Search Results - (Author, Cooperation:J. Lohr)

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  1. 1
    Staff View
    Publication Date:
    2018-10-04
    Publisher:
    American Physical Society (APS)
    Print ISSN:
    1098-0121
    Electronic ISSN:
    1095-3795
    Topics:
    Physics
    Keywords:
    Magnetism
    Published by:
    http://www.aps.org/

    Latest Papers from Table of Contents or Articles in Press
  2. 2
    M. S. Lawrence ; P. Stojanov ; P. Polak ; G. V. Kryukov ; K. Cibulskis ; A. Sivachenko ; S. L. Carter ; C. Stewart ; C. H. Mermel ; S. A. Roberts ; A. Kiezun ; P. S. Hammerman ; A. McKenna ; Y. Drier ; L. Zou ; A. H. Ramos ; T. J. Pugh ; N. Stransky ; E. Helman ; J. Kim ; C. Sougnez ; L. Ambrogio ; E. Nickerson ; E. Shefler ; M. L. Cortes ; D. Auclair ; G. Saksena ; D. Voet ; M. Noble ; D. DiCara ; P. Lin ; L. Lichtenstein ; D. I. Heiman ; T. Fennell ; M. Imielinski ; B. Hernandez ; E. Hodis ; S. Baca ; A. M. Dulak ; J. Lohr ; D. A. Landau ; C. J. Wu ; J. Melendez-Zajgla ; A. Hidalgo-Miranda ; A. Koren ; S. A. McCarroll ; J. Mora ; R. S. Lee ; B. Crompton ; R. Onofrio ; M. Parkin ; W. Winckler ; K. Ardlie ; S. B. Gabriel ; C. W. Roberts ; J. A. Biegel ; K. Stegmaier ; A. J. Bass ; L. A. Garraway ; M. Meyerson ; T. R. Golub ; D. A. Gordenin ; S. Sunyaev ; E. S. Lander ; G. Getz
    Nature Publishing Group (NPG)
    Published 2013
    Staff View
    Publication Date:
    2013-06-19
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Artifacts ; DNA Replication Timing ; Exome/genetics ; False Positive Reactions ; Gene Expression ; *Genetic Heterogeneity ; Genome, Human/genetics ; Humans ; Lung Neoplasms/genetics ; Mutation/*genetics ; Mutation Rate ; Neoplasms/classification/*genetics/pathology ; Neoplasms, Squamous Cell/genetics ; Oncogenes/*genetics ; Reproducibility of Results ; Sample Size
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  3. 3
    Forest, C. B. ; Hwang, Y. S. ; Ono, M. ; Greene, G. ; Jones, T. ; Choe, W. ; Schaffer, M. ; Hyatt, A. ; Osborne, T. ; Pinsker, R. I. ; Petty, C. C. ; Lohr, J. ; Lippmann, S.

    [S.l.] : American Institute of Physics (AIP)
    Published 1994
    Staff View
    ISSN:
    1089-7674
    Source:
    AIP Digital Archive
    Topics:
    Physics
    Notes:
    A noninductive current drive concept, based on internal pressure-driven currents in a low-aspect-ratio toroidal geometry, has been demonstrated on the Current Drive Experiment Upgrade (CDX-U) [Forest et al., Phys. Rev. Lett. 68, 3559 (1992)] and further tested on DIII-D [in Plasma Physics and Controlled Nuclear Fusion Research, 1986, Proceedings of the 11th International Conference, Kyoto (International Atomic Energy Agency, Vienna, 1987), Vol. 1, p. 159]. For both experiments, electron cyclotron power provided the necessary heating to breakdown and maintain a plasma with high-βp and low collisionality (εβp∼1, ν*≤1). A poloidal vacuum field similar to a simple magnetic mirror is superimposed on a much stronger toroidal field to provide the initial confinement for a hot, trapped electron species. With application of electron cyclotron heating (ECH), toroidal currents spontaneously flow within the plasma and increase with applied ECH power. The direction of the generated current is independent of the toroidal field direction and depends only on the direction of the poloidal field, scaling inversely with magnitude of the later. On both CDX-U and DIII-D, these currents were large enough that stationary closed flux surfaces were observed to form with no additional Ohmic heating. The existence of such equilibria provides further evidence for the existence of some type of bootstrap current. Equilibrium reconstructions show the resulting plasma exhibits properties similar to more conventional tokamaks, including a peaked current density profile which implies some form of current on axis or nonclassical current transport.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1063/1.870708

    Articles: DFG German National Licenses
  4. 4
    La Haye, R. J. ; Günter, S. ; Humphreys, D. A. ; Lohr, J. ; Luce, T. C. ; Maraschek, M. E. ; Petty, C. C. ; Prater, R. ; Scoville, J. T. ; Strait, E. J.

    [S.l.] : American Institute of Physics (AIP)
    Published 2002
    Staff View
    ISSN:
    1089-7674
    Source:
    AIP Digital Archive
    Topics:
    Physics
    Notes:
    The development of techniques for neoclassical tearing mode (NTM) suppression or avoidance is crucial for successful high beta/high confinement tokamaks. Neoclassical tearing modes are islands destabilized and maintained by a helically perturbed bootstrap current and represent a significant limit to performance at higher poloidal beta. The confinement-degrading islands can be reduced or completely suppressed by precisely replacing the "missing" bootstrap current in the island O-point or by interfering with the fundamental helical harmonic of the pressure. Implementation of such techniques is being studied in the DIII-D tokamak [J. L. Luxon et al., Plasma Physics and Controlled Fusion Research (International Atomic Energy Agency, Vienna, 1987), Vol. 1, p. 159] in the presence of periodic q=1 sawtooth instabilities, a reactor relevant regime. Radially localized off-axis electron cyclotron current drive (ECCD) must be precisely located on the island. In DIII-D the plasma control system is put into a "search and suppress" mode to make either small rigid radial position shifts of the entire plasma (and thus the island) or small changes in the toroidal field (and, thus, the ECCD location) to find and lock onto the optimum position for complete island suppression by ECCD. This is based on real-time measurements of an m/n=3/2 mode amplitude dBθ/dt. The experiment represents the first use of active feedback control to provide continuous, precise positioning. An alternative to ECCD makes use of the six toroidal section "C-Coil" on DIII-D to provide a large nonresonant static m=1, n=3 helical field to interfere with the fundamental harmonic of an m/n=3/2 NTM. While experiments show success in inhibiting the NTM if a large enough n=3 field is applied before the island onset, there is a considerable plasma rotation decrease due to n=3 "ripple." © 2002 American Institute of Physics.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1063/1.1456066

    Articles: DFG German National Licenses
  5. 5
    Staff View
    ISSN:
    1089-7674
    Source:
    AIP Digital Archive
    Topics:
    Physics
    Notes:
    In DIII-D [J. L. Luxon and L. G. Davis, Fusion Technol. 8, 441 (1985)] tokamak plasmas with an internal transport barrier (ITB), the comparison of gyrokinetic linear stability (GKS) predictions with experiments in both low and strong negative magnetic shear plasmas provide improved understanding for electron thermal transport within the plasma. Within a limited region just inside the ITB, the electron temperature gradient (ETG) modes appear to control the electron temperature gradient and, consequently, the electron thermal transport. The increase in the electron temperaturegradient with more strongly negative magnetic shear is consistent with the increase in the ETG mode marginal gradient. Closer to the magnetic axis the Te profile flattens and the ETG modes are predicted to be stable. With additional core electron heating, FIR scattering measurements near the axis show the presence of high k fluctuations (12 cm−1), rotating in the electron diamagnetic drift direction. This turbulence could impact electron transport and possibly also ion transport. Thermal diffusivities for electrons, and to a lesser degree ions, increase. The ETG mode can exist at this wave number, but it is computed to be robustly stable near the axis. Consequently, in the plasmas we have examined, calculations of drift