Search Results - (Author, Cooperation:J. Porter)

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  1. 1
  2. 2
    Nicholas J. Porter, Florence F. Wagner, David W. Christianson
    American Chemical Society (ACS)
    Published 2018
    Staff View
    Publication Date:
    2018-05-19
    Publisher:
    American Chemical Society (ACS)
    Print ISSN:
    0006-2960
    Electronic ISSN:
    1520-4995
    Topics:
    Biology
    Chemistry and Pharmacology
    Published by:
    Latest Papers from Table of Contents or Articles in Press
  3. 3
    Staff View
    Publication Date:
    2018-08-23
    Publisher:
    American Chemical Society (ACS)
    Print ISSN:
    0002-7863
    Electronic ISSN:
    1520-5126
    Topics:
    Chemistry and Pharmacology
    Published by:
    Latest Papers from Table of Contents or Articles in Press
  4. 4
    C. Y. Ewald ; J. N. Landis ; J. Porter Abate ; C. T. Murphy ; T. K. Blackwell
    Nature Publishing Group (NPG)
    Published 2014
    Staff View
    Publication Date:
    2014-12-18
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Aging/physiology ; Animals ; Caenorhabditis elegans/growth & development/*metabolism ; Caenorhabditis elegans Proteins/*metabolism ; Collagen/biosynthesis/genetics/*metabolism ; DNA-Binding Proteins/*metabolism ; Extracellular Matrix/metabolism ; Forkhead Transcription Factors ; Insulin/*metabolism ; Insulin-Like Growth Factor I/*metabolism ; Larva/growth & development ; Longevity/*physiology ; *Signal Transduction ; Transcription Factors/*metabolism
    Published by:
    Latest Papers from Table of Contents or Articles in Press
  5. 5
    Staff View
    Publication Date:
    2018-09-26
    Publisher:
    American Physical Society (APS)
    Electronic ISSN:
    2160-3308
    Topics:
    Physics
    Published by:
    Latest Papers from Table of Contents or Articles in Press
  6. 6
    J. Barretina ; G. Caponigro ; N. Stransky ; K. Venkatesan ; A. A. Margolin ; S. Kim ; C. J. Wilson ; J. Lehar ; G. V. Kryukov ; D. Sonkin ; A. Reddy ; M. Liu ; L. Murray ; M. F. Berger ; J. E. Monahan ; P. Morais ; J. Meltzer ; A. Korejwa ; J. Jane-Valbuena ; F. A. Mapa ; J. Thibault ; E. Bric-Furlong ; P. Raman ; A. Shipway ; I. H. Engels ; J. Cheng ; G. K. Yu ; J. Yu ; P. Aspesi, Jr. ; M. de Silva ; K. Jagtap ; M. D. Jones ; L. Wang ; C. Hatton ; E. Palescandolo ; S. Gupta ; S. Mahan ; C. Sougnez ; R. C. Onofrio ; T. Liefeld ; L. MacConaill ; W. Winckler ; M. Reich ; N. Li ; J. P. Mesirov ; S. B. Gabriel ; G. Getz ; K. Ardlie ; V. Chan ; V. E. Myer ; B. L. Weber ; J. Porter ; M. Warmuth ; P. Finan ; J. L. Harris ; M. Meyerson ; T. R. Golub ; M. P. Morrissey ; W. R. Sellers ; R. Schlegel ; L. A. Garraway
    Nature Publishing Group (NPG)
    Published 2012
    Staff View
    Publication Date:
    2012-03-31
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Antineoplastic Agents/pharmacology ; Cell Line, Tumor ; Cell Lineage ; Chromosomes, Human/genetics ; Clinical Trials as Topic/methods ; *Databases, Factual ; Drug Screening Assays, Antitumor/*methods ; *Encyclopedias as Topic ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic ; Genes, ras/genetics ; Genome, Human/genetics ; Genomics ; Humans ; Mitogen-Activated Protein Kinase Kinases/antagonists & inhibitors/metabolism ; *Models, Biological ; Neoplasms/*drug therapy/genetics/metabolism/*pathology ; Pharmacogenetics ; Plasma Cells/cytology/drug effects/metabolism ; Precision Medicine/methods ; Receptor, IGF Type 1/antagonists & inhibitors/metabolism ; Receptors, Aryl Hydrocarbon/genetics/metabolism ; Sequence Analysis, DNA ; Topoisomerase Inhibitors/pharmacology
    Published by:
    Latest Papers from Table of Contents or Articles in Press
  7. 7
    Latest Papers from Table of Contents or Articles in Press
  8. 8
  9. 9
    A. Stafford, H. ; H. Lester, H. ; J. Porter, L.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    0031-9422
    Keywords:
    Pinaceae ; Pseudotsuga menziesii ; cell suspension cultures ; dihydroquercetin ; enzymatic reduction ; leucocyanidin ; procyanidin biosynthesis.
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Biology
    Chemistry and Pharmacology
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  10. 10
    Markham, K.R. ; J. Porter, L.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    0031-9422
    Keywords:
    Hepaticae ; Riccia crystallina ; Ricciocarpus natans ; chemotaxonomy. ; liverworts ; simple flavone glycosides
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Biology
    Chemistry and Pharmacology
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  11. 11
    Staff View
    Type of Medium:
    Online
    Publication Date:
    2024
    Keywords:
    Bildungspolitik ; Sprache ; Bilingualer Unterricht ; Indigenes Volk ; Lateinamerika
    In:
    International review of education, Bd. 70 (2024) H. 1, S. 11-28, 1573-0638
    Language:
    English
    FIS Bildung Literaturdatenbank
  12. 12
    Staff View
    Publication Date:
    2018-11-20
    Publisher:
    The American Association of Immunologists (AAI)
    Print ISSN:
    0022-1767
    Electronic ISSN:
    1550-6606
    Topics:
    Medicine
    Published by:
    Latest Papers from Table of Contents or Articles in Press
  13. 13
    Hanson, D. L. ; Porter, J. L. ; Williams, R. R.

    [S.l.] : American Institute of Physics (AIP)
    Published 1991
    Staff View
    ISSN:
    1089-7550
    Source:
    AIP Digital Archive
    Topics:
    Physics
    Notes:
    Experiments are described in which a high-purity, high-power (0.15 TW, 1 MeV) proton beam is generated from an ion source consisting of H2 gas frozen onto a liquid-helium-cooled copper anode at 4.2 K in a series-field-coil extraction diode on the 0.7 TW HydraMITE-II accelerator. Peak anode proton current densities of 2 kA/cm2 were measured. This current density is a factor of 100 higher than those obtained in previous liquid-helium-cooled cryogenic diode experiments on small accelerators and is in the range required for high-power ion beam applications. Thomson parabola, Faraday cup, and carbon activation measurements indicate an ion beam proton fraction close to 100% for the cryogenic source, compared to 50–70% for the standard hydrocarbon anode tested. The cryogenic proton source is believed to consist of no more than a few monolayers of molecular hydrogen. The hydrogen-coated cryogenic anode shows a faster initial anode turn-on than other materials. However, source-limited emission from the thin hydrogen layer results in a somewhat longer current risetime, reduced ion diode efficiency, lower proton current enhancement over the Child–Langmuir limit, and a proton spectrum of lower average energy than for the hydrocarbon anode. Techniques to overcome these limitations are discussed. Cryogenic ion sources consisting of frozen N2, CH4, and Ne have also been studied. In each case, high intensity beams consisting predominantly of components of the refrigerated gas were produced.
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  14. 14
    Hanson, D. L. ; Williams, R. R. ; Porter, J. L. ; Spielman, R. B. ; Matzen, M. K.

    [S.l.] : American Institute of Physics (AIP)
    Published 1990
    Staff View
    ISSN:
    1089-7550
    Source:
    AIP Digital Archive
    Topics:
    Physics
    Notes:
    Accurate modeling of load behavior in Z-pinch plasma radiation sources driven by high-current generators requires the measurement of fast-rise-time multimegampere currents close to the load. Conventional current diagnostics mounted in inductive cavities (such as B-dot loops and Rogowski coils) fail at small radius because of electrical breakdown produced by high dI/dt. In this paper, we describe the use of large-signal, nanosecond-time-resolution lithium niobate piezoelectric stress gauges to directly measure the magnetic pressure B2/2μ0=μ0I2/8π2r2 generated at radius r by a current I flowing in a radial transmission line. Current measurements have been performed at radius r=2.54×10−2 m on Sandia National Laboratories' Proto-II (10 TW) and SATURN (30 TW) gas puff Z-pinch experiments with maximum currents of 10.1 MA and dI/dt to 2.1×1014 A/s. Comparisons with Faraday rotation and B-dot current diagnostic measurements at large radius are presented. Bremsstrahlung noise problems unique to the SATURN gas puff source are discussed. For a Y-cut lithium niobate stress gauge on a pure tungsten electrode, current densities up to I/2πr=78 MA/m can be measured before the electrode yield strength and the piezoelectric operating stress limit are exceeded. Above the Hugoniot elastic limit of the electrode material, the dynamic range and accuracy of the diagnostic are greatly reduced, but it appears that the technique can be extended to higher current densities using an X-cut quartz piezoelectric element and a tungsten-sapphire electrode impedance stack.
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  15. 15
    Staff View
    ISSN:
    1089-7674
    Source:
    AIP Digital Archive
    Topics:
    Physics
    Notes:
    The Z-pinch-driven hohlraum (ZPDH) [J. H. Hammer et al., Phys. Plasmas 6, 2129 (1999)] is a promising approach to high yield inertial confinement fusion currently being characterized in experiments on the Sandia Z accelerator [M. E. Cuneo et al., Phys. Plasmas 8, 2257 (2001)]. Simulations show that capsule radiation symmetry, a critical issue in ZPDH design, is governed primarily by hohlraum geometry, dual-pinch power balance, and pinch timing. In initial symmetry studies on Z without the benefit of a laser backlighter, highly-asymmetric pole-hot and equator-hot single Z-pinch hohlraum geometries were diagnosed using solid low density foam burnthrough spheres. These experiments demonstrated effective geometric control and prediction of polar flux symmetry at the level where details of the Z-pinch implosion and other higher order effects are not critical. Radiation flux symmetry achieved in Z double-pinch hohlraum configurations exceeds the measurement sensitivity of this self-backlit foam ball symmetry diagnostic. To diagnose radiation symmetry at the 2%–5% level attainable with present ZPDH designs, high-energy x rays produced by the recently-completed Z-Beamlet laser backlighter are being used for point-projection imaging of thin-wall implosion and symmetry capsules. © 2002 American Institute of Physics.
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  16. 16
    Staff View
    ISSN:
    1089-7674
    Source:
    AIP Digital Archive
    Topics:
    Physics
    Notes:
    In this article we investigate the partial closure of diagnostic holes in Z-pinch driven hohlraums. These hohlraums differ from current laser-driven hohlraums in a number of ways such as their larger size, greater x-ray drive energy, and lower temperature. Although the diameter of the diagnostic holes on these Z-pinch driven hohlraums can be much greater than their laser-driven counterparts, 4 mm in diameter or larger, radiation impinges on the wall material surrounding the hole for the duration of the Z pinch, nearly 100 ns. This incident radiation causes plasma to ablate from the hohlraum walls surrounding the diagnostic hole and partially obscure this diagnostic hole. This partial obscuration reduces the effective area over which diagnostics view the hohlraum's radiation. This reduction in area can lead to an underestimation of the wall temperature when nonimaging diagnostics such as x-ray diodes and bolometers are used to determine power and later to infer a wall temperature. In this article we describe the techniques used to characterize the hole-closure in these hohlraums and present the experimental measurements of this process. © 2000 American Institute of Physics.
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  17. 17
    Staff View
    ISSN:
    1089-7674
    Source:
    AIP Digital Archive
    Topics:
    Physics
    Notes:
    Here Z, a 60 TW/5 MJ electrical accelerator located at Sandia National Laboratories, has been used to implode tungsten wire-array Z pinches. These arrays consisted of large numbers of tungsten wires (120–300) with wire diameters of 7.5 to 15 μm placed in a symmetric cylindrical array. The experiments used array diameters ranging from 1.75 to 4 cm and lengths from 1 to 2 cm. A 2 cm long, 4 cm diam tungsten array consisting of 240, 7.5 μm diam wires (4.1 mg mass) achieved an x-ray power of ∼200 TW and an x-ray energy of nearly 2 MJ. Spectral data suggest an optically thick, Planckian-like radiator below 1000 eV. One surprising experimental result was the observation that the total radiated x-ray energies and x-ray powers were nearly independent of pinch length. These data are compared with two-dimensional radiation magnetohydrodynamic code calculations. © 1998 American Institute of Physics.
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  18. 18
    Staff View
    ISSN:
    1089-7674
    Source:
    AIP Digital Archive
    Topics:
    Physics
    Notes:
    Nearly 10 years of Nova [E. M. Campbell, Laser Part. Beams 9, 209 (1991)] experiments and analysis have lead to a relatively detailed quantitative and qualitative understanding of radiation drive in laser-heated hohlraums. Our most successful quantitative modeling tool is two-dimensional (2-D) LASNEX numerical simulations [G. B. Zimmerman and W. L. Kruer, Comments Plasma Phys. Controlled Fusion 2, 51 (1975)]. Analysis of the simulations provides us with insight into the physics of hohlraum drive. In particular we find hohlraum radiation conversion efficiency becomes quite high with longer pulses as the accumulated, high-Z blow-off plasma begins to radiate. Extensive Nova experiments corroborate our quantitative and qualitative understanding. © 1996 American Institute of Physics.
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  19. 19
    Staff View
    ISSN:
    1089-7674
    Source:
    AIP Digital Archive
    Topics:
    Physics
    Notes:
    The Saturn pulsed power accelerator [R. B. Spielman et al., in Proceedings of the 2nd International Conference on Dense Z-pinches, Laguna Beach, CA, 1989, edited by N. R. Pereira, J. Davis, and N. Rostoker (American Institute of Physics, New York, 1989), p. 3] at Sandia National Laboratories (SNL) and the Nova laser [J. T. Hunt and D. R. Speck, Opt. Eng. 28, 461 (1989)] at Lawrence Livermore National Laboratory (LLNL) have been used to explore techniques for studying the behavior of ablator material in x-ray radiation environments comparable in magnitude, spectrum, and duration to those that would be experienced in National Ignition Facility (NIF) hohlraums [J. D. Lindl, Phys. Plasmas 2, 3933 (1995)]. The large x-ray outputs available from the Saturn pulsed-power-driven z pinch have enabled us to drive hohlraums of full NIF ignition scale size at radiation temperatures and time scales comparable to those required for the low-power foot pulse of an ignition capsule. The high-intensity drives available in the Nova laser have allowed us to study capsule ablator physics in smaller-scale hohlraums at radiation temperatures and time scales relevant to the peak power pulse for an ignition capsule. Taken together, these experiments have pointed the way to possible techniques for testing radiation-hydrodynamics code predictions of radiation flow, opacity, equation of state, and ablator shock velocity over the range of radiation environments that will be encountered in a NIF hohlraum. © 1997 American Institute of Physics.
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  20. 20
    Ruggles, L. E. ; Porter, J. L. ; Simpson, W. W. ; Vargas, M. F.

    [S.l.] : American Institute of Physics (AIP)
    Published 1999
    Staff View
    ISSN:
    1089-7623
    Source:
    AIP Digital Archive
    Topics:
    Physics
    Electrical Engineering, Measurement and Control Technology
    Notes:
    Microchannel plate intensified (MPI) x-ray detectors are commonly used for imaging and spectral measurements in the 100–1500 eV photon energy range. Using a laser-produced plasma x-ray source, we measured the integrated detector response versus incident x-ray intensity and the relative efficiency versus photon energy of a MPI x-ray detector. Two identical 2000 lines/mm transmission grating spectrometers simultaneously record broadband plasma source emission from a tantalum target. The relative efficiency was determined by comparing the spectrum recorded with an absolutely calibrated x-ray CCD reference detector on one spectrometer to the spectrum recorded with a MPI x-ray detector on the other spectrometer. The integrated detector response versus incident x-ray intensity was measured by simultaneously illuminating the CCD reference detector and the MPI detector with step-wedge-filtered magnesium plasma emission. The aluminum step wedge x-ray filters pass the 1s–2p emission lines of H-like Mg at 1470 eV and the 1s2–1s2p emission lines of He-like Mg at 1350 eV, and provide a four order of magnitude range in incident intensity on the detectors.© 1999 American Institute of Physics.
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses