Search Results - (Author, Cooperation:J. M. Thomas)

0142-2421

Chemistry ; Polymer and Materials Science

Wiley InterScience Backfile Collection 1832-2000

Physics

X-ray photoelectron spectroscopy (XPS) has been used to investigate the interaction of fluorine-containing intermediates with the basal plane of freshly cleaved graphite. A polymeric film of polytetrafluoroethylene (PTFE) on the carbon surface was formed on the basal plane by the interaction of microwave discharged hexafluoroethane and tetrafluoroethylene at 0.1 Torr pressure. Photolysis of tetrafluoroethylene near the graphite deposited submonolayer quantities of PTFE on the basal surface. Similar photolysis of hexafluoroacetone produced a reaction of trifluoromethyl radicals with carbon atoms in the graphite surface.

9 Ill.

Electronic Resource

2018-06-05

The American Association of Immunologists (AAI)

0022-1767

1550-6606

Medicine

2012-11-09

Nature Publishing Group (NPG)

0028-0836

1476-4687

Biology

Chemistry and Pharmacology

Medicine

Natural Sciences in General

Physics

Crystallography, X-Ray/*history ; Great Britain ; History, 20th Century ; History, 21st Century ; Nobel Prize

2015-09-19

Nature Publishing Group (NPG)

0028-0836

1476-4687

Biology

Chemistry and Pharmacology

Medicine

Natural Sciences in General

Physics

2018-06-19

Institute of Physics (IOP)

1757-8981

1757-899X

Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics

2014-11-02

American Association for the Advancement of Science (AAAS)

0036-8075

1095-9203

Biology

Chemistry and Pharmacology

Computer Science

Medicine

Natural Sciences in General

Physics

Alleles ; Animals ; Blood Coagulation/genetics ; Capillary Permeability/genetics ; *Disease Models, Animal ; Endothelium, Vascular/physiopathology ; *Genetic Predisposition to Disease ; Hemorrhagic Fever, Ebola/blood/*genetics/*immunology ; Host-Pathogen Interactions/*genetics ; Liver/blood supply/metabolism/pathology ; Lymphocyte Activation/immunology ; *Mice ; Mice, Inbred C57BL ; Neovascularization, Physiologic/genetics ; Receptor, TIE-2/*genetics

2018-08-23

American Chemical Society (ACS)

Chemistry and Pharmacology

2018-02-09

Genetics Society of America (GSA)

2160-1836

Biology

1089-7623

AIP Digital Archive

Physics

Electrical Engineering, Measurement and Control Technology

An in situ experiment to measure both x-ray absorption spectroscopy and x-ray diffraction of aurichalcite is described. The experiment uses position sensitive detectors to enable both data sets to be collected while the sample is slowly decomposed in air and then reduced in hydrogen.

Electronic Resource

1471-0528

Blackwell Publishing Journal Backfiles 1879-2005

Medicine

The accuracy of high resolution ultrasound with guided fine needle aspiration cytology in detecting inguinal lymph node involvement was assessed in 24 women undergoing radical vulvectomy and groin node dissection for squamous cell vulval cancer. Of the 43 groins dissected, ultrasound correctly diagnosed the lymph node status in 36, with five false positive and two false negative results. Cytology in 40 groins showed no false positive and five false negative results. The sensitivity and specificity for the combined techniques were 83% and 82% respectively. Assessed together, the combined technique failed to detect metastatic disease in two groins; in both cases the extent of nodal metastatic involvement was a solitary focus 〈 3 mm in diameter. The ultrasound and fine needle aspiration procedure is safe and well tolerated and can be repeated as needed for surveillance. The authors suggest that this procedure should be evaluated further to determine whether a policy of individual selection for lymphadenectomy can be implemented based on this technique.

Electronic Resource

1089-7690

AIP Digital Archive

Physics

Chemistry and Pharmacology

Overall rate constants for the removal of N2(A,v) by O2 and O were measured at 298 K in a rapidly pumped flow reactor using laser-induced fluorescence (LIF) detection of N2(A,v) by excitation in the first positive system of N2, B(3πg)←A(3Σ+u). O atoms were generated in microwave discharges of pure O2 prepared by thermal decomposition of KMnO4. Measured rate constants for N2(A,v)+O2 increased from 2.5×10−12(v=0) to 5.7×10−12 cm3 s−1(v=3). For N2(A,v)+O(3P), they were an order of magnitude larger, rising from 3.5×10−11(v=(0) to 5.2×10−11 cm3 s−1(v=3). They are compared with previous work and discussed in terms of the likely molecular interaction that they represent.

Electronic Resource

1600-065X

Blackwell Publishing Journal Backfiles 1879-2005

Medicine

Summary: We review a novel strategy for tolerance induction developed in rhesus macaques and termed STEALTH. We summarize the evolution of the STEALTH model, the results of successful trials in inducing long-term, stable transplant tolerance in rhesus kidney and diabetic islet recipients and discuss information related to the mechanism by which durable tolerance is induced. STEALTH tolerance is induced by a 3-day treatment course of CD3ε immunotoxin (IT) combined with a 14-day treatment with deoxyspergualin (DSG). IT causes profound depletion of sessile lymph node T cells as well as the more accessible circulating T cells. DSG, an inhibitor of HSC 70-mediated NF-κB nuclear translocation, arrests maturation of myeloid dendritic cells, blocks production of proinflammatory cytokines induced by IT administration, and promotes systemic production of Th2 type cytokines that persist indefinitely. Such Th2 cytokine deviation has not been reported in NHP transplant recipients. These studies provide proof of principle in a preclinical model that prevention of both acute and chronic allograft rejection, for at least 2.2–4.9 years of follow-up, can be achieved in NHP in the absence of chronic immunosuppressive drugs or other interventions. This strategy for inducing NHP tolerance is discussed in relation to current tolerance paradigms.

Electronic Resource

1365-3059

Blackwell Publishing Journal Backfiles 1879-2005

Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition

Data from field experiments were used to test whether disease observations on lower leaves of wheat were good predictors of future epidemic development in the upper canopy. Fungicide treatments to replicated plots in 1994 and 1995 caused variation in levels of initial inoculum of urediniospores of yellow rust (Puccinia striiformis). Observations of symptom severity were made on individual leaf layers throughout the season. Sporulating lesions on lower leaves were considered to be a measure of inoculum source strength for transfer to upper culm leaves. Low source strengths were associated with delays in epidemic development on the upper leaves, as quantified by a location parameter, tm, the time at which severity reached half of the asymptote value in logistic fits to disease progress data on the upper leaves. However, there was much unexplained variation, probably due to extraneous variation in upward transfer efficiency of inoculum and rates of epidemic development. Vanderplank's sanitation ratio theory was used to account for variation in inoculum transfer and epidemic rate. The analysis revealed that if the aim is to predict disease on a newly emerged culm leaf, during the period when it can be treated effectively with fungicide, then observations of disease two leaves further down the culm were of the greatest predictive value (R2 = 86%). These observations, however, need to be integrated with information about factors affecting upward inoculum transfer and rates of epidemic development if acceptable predictive precision is to be achieved.

Electronic Resource

1365-3059

Blackwell Publishing Journal Backfiles 1879-2005

Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition

A function was derived to predict fungicide efficacy when more than one application of a single active ingredient is made to a crop, given parameters describing the dose–response curves of the component single-spray applications. In the function, a second application is considered to act on that proportion of the total pathogen population which was uncontrollable at the time of the first application (represented by the lower asymptote of the dose–response curve for the first treatment), plus any additional part of the population which survived the first application as a result of a finite dose being applied. Data to estimate the single-spray dose–response curve parameters and validate predictions of two-spray programme efficacy were obtained from separate subsets of treatments in four field experiments. A systemic fungicide spray was applied to wheat at a range of doses, at one or both of two times (t1 and t2), in all dose combinations. Observed values of the area under the disease progress curve (AUDPC) for septoria leaf blotch (Mycosphaerella graminicola) were used to construct response surfaces of dose at t1 by dose at t2 for each culm leaf layer. Parameters were estimated from single-spray and zero-dose treatment data only. The model predicted a high proportion (R2 = 71–95%) of the variation in efficacy of the two-spray programmes. AUDPC isobols showed that the dose required at t2 was inversely related to the dose at t1, but the slope of the relationship varied with the relative timings of t1 and t2 in relation to culm leaf emergence. Isobols were curved, so the effective dose – the total dose required to achieve a given level of disease suppression – was lower when administered as two applications.

Electronic Resource

1476-4687

Nature Archives 1869 - 2009

Biology

Chemistry and Pharmacology

Medicine

Natural Sciences in General

Physics

[Auszug] The cubic structure of thallium zeolite-A has been studied by high resolution powder neutron diffraction. Refinements in which Si and Al are strictly alternating within the aluminosilicate framework (space group Fm3c) are better than those in which each Si is linked, by oxygen bridges, to three Al ...

Electronic Resource

1476-4687

Nature Archives 1869 - 2009

Biology

Chemistry and Pharmacology

Medicine

Natural Sciences in General

Physics

[Auszug] For the present study the UO2/2+ ion has two advantages. First, its propensity to form strong links with surrounding oxygen ligands: this along with the space-filling nature of this bulky ion should strengthen and rigidity the relatively fragile aluminosilicate framework of the zeolite. Second, the ...

Electronic Resource

1476-4687

Nature Archives 1869 - 2009

Biology

Chemistry and Pharmacology

Medicine

Natural Sciences in General

Physics

[Auszug] We recently reported6 the facile production of a metastable phase of anthracene which was discovered from analysis of the electron diffraction patterns of anthracene (I) that had suffered stress at room temperature. Phase II is produced topotactically7 inside I such that (001)II||(001)I, ...

Electronic Resource

1476-4687

Nature Archives 1869 - 2009

Biology

Chemistry and Pharmacology

Medicine

Natural Sciences in General

Physics

[Auszug] One specialized technique which seems appropriate is X-ray topography6'7, and a study of dislocations in anthracene by using this approach has recently been reported8. Another procedure, which came into prominence following Mitchell's work9 on the photolytic deposition of silver at dislocations in ...

Electronic Resource

1476-4687

Nature Archives 1869 - 2009

Biology

Chemistry and Pharmacology

Medicine

Natural Sciences in General

Physics

[Auszug] Interpretable images at 3–5 Å resolution of synthetic A-type zeolite suggest possible mechanisms of vitrification and introduction of dislocations into zeolitic structures. Techniques may be developed to extend the lifetime of these, and possibly other, beam-sensitive cage or tunnel ...

Electronic Resource

1476-4687

Nature Archives 1869 - 2009

Biology

Chemistry and Pharmacology

Medicine

Natural Sciences in General

Physics

[Auszug] An Escherichia coli mutant, hd B3-1, cold sensitive for T4+ capsid assembly is described. The hd B3-1 character seems to be caused by altered lipid components of the bacterial inner membrane. The genetic locus for the hd B3-1 phenotype is designated fat A and is closely linked to ...

Electronic Resource