Search Results - (Author, Cooperation:J. Norton)
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1Latest Papers from Table of Contents or Articles in PressC. Cruchaga ; C. M. Karch ; S. C. Jin ; B. A. Benitez ; Y. Cai ; R. Guerreiro ; O. Harari ; J. Norton ; J. Budde ; S. Bertelsen ; A. T. Jeng ; B. Cooper ; T. Skorupa ; D. Carrell ; D. Levitch ; S. Hsu ; J. Choi ; M. Ryten ; J. Hardy ; D. Trabzuni ; M. E. Weale ; A. Ramasamy ; C. Smith ; C. Sassi ; J. Bras ; J. R. Gibbs ; D. G. Hernandez ; M. K. Lupton ; J. Powell ; P. Forabosco ; P. G. Ridge ; C. D. Corcoran ; J. T. Tschanz ; M. C. Norton ; R. G. Munger ; C. Schmutz ; M. Leary ; F. Y. Demirci ; M. N. Bamne ; X. Wang ; O. L. Lopez ; M. Ganguli ; C. Medway ; J. Turton ; J. Lord ; A. Braae ; I. Barber ; K. Brown ; P. Passmore ; D. Craig ; J. Johnston ; B. McGuinness ; S. Todd ; R. Heun ; H. Kolsch ; P. G. Kehoe ; N. M. Hooper ; E. R. Vardy ; D. M. Mann ; S. Pickering-Brown ; N. Kalsheker ; J. Lowe ; K. Morgan ; A. David Smith ; G. Wilcock ; D. Warden ; C. Holmes ; P. Pastor ; O. Lorenzo-Betancor ; Z. Brkanac ; E. Scott ; E. Topol ; E. Rogaeva ; A. B. Singleton ; M. I. Kamboh ; P. St George-Hyslop ; N. Cairns ; J. C. Morris ; J. S. Kauwe ; A. M. Goate
Nature Publishing Group (NPG)
Published 2013Staff ViewPublication Date: 2013-12-18Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: African Americans/genetics ; Age of Onset ; Aged ; Aged, 80 and over ; Alzheimer Disease/*genetics/metabolism ; Amyloid beta-Peptides/metabolism ; Amyloid beta-Protein Precursor/metabolism ; Brain/metabolism ; Case-Control Studies ; Europe/ethnology ; Exome/genetics ; Female ; Genetic Predisposition to Disease/*genetics ; Genetic Variation/*genetics ; Humans ; Male ; Peptide Fragments/metabolism ; Phospholipase D/deficiency/*genetics/metabolism ; Protein Processing, Post-Translational/genetics ; ProteolysisPublished by: -
2Latest Papers from Table of Contents or Articles in PressMiao, D., Margolis, C. A., Gao, W., Voss, M. H., Li, W., Martini, D. J., Norton, C., Bosse, D., Wankowicz, S. M., Cullen, D., Horak, C., Wind-Rotolo, M., Tracy, A., Giannakis, M., Hodi, F. S., Drake, C. G., Ball, M. W., Allaf, M. E., Snyder, A., Hellmann, M. D., Ho, T., Motzer, R. J., Signoretti, S., Kaelin, W. G., Choueiri, T. K., Van Allen, E. M.
American Association for the Advancement of Science (AAAS)
Published 2018Staff ViewPublication Date: 2018-02-16Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyGeosciencesComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Medicine, DiseasesPublished by: -
3Latest Papers from Table of Contents or Articles in PressT. Masuda ; X. Wang ; M. Maeda ; M. C. Canver ; F. Sher ; A. P. Funnell ; C. Fisher ; M. Suciu ; G. E. Martyn ; L. J. Norton ; C. Zhu ; R. Kurita ; Y. Nakamura ; J. Xu ; D. R. Higgs ; M. Crossley ; D. E. Bauer ; S. H. Orkin ; P. V. Kharchenko ; T. Maeda
American Association for the Advancement of Science (AAAS)
Published 2016Staff ViewPublication Date: 2016-01-28Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Anemia, Sickle Cell/genetics ; Animals ; Carrier Proteins/genetics/*metabolism ; Cell Line ; Chromatin/metabolism ; DNA-Binding Proteins/genetics/*metabolism ; Erythroblasts/cytology ; Erythropoiesis/genetics ; Fetal Hemoglobin/*genetics ; *Gene Silencing ; Humans ; Mice ; Mice, Knockout ; Nuclear Proteins/genetics/*metabolism ; Repressor Proteins/genetics/*metabolism ; Sequence Deletion ; Thalassemia/genetics ; Transcription Factors/genetics/*metabolism ; gamma-Globins/*geneticsPublished by: -
4Articles: DFG German National LicensesStaff View
ISSN: 0034-6551Topics: English, American StudiesNotes: NOTESURL: -
5Articles: DFG German National LicensesStaff View
ISSN: 0025-8385Topics: Linguistics and Literary StudiesURL: -
6Articles: DFG German National LicensesStaff View
ISSN: 0025-8385Topics: Linguistics and Literary StudiesNotes: REVIEWSURL: -
7Articles: DFG German National LicensesStaff View
ISSN: 0025-8385Topics: Linguistics and Literary StudiesNotes: REVIEWSURL: -
8Articles: DFG German National LicensesScheetz, Howard A. ; Koh, Severino L. ; Brennan, J. Norton
New York, NY [u.a.] : Wiley-Blackwell
Published 1960Staff ViewISSN: 0021-8995Keywords: Chemistry ; Polymer and Materials ScienceSource: Wiley InterScience Backfile Collection 1832-2000Topics: Chemistry and PharmacologyMechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision MechanicsPhysicsNotes: It has been shown that use of wide-band instrumentation in dynamic mechanical measurements can reveal the presence of high-frequency ringing and other mechanical defects in the wave form. The use of low-pass filters to suppress electrical noise can hide such defects. It is therefore better to eliminate the electrical noise at the source. If the mechanical irregularities in the waveform are not tolerable, they must be removed by improving the design of the testing device. The drop tester described in this report illustrates one possible way in which this may be done.Additional Material: 29 Ill.Type of Medium: Electronic ResourceURL: -
9Articles: DFG German National LicensesScheetz, Howard A. ; Koh, Severino L. ; Brennan, J. Norton
New York, NY [u.a.] : Wiley-Blackwell
Published 1961Staff ViewISSN: 0021-8995Keywords: Chemistry ; Polymer and Materials ScienceSource: Wiley InterScience Backfile Collection 1832-2000Topics: Chemistry and PharmacologyMechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision MechanicsPhysicsType of Medium: Electronic ResourceURL: -
10Articles: DFG German National LicensesCHRISTIAN, J. C. ; MORZORATI, S. ; NORTON, J. A. ; WILLIAMS, C. J. ; O'CONNOR, S. ; LI, T.-K.
Oxford, UK : Blackwell Publishing Ltd
Published 1996Staff ViewISSN: 1469-8986Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicinePsychologyNotes: Most twin studies have provided evidence for genetic effects on the electroencephalogram (EEG). In two twin studies, monozygotic (MZ) cotwin covariance for EEG power was greater than expected for additive gene actions, as compared with dizygotic (DZ) cotwin covariance. These findings were attributed to complex gene interactions, termed emergenesis. In the present study of 53 MZ and 38 DZ twin pairs departures from the additive genetic model were tested on resting EEG power. Total spectral power and the quotient of (beta band power)/(total power) both fit gene interaction models significantly better than did additive genetic models. These findings support the previous findings of MZ covariance for EEG power as much greater than DZ covariance; these findings can be explained entirely by the additive effects of genes. This pattern of twin covariances could be due to gene interactions but also to greater MZ than DZ environmental covariance.Type of Medium: Electronic ResourceURL: -
11Articles: DFG German National LicensesROBERTSON, J. A. ; MEREDITH, F. I. ; LYON, B. G. ; NORTON, J. D.
Oxford, UK : Blackwell Publishing Ltd
Published 1991Staff ViewISSN: 1745-4557Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: Process Engineering, Biotechnology, Nutrition TechnologyNotes: The effect of cold storage (0°C) and maturity on the physical, chemical and sensory characteristics of plums (cv. ‘AU-Rubrum’) was determined. The size, weight, soluble solids and total sugar contents of the more mature fruit were significantly higher (P〈0.05) and the “L” and hue angle were significantly lower (P〈0.05) than plums in the less mature class. ‘AU-Rubrum’ fruit contained glucose, fructose and sorbitol but had no sucrose. Artificially ripening fruit at 20°C had a significant effect (P〈0.01) on all color values for both maturity 1 and 2 fruit. The titratable acidity and sugar contents of the fruit ripened at 20°C were lower for ripened than for unripened fruit. Storage of the plums at 0°C for 5 weeks followed by subsequent ripening at 20°C had no significant effect on physical, chemical or sensory characteristics. Data indicate that ‘A U-Rubrum’ plums which have one-half red ground color (maturity 1) will develop full color and complete the normal ripening process. Data also indicate that the plums can be stored for at least 5 weeks at O°C without loss of quality and that the cultivar has potential for shipping to distant markets.Type of Medium: Electronic ResourceURL: -
12Articles: DFG German National LicensesJones, R. D. ; Mead, W. C. ; Coggeshall, S. V. ; Aldrich, C. H. ; Norton, J. L. ; Pollak, G. D. ; Wallace, J. M.
[S.l.] : American Institute of Physics (AIP)
Published 1988Staff ViewISSN: 1089-7666Source: AIP Digital ArchiveTopics: PhysicsNotes: Self-focusing and filamentation of short wavelength laser light in high Z plasmas of interest to laser fusion are discussed. It is found that self-focusing behavior is very dependent on the details of the characteristics of the laser beam, the plasma conditions, and the energy transport processes. Laser light absorption and self-focusing are strongly competitive processes. At. 0.26 μm wavelength the collisional absorption is often so great that there is no intensity amplification of the beam despite the fact that strong self-focusing is present. Wide variations are found in laser light penetration, affected by several factors. Diverging optics reduce the likelihood of self-focusing. Large scale length density gradients have little effect on focusing behavior. The self-focusing behavior is very dependent on beam shape. Large scale hot spots can have a significant effect on whole beam self-focusing early in the pulse. The behavior of small scale hot spots can be qualitatively different than the standard picture. The calculations indicate that small scale hot spots do not achieve a steady state in some cases. Sound waves cause chaotic interactions among neighboring hot spots. It is found that sub-beam size structures are also generated when nonlocal thermodynamic equilibrium (non-LTE) radiation and atomic physics are used in the calculations. The nature of the heat flux and thermoelectric magnetic field generation are examined with a kinetic model. Stimulated Raman backscattering levels in self-focused light are significantly reduced for short wavelengths and high Z plasmas Landau damping plays an important role in determining the Raman levels. Implications for suprathermal electron production, symmetric illumination, x-ray conversion efficiency, and laser light absorption are discussed.Type of Medium: Electronic ResourceURL: -
13Articles: DFG German National LicensesCohen, S. S. ; Norton, J. F. ; Koch, E. F. ; Weisel, G. J.
[S.l.] : American Institute of Physics (AIP)
Published 1985Staff ViewISSN: 1089-7550Source: AIP Digital ArchiveTopics: PhysicsNotes: Shallow boron-doped junctions in silicon have been investigated by means of secondary ion mass spectrometry, scanning electron microscopy, transmission electron microscopy, spreading resistance profiling, and four-point probe techniques. The junctions were formed by implanting BF+2 ions into n-type Si at the dose range of 1–5×1015 ions/cm2, through a thin (25-nm) screen layer of silicon dioxide. We have emphasized the higher dose range (3–5×1015 ions/cm2) as it is more relevant to processes in the current level of device integration. The use of BF+2 species and the screen oxide layer is necessary in order to form junctions whose depths xj≤0.4 μm, when conventional annealing techniques are employed. We have also examined junctions that were activated in a rapid thermal annealing system that utilizes an incoherent light source. One of the main objectives of this study is to compare conventional and rapid thermal annealing techniques. We thus evaluate the results obtained by these two methods of annealing for both the junction depth xj and the sheet resistivity Rs. Other relevant variables such as a low-temperature (77-K) implantation, surface amorphization by Si implantation, and preactivation annealing have also been examined and their effects are discussed. Based on the results of the present study, a mechanism for boron activation in silicon is discussed.Type of Medium: Electronic ResourceURL: -
14Articles: DFG German National LicensesStaff View
ISSN: 1365-2559Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineType of Medium: Electronic ResourceURL: -
15Articles: DFG German National LicensesStaff View
ISSN: 1365-2559Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: The relative importance of previous chemotherapy, conditioning and graft v. host disease in producing the epidermal damage associated with allogeneic bone marrow transplantation was investigated by enumerating individually necrotic cells. A small number was seen in many pre-transplant biopsies and was related to the time interval between biopsy and the last dose of chemotherapy. Their presence did not predispose patients to develop graft v. host disease in the post-transplant period. In post-transplant patients without rashes the degree of epidermal damage at 14 days was similar to that seen in the pre-transplant period indicating that the effects of the conditioning regime were insignificant. In patients with rashes clinically classical of graft v. host disease, necrotic cells were increased above the pre-transplant levels even in the absence of a lymphocytic infiltrate. Lymphocytic infiltration was seen more frequently in biopsies taken later after transplantation and after the onset of the rash and was associated with the maximal amount of epidermal damage. Comparison of the degree of epidermal damage in pre- and post-transplantation specimens lacking a lymphocytic infiltrate resulted in the correct identification of the majority of patients with clinical evidence of graft v. host disease. This approach may, thus, be useful in diagnosing early graft v. host disease especially if combined with keratinocyte HLA-DR staining.Type of Medium: Electronic ResourceURL: -
16Articles: DFG German National LicensesSolà, C. ; Mengod, G. ; Low, W. C. ; Norton, J. ; Ghetti, B. ; Palacios, J. M. ; Triarhou, L. C.
Oxford, UK : Blackwell Publishing Ltd
Published 1993Staff ViewISSN: 1460-9568Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Using in situ hybridization histochemistry with [32P]oligonucleotide probes, we studied the cellular localization of RNA transcripts for amyloid β-protein precursor (βAPP), growth-associated phosphoprotein-43 (GAP-43) and microtubule-associated protein 2 (MAP2) in the mesostriatal system of normal (+/+) and weaver (wv/wv) mutant mice, which lose mesencephalic dopamine neurons. In addition, expression of the same messages was studied in ventral mesencephalic cell suspensions transplanted to the weaver striatum. Transcripts encoding GAP-43, MAP2 and isoforms βAPP695, βAPP714 and βAPP751 were present in normal substantia nigra and progressively reduced in weaver substantia nigra; such a reduction was correlated with dopamine neuron loss. The survival of dopamine neurons in unilateral intrastriatal grafts was documented by methamphetamine-induced rotational asymmetry tests and by tyrosine hydroxylase immunocytochemistry. High hybridization signals were obtained for GAP-43, MAP2, βAPP695, βAPP714 and βAPP751 RNA transcripts in the grafted tissue; the βAPP770 species-normally seen in striatum and not substantia nigra-was not expressed in the grafts, but it was present in the recipient striatum. Following immunocytochemical labelling with antibodies, GAP-43 and MAP2 immunoreactivities were seen in cell processes in the grafts and surrounding tissue, whereas βAPP immunoreactivity was mainly found in grafted cell bodies. These results suggest that the transplanted mesencephalic cells mature very similarly to those in the normal substantia nigra, expressing different mRNAs that are normally present in the ventral midbrain and which are reduced in the weaver mutant as a consequence of dopamine neuron loss.Type of Medium: Electronic ResourceURL: -
17Articles: DFG German National LicensesStaff View
ISSN: 1365-2559Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: The pathological complications of bone marrow transplantation are complex and may affect any organ in the body. The causes are often multifactorial and include the effects of chemotherapy, the conditioning regimen, drugs used in the post-transplant period such as immunosuppressants and antibiotics, graft-versus-host disease (GvHD) and the effects of the primary disease itself. Infections are common and result from the immunosuppressive effects of cytotoxic drugs and irradiation, GvHD and marrow failure. Haemorrhage is not infrequent. Graft-versws-host disease remains a significant problem and can be difficult to diagnose. Some of its histological features simulate the effects of chemo-radhtion and the diagnostic lesions may not be present early in the disease, when treatment is most effective. Evidence has accumulated that inflammatory cytokines have a key role in the pathogenesis of GvHD. It can be prevented by eliminating T-cells from the donor marrow but this procedure adversely affects marrow engraftment, increases the chances of rejection and results in a higher incidence of leukaemic relapse. Immunohistochemical staining for various cytokine-inducible molecules has led to some improvement in early diagnosis.Type of Medium: Electronic ResourceURL: -
18Articles: DFG German National LicensesClark, R.F. ; Hutton, M. ; Fuldner, M. ; Froelich, S. ; Karran, E. ; Talbot, C. ; Crook, R. ; Lendon, C. ; Prihar, G. ; He, C. ; Korenblat, K. ; Martinez, A. ; Wragg, M. ; Busfield, F. ; Behrens, M.I. ; Myers, A. ; Norton, J. ; Morris, J. ; Mehta, N. ; Pearson, C. ; Lincoln, S. ; Baker, M. ; Duff, K. ; Zehr, C. ; Perez-Tur, J.
[s.l.] : Nature Publishing Group
Published 1995Staff ViewISSN: 1546-1718Source: Nature Archives 1869 - 2009Topics: BiologyMedicineNotes: [Auszug] We isolated full length cDNA clones for the PS-1 gene. Analysis of the sequence of this clone revealed that it was identical in predicted amino acid sequence to that previously reported5 with the exception of the absence of amino acids VRSQ at position 26-29. Comparison of this sequence in Genbank ...Type of Medium: Electronic ResourceURL: -
19Articles: DFG German National LicensesMETZ, D. C. ; BENYA, R. V. ; FISHBEYN, V. A. ; PISEGNA, J. R. ; ORBUCH, M. ; STRADER, D. B. ; NORTON, J. A. ; JENSEN, R. T.
Oxford, UK : Blackwell Publishing Ltd
Published 1993Staff ViewISSN: 1365-2036Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: A long-term cure is now possible in more than 30% of selected patients with Zollinger–Ellison syndrome who undergo gastrinoma resection. The need, however, for continued gastric acid antisecretory therapy in these patients remains controversial. The current study was designed to determine whether post-operative antisecretory therapy is needed in patients who have undergone successful gastrinoma resection and, if so, to attempt to define criteria with which to identify patients who require therapy. Twenty-eight consecutive patients who had previously undergone curative gastrinoma resection were prospectively studied. When antisecretory therapy was discontinued, 43% (12/28) of these patients developed gastro-oesophageal reflux, diarrhoea, acid–peptic symptoms or endoscopic evidence of acid-peptic disease within 2 weeks and were deemed to have failed a trial of antisecretory drug withdrawal. The remaining 57% (16/28) of patients who successfully discontinued antisecretory therapy were followed for a mean time of 31 months after withdrawal of therapy. Analysis of acid output studies pre-operatively, as well as at the time of drug withdrawal, demonstrated that patients who were unable to discontinue antisecretory therapy exhibited higher pre-operative maximal acid output values and higher basal acid output values at the time of attempted drug withdrawal than patients who were able to discontinue therapy. Despite these findings, there was significant overlap in acid output values between groups so that it was not possible to define specific acid output criteria for successful drug withdrawal. Pre-operative clinical characteristics, such as the presence or absence of gastro-esophageal reflux or acid-peptic disease, or post-operative laboratory values, such as the fasting serum gastrin level, did not correlate with the ability to discontinue antisecretory therapy. We conclude that following successful curative gastrinoma resection, 40% of patients still require antisecretory therapy and that both symptom evaluation as well as upper endoscopy should be used to guide attempted drug withdrawal. Although patients who are not able to discontinue therapy have significantly higher acid output measurements than those who are able to discontinue therapy, neither acid output criteria nor any other laboratory or clinical characteristics are able to predict the need for continued antisecretory therapy in these patients.Type of Medium: Electronic ResourceURL: -
20Articles: DFG German National LicensesAvery, R. J. ; Norton, J. D. ; Jones, J. S. ; Burke, D. C. ; Morris, A. G.
[s.l.] : Nature Publishing Group
Published 1980Staff ViewISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] We initially sought to establish whether the IFN clones contained integrated KiMSV provirus in their cellular genomes, by hybridizing cell DNA with a representative 3H-cDNA probe synthesized from purified KiMSV (KiMLV) RNA. As normal uninfected mouse DNA contains multiple copies of endogenous ...Type of Medium: Electronic ResourceURL: