Search Results - (Author, Cooperation:J. Pines)

Showing 1 - 15 results of 15, query time: 0.27s Refine Results
  1. 1
    S. Boutet ; L. Lomb ; G. J. Williams ; T. R. Barends ; A. Aquila ; R. B. Doak ; U. Weierstall ; D. P. DePonte ; J. Steinbrener ; R. L. Shoeman ; M. Messerschmidt ; A. Barty ; T. A. White ; S. Kassemeyer ; R. A. Kirian ; M. M. Seibert ; P. A. Montanez ; C. Kenney ; R. Herbst ; P. Hart ; J. Pines ; G. Haller ; S. M. Gruner ; H. T. Philipp ; M. W. Tate ; M. Hromalik ; L. J. Koerner ; N. van Bakel ; J. Morse ; W. Ghonsalves ; D. Arnlund ; M. J. Bogan ; C. Caleman ; R. Fromme ; C. Y. Hampton ; M. S. Hunter ; L. C. Johansson ; G. Katona ; C. Kupitz ; M. Liang ; A. V. Martin ; K. Nass ; L. Redecke ; F. Stellato ; N. Timneanu ; D. Wang ; N. A. Zatsepin ; D. Schafer ; J. Defever ; R. Neutze ; P. Fromme ; J. C. Spence ; H. N. Chapman ; I. Schlichting
    American Association for the Advancement of Science (AAAS)
    Published 2012
    Staff View
    Publication Date:
    2012-06-02
    Publisher:
    American Association for the Advancement of Science (AAAS)
    Print ISSN:
    0036-8075
    Electronic ISSN:
    1095-9203
    Topics:
    Biology
    Chemistry and Pharmacology
    Computer Science
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Animals ; Crystallography, X-Ray/*methods ; Lasers ; Muramidase/chemistry/radiation effects ; *Protein Conformation
    Published by:
    http://www.aaas.org/

    Latest Papers from Table of Contents or Articles in Press
  2. 2
    A. Grallert ; E. Boke ; A. Hagting ; B. Hodgson ; Y. Connolly ; J. R. Griffiths ; D. L. Smith ; J. Pines ; I. M. Hagan
    Nature Publishing Group (NPG)
    Published 2014
    Staff View
    Publication Date:
    2014-12-10
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Amino Acid Motifs ; Amino Acid Sequence ; Binding Sites ; CDC2 Protein Kinase/metabolism ; Chromosome Segregation ; Conserved Sequence ; Cyclin B/metabolism ; Enzyme Activation ; HeLa Cells ; Holoenzymes/metabolism ; Humans ; Isoenzymes/metabolism ; *Mitosis ; Molecular Sequence Data ; Phosphorylation ; Protein Phosphatase 1/*metabolism ; Protein Phosphatase 2/chemistry/*metabolism ; Protein Subunits/chemistry/metabolism ; Schizosaccharomyces/*cytology/*enzymology ; Schizosaccharomyces pombe Proteins/chemistry/metabolism ; Signal Transduction
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  3. 3
    D. Izawa ; J. Pines
    Nature Publishing Group (NPG)
    Published 2014
    Staff View
    Publication Date:
    2014-11-11
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Anaphase ; Anaphase-Promoting Complex-Cyclosome/*antagonists & inhibitors/metabolism ; Animals ; Cdc20 Proteins/*metabolism ; Cytoplasm/enzymology/metabolism ; HeLa Cells ; Humans ; M Phase Cell Cycle Checkpoints ; *Mitosis ; Multiprotein Complexes/*metabolism ; Protein Binding ; Protein Structure, Tertiary ; Protein-Serine-Threonine Kinases/chemistry/metabolism ; Spindle Apparatus/metabolism ; Substrate Specificity
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  4. 4
    Pines, J.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    0955-0674
    Keywords:
    CDK-cyclin-dependent kinase ; CSF-colony-stimulating factor ; Rb-retinoblastoma
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Biology
    Medicine
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1016/0955-0674(92)90024-7

    Articles: DFG German National Licenses
  5. 5
    Pines, J. ; Hunter, T.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    0962-8924
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Biology
    Medicine
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1016/0962-8924(91)90116-Q

    Articles: DFG German National Licenses
  6. 6
    Staff View
    ISSN:
    0888-7543
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Biology
    Medicine
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1016/0888-7543(92)90262-Q

    Articles: DFG German National Licenses
  7. 7
    Pines, J. ; Hunter, T.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    0962-8924
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Biology
    Medicine
    Type of Medium:
    Electronic Resource
    URL:
    http://linkinghub.elsevier.com/retrieve/pii/0962-8924(92)90129-B

    Articles: DFG German National Licenses
  8. 8
    Staff View
    ISSN:
    0012-1606
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Biology
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1016/0012-1606(91)90347-6

    Articles: DFG German National Licenses
  9. 9
    Standart, N. ; Minshull, J. ; Pines, J. ; Hunt, T.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    0012-1606
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Biology
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1016/0012-1606(87)90476-3

    Articles: DFG German National Licenses
  10. 10
    Pines, J.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    0968-0004
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1016/0968-0004(94)90272-0

    Articles: DFG German National Licenses
  11. 11
    Pines, J.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    0968-0004
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Type of Medium:
    Electronic Resource
    URL:
    http://linkinghub.elsevier.com/retrieve/pii/0968-0004(93)90185-P

    Articles: DFG German National Licenses
  12. 12
    Pines, J.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    1043-4682
    Keywords:
    cell cycle/cyclins/cdc2/CDK/protein kinases
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Biology
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1006/scel.1994.1047

    Articles: DFG German National Licenses
  13. 13
    Pines, J. L. ; Maiman, R.
    Springer
    Published 1927
    Staff View
    ISSN:
    1433-8491
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF01814274

    Articles: DFG German National Licenses
  14. 14
    Pines, Anna ; Pines, J. -L. Ja.
    Springer
    Published 1927
    Staff View
    ISSN:
    1433-8491
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF01825645

    Articles: DFG German National Licenses
  15. 15
    Arnaud, L. ; Pines, J. ; Nigg, E. A.
    Springer
    Published 1998
    Staff View
    ISSN:
    1432-0886
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Biology
    Medicine
    Notes:
    Abstract. Polo-like kinases (Plks) have been implicated in various aspects of M-phase progression in organisms ranging from yeast to man. In vertebrates, Plks participate in centrosome maturation and spindle assembly, as well as the activation of the Cdk1/cyclin B complex. Moreover, Plks are required for the destruction of mitotic cyclins, indicating that they play an important role in the regulation of the ubiquitin-dependent proteolytic degradation machinery that controls exit from M-phase. Here, we have fused Green Fluorescent Protein (GFP) to the N-terminus of human Plk1, and expressed this chimeric construct in human cells. We found that GFP-Plk1 associates with centrosomes, the equatorial spindle midzone and the postmitotic bridge of dividing cells, confirming and extending previous results obtained with conventional immunofluorescence microscopy. In addition, however, we observed fluorescence emanating from the midbody between dividing cells, and from discrete dots associated with mitotic chromosomes. This latter staining pattern being reminiscent of centromeres, we performed double-labeling experiments with antibodies against the centromeric marker CENP-B, and reexamined the subcellular localization of endogenous Plk1 using different fixation procedures. Our data clearly show that both GFP-tagged Plk1 and endogenous Plk1 associate with the kinetochore/centromere region of human mitotic chromosomes. This novel localization of Plk1 suggests that substrates and/or regulators of Plks may be found among kinetochore-associated proteins with important functions in chromosome segregation and/or spindle checkpoint mechanisms.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/s004120050326

    Articles: DFG German National Licenses