Search Results - (Author, Cooperation:J. P. Rast)
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1Latest Papers from Table of Contents or Articles in PressL. L. Moroz ; K. M. Kocot ; M. R. Citarella ; S. Dosung ; T. P. Norekian ; I. S. Povolotskaya ; A. P. Grigorenko ; C. Dailey ; E. Berezikov ; K. M. Buckley ; A. Ptitsyn ; D. Reshetov ; K. Mukherjee ; T. P. Moroz ; Y. Bobkova ; F. Yu ; V. V. Kapitonov ; J. Jurka ; Y. V. Bobkov ; J. J. Swore ; D. O. Girardo ; A. Fodor ; F. Gusev ; R. Sanford ; R. Bruders ; E. Kittler ; C. E. Mills ; J. P. Rast ; R. Derelle ; V. V. Solovyev ; F. A. Kondrashov ; B. J. Swalla ; J. V. Sweedler ; E. I. Rogaev ; K. M. Halanych ; A. B. Kohn
Nature Publishing Group (NPG)
Published 2014Staff ViewPublication Date: 2014-05-23Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Ctenophora/classification/*genetics/immunology/physiology ; *Evolution, Molecular ; Genes, Developmental ; Genes, Homeobox ; Genome/*genetics ; Mesoderm/metabolism ; Metabolomics ; MicroRNAs ; Molecular Sequence Data ; Muscles/physiology ; *Nervous System/metabolism ; Neurons/metabolism ; Neurotransmitter Agents ; Phylogeny ; Transcriptome/geneticsPublished by: -
2Articles: DFG German National LicensesDistinct patterns of IgH structure and organization in a divergent lineage of chrondrichthyan fishesRast, J. P. ; Amemiya, Chris T. ; Litman, Ronda T. ; Strong, Scott J. ; Litman, G. W.
Springer
Published 1998Staff ViewISSN: 1432-1211Keywords: Key words MHC class I ; Chimpanzee ; Inter-species allele ; Intron ; EvolutionSource: Springer Online Journal Archives 1860-2000Topics: BiologyMedicineNotes: Abstract Immunoglobulin heavy chain (IgH) genes in representative chondrichthyan fishes (sharks and skates) consist of independently functioning clusters, containing separate variable (V H ), diversity (D H ), and joining (J H ) region elements and constant (C H ) region exons. IgH loci have been characterized in Hydrolagus colliei (spotted ratfish), a modern representative of a major independent chondrichthyan lineage. Three distinct families of IgH gene clusters were identified. The most numerous genes consist of unjoined V H -D 1 -D 2 -J H segments that correspond to the most abundant Hydrolagus spleen (cDNA) transcripts which apparently arise from a diversified gene family. In the second cluster type, V H , D H , and J H segments are germline-joined, whereas the C H exons exhibit typical organization. This gene type is found in only a few copies per haploid genome and both transmembrane and secretory transcripts have been identified. A third cluster type has been identified that consists of unjoined V H elements but lacks a typical C H 1 exon, which is substituted with a second C H 2-like exon. Transcripts from this third cluster type also appear to derive from a diversified gene family. Genomic D regions of the two unjoined clone types exhibit structural differences that are consistent with incorporation of recombination machinery-mediated events. Genomic library screening indicates that 90% of V H + clones are truncated, nearly identical pseudogenes (lacking J H and C H ). These studies demonstrate an early phylogenetic origin for the cluster type of gene organization and document extensive organizational diversification within an apparent single class of IgH genes.Type of Medium: Electronic ResourceURL: