Search Results - (Author, Cooperation:J. M. Penninger)
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1Latest Papers from Table of Contents or Articles in PressL. Senovilla ; I. Vitale ; I. Martins ; M. Tailler ; C. Pailleret ; M. Michaud ; L. Galluzzi ; S. Adjemian ; O. Kepp ; M. Niso-Santano ; S. Shen ; G. Marino ; A. Criollo ; A. Boileve ; B. Job ; S. Ladoire ; F. Ghiringhelli ; A. Sistigu ; T. Yamazaki ; S. Rello-Varona ; C. Locher ; V. Poirier-Colame ; M. Talbot ; A. Valent ; F. Berardinelli ; A. Antoccia ; F. Ciccosanti ; G. M. Fimia ; M. Piacentini ; A. Fueyo ; N. L. Messina ; M. Li ; C. J. Chan ; V. Sigl ; G. Pourcher ; C. Ruckenstuhl ; D. Carmona-Gutierrez ; V. Lazar ; J. M. Penninger ; F. Madeo ; C. Lopez-Otin ; M. J. Smyth ; L. Zitvogel ; M. Castedo ; G. Kroemer
American Association for the Advancement of Science (AAAS)
Published 2012Staff ViewPublication Date: 2012-09-29Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Calreticulin/immunology ; Cell Line, Tumor ; Common Variable Immunodeficiency/genetics ; DNA, Neoplasm/analysis/genetics ; Endoplasmic Reticulum Stress/*immunology ; Eukaryotic Initiation Factor-2/metabolism ; Humans ; Immunocompetence ; *Immunologic Surveillance ; Mice ; Mice, Inbred BALB C ; Neoplasms/chemically induced/*genetics/*immunology ; Phosphorylation ; *PloidiesPublished by: -
2Latest Papers from Table of Contents or Articles in PressP. van der Harst ; W. Zhang ; I. Mateo Leach ; A. Rendon ; N. Verweij ; J. Sehmi ; D. S. Paul ; U. Elling ; H. Allayee ; X. Li ; A. Radhakrishnan ; S. T. Tan ; K. Voss ; C. X. Weichenberger ; C. A. Albers ; A. Al-Hussani ; F. W. Asselbergs ; M. Ciullo ; F. Danjou ; C. Dina ; T. Esko ; D. M. Evans ; L. Franke ; M. Gogele ; J. Hartiala ; M. Hersch ; H. Holm ; J. J. Hottenga ; S. Kanoni ; M. E. Kleber ; V. Lagou ; C. Langenberg ; L. M. Lopez ; L. P. Lyytikainen ; O. Melander ; F. Murgia ; I. M. Nolte ; P. F. O'Reilly ; S. Padmanabhan ; A. Parsa ; N. Pirastu ; E. Porcu ; L. Portas ; I. Prokopenko ; J. S. Ried ; S. Y. Shin ; C. S. Tang ; A. Teumer ; M. Traglia ; S. Ulivi ; H. J. Westra ; J. Yang ; J. H. Zhao ; F. Anni ; A. Abdellaoui ; A. Attwood ; B. Balkau ; S. Bandinelli ; F. Bastardot ; B. Benyamin ; B. O. Boehm ; W. O. Cookson ; D. Das ; P. I. de Bakker ; R. A. de Boer ; E. J. de Geus ; M. H. de Moor ; M. Dimitriou ; F. S. Domingues ; A. Doring ; G. Engstrom ; G. I. Eyjolfsson ; L. Ferrucci ; K. Fischer ; R. Galanello ; S. F. Garner ; B. Genser ; Q. D. Gibson ; G. Girotto ; D. F. Gudbjartsson ; S. E. Harris ; A. L. Hartikainen ; C. E. Hastie ; B. Hedblad ; T. Illig ; J. Jolley ; M. Kahonen ; I. P. Kema ; J. P. Kemp ; L. Liang ; H. Lloyd-Jones ; R. J. Loos ; S. Meacham ; S. E. Medland ; C. Meisinger ; Y. Memari ; E. Mihailov ; K. Miller ; M. F. Moffatt ; M. Nauck ; M. Novatchkova ; T. Nutile ; I. Olafsson ; P. T. Onundarson ; D. Parracciani ; B. W. Penninx ; L. Perseu ; A. Piga ; G. Pistis ; A. Pouta ; U. Puc ; O. Raitakari ; S. M. Ring ; A. Robino ; D. Ruggiero ; A. Ruokonen ; A. Saint-Pierre ; C. Sala ; A. Salumets ; J. Sambrook ; H. Schepers ; C. O. Schmidt ; H. H. Sillje ; R. Sladek ; J. H. Smit ; J. M. Starr ; J. Stephens ; P. Sulem ; T. Tanaka ; U. Thorsteinsdottir ; V. Tragante ; W. H. van Gilst ; L. J. van Pelt ; D. J. van Veldhuisen ; U. Volker ; J. B. Whitfield ; G. Willemsen ; B. R. Winkelmann ; G. Wirnsberger ; A. Algra ; F. Cucca ; A. P. d'Adamo ; J. Danesh ; I. J. Deary ; A. F. Dominiczak ; P. Elliott ; P. Fortina ; P. Froguel ; P. Gasparini ; A. Greinacher ; S. L. Hazen ; M. R. Jarvelin ; K. T. Khaw ; T. Lehtimaki ; W. Maerz ; N. G. Martin ; A. Metspalu ; B. D. Mitchell ; G. W. Montgomery ; C. Moore ; G. Navis ; M. Pirastu ; P. P. Pramstaller ; R. Ramirez-Solis ; E. Schadt ; J. Scott ; A. R. Shuldiner ; G. D. Smith ; J. G. Smith ; H. Snieder ; R. Sorice ; T. D. Spector ; K. Stefansson ; M. Stumvoll ; W. H. Tang ; D. Toniolo ; A. Tonjes ; P. M. Visscher ; P. Vollenweider ; N. J. Wareham ; B. H. Wolffenbuttel ; D. I. Boomsma ; J. S. Beckmann ; G. V. Dedoussis ; P. Deloukas ; M. A. Ferreira ; S. Sanna ; M. Uda ; A. A. Hicks ; J. M. Penninger ; C. Gieger ; J. S. Kooner ; W. H. Ouwehand ; N. Soranzo ; J. C. Chambers
Nature Publishing Group (NPG)
Published 2012Staff ViewPublication Date: 2012-12-12Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Cell Cycle/genetics ; Cytokines/metabolism ; Drosophila melanogaster/genetics ; Erythrocytes/cytology/*metabolism ; Female ; Gene Expression Regulation/genetics ; *Genetic Loci ; *Genome-Wide Association Study ; Hematopoiesis/genetics ; Hemoglobins/genetics ; Humans ; Male ; Mice ; Organ Specificity ; *Phenotype ; Polymorphism, Single Nucleotide/genetics ; RNA Interference ; Signal Transduction/geneticsPublished by: -
3Latest Papers from Table of Contents or Articles in PressS. Cheloufi ; U. Elling ; B. Hopfgartner ; Y. L. Jung ; J. Murn ; M. Ninova ; M. Hubmann ; A. I. Badeaux ; C. Euong Ang ; D. Tenen ; D. J. Wesche ; N. Abazova ; M. Hogue ; N. Tasdemir ; J. Brumbaugh ; P. Rathert ; J. Jude ; F. Ferrari ; A. Blanco ; M. Fellner ; D. Wenzel ; M. Zinner ; S. E. Vidal ; O. Bell ; M. Stadtfeld ; H. Y. Chang ; G. Almouzni ; S. W. Lowe ; J. Rinn ; M. Wernig ; A. Aravin ; Y. Shi ; P. J. Park ; J. M. Penninger ; J. Zuber ; K. Hochedlinger
Nature Publishing Group (NPG)
Published 2015Staff ViewPublication Date: 2015-12-15Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Cells, Cultured ; Cellular Reprogramming/*genetics ; Chromatin/metabolism ; Chromatin Assembly Factor-1/antagonists & inhibitors/genetics/*metabolism ; Gene Expression Regulation/genetics ; Heterochromatin/metabolism ; Mice ; Nucleosomes/metabolism ; RNA Interference ; Transduction, GeneticPublished by: -
4Latest Papers from Table of Contents or Articles in PressM. Paolino ; A. Choidas ; S. Wallner ; B. Pranjic ; I. Uribesalgo ; S. Loeser ; A. M. Jamieson ; W. Y. Langdon ; F. Ikeda ; J. P. Fededa ; S. J. Cronin ; R. Nitsch ; C. Schultz-Fademrecht ; J. Eickhoff ; S. Menninger ; A. Unger ; R. Torka ; T. Gruber ; R. Hinterleitner ; G. Baier ; D. Wolf ; A. Ullrich ; B. M. Klebl ; J. M. Penninger
Nature Publishing Group (NPG)
Published 2014Staff ViewPublication Date: 2014-02-21Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Adaptor Proteins, Signal Transducing/deficiency/genetics/*metabolism ; Animals ; Anticoagulants/pharmacology/therapeutic use ; Female ; Killer Cells, Natural/drug effects/*immunology/metabolism ; Male ; Mammary Neoplasms, Experimental/drug therapy/genetics/immunology/*pathology ; Melanoma, Experimental/drug therapy/genetics/immunology/*pathology ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Neoplasm Metastasis/drug therapy/*immunology/prevention & control ; Proto-Oncogene Proteins/antagonists & inhibitors/metabolism ; Proto-Oncogene Proteins c-cbl/deficiency/genetics/*metabolism ; Receptor Protein-Tyrosine Kinases/antagonists & inhibitors/*metabolism ; Ubiquitin-Protein Ligases/deficiency/genetics/*metabolism ; Ubiquitination ; Warfarin/pharmacology/therapeutic usePublished by: -
5Latest Papers from Table of Contents or Articles in PressM. A. Lancaster ; M. Renner ; C. A. Martin ; D. Wenzel ; L. S. Bicknell ; M. E. Hurles ; T. Homfray ; J. M. Penninger ; A. P. Jackson ; J. A. Knoblich
Nature Publishing Group (NPG)
Published 2013Staff ViewPublication Date: 2013-09-03Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Brain/anatomy & histology/cytology/*growth & development/*pathology ; Cerebral Cortex/cytology/embryology/growth & development/pathology ; Humans ; Induced Pluripotent Stem Cells/cytology/pathology ; Mice ; Microcephaly/*pathology ; *Models, Biological ; Neural Stem Cells/cytology/pathology ; Neurogenesis ; Neurons/cytology/pathology ; Organoids/*cytology/embryology/*growth & development/pathology ; Tissue Culture Techniques/*methodsPublished by: -
6Latest Papers from Table of Contents or Articles in PressT. Hashimoto ; T. Perlot ; A. Rehman ; J. Trichereau ; H. Ishiguro ; M. Paolino ; V. Sigl ; T. Hanada ; R. Hanada ; S. Lipinski ; B. Wild ; S. M. Camargo ; D. Singer ; A. Richter ; K. Kuba ; A. Fukamizu ; S. Schreiber ; H. Clevers ; F. Verrey ; P. Rosenstiel ; J. M. Penninger
Nature Publishing Group (NPG)
Published 2012Staff ViewPublication Date: 2012-07-28Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Biocatalysis ; Colitis/drug therapy/*etiology/*microbiology/pathology ; Dextran Sulfate ; Diarrhea/complications ; Dietary Proteins/metabolism/pharmacology ; Female ; Gene Deletion ; Genetic Predisposition to Disease ; Germ-Free Life ; Homeostasis ; Immunity, Innate ; Intestines/*microbiology/pathology ; Male ; Malnutrition/*complications/metabolism ; *Metagenome ; Mice ; Models, Biological ; Niacinamide/metabolism/pharmacology/therapeutic use ; Peptidyl-Dipeptidase A/deficiency/genetics/*metabolism ; Renin-Angiotensin System/physiology ; TOR Serine-Threonine Kinases/metabolism ; Trinitrobenzenesulfonic Acid ; Tryptophan/*metabolism/pharmacology/therapeutic usePublished by: -
7Latest Papers from Table of Contents or Articles in PressT. Hanada ; S. Weitzer ; B. Mair ; C. Bernreuther ; B. J. Wainger ; J. Ichida ; R. Hanada ; M. Orthofer ; S. J. Cronin ; V. Komnenovic ; A. Minis ; F. Sato ; H. Mimata ; A. Yoshimura ; I. Tamir ; J. Rainer ; R. Kofler ; A. Yaron ; K. C. Eggan ; C. J. Woolf ; M. Glatzel ; R. Herbst ; J. Martinez ; J. M. Penninger
Nature Publishing Group (NPG)
Published 2013Staff ViewPublication Date: 2013-03-12Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Amyotrophic Lateral Sclerosis ; Animals ; Animals, Newborn ; Axons/metabolism/pathology ; Cell Death ; Diaphragm/innervation ; Embryo Loss ; Embryo, Mammalian/metabolism/pathology ; Exons/genetics ; Female ; Fibroblasts ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Mice, Transgenic ; Motor Neurons/*metabolism/*pathology ; Muscular Atrophy, Spinal ; Neuromuscular Diseases/metabolism/pathology ; Oxidative Stress ; RNA Processing, Post-Transcriptional ; RNA, Transfer, Tyr/genetics/*metabolism ; Respiration ; Spinal Nerves/cytology ; Transcription Factors/deficiency/*metabolism ; Tumor Suppressor Protein p53/metabolism ; Tyrosine/genetics/metabolismPublished by: -
8Articles: DFG German National LicensesTani-Ishii, N. ; Penninger, J. M. ; Matsumoto, G. ; Teranaka, T. ; Umemoto, T.
Oxford, UK : Munksgaard International Publishers
Published 2002Staff ViewISSN: 1600-0765Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Interactions between leukocyte function-associated antigen-1 (LFA-1) and intercellular adhesion molecule-1 (ICAM−1) influence the development of osteoclasts. However, little is known about how these adhesion molecules are involved in the process of osteoclast development. This study evaluated the role of LFA-1 and its ligands in osteoclast development and bone resorption. Co-cultures of bone marrow cells from LFA-1-deficient mice and MC3T3-G2/PA6 (PA6) cells were cultured in the presence of 1α,25(OH)2D3 and dexamethasone for 7 days. The number of TRAP-positive cells that were generated by bone marrow cells from LFA-1-deficient mice was smaller than that generated by bone marrow cells from wild-type mice. In addition, the bone-resorbing activity of osteoclast-like cells that were generated from LFA-1-deficient mice was lower than that generated by osteoclast-like cells from wild-type mice. Immunofluorescence flow cytometry showed that osteoclast stromal PA6 cells expressed the cell adhesion molecules, ICAM-1 and VCAM-1. When monoclonal antibodies to mice VCAM-1, CD11b or CD18 were added separately to the co-culture system, the number of TRAP-positive cells that were generated from LFA-1-deficient mice was 20–30% smaller than that generated from wild-type mice. The formation of TRAP-positive cells from both LFA-1 deficient and wild-type mice was especially inhibited by anti-CD18 antibody, in comparison to the addition of normal IgG serum. These results suggest that LFA-1 adhesion molecules play a role in osteoclast development by affecting adhesion between stromal cells and osteoclast progenitors before the occurrence of ODF-ODF receptor signaling. CD18 appears to be a key adhesion molecule in cell-to-cell contacts during the early stage of osteoclast development.Type of Medium: Electronic ResourceURL: -
9Articles: DFG German National LicensesStaff View
ISSN: 1435-1536Source: Springer Online Journal Archives 1860-2000Topics: Chemistry and PharmacologyMechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision MechanicsType of Medium: Electronic ResourceURL: -
10Articles: DFG German National LicensesStaff View
ISSN: 0538-8066Keywords: Chemistry ; Physical ChemistrySource: Wiley InterScience Backfile Collection 1832-2000Topics: Chemistry and PharmacologyNotes: The kinetics of the thermal hydrocracking of indan were investigatedin a high-pressure flow reactor at temperatures from 470 to 530°C, total pressures of up to 300 atm, and molar ratios from 3 to 40. The effect of the hydrogen pressure was reflected especially in a change of the experimental rate equations for the formation of toluene from rT=k [indan]0.5 [hydrogen] to rT=k′ [indan] 0.75[hydrogen]0.75 with hydrogen partial pressureincreasing from 73 to 230 atm. The rate equation of n-propylbenzene remained constant at rPr=k″ [indan] [hydrogen]1.5. Simultaneously the Arrheniusparameters of toluene changed significantly, while those of n-propylbenzene remained unchanged.The observed effect of the hydrogen pressure is explained as a change inthe rates of the intermediate reactions; it provides an excellent agreementbetween the theoretical and experimental data. It was found that the steady-state concentration of the hydrogen atoms, which act as chain carriers in the thermal hydrocracking, was much smaller than the thermodynamic equilibrium concentrationsAdditional Material: 7 Ill.Type of Medium: Electronic ResourceURL: