Search Results - (Author, Cooperation:J. M. Jorgensen)

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  1. 1
    Staff View
    Publication Date:
    2016-02-26
    Publisher:
    American Association for the Advancement of Science (AAAS)
    Print ISSN:
    0036-8075
    Electronic ISSN:
    1095-9203
    Topics:
    Biology
    Chemistry and Pharmacology
    Computer Science
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Animals ; Bacteria/*classification ; Bifidobacterium/physiology ; Body Weight ; Bone Development ; Clostridiales/physiology ; Disease Models, Animal ; Feces/microbiology ; Femur/growth & development ; Gastrointestinal Microbiome/*physiology ; Germ-Free Life ; Humans ; Infant ; Infant Nutrition Disorders/metabolism/*microbiology ; Malawi ; Male ; Mice ; Mice, Inbred C57BL
    Published by:
    http://www.aaas.org/

    Latest Papers from Table of Contents or Articles in Press
  2. 2
    Kirkegaard, M. ; Jørgensen, J. M.
    Springer
    Published 2000
    Staff View
    ISSN:
    1432-1904
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Biology
    Chemistry and Pharmacology
    Natural Sciences in General
    Notes:
    Abstract  In both humans and mice the number of hair cells in the inner ear sensory epithelia declines with age, indicating cell death (Park et al. 1987; Rosenhall 1973). However, recent reports demonstrate the ability of the vestibular sensory epithelia to regenerate after injury (Forge et al. 1993, 1998; Kuntz and Oesterle 1998; Li and Forge 1997; Rubel et al. 1995; Tanyeri et al. 1995). Still, a continuous hair cell turnover in the vestibular epithelia has not previously been demonstrated in mature mammals. Bats are the only flying mammals, and they are known to live to a higher age than animals of equal size. The maximum age of many species is 20 years, with average lifespans of 4–6 years (Schober and Grimmberger 1989). Further, the young are fully developed and able to fly at the age of 2 months, and thus the vestibular organs are thought to be differentiated at that age. Consequently, long-lived mammals such as bats might compensate for the loss of hair cells by producing new hair cells in their postembryonic life. Here we show that the utricular macula of adult Daubenton's bats (more than 6 months old) contains innervated immature hair cells as well as apoptotic hair cells, which strongly indicates a continuous turnover of hair cells, as previously demonstrated in birds.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/s001140050015

    Articles: DFG German National Licenses
  3. 3
    Jørgensen, J. M. ; Mathiesen, C.
    Springer
    Published 1988
    Staff View
    ISSN:
    1432-1904
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Biology
    Chemistry and Pharmacology
    Natural Sciences in General
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF00367330

    Articles: DFG German National Licenses
  4. 4
    Bleckmann, H. ; Bullock, T. H. ; Jørgensen, J. M.
    Springer
    Published 1987
    Staff View
    ISSN:
    1432-1351
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Biology
    Medicine
    Notes:
    Summary Central lateral line pathways were mapped in the thornback ray,Platyrhinoidis triseriata, by analyzing depth profiles of averaged evoked potentials (AEPs), multiunit activity (MUA), and single unit recordings. 1. Neural activity evoked by contra- or ipsilateral posterior lateral line nerve (pLLN) shock is restricted to the tectum mesencephali, the dorsomedial nucleus (DMN) and anterior nucleus (AN) of the mesencephalic nuclear complex, the posterior central thalamic nucleus (PCT), the lateral tuberal nucleus of the hypothalamus, and the deep medial pallium of the telencephalon (Figs. 2, 3, 4, 6, 7). 2. Neural responses (AEPs and MUA) recorded in different lateral line areas differ with respect to shape, dynamic response properties, and/or latencies (Figs. 9, 10 and Table 1). 3. Ipsilaterally recorded mesencephalic and diencephalic AEPs are less pronounced and of longer latency than their contralateral counterpart (Fig. 9 and Table 1). In contrast, AEP recorded in the telencephalon show a weak ipsilateral preference. 4. If stimulated with a low amplitude water wave most DMN, AN, and tectal lateral line units respond in the frequency range 6.5 Hz to 200 Hz. Best frequencies (in terms of least displacement) are 75–150 Hz with a peak-to-peak water displacement of 0.04 μm sufficient to evoke a response in the most sensitive units (Fig. 11A, B, C). 5. DMN and AN lateral line units have small excitatory receptive fields (RFs). Anterior, middle, and posterior body surfaces map onto the rostral, middle, and posterior brain surfaces of the contralateral DMN (Fig. 12). 6. Some units recorded in the PCT are bimodal; they respond to a hydrodynamic flow field — generated with a ruler approaching the fish — only if the light is on and the eye facing the ruler is left uncovered (Fig. 13).
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF00609456

    Articles: DFG German National Licenses