Search Results - (Author, Cooperation:J. Rosenbaum)

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  1. 1
    Staff View
    Publication Date:
    2014-11-05
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Child ; Child Development Disorders, Pervasive/*genetics ; Cluster Analysis ; Exome/genetics ; Female ; Genes ; Genetic Predisposition to Disease/*genetics ; Humans ; Intelligence Tests ; Male ; Mutation/*genetics ; Open Reading Frames/*genetics ; Reproducibility of Results
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  2. 2
    Gillibert-Duplantier, J ; Neaud, V ; Desmoulière, A ; Bioulac-Sage, P ; Rosenbaum, J

    Oxford, UK; Malden, USA : Blackwell Science Inc
    Published 2005
    Staff View
    ISSN:
    1524-475X
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Notes:
    Liver myofibroblasts are the key cells of liver fibrogenesis. Recent data show that the serine proteinase thrombin is involved in fibrogenesis through a mitogenic effect on myofibroblasts. The aim of this study was to evaluate the effects of thrombin on the migration of human liver myofibroblasts; another major parameter in fibrogenesis.In a Boyden chamber assay, thrombin dose-dependently (10−10–10−7 M) decreased spontaneous myofibroblast migration down to 49 ± 1% of control values (p = 5.10−10) without affecting cell adhesion or viability. Thrombin effect was blocked by its specific catalytic inhibitor hirudin and could be reproduced by using the proteinase-activated receptor-1 (PAR-1) agonist SFLLRNP. Thrombin also completely inhibited migration when induced by the chemotactic agent platelet-derived growth factor-BB. We then investigated the signaling mechanisms involved. The COX-2 inhibitor NS398 dose-dependently (2.5–10 μM) blunted the inhibitory effect of thrombin on spontaneous migration. However, NS398 did not reverse the inhibitory effect of thrombin on PDGF-BB-induced migration. Phosphatidylinositol 3-kinase (PI3-K) is a major determinant of chemotaxis induced by PDGF. Whereas thrombin did not itself induce PI3-K activity, as shown by the lack of detectable phosphorylation of Akt-1, it inhibited PDGF-BB-induced Akt-1 phosphorylation. This effect was dependent of the Rho/ROCK pathway since it was abolished in the presence of the ROCK inhibitor Y-27632.In summary, thrombin, acting via a proteinase-activated receptor, inhibits human liver myofibroblasts migration. Inhibition of basal migration is dependent on COX-2, while inhibition of PDGF-BB-induced migration involves decreased PI3-K activation via a Rho/ROCK mechanism. We suggest that thrombin could thus stabilize activated myofibroblasts on the site of active fibrogenesis.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1111/j.1067-1927.2005.130117j.x

    Articles: DFG German National Licenses
  3. 3
    SATIR, B. ; ROSENBAUM, J. L.

    Oxford, UK : Blackwell Publishing Ltd
    Published 1965
    Staff View
    ISSN:
    1550-7408
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Biology
    Notes:
    SYNOPSIS. Axenic cultures of Tetrahymena pyriformis W were used to obtain fractions rich in kinetosomes by alcoholdigitonin extraction techniques followed by centrifugation. The morphology of the kinetosomes was examined in the electron microscope at various stages during the isolation procedure, and compared to the morphology of the in situ kinetosome. In the latter preparation the well known cartwheel structure was present, and in addition 9 electron dense dots were displayed at the end of each spoke of the cartwheel.The prepared kinetosomes could easily be identified during the entire process, and there was no apparent change until after the digitonin step. However, with the further fractionation, alteration was found to have taken place in the interior and in the kinetosome wall. The inside appeared “empty,” and we were not able to find 9 triplets in the wall but only doublets.In view of the morphological alterations in the kinetosomerich fractions, chemical analysis still appears to us to be premature.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1111/j.1550-7408.1965.tb03232.x

    Articles: DFG German National Licenses
  4. 4
    Rosenbaum, J. ; Mavier, P. ; Preaux, A.-M. ; Dhumeaux, D.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    0006-291X
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Biology
    Chemistry and Pharmacology
    Physics
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1016/0006-291X(89)91782-8

    Articles: DFG German National Licenses
  5. 5
    Rosenbaum, J. T. ; McDevitt, H. O. ; Guss, R. B. ; Egbert, P. R.

    [s.l.] : Nature Publishing Group
    Published 1980
    Staff View
    ISSN:
    1476-4687
    Source:
    Nature Archives 1869 - 2009
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Notes:
    [Auszug] The typical eye histology produced is shown in Fig. 1. This response could be produced by 1 mg of Escherichia coli, Kleb-siella or Shigella but not by 1 mg of Staphylococcus or by 0.1 mg of E. coli. The different response following Gram-negative as opposed to Gram-positive bacteria encouraged us to ...
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1038/286611a0

    Articles: DFG German National Licenses
  6. 6
    Staff View
    ISSN:
    0005-7894
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Psychology
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1016/S0005-7894(05)80284-9

    Articles: DFG German National Licenses
  7. 7
    Staff View
    ISSN:
    0006-291X
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Biology
    Chemistry and Pharmacology
    Physics
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1016/0006-291X(84)90387-5

    Articles: DFG German National Licenses
  8. 8
    Rosenbaum, J. ; Tobelem, G. ; Molho, P. ; Barzu, T. ; Caen, J.P.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    0309-1651
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Biology
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1016/0309-1651(86)90039-1

    Articles: DFG German National Licenses
  9. 9
    Rosenbaum, J.
    Springer
    Published 1980
    Staff View
    ISSN:
    1572-817X
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Electrical Engineering, Measurement and Control Technology
    Physics
    Notes:
    Abstract A first-order perturbation technique is used to obtain the eigenfunction correction due to the cladding in a square-law dielectric waveguide. Regions both near to and far from cut-off are considered separately. It is shown that far from cut-off the fractional power carried by the guide core increases over that in the homogeneous case but that near cut-off the power in the core is less than in a homogeneous guide. Thus the stability of the modal power with variation of wavelength is increased over that in a homogeneous guide.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF00625498

    Articles: DFG German National Licenses
  10. 10
    Rosenbaum, J. ; Coren, R.
    Springer
    Published 1980
    Staff View
    ISSN:
    1572-817X
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Electrical Engineering, Measurement and Control Technology
    Physics
    Notes:
    Abstract The effects of a homogeneous cladding on the dispersion of a square-law dielectric guide are investigated using a perturbation technique. Assuming a Gaussian, band-limited input it is shown that for single mode operation the waveguide dispersion is of the order of the material dispersion. For multimode operation the effect of the cladding on the uniformly polarized modes is examined and it is shown that a significant interaction occurs only for the two modes closest to cut-off. Comparison is made between theoretical and experimental results. The perturbation technique is used to analyse the optimum index profile proposed by Okamoto and Okoshi. It is shown that this variation reduces the dispersion to below that of the infinite medium approximation.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF00619555

    Articles: DFG German National Licenses
  11. 11
    Rosenbaum, J.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    0160-791X
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Sociology
    Technology
    Type of Medium:
    Electronic Resource
    URL:
    http://linkinghub.elsevier.com/retrieve/pii/0160-791X(94)90022-1

    Articles: DFG German National Licenses
  12. 12
    DAVIS, M. ; LUCAS, J. M. S. ; ROSENBAUM, J. ; WRIGHT, D. E.

    [s.l.] : Nature Publishing Group
    Published 1966
    Staff View
    ISSN:
    1476-4687
    Source:
    Nature Archives 1869 - 2009
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Notes:
    [Auszug] For several years we have sought novel fasciolicides1. An interesting level of activity against the mature fluke found for the known anthelmintic 2,6-di-iodo-4-nitro-phenol (disophenol) (I)2 led us to synthesize and test a wide range of substituted phenols and their derivatives: One of these, ...
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1038/211882a0

    Articles: DFG German National Licenses
  13. 13
    Staff View
    ISSN:
    1432-0967
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Geosciences
    Notes:
    Abstract Late Hercynian U-bearing carbonate veins within the metamorphic complex of La Lauzière are characterized by two parageneses. The first is dominated by dolomite or ankerite and the second by calcite and pitchblende. Fluids trapped in the dolomites and ankerites at 350–400° C are saline waters (20 to 15 wt % eq. NaCl) with δD∼ −34 to −49‰. In the calcite they are less saline (17 to 8 wt % eq. NaCl) and trapped at 300–350° C with δD∼ −50 to −65‰. All fluids contain trace N2, CO2 and probably CH4. The carbonates have Δ 13C∼ −8 to −14‰. and derived their carbon from organic matter. Evolution of the physico-chemical conditions from dolomite (ankerite) to calcite deposition was progressive. H and O-isotope studies indicate the involvement of two externally derived fluids during vein development. A D-rich (∼ −35‰) low fO2, saline fluid is interpreted to have come from underlying sediments and entered the hotter overlying metamorphic slab and mixed with more oxidizing and less saline U bearing meteoric waters during regional uplift. This evidence for a sedimentary formation water source for the deep fluid implies that the metamorphic complex overthrusted sedimentary formations during the Late-Hercynian.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF00371319

    Articles: DFG German National Licenses