Search Results - (Author, Cooperation:J. Napier)
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1Latest Papers from Table of Contents or Articles in PressB. A. Read ; J. Kegel ; M. J. Klute ; A. Kuo ; S. C. Lefebvre ; F. Maumus ; C. Mayer ; J. Miller ; A. Monier ; A. Salamov ; J. Young ; M. Aguilar ; J. M. Claverie ; S. Frickenhaus ; K. Gonzalez ; E. K. Herman ; Y. C. Lin ; J. Napier ; H. Ogata ; A. F. Sarno ; J. Shmutz ; D. Schroeder ; C. de Vargas ; F. Verret ; P. von Dassow ; K. Valentin ; Y. Van de Peer ; G. Wheeler ; J. B. Dacks ; C. F. Delwiche ; S. T. Dyhrman ; G. Glockner ; U. John ; T. Richards ; A. Z. Worden ; X. Zhang ; I. V. Grigoriev
Nature Publishing Group (NPG)
Published 2013Staff ViewPublication Date: 2013-06-14Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Calcification, Physiologic ; Calcium/metabolism ; Carbonic Anhydrases/genetics/metabolism ; Ecosystem ; Genome/*genetics ; Haptophyta/classification/*genetics/*isolation & purification/metabolism ; Oceans and Seas ; Phylogeny ; Phytoplankton/*genetics ; Proteome/genetics ; SeawaterPublished by: -
2Articles: DFG German National LicensesStaff View
ISSN: 1618-2650Source: Springer Online Journal Archives 1860-2000Topics: Chemistry and PharmacologyType of Medium: Electronic ResourceURL: -
3Articles: DFG German National LicensesStaff View
ISSN: 1471-0528Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: A total of 733 rhesus positive women with antibodies were found during antenatal screening of 380 790 pregnancies in South and Mid Wales over a 30-year-period. A steady increase was observed in the frequency of antibodies, particularly non-rhesus antibodies and the mothers concerned had a significantly increased history of previous blood transfusion. In 50 per cent of those with non-rhesus antibodies, transfusion was the only stimulus. Conversely, for the majority (61 per cent) of women with rhesus antibodies feto-maternal incompatibility was the sole apparent stimulus. No identifiable stimulus could be found in 25 per cent of women with anti-E and 13 per cent of those with anti-Kell. Compared to rhesus negative mothers with anti-D severe clinical haemolytic disease of the newborn was uncommon, but in 75 per cent of rhesus positive mothers with infants carrying the homologous antigen, there was some evidence of haemolytic disease. Anti-c̄ was much the worst in this respect with 19.4 per cent of infants needing transfusion. The probability of having an incompatible infant was much less for the mothers with non-rhesus antibodies (27.3 per cent) and of these infants only 5.7 per cent needed transfusion.Type of Medium: Electronic ResourceURL: -
4Articles: DFG German National LicensesStaff View
ISSN: 1471-0528Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Summary. Fourteen mothers carrying ABO compatible but Rh D incompatible pregnancies experienced large feto-maternal haemorrhages (estimated 188 ml, range 50–400 ml red cells). These were all treated with infusions of fresh frozen plasma containing anti-D at a mean immunoglobulin to fetal cell ratio of 129 i.u. (25·8 μg)/ml of fetal cells. At 48 h after the infusion 95% of fetal cells had been removed but 3 to 4 days were required for complete removal. The passively administered anti-D was detectable for up to 6–9 months but not after that time. Four of the 14 women had successful pregnancies subsequently although in two of these anti-C + D was present. Of these, one resulted in a clinically affected baby who survived exchange transfusion.Type of Medium: Electronic ResourceURL: -
5Articles: DFG German National LicensesStaff View
ISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] THE recent discoveries of fossil hominid remains at Olduvai Gorge have strengthened the conclusions- which each of us had reached independently through our respective investigations-that the fossil hominid remains found in 1960 at site F.L.K.N.N. I, Olduvai, did not represent a creature belonging ...Type of Medium: Electronic ResourceURL: -
6Articles: DFG German National LicensesStaff View
ISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] IN Nature of December 17, 1960, Dr. L. S. B. Leakey reported the discovery of a group of hominid fossil bones from a living floor approximately 20 ft. below the upper limit of Bed I, Olduvai Gorge, Tanganyika. Later (Nature, 189, 649; 1961), further finds were reported by Dr. Leakey from the same ...Type of Medium: Electronic ResourceURL: -
7Articles: DFG German National LicensesStaff View
ISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] DURING the excavation of site FLK North (FLK NI) at Olduvai Gorge, a hominid toe bone (Fig. 1, a-e) was recovered on November 16, 1961, by Mr. Joseph Mutaba, an assistant of Dr. L. S. B. Leakey. The bone was found at Level 5, one of four superimposed occupation levels 3-3-5 ft. below the marker ...Type of Medium: Electronic ResourceURL: -
8Articles: DFG German National LicensesWatts, J. ; Rankine, J. M. ; Barnes, F. R. ; Napier, J. R.
London : Periodicals Archive Online (PAO)
Published 1863Staff ViewISSN: 0958-0433Topics: Art HistoryURL: -
9Articles: DFG German National LicensesStaff View
ISSN: 0958-0433Topics: Art HistoryURL: -
10Articles: DFG German National LicensesStaff View
ISSN: 0958-0433Topics: Art HistoryURL: -
11Articles: DFG German National LicensesStaff View
ISSN: 1432-2048Keywords: Abscisic acid and protein synthesis ; Aleurone ; Calcium and protein synthesis ; Protein synthesis ; Protein phosphorylation ; Seed development ; Triticum (ABA, Ca2+, protein synthesis)Source: Springer Online Journal Archives 1860-2000Topics: BiologyNotes: Abstract Aleurone tissue of mature wheat (Triticum aestivum L. cv. Sappo) grains make novel polypeptides in response to abscisic acid (ABA), but only in the presence of Ca2+. Effects of ABA plus Ca2+ include up- and down-modulation of other polypeptides. The ABA-induced polypeptides appear not to be the 21-kilodalton (kDa) amylase inhibitor which has been reported to be ABA-inducible in barley. Aleurone tissue from developing grains of different ages failed to respond to ABA plus Ca2+ in any way. Endogenous ABA levels were determined by monoclonal radioimmunoassay in developing, mature, and “sensitised” developing tissues. The ABA level rose to a maximum at 35 days post anthesis but was not detectable in mature cells. Developing layers sensitised to gibberellic acid (GA) showed decreased levels of ABA, similar to those in mature tissue, concurrent with acquired responsiveness to GA in respect of its induction of α-amylase. However, these sensitised cells still remained non-responsive to added ABA in terms of modulation of polypeptide pattern, though they did respond to ABA in the blocking of GA-induced α-amylase production. The role of protein phosphorylation in signal transduction was examined. The implications of these findings are discussed with reference to the role of ABA in developing and mature aleurone cells.Type of Medium: Electronic ResourceURL: -
12Articles: DFG German National LicensesStaff View
ISSN: 1432-0924Source: Springer Online Journal Archives 1860-2000Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision MechanicsNotes: Abstract The search for a numerical method to model fracture formation around deep level gold mine excavations had led to the development of the DIGS (Discontinuity Interaction and Growth Simulation) boundary element code to simulate the incremental growth of fractures. However, the need to develop constitutive models of basic failure processes resulted in the adoption of a tessellation approach to simulate grain interaction and breakage. Linear variation displacement discontinuity elements are arranged in structures which simulate the microstructure of the rock by applying either a Voronoi (polygonal) or Delaunay (triangular) tessellation procedure. The tessellation approach has been applied to investigate the role of micromechanical mechanisms such as pre-existing pores and sliding flaws on the macroscopic failure patterns at a scale that is representative of realistic rock microstructures. Procedures for calculating the crack density tensors and the average stress and strain in a sample permit comparison of the results with alternative models of brittle fracture such as continuum damage mechanics. Simulations of laboratory tests have revealed that the tessellation approach can represent experimentally observed macroscopic failure modes such as splitting in uniaxial compression and shear band formation in biaxial compression, as well as the dependence of strength and inelastic deformation on the flaw density.Type of Medium: Electronic ResourceURL: -
13Articles: DFG German National LicensesStaff View
ISSN: 1573-5028Keywords: ATP synthase ; presequence ; chloroplast import ; stromal processing peptidaseSource: Springer Online Journal Archives 1860-2000Topics: BiologyNotes: Abstract A cDNA clone encoding the complete precursor of the γ subunit of chloroplast ATP synthase has been isolated from a tobacco (Nicotiana tabacum) leaf cDNA library in λgt11. The 1.4 kb insert encodes a polypeptide of 377 amino acid residues, of which 55 residues constitute an N-terminal presequence and 322 residues make up the mature γ subunit. Hybridisation of the cDNA to Southern blots of tobacco genomic DNA indicates the presence of two genes in the haploid genome. Transcription and translation of the cDNA in vitro produced a protein of 41 kDa which was imported by isolated pea chloroplasts and processed to the mature 36 kDa subunit. The γ subunit precursor was processed to the mature size by a processing peptidase of 180 kDa present in pea stromal extracts.Type of Medium: Electronic ResourceURL: -
14Articles: DFG German National LicensesStaff View
ISSN: 1573-5028Keywords: ATP synthase ; CF1CF0 ; coupling factor ; chloroplast import ; presequenceSource: Springer Online Journal Archives 1860-2000Topics: BiologyNotes: Abstract A cDNA clone encoding the complete precursor of the δ subunit of chloroplast ATP synthase has been isolated from a tobacco (Nicotiana tabacum) leaf cDNA library in λgt11. The 880 bp insert encodes a polypeptide of 248 amino acid residues, of which 61 residues constitute an N-terminal presequence and 187 residues make up the mature δ subunit. Transcription and translation of the cDNA in vitro produced a protein of 29 kDa which was imported by isolated pea chloroplasts and processed to the mature 20 kDa subunit. The δ subunit precursor was processed to the mature size by a processing peptidase present in pea stromal extracts. Hybridisation of the cDNA to Southern blots of tobacco genomic DNA suggests the presence of two genes in the haploid genome.Type of Medium: Electronic ResourceURL: -
15Articles: DFG German National LicensesStaff View
ISSN: 1573-5028Keywords: chloroplast ; cytochrome bf complex ; presequence ; Rieske FeS protein ; stromal processing peptidaseSource: Springer Online Journal Archives 1860-2000Topics: BiologyNotes: Abstract cDNA clones encoding the precursor of the Rieske FeS protein of tobacco chloroplasts have been characterised and shown to derive from two different genes. The 5′ ends of the corresponding transcripts have been cloned using primer extension and PCR. The nucleotide sequences of the cDNAs (and their 5′ extensions) predict precursors for the tobacco proteins which differ in 4 amino acid residues out of a total of 228 residues and show high homology with the pea and spinach precursors. The tobacco precursor proteins contain N-terminal presequences of 49 amino acid residues which lack 17 amino acid residues present at the N-terminus of the spinach presequence. The 26 kDa precursor obtained by transcription and translation of one of these cDNAs in vitro was efficiently imported and correctly processed to the mature 20 kDa protein by isolated pea or tobacco chloroplasts. The precursor was also processed to its mature size by a peptidase present in the stroma of chloroplasts.Type of Medium: Electronic ResourceURL: -
16Articles: DFG German National LicensesStaff View
ISSN: 1573-5028Keywords: ATP synthase ; CF1CF0 complex ; chloroplast import ; thylakoid membraneSource: Springer Online Journal Archives 1860-2000Topics: BiologyNotes: Abstract A cDNA clone encoding the complete precursor of the γ subunit of the pea chloroplast ATP synthase has been isolated from a pea leaf cDNA library in λgt11 following detection with antibodies to the purified γ subunit. The cDNA insert of 1.4 kbp is smaller than transcripts of about 1.6 kb detected by northern hybridisation of RNA from both light- and darkgrown pea leaves. The cDNA encodes a polypeptide of 376 amino acid residues, of which 52 residues constitute an N-terminal presequence and 324 residues make up the mature protein. Transcription and translation of the cDNA in vitro produced a protein of 42 kDa, which was imported by isolated pea chloroplasts and processed to the mature 36 kDa subunit.Type of Medium: Electronic ResourceURL: -
17Articles: DFG German National LicensesSteventon, G. B. ; Sturman, S. G. ; Heafield, M. T. E. ; Waring, R. H. ; Napier, J. ; Williams, A. C.
Springer
Published 1989Staff ViewISSN: 1435-1463Keywords: Platelet ; monoamine oxidase-B ; Parkinson's diseaseSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Summary Platelet MAO-B levels have been investigated in seventeen consecutively diagnosed and previously untreated patients with idiopathic Parkinson's disease using the non-hydroxylated catecholamine, β-phenylethylamine, as substrate. Patients with Parkinson's disease had MAO-B activity levels that were considerably higher than sex and age matched normal controls or patients with Motor neurone disease or Myasthenia gravis.Type of Medium: Electronic ResourceURL: -
18Articles: DFG German National LicensesStaff View
ISSN: 0029-5981Keywords: boundary elements ; damage mechanics ; fracture growth ; multipole algorithms ; plasticity ; Engineering ; Engineering GeneralSource: Wiley InterScience Backfile Collection 1832-2000Topics: MathematicsTechnologyNotes: In this paper we introduce a method to reduce the solution cost for Boundary Element (BE) models from O(N3)operations to O(N2logN) operations (where N is the number of elements in the model). Previous attempts to achieve such an improvement in efficiency have been restricted in their applicability to problems with regular geometries defined on a uniform mesh. We have developed the Spectral Multipole Method (SMM) which can be used not only for problems with arbitrary geometries but also with a variety of element types. The memory necessary to store the required influence coefficients for the spectral multipole method is O(N) whereas the memory required for the traditional Boundary Element method is O(N2). We demonstrate the savings in computational speed and fast memory requirements in some numerical examples. We have established that the break-even point for the method can be as low as 500 elements, which implies that the method is not only suitable for extremely large-scale problems, but that it also provides a useful bridge between the small-scale and large-scale problems. We also demonstrate the performance of the multipole algorithm on the solution of large-scale granular assembly models. The large-scale BE capacity provided by this algorithm will not only prove to be useful in large macroscopic models but it will also make it possible to model microscopic damage processes that form the fundamental mechanisms in plastic flow and brittle fracture.Additional Material: 11 Ill.Type of Medium: Electronic ResourceURL: