategic plan, in both the long- and short-term, is assessed, and the scope for corrective action to deal with deviations from the plan is explored. The flexibility and robustness of suitable strategic plans are demonstrated by the use of simulation.Type of Medium: Electronic ResourceURL: -
10Articles: DFG German National LicensesCox, J. S. G. ; Millane, B. V. ; Styles, A. E. J.
Oxford, UK : Blackwell Publishing Ltd
Published 1975Staff ViewISSN: 1467-9310Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: EconomicsNotes: Despite the popular view that pharmaceutical research is a random process, and by inference unplannable, the long-term survival and development of a pharmaceutical company must be based on a steady flow of new products with a full understanding by management of the relationships between research expenditure and the likely revenues they will produce. In this paper is developed a model of the R&D function which uses probabilistic assumptions to compute the expected stream of revenues from a portfolio of projects involving the major development routes from which pharmaceutical products usually arise. The model is based on expected values of market and technical research performance and hence gives expected or indicated sales in the future as output.Type of Medium: Electronic ResourceURL: -
11Articles: DFG German National LicensesStaff View
ISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] Several theories have been put forward as to the chemical nature of this iron dextran preparation. These, broadly speaking, fall into two groups, namely, that: (1) ferric iron is chemically bonded to the dextran; (2) ferric iron is present as colloidal ferric hydroxide protected by the dextran. ...Type of Medium: Electronic ResourceURL: -
12Articles: DFG German National LicensesStaff View
ISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] It is generally accepted that in the immediate hyper-sensitivity type reaction antibody is attached to the mast cell membrane and union with antigen occurs at this site5. Fine structure studies using "reaginic" antiferritin sera have revealed antigen on the mast cell membrane6 and some evidence of ...Type of Medium: Electronic ResourceURL: -
13Articles: DFG German National LicensesStaff View
ISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] In experiments on an asthmatic volunteer, inhaling the compound inhibited the acute effect of subsequent antigen inhalation1. In patients suffering from allergic asthma, inhalation of this compound was followed by clinical improvement2. Disodium cromoglycate is the sodium salt of ...Type of Medium: Electronic ResourceURL: -
14Articles: DFG German National LicensesRICKETTS, C. R. ; COX, J. S. G. ; FITZMAURICE, C. ; MOSS, G. F.
[s.l.] : Nature Publishing Group
Published 1965Staff ViewISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] T)HARMACEUTICAL preparations ('Imferon' and 'Im-Jl posil', Fisons Pharrnaceuticals, Ltd. (Benger Laboratories)) containing iron and dextran are used for the treatment of iron-deficiency anaemia in man and farm animals. They are prepared by neutralizing ferric chloride in the presence of an ...Type of Medium: Electronic ResourceURL: