Search Results - (Author, Cooperation:J. R. Shaw)
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1Latest Papers from Table of Contents or Articles in PressJ. K. Colbourne ; M. E. Pfrender ; D. Gilbert ; W. K. Thomas ; A. Tucker ; T. H. Oakley ; S. Tokishita ; A. Aerts ; G. J. Arnold ; M. K. Basu ; D. J. Bauer ; C. E. Caceres ; L. Carmel ; C. Casola ; J. H. Choi ; J. C. Detter ; Q. Dong ; S. Dusheyko ; B. D. Eads ; T. Frohlich ; K. A. Geiler-Samerotte ; D. Gerlach ; P. Hatcher ; S. Jogdeo ; J. Krijgsveld ; E. V. Kriventseva ; D. Kultz ; C. Laforsch ; E. Lindquist ; J. Lopez ; J. R. Manak ; J. Muller ; J. Pangilinan ; R. P. Patwardhan ; S. Pitluck ; E. J. Pritham ; A. Rechtsteiner ; M. Rho ; I. B. Rogozin ; O. Sakarya ; A. Salamov ; S. Schaack ; H. Shapiro ; Y. Shiga ; C. Skalitzky ; Z. Smith ; A. Souvorov ; W. Sung ; Z. Tang ; D. Tsuchiya ; H. Tu ; H. Vos ; M. Wang ; Y. I. Wolf ; H. Yamagata ; T. Yamada ; Y. Ye ; J. R. Shaw ; J. Andrews ; T. J. Crease ; H. Tang ; S. M. Lucas ; H. M. Robertson ; P. Bork ; E. V. Koonin ; E. M. Zdobnov ; I. V. Grigoriev ; M. Lynch ; J. L. Boore
American Association for the Advancement of Science (AAAS)
Published 2011Staff ViewPublication Date: 2011-02-05Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Adaptation, Physiological ; Amino Acid Sequence ; Animals ; Base Sequence ; Chromosome Mapping ; Daphnia/*genetics/physiology ; *Ecosystem ; Environment ; Evolution, Molecular ; Gene Conversion ; Gene Duplication ; Gene Expression ; Gene Expression Profiling ; Gene Expression Regulation ; Genes ; Genes, Duplicate ; *Genome ; Metabolic Networks and Pathways/genetics ; Molecular Sequence Annotation ; Molecular Sequence Data ; Multigene Family ; Phylogeny ; Sequence Analysis, DNAPublished by: -
2Latest Papers from Table of Contents or Articles in PressPhosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagyD. F. Egan ; D. B. Shackelford ; M. M. Mihaylova ; S. Gelino ; R. A. Kohnz ; W. Mair ; D. S. Vasquez ; A. Joshi ; D. M. Gwinn ; R. Taylor ; J. M. Asara ; J. Fitzpatrick ; A. Dillin ; B. Viollet ; M. Kundu ; M. Hansen ; R. J. Shaw
American Association for the Advancement of Science (AAAS)
Published 2011Staff ViewPublication Date: 2011-01-06Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: AMP-Activated Protein Kinases/*metabolism ; Adaptor Proteins, Signal Transducing/metabolism ; Animals ; *Autophagy ; Caenorhabditis elegans/metabolism ; Caenorhabditis elegans Proteins/genetics/metabolism ; Cell Line ; Cell Line, Tumor ; Cell Survival ; Energy Metabolism ; Hepatocytes/metabolism ; Humans ; Insulin/metabolism ; Intracellular Signaling Peptides and Proteins/chemistry/genetics/*metabolism ; Liver/metabolism ; Metformin/pharmacology ; Mice ; Mitochondria, Liver/metabolism/ultrastructure ; Phenformin/pharmacology ; Phosphorylation ; Protein-Serine-Threonine Kinases/chemistry/genetics/*metabolism ; Signal Transduction ; Transcription Factors/metabolismPublished by: -
3Latest Papers from Table of Contents or Articles in PressStaff View
Publication Date: 2011-02-19Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Adenylate Kinase/metabolism ; Animals ; Ataxia Telangiectasia Mutated Proteins ; Blood Glucose/analysis/biosynthesis ; Cell Cycle Proteins/antagonists & inhibitors/*genetics/*metabolism ; DNA-Binding Proteins/antagonists & inhibitors/*genetics/*metabolism ; Diabetes Mellitus, Type 2/complications/*drug therapy/*genetics ; Energy Intake ; Enzyme Activation/drug effects ; Female ; Genome-Wide Association Study ; Humans ; Hypoglycemic Agents/*pharmacology ; Metformin/*pharmacology ; Neoplasms/drug therapy/*genetics/pathology ; Pharmacogenetics ; Polycystic Ovary Syndrome/complications ; Protein-Serine-Threonine Kinases/antagonists & inhibitors/*genetics/*metabolism ; Tumor Suppressor Proteins/antagonists & inhibitors/*genetics/*metabolismPublished by: -
4Latest Papers from Table of Contents or Articles in PressStaff View
Publication Date: 2013-06-01Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Amino Acids/*metabolism ; Carrier Proteins/*metabolism ; Humans ; Lysosomes/*enzymology ; Monomeric GTP-Binding Proteins/*metabolism ; Multiprotein Complexes ; Neoplasms/*enzymology ; Proteins/*metabolism ; TOR Serine-Threonine Kinases ; Tumor Suppressor Proteins/*metabolismPublished by: -
5Latest Papers from Table of Contents or Articles in PressMetabolism. AMP-activated protein kinase mediates mitochondrial fission in response to energy stressE. Q. Toyama ; S. Herzig ; J. Courchet ; T. L. Lewis, Jr. ; O. C. Loson ; K. Hellberg ; N. P. Young ; H. Chen ; F. Polleux ; D. C. Chan ; R. J. Shaw
American Association for the Advancement of Science (AAAS)
Published 2016Staff ViewPublication Date: 2016-01-28Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: AMP-Activated Protein Kinases/chemistry/genetics/*metabolism ; Adenosine Monophosphate/metabolism ; Amino Acid Motifs ; Cell Line, Tumor ; Cytoplasm/enzymology ; Dactinomycin/analogs & derivatives/pharmacology ; *Energy Metabolism ; Enzyme Activation ; GTP Phosphohydrolases/genetics/metabolism ; Humans ; Microtubule-Associated Proteins/genetics/metabolism ; Mitochondria/drug effects/enzymology/*physiology ; *Mitochondrial Dynamics ; Mitochondrial Proteins/genetics/metabolism ; Molecular Sequence Data ; Rotenone/pharmacology ; *Stress, PhysiologicalPublished by: -
6Latest Papers from Table of Contents or Articles in PressR. J. Shaw ; L. C. Cantley
American Association for the Advancement of Science (AAAS)
Published 2012Staff ViewPublication Date: 2012-05-19Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: AMP-Activated Protein Kinases/*metabolism ; Animals ; Humans ; Salicylates/*metabolism/*pharmacologyPublished by: -
7Latest Papers from Table of Contents or Articles in PressW. Mair ; I. Morantte ; A. P. Rodrigues ; G. Manning ; M. Montminy ; R. J. Shaw ; A. Dillin
Nature Publishing Group (NPG)
Published 2011Staff ViewPublication Date: 2011-02-19Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: AMP-Activated Protein Kinases/*metabolism ; Aging/metabolism/physiology ; Animals ; Caenorhabditis elegans/enzymology/genetics/metabolism/*physiology ; Caenorhabditis elegans Proteins/biosynthesis/chemistry/genetics/*metabolism ; Calcineurin/*metabolism ; Calcineurin Inhibitors ; Cyclic AMP Response Element-Binding Protein/biosynthesis/*metabolism ; Down-Regulation ; Energy Metabolism ; Enzyme Activation ; Gene Knockdown Techniques ; HEK293 Cells ; Humans ; Longevity/genetics/*physiology ; Phosphorylation ; Protein-Serine-Threonine Kinases/metabolism ; Trans-Activators/chemistry/deficiency/genetics/*metabolism ; Transcription Factors/biosynthesis/*metabolism ; Transcription, GeneticPublished by: -
8Latest Papers from Table of Contents or Articles in PressStaff View
Publication Date: 2012-06-05Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: AMP-Activated Protein Kinases/*metabolism ; Animals ; *Energy Metabolism ; Female ; *Homeostasis ; Male ; NADP/*metabolism ; Neoplasms/*metabolism/*pathology ; *Oxidative StressPublished by: -
9Articles: DFG German National LicensesHogstrand, C. ; Ferguson, E. A. ; Galvez, F. ; Shaw, J. R. ; Webb, N. A. ; Wood, C. M.
Springer
Published 1999Staff ViewISSN: 1432-136XKeywords: Key words Ag ; Osmoregulation ; Ionoregulation ; Marine ; FishSource: Springer Online Journal Archives 1860-2000Topics: BiologyMedicineNotes: Abstract Physiological effects of exposure to silver (AgCln n−1; 250 μg Ag l−1 or 1000 μg Ag l−1) in seawater fish were investigated using adult starry flounders. While all fish survived up to 10 days in 250 μg Ag l−1, flounders started to die after day 4 in 1000 μg l−1. Dose-dependent increases in plasma and hepatic silver concentrations showed that silver was available for uptake. There were minimal negative effects on hematological parameters, acid-base status, and blood gases. Plasma ammonia showed a pronounced (three- to four-fold), but transient increase in flounders exposed to either 250 μg Ag l−1 or 1000 μg Ag l−1. Whole body ammonia and acid equivalent efflux measurements indicated that ammonia retention was due to a combination of stimulated production and inhibited excretion. In the 1000-μg Ag l−1 group there was a similar transient increase in plasma [magnesium], which was restored by day 4. In contrast, plasma chloride and sodium levels increased gradually towards the point when fish began to die. At 250 μg Ag l−1, the Na+/K+-ATPase activity of the intestine was unaffected but there was a two-fold increase in branchial Na+/K+-ATPase activity. The latter effect was interpreted as compensation for an elevated chloride and sodium load. The increases in plasma chloride and sodium concentrations were accompanied by a marked suppression of drinking, thereby indicating that acute silver toxicity was likely caused by a combination of elevated electrolyte concentrations and dehydration.Type of Medium: Electronic ResourceURL: