Search Results - (Author, Cooperation:J. R. Cook)
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1Articles: DFG German National LicensesStaff View
ISSN: 0021-9541Keywords: Life and Medical Sciences ; Cell & Developmental BiologySource: Wiley InterScience Backfile Collection 1832-2000Topics: BiologyMedicineNotes: Growth characteristics of Euglena gracilis Z as functions of culture pH, CO2 tension, temperature, and lighting regime were investigated. The results are consistent with the possibility that cell division is preceded by a lowered intracellular pH. Also consistent with this possibility is the finding that division rhythmicity can be induced by periodic changes in CO2 tension. It is suggested that the rhythmicity is induced by changes in intracellular pH produced by carbonic acid.Additional Material: 4 Ill.Type of Medium: Electronic ResourceURL: -
2Latest Papers from Table of Contents or Articles in PressV. N. Ngo ; R. M. Young ; R. Schmitz ; S. Jhavar ; W. Xiao ; K. H. Lim ; H. Kohlhammer ; W. Xu ; Y. Yang ; H. Zhao ; A. L. Shaffer ; P. Romesser ; G. Wright ; J. Powell ; A. Rosenwald ; H. K. Muller-Hermelink ; G. Ott ; R. D. Gascoyne ; J. M. Connors ; L. M. Rimsza ; E. Campo ; E. S. Jaffe ; J. Delabie ; E. B. Smeland ; R. I. Fisher ; R. M. Braziel ; R. R. Tubbs ; J. R. Cook ; D. D. Weisenburger ; W. C. Chan ; L. M. Staudt
Nature Publishing Group (NPG)
Published 2010Staff ViewPublication Date: 2010-12-24Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Amino Acid Sequence ; Amino Acid Substitution ; Burkitt Lymphoma/genetics ; Cell Line, Tumor ; Cell Survival ; Cytokines/metabolism/secretion ; High-Throughput Nucleotide Sequencing ; Humans ; Hydrophobic and Hydrophilic Interactions ; Interleukin-1 Receptor-Associated Kinases/biosynthesis/genetics/metabolism ; Janus Kinases/metabolism ; Lymphoma, B-Cell, Marginal Zone/genetics ; Lymphoma, Large B-Cell, Diffuse/classification/*genetics/*pathology ; Molecular Sequence Data ; Mutant Proteins/chemistry/genetics/metabolism ; Mutation/*genetics ; Myeloid Differentiation Factor 88/chemistry/*genetics/*metabolism ; NF-kappa B/metabolism ; Oncogenes/*genetics ; Phosphorylation ; Protein Structure, Tertiary ; RNA Interference ; Receptors, Interleukin-1/metabolism ; STAT3 Transcription Factor/metabolism ; Sequence Analysis, RNA ; Signal Transduction ; Toll-Like Receptors/metabolismPublished by: -
3Latest Papers from Table of Contents or Articles in PressR. Schmitz ; R. M. Young ; M. Ceribelli ; S. Jhavar ; W. Xiao ; M. Zhang ; G. Wright ; A. L. Shaffer ; D. J. Hodson ; E. Buras ; X. Liu ; J. Powell ; Y. Yang ; W. Xu ; H. Zhao ; H. Kohlhammer ; A. Rosenwald ; P. Kluin ; H. K. Muller-Hermelink ; G. Ott ; R. D. Gascoyne ; J. M. Connors ; L. M. Rimsza ; E. Campo ; E. S. Jaffe ; J. Delabie ; E. B. Smeland ; M. D. Ogwang ; S. J. Reynolds ; R. I. Fisher ; R. M. Braziel ; R. R. Tubbs ; J. R. Cook ; D. D. Weisenburger ; W. C. Chan ; S. Pittaluga ; W. Wilson ; T. A. Waldmann ; M. Rowe ; S. M. Mbulaiteye ; A. B. Rickinson ; L. M. Staudt
Nature Publishing Group (NPG)
Published 2012Staff ViewPublication Date: 2012-08-14Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Basic Helix-Loop-Helix Transcription Factors/antagonists & ; inhibitors/genetics/metabolism ; Burkitt Lymphoma/*drug therapy/*genetics/metabolism/pathology ; Cell Cycle ; Cyclin D3/genetics/metabolism ; Cyclin-Dependent Kinase 6/metabolism ; Genes, myc/genetics ; *Genomics ; High-Throughput Nucleotide Sequencing ; Humans ; Inhibitor of Differentiation Proteins/genetics/metabolism ; *Molecular Targeted Therapy ; Neoplasm Proteins/genetics/metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; RNA Interference ; Receptors, Antigen, B-Cell/metabolism ; Signal TransductionPublished by: -
4Latest Papers from Table of Contents or Articles in PressJ. R. Muppidi ; R. Schmitz ; J. A. Green ; W. Xiao ; A. B. Larsen ; S. E. Braun ; J. An ; Y. Xu ; A. Rosenwald ; G. Ott ; R. D. Gascoyne ; L. M. Rimsza ; E. Campo ; E. S. Jaffe ; J. Delabie ; E. B. Smeland ; R. M. Braziel ; R. R. Tubbs ; J. R. Cook ; D. D. Weisenburger ; W. C. Chan ; N. Vaidehi ; L. M. Staudt ; J. G. Cyster
Nature Publishing Group (NPG)
Published 2014Staff ViewPublication Date: 2014-10-03Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; B-Lymphocytes/*metabolism/*pathology ; Blood/immunology ; Burkitt Lymphoma/metabolism/pathology ; Cell Line, Tumor ; Cell Movement/genetics ; GTP-Binding Protein alpha Subunits, G12-G13/*metabolism ; Germinal Center/*pathology ; Humans ; Lymph/cytology ; Lymphoma, Large B-Cell, Diffuse/genetics/*metabolism/*pathology ; Mice ; Mice, Inbred C57BL ; Mutation/genetics ; Oncogene Protein v-akt/genetics/metabolism ; Receptors, Lysosphingolipid/deficiency/genetics/metabolism ; Receptors, Purinergic P2Y/genetics/metabolism ; Rho Guanine Nucleotide Exchange Factors/deficiency/genetics ; *Signal TransductionPublished by: -
