Search Results - (Author, Cooperation:J. M. Rowe)

2014-08-19

Nature Publishing Group (NPG)

0028-0836

1476-4687

Biology

Chemistry and Pharmacology

Medicine

Natural Sciences in General

Physics

Animals ; Benzazepines/pharmacology ; Epigenesis, Genetic/drug effects ; Histone Demethylases/genetics/*metabolism ; Histones/chemistry/metabolism ; Jumonji Domain-Containing Histone Demethylases/antagonists & ; inhibitors/*metabolism ; Lysine/metabolism ; Methylation/drug effects ; Mice ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/drug ; therapy/*enzymology/genetics/pathology ; Pyrimidines/pharmacology ; Tumor Suppressor Proteins/genetics/metabolism

1089-7690

AIP Digital Archive

Physics

Chemistry and Pharmacology

The first results of a study of the vibrational spectrum of hydrogen, chemisorbed on the surface of platinum by isotope dilution neutron spectroscopy are presented. (AIP)

Electronic Resource

1476-4687

Nature Archives 1869 - 2009

Biology

Chemistry and Pharmacology

Medicine

Natural Sciences in General

Physics

[Auszug] In this study we have investigated a possible mechanism which is derived from the earlier (in evolution), osmoregulatory function of prolactin. In estuarine fishes, prolactin maintains internal osmolarity by regulating Na+ diffusion across the gills, and by controlling the activity of ...

Electronic Resource

1570-7458

Springer Online Journal Archives 1860-2000

Biology

Résumé Oscinella frit a été élevé en grand nombre pendant une période de 2 ans sur pieds d'avoine. L'influence des pousses d'avoine sur la Mouche de Hesse peut être considérée comme partiellement visuelle et partiellement chimique. L'extractio par quatre types de solvants (éthanol à 80%, acétone, chloroforme-éthanol, chloroforme) permet d'obtenir une fraction active attirant les mouches. Une interaction synergique entre les fractions lipidiques ou non des pousses d'avoine, a été observée pour la première fois. La partie lipidique a été analysée et la substance vraisemblablement attractive a été identifiée comme une hydroxybetadiketone.

Abstract Oscinella frit have been reared in large numbers over a 2-year period using oat plants as host. The attraction between frit fly and oat shoots can be said to be partly visual and partly chemical. Extraction of oat plants with four solvent systems, e.g. 80% ethanol, acetone, chloroform: methanol and chloroform enabled an active fraction to be obtained which attracts frit fly. A synergistic interaction between the lipid and non-lipid fraction of oats is reported for the first time. The lipid material has been separated and the substance suspected to be responsible for the attraction of frit fly has been classified as a hydroxybetadiketone.

Electronic Resource

1570-7458

Springer Online Journal Archives 1860-2000

Biology

Résumé On a élevéO. frit en grands nombres pendant une période de deux ans en utilisant des pieds d'avoine comme hôtes. L'interaction entreO. frit et les pousses d'avoine s'est avérée être en partie visuelle et en partie chimique.

Abstract Oscinella frit has been reared in large numbers over a 2-year period using oat plants as host. The interaction betweenOscinella frit and oat shoots has been noted as part visual and part chemical.

Electronic Resource

1432-0584

ABO blood group ; Platelet transfusion ; Platelet immunology ; Adverse effects

Springer Online Journal Archives 1860-2000

Medicine

Summary Historically, ABO compatibility between donor and recipicnt has been considered of minor importance for platelet transfusion. However, in a recent ran-domized trial we showed that provision of only ABO-identical platelets was associated with a significantly higher corrected count increment (CCI) in the early transfusions and with a twofold reduction in refractoriness, as compared with platelets given unmatched for ABO. In older studies this phenomenon was not observed. We wondered whether in these previous studies the use of the conventional term “ABO compatible,” whereby ABO-identical platelet transfusions are grouped with those that are merely ABO compatible, might have obscured the advantages of the ABO-identical platelets. In this paper the CCI from our original study are compared with what would have been found had the conventional terminology of “ABO compatible” and “ABO incompatible” been used. In our original study the mean CCI in patients receiving only ABO-identical platelets was 64% higher than that achicved with ABO-unmatched products. However, when the transfusions were reanalyzed according to conventional terminology of ABO “compatible” and “incompatible,” the actual benefits of ABO-identical platelets were no longer detected. Thus, ha dwe used the conventional terminology in the original study we would have come to completely different conclusions about the importance of ABO in platelet transfusion. We hypothesize that transfusion of ABO-incompatible plasma leads to the formation of immune complexes that can destroy compatible platelets by indirect mechanisms. This model predicts that the success of a transfusion could be affected by previous incompatible transfusions. When transfusions were classificd as to whether they were first, second, or third unmatched transfusion, increasing numbers of transfusions of ABO-incompatible plasma were associated with progressively poorer mean increments. The same was true for platelet ABO-incompatible transfusions. In contrast, increasing numbers of ABO-identical transfusions were not associated with poorer increments. The failure to appreciate that (a) transfusions containing ABO-incompatible plasma yield poor increments and (b) the effects of ABO-nonidentical transfusions are cumulative, and therefore affect the success of subsequent identical transfusions, may have led in the past to the incorrect conclusion that ABO matching was of minor importance in repetitively transfused patients.

Electronic Resource

1432-0584

Key words Myelodysplastic syndromes ; High-dose cytosine arabinoside ; GM-CSF

Springer Online Journal Archives 1860-2000

Medicine

Abstract  Thirty-one adult patients with high-risk myelodysplastic syndromes (MDS) were enrolled in a prospective randomized double-blind placebo-controlled trial evaluating the efficacy of sequential high-dose Ara C/mitoxantrone chemotherapy with or without GM-CSF. GM-CSF or placebo was given subcutaneously once daily at a dose of 250 μg/m2 starting 48 h prior to chemotherapy and continued until neutrophil recovery. This design allowed us to investigate the role of GM-CSF as a priming factor for the leukemic clone, as well as its effect on the recovery of normal hematopoiesis. Twenty-eight patients are currently evaluable for response. Ten patients reached a complete remission (36%), eight patients had persistent MDS (29%), and ten patients died within 6 weeks after the onset of treatment (early death). Infectious complications during cytopenia were the major cause of death (8/10). Median time to complete hematologic recovery (neutrophils 〉500/μl and platelets 20 000/μl) and time to neutrophil recovery above 1500/μl was 29 and 35 days, respectively. Median remission duration was 190 days (6.4 months). Analysis of prognostic subgroups showed a low CR rate (25%) and a high early-death rate (44%) in patients 〉55 years of age, suggesting that the intensified treatment approach should be limited to younger patients. No data concerning the influence of GM-CSF on response to chemotherapy or duration of neutropenia are presently available.

Electronic Resource

1569-8041

cost-effectiveness ; costs ; leukemia ; sargramostim (GM-CSF)

Springer Online Journal Archives 1860-2000

Medicine

Abstract Purpose: Considerable morbidity and mortality and costs occur during induction therapy for acute myeloid leukemia (AML). Colony-stimulating factors (CSFs) can shorten neutropenia, and may lower costs. We performed a cost-minimization analysis of granulocyte macrophage colony stimulating factor (GM-CSF) for AML patients 〉55 to 70 years of age during an Eastern Cooperative Oncology Group Study. Patients and methods: Clinical data were from a randomized double-blind phase III trial of 117 AML patients. Estimates of costs were from financial accounts from seven participating institutions. Costs were reported from the third party payor perspective. Analyses were conducted utilizing a decision analytic model. The primary source of event probabilities was in- hospital care with or without an active infection. Sensitivity analyses were also reported. Results: When compared to AML patients who received placebo, GM-CSF patients had fewer grade 4–5 infections (9.6% versus 36.2%, P = 0.002) and grade 3–5 infections (52% versus 70%, P = 0.07) and $2,310 in savings. Sensitivity analyses indicated that similar cost estimates applied over a range of clinical and economic assumptions. Conclusions: This analysis can serve as a template for cooperative group cost analyses. Cooperation on study methodologies may allow for results that are relevant to both clinicians and policy makers.

Electronic Resource

1573-1987

Springer Online Journal Archives 1860-2000

Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics

Electronic Resource

1434-6036

Springer Online Journal Archives 1860-2000

Physics

Abstract The vibration spectra of α and β-phase PdH(D)x have been measured by neutron inelastic scattering. From a detailed analysis of the spectra, we conclude that the potentials for hydrogen and deuterium are very similar and strongly anharmonic. The results show definitively that anharmonicity is the principal contribution to the anomalous isotope dependence of the superconducting transition temperature in PdH(D).

Electronic Resource