Search Results - (Author, Cooperation:J. Ruel)

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  1. 1
    M. McDonald ; M. Bayliss ; B. A. Benson ; R. J. Foley ; J. Ruel ; P. Sullivan ; S. Veilleux ; K. A. Aird ; M. L. Ashby ; M. Bautz ; G. Bazin ; L. E. Bleem ; M. Brodwin ; J. E. Carlstrom ; C. L. Chang ; H. M. Cho ; A. Clocchiatti ; T. M. Crawford ; A. T. Crites ; T. de Haan ; S. Desai ; M. A. Dobbs ; J. P. Dudley ; E. Egami ; W. R. Forman ; G. P. Garmire ; E. M. George ; M. D. Gladders ; A. H. Gonzalez ; N. W. Halverson ; N. L. Harrington ; F. W. High ; G. P. Holder ; W. L. Holzapfel ; S. Hoover ; J. D. Hrubes ; C. Jones ; M. Joy ; R. Keisler ; L. Knox ; A. T. Lee ; E. M. Leitch ; J. Liu ; M. Lueker ; D. Luong-Van ; A. Mantz ; D. P. Marrone ; J. J. McMahon ; J. Mehl ; S. S. Meyer ; E. D. Miller ; L. Mocanu ; J. J. Mohr ; T. E. Montroy ; S. S. Murray ; T. Natoli ; S. Padin ; T. Plagge ; C. Pryke ; T. D. Rawle ; C. L. Reichardt ; A. Rest ; M. Rex ; J. E. Ruhl ; B. R. Saliwanchik ; A. Saro ; J. T. Sayre ; K. K. Schaffer ; L. Shaw ; E. Shirokoff ; R. Simcoe ; J. Song ; H. G. Spieler ; B. Stalder ; Z. Staniszewski ; A. A. Stark ; K. Story ; C. W. Stubbs ; R. Suhada ; A. van Engelen ; K. Vanderlinde ; J. D. Vieira ; A. Vikhlinin ; R. Williamson ; O. Zahn ; A. Zenteno
    Nature Publishing Group (NPG)
    Published 2012
    Staff View
    Publication Date:
    2012-08-17
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Published by:
    Latest Papers from Table of Contents or Articles in Press
  2. 2
  3. 3
    Rebillard, G. ; Ruel, J. ; Nouvian, R. ; Saleh, H. ; Pujol, R. ; Dehnes, Y. ; Raymond, J. ; Puel, J. L. ; Devau, G.

    Oxford, UK : Blackwell Science, Ltd
    Published 2003
    Staff View
    ISSN:
    1460-9568
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Notes:
    In the cochlea, glutamate plays a major role in synaptic transmission between the inner hair cell and the primary auditory neurons. Extracellular glutamate concentration must be regulated to prevent excitotoxicity. This regulation is mediated by excitatory amino acid transporters, membrane proteins that remove glutamate from the synaptic cleft. In this study, we investigated the distribution and activity of three excitatory amino acid transporters subtypes in the guinea-pig cochlea: glutamate aspartate transporter, glutamate transporter and excitatory amino acid carrier. A partial messenger ribonucleic acid sequence was determined for each of these transporters, by polymerase chain reaction with degenerate primers, using guinea-pig brain complementary deoxyribonucleic acid as the template. Primers specific for each transporter were then designed and used to screen a dissected organ of Corti complementary deoxyribonucleic acid library. The cellular distribution of each transporter was examined by immunocytochemistry. We investigated the functional consequences of inhibiting glutamate uptake by recording cochlear potentials during intracochlear perfusion with either l-trans-pyrrolidine-2,4-dicarboxylic acid or dihydrokainate. At the end of the electrophysiological session, cochleas were processed for electron microscopy. Only the glutamate aspartate transporter messenger ribonucleic acid was detected in the organ of Corti. Consistently, glutamate aspartate transporter protein was detected in the inner hair cell-supporting cells and in the ganglion of Corti satellite cells. Glutamate transporter and excitatory amino acid carrier were found in the afferent auditory neurons. Only intracochlear perfusions with l-trans-pyrrolidine-2,4-dicarboxylic acid resulted in a dose-dependent decrease in the amplitude of the cochlear compound action potential, leaving cochlear microphonic potential unaffected. After l-trans-pyrrolidine-2,4-dicarboxylic acid perfusion, cochleas displayed a swelling of the afferent endings typical of excitotoxicity. [(–)1-(4-aminophenyl)-4-methyl-7,8-methylenedioxy-4,5-dihydro-3-methylcarbamyl-2,3-benzodiazepine], a selective α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor antagonist protects the cochlea against l-trans-pyrrolidine-2,4-dicarboxylic acid effect.
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  4. 4
    THIVOLET, J. ; MONIER, J. C. ; RUEL, J. P. ; RICHARD, M. H.

    [s.l.] : Nature Publishing Group
    Published 1967
    Staff View
    ISSN:
    1476-4687
    Source:
    Nature Archives 1869 - 2009
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Notes:
    [Auszug] Fifty-seven Swiss/Giff mice were operated on within 12 h of birth by Dischlers method2. Just before the birth of the young the mothers received Librium in water. This treatment was continued for 1 week in order to reduce the likelihood of cannibalism. Control mice were subjected to sham-thymectomy. ...
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  5. 5
    Tzortzis, C. ; Ruel, J. ; Masure, M.C.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    0911-6044
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Linguistics and Literary Studies
    Biology
    Medicine
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  6. 6
    Tzortzis, C. ; Ruel, J. ; Masure, M.C.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    0911-6044
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Linguistics and Literary Studies
    Biology
    Medicine
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  7. 7
    Ruel, J.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    0028-3932
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Psychology
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  8. 8
    Ruel, J.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    0028-3932
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Psychology
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  9. 9
    Ruel, J.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    0028-3932
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Psychology
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  10. 10
    Ruel, J. ; Gavaret, J.-M. ; Luo, M. ; Dussault, J.H.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    0303-7207
    Keywords:
    brain ; protein phosphorylation ; thyroid hormones
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Biology
    Medicine
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  11. 11
    Ruel, J. ; Gavaret, J.-M. ; Luo, M. ; Dussault, J.H.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    0303-7207
    Keywords:
    brain ; protein phosphorylation ; thyroid hormones
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Biology
    Medicine
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  12. 12
    Bandrauk, André D. ; Ruel, J. ; Zuo, Tao ; Yu, Hengtai

    New York, NY : Wiley-Blackwell
    Published 1997
    Staff View
    ISSN:
    0020-7608
    Keywords:
    Chemistry ; Theoretical, Physical and Computational Chemistry
    Source:
    Wiley InterScience Backfile Collection 1832-2000
    Topics:
    Chemistry and Pharmacology
    Notes:
    Combinations of circularly polarized intense laser pulses (I≥1014 W/cm2) and intense magnetic fields (B≃107 gauss) are shown to lead to control of electron orbits in atoms and molecules. In particular, it is proposed to use such intense field experiments to produce high-order harmonic generation into the ultraviolet and X-ray regions.   © 1997 John Wiley & Sons, Inc. Int J Quant Chem 64: 613-617, 1997
    Additional Material:
    2 Ill.
    Type of Medium:
    Electronic Resource
    Articles: DFG German National Licenses