5Latest Papers from Table of Contents or Articles in PressSchultz, A. S. H., Dahl, L., McGibbon, E., Brownlie, R. J., Cook, C., Elbarouni, B., Katz, A., Nguyen, T., Sawatzky, J. A., Sinclaire, M., Throndson, K., Fransoo, R.
BMJ Publishing
Published 2018Staff ViewPublication Date: 2018-03-27Publisher: BMJ PublishingElectronic ISSN: 2044-6055Topics: MedicineKeywords: Open access, Cardiovascular medicine, EpidemiologyPublished by: -
6Latest Papers from Table of Contents or Articles in PressMottok, A., Wright, G., Rosenwald, A., Ott, G., Ramsower, C., Campo, E., Braziel, R. M., Delabie, J., Weisenburger, D. D., Song, J. Y., Chan, W. C., Cook, J. R., Fu, K., Greiner, T., Smeland, E., Holte, H., Savage, K. J., Glinsmann-Gibson, B. J., Gascoyne, R. D., Staudt, L. M., Jaffe, E. S., Connors, J. M., Scott, D. W., Steidl, C., Rimsza, L. M.
American Society of Hematology (ASH)
Published 2018Staff ViewPublication Date: 2018-11-30Publisher: American Society of Hematology (ASH)Print ISSN: 0006-4971Electronic ISSN: 1528-0020Topics: BiologyMedicineKeywords: Lymphoid Neoplasia, Brief ReportsPublished by: -
7Articles: DFG German National LicensesCOOK, J. R. ; HAGGARD, SANDRA SMITH ; HARRIS, PATRICIA
Oxford, UK : Blackwell Publishing Ltd
Published 1976Staff ViewISSN: 1550-7408Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: BiologyNotes: SYNOPSIS. In populations of Euglena gracilis strain Z synchronized by cultivation on a repetitive light-dark cycle, chloroplasts undergo cyclic changes in structure. During most of the light period chloroplasts are relatively compact with closely appressed lamellae; during the dark (division) period the chloroplasts become quite distended. This change persists for at least one cycle even when the cells are left in continuous light, suggesting that the periodicity may be related more to the age of the cell than to a direct effect of light. In addition, the pyrenoid in synchronized cells has a transient existence, being present only in the first half of the light period.Type of Medium: Electronic ResourceURL: -
8Articles: DFG German National LicensesStaff View
ISSN: 1550-7408Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: BiologyNotes: Variations in DNA levels for log-phase Euglena have been shown to be directly related to the pH of the culture medium. Data are presented here for cultures grown in Cramer and Myer's medium at pH 3.0 and 6.8. DNA levels are ∼50% greater for Euglena at the higher pH value, confirming earlier reports.Type of Medium: Electronic ResourceURL: -
9Articles: DFG German National LicensesStaff View
ISSN: 1550-7408Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: BiologyNotes: Inhibition of cell division in Euglena gracilis by visible light is pH-dependent, being most severe in the pH range 3.5–5.0. Transfer of phototrophic cells from pH 6.8 to pH 4.2 can lead to cell death at modest light intensities (500 ft-cd) and inhibition of division at lower intensities (300 ft-cd). Inhibition is preceded by a large influx of phosphate, most of which remains in the cold PCA pool. It is suggested that light may act to reduce control over phosphate entry at these intermediate pH levels, and excess phosphate leads to inhibition of cell division or death.Type of Medium: Electronic ResourceURL: -
10Articles: DFG German National LicensesStaff View
ISSN: 1550-7408Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: BiologyNotes: SYNOPSIS. A technic is described for the quantitative assay of paramylum content of euglenoid flagellates. The method relies on the alkaline solubility of paramylum followed by treatment with the anthrone reagent. The intensity of the color developed by paramylum is about 14% greater than that developed by an equivalent amount of glucose. The method is sensitive down to about 10 μg.Type of Medium: Electronic ResourceURL: -
11Articles: DFG German National LicensesStaff View
ISSN: 1550-7408Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: BiologyNotes: SYNOPSIS. Light-dependent incorporation of acetate occurs in an obligate phototrophic strain of Euglena gracilis (strain L). Assimilation is into all major biochemical fractions. Acetate does not induce operation of the glyoxylate by-pass as it does in heterotrophic strains; neither does it stimulate oxygen consumption. Acetate will not replace CO2 in phototrophic growth. A number of carbon sources tested would not support growth in the dark, and glucose was not incorporated either in the light or the dark.Type of Medium: Electronic ResourceURL: -
12Articles: DFG German National LicensesStaff View
ISSN: 1550-7408Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: BiologyNotes: SYNOPSIS. The glyoxylate cycle operates at a high level in Euglena gracilis when acetate is the only carbon source, and at a low level when glucose is the only carbon source, as indicated by activities of malate synthase. Altho glucose causes a moderate repression of some of the enzymes of the glyoxylate cycle, it neither represses nor inhibits malate synthase. The specific activity of the malic enzyme was about 5-fold greater in acetate-grown Euglena than in glucose-grown cells, but the absolute rate of CO2 fixation was about twice as great in cells grown on glucose. The respiratory quotient was unity regardless of substrate.Type of Medium: Electronic ResourceURL: -
13Articles: DFG German National LicensesStaff View
ISSN: 1550-7408Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: BiologyNotes: SYNOPSIS. Properties of partially purified malate synthase from Euglena gracilis were characterized. The pH optimum is 7.0 and the temperature optimum about 30 C; the activation energy is 12,000 calories. A Km of 4 × 10−5 M was found for both reactants, glyoxylate and acetyl-CoA. The reaction is partially inhibited by a number of normal metabolites, suggesting allosteric control; glycolate is severely inhibitory. The enzyme is not active in cells grown with phototrophic nutrition, but is found in all heterotrophic cells grown on a wide range of carbon sources; the specific activity is greatly dependent on carbon source. High rates of oxygen consumption are usually, but not always, correlated with high enzyme levels.Type of Medium: Electronic ResourceURL: -
14Articles: DFG German National LicensesStaff View
ISSN: 1550-7408Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: BiologyNotes: Chloroplasts of Euglena gracilis grown with phototrophic nutrition at pH 3.0 were compact, while those in cells grown at pH 8.1 were swollen with widely separated lamellae.Type of Medium: Electronic ResourceURL: -
15Articles: DFG German National LicensesStaff View
ISSN: 1550-7408Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: BiologyNotes: SYNOPSIS. Euglena gracilis strain Z cells cultured in an inorganic medium with glucose as carbon and energy source differ from cells grown on acetate. Over optimal ranges of pH and substrate concentration, both glucose and acetate support essentially the same rates of growth, and mass and protein synthesis. Glucose, however, yields population densities 10X greater than acetate. Furthermore, in adapted cells glucose does not stimulate respiration above endogenous levels, whereas O2 consumption on acetate is 4X greater than endogenous; and acetate-grown cells have 50% more RNA than glucose-grown cells.Type of Medium: Electronic ResourceURL: -
16Articles: DFG German National LicensesStaff View
ISSN: 1550-7408Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: BiologyNotes: SYNOPSIS. Euglena gracilis (strain Z) was grown auto-trophically at different light intensities, saturating or limiting for cell division. Adaptation to culture at each light intensity was gauged from division rate, mass, protein, photosynthetic pigments, nucleic acids, volume, paramylum, lipids, respiration, and photosynthesis. Illumination above 1200 foot-, candles was saturating for all aspects of cell growth; the highest intensity examined (3,000 ft-c) slightly inhibited cell division. Intensities between 400 and 1200 ft-c were saturating for all except photosynthesis and paramylum accumulation. Intensities less than about 200 ft-c became limiting for all fractions except protein, which remained constant over the range 120–3000 ft-c, dropping, however, at 65 ft-c. Concentration of photosynthetic pigments increased as light intensity decreased.Absolute synthetic rates were estimated for the individual Euglena cell for the measured cell constituents. While most followed a predictable pattern, increasing with light intensity to saturating levels, the synthetic rates for the pigments went through maxima at 190 ft-c. Since fixed carbon in limiting light is so apportioned that protein is synthesized to the exclusion of paramylum, one concludes that the energy requirements for cell growth (measured as protein synthesis), and to a lesser extent cell division, have a higher priority than do those activities concerned more directly with maintenance.Type of Medium: Electronic ResourceURL: -
17Articles: DFG German National LicensesStaff View
ISSN: 1550-7408Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: BiologyNotes: SYNOPSIS. A continuous culture device suitable for controlled growth of Euglna gracilis is described. It could probably be adapted to other similar cell types with generation times no greater than 150–200 hrs.Type of Medium: Electronic ResourceURL: -
18Articles: DFG German National LicensesStaff View
ISSN: 1432-1106Keywords: Inferior olive ; Trigeminal nerve ; RatSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Summary Extracellular recordings were obtained from inferior olivary neurones of the rat. The responses of fifty neurones evoked by electrical stimulation of a branch of the trigeminal nerve were recorded. Maxillary nerve stimulation was most effective. The response was characterized by an early discharge (single spike and wave, typically with latencies between 16 and 30 msec) and a weak late discharge which followed a period of inhibition of about 100 msec. Half of the neurones responded to one branch of the trigeminal nerve only whereas the other neurones displayed a varying degree of convergence, including sometimes a convergence from limb nerves. Forty-nine olivary neurones were tested for cutaneous receptive fields. Ten out of these had small receptive fields (〈20% of the contralateral face) and a low threshold to mechanical stimuli. Twenty neurones which had larger receptive fields responded also to low-threshold or to medium-threshold (i.e. non-nociceptive) mechanical stimuli. None of the neurones displayed receptive fields more extensive than half of the contralateral face and some of the larger fields had a small, low-threshold focus. Olivary neurones responding to electrical stimulation of trigeminal nerves or mechanical stimulation of the face were located in the medial segment of the olivary complex (dorsal accessory and principal olive). A few cells only were located in the lateral segment. It is concluded that neurones of the inferior olive receive a substantial input from trigeminal afferents and are capable of transmitting precise somatotopical information to the cerebellum.Type of Medium: Electronic ResourceURL: -
19Articles: DFG German National LicensesStaff View
ISSN: 1432-0428Keywords: Keywords Scandinavian Simvastatin Survival Study (4S) ; cost-effectiveness ; cholesterol ; lipid lowering.Source: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract Aims/hypothesis. The purpose of this study is to investigate the cost-effectiveness of simvastatin in diabetic patients, using prospectively collected outcomes data from the Scandinavian Simvastatin Survival Study. Methods. Diabetic patients were identified using two different classifications schemes: Clinical history (diabetic, non-diabetic) and the new American Diabetes Association definition (diabetic, impaired fasting glucose, normal fasting glucose). The analysis is based on prospectively collected data from the trial on hospitalization for cardiovascular problems, study drug utilization and mortality. The incremental cost per life year saved with simvastatin is estimated using costs from Sweden (primary) and other European countries. Results. Hospitalizations for cardiovascular problems were considerably reduced with simvastatin therapy, with the greatest differences in the diabetic subgroups. Reductions in hospitalizations in the diabetic group resulted in substantial hospital cost savings that offset 67 to 76 % of the drug cost (depending on the classification used). For the diabetic patients, the estimates of the cost per life-year gained ranged from 1600 Euros (based on clinical history) to 3200 Euros (based on American Diabetes Association) using Swedish costs. In the other evaluated European countries treatment with simvastatin showed a favourable cost-effectiveness ratio independent of differences in local health care unit costs. Conclusion/interpretation. For all subgroups in the diabetic classification schemes, treatment with simvastatin resulted in estimates of cost per life-year gained that were well within the range generally considered to be cost effective. Based on the Scandinavian Simvastatin Survival Study, simvastatin therapy provides good value for money in both diabetic and non-diabetic patients with cardiovascular disease. [Diabetologia (1999) 42: 1293–1301]Type of Medium: Electronic ResourceURL: -
20Articles: DFG German National LicensesStaff View
ISSN: 1420-9071Source: Springer Online Journal Archives 1860-2000Topics: BiologyMedicineNotes: Summary Quantitative structure activity relationships suggest that the binding of quinoline and phenanthroline analogs to D-lactate dehydrogenase from the barnacle,Balanus nubilus Darwin, does not involve primarily hydrophobic effects. This phenomenon appears to exist also for other lactate dehydrogenases.Type of Medium: Electronic ResourceURL: