Search Results - (Author, Cooperation:J. Lucero)
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1Latest Papers from Table of Contents or Articles in PressR. Lister ; E. A. Mukamel ; J. R. Nery ; M. Urich ; C. A. Puddifoot ; N. D. Johnson ; J. Lucero ; Y. Huang ; A. J. Dwork ; M. D. Schultz ; M. Yu ; J. Tonti-Filippini ; H. Heyn ; S. Hu ; J. C. Wu ; A. Rao ; M. Esteller ; C. He ; F. G. Haghighi ; T. J. Sejnowski ; M. M. Behrens ; J. R. Ecker
American Association for the Advancement of Science (AAAS)
Published 2013Staff ViewPublication Date: 2013-07-06Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: 5-Methylcytosine/metabolism ; Adult ; Animals ; Base Sequence ; Conserved Sequence ; Cytosine/*analogs & derivatives/metabolism ; *DNA Methylation ; *Epigenesis, Genetic ; Epigenomics ; Frontal Lobe/*growth & development ; *Gene Expression Regulation, Developmental ; Genome-Wide Association Study ; Humans ; Longevity ; Mice ; Mice, Inbred C57BL ; X Chromosome Inactivation/geneticsPublished by: -
2Articles: DFG German National LicensesStaff View
ISSN: 1432-0800Source: Springer Online Journal Archives 1860-2000Topics: Energy, Environment Protection, Nuclear Power EngineeringMedicineNotes: Summary Male rats were orally dosed with Aroclor 5460 for 7 days and residues were found in all tissues analysed, with the greatest concentration in the liver. The GC-EC pattern of the residue in the liver was different from the standard mixture administered indicating that all components are not metabolised at the same rate. Administration of Aroclor 5460 at 10 ppm level produced no observable changes in the microsomal enzyme systems, however, at the 1000 ppm level a significant increase in liver size was observed and an inductive effect is clearly evidenced, Aminopyrine n-demethylase (Type I) and aniline hydroxylase (Type II) activities were significantly raised in the microsomal fractions of the livers of this group. The increased levels in drug metabolising enzyme activities and the parallel increase in the content of microsomal protein, phospholipids and Cytochrome P-450 would indicate a truly inductive effect of Aroclor 5460 on the hepatic microsomal enzyme systems in the male rat.Type of Medium: Electronic ResourceURL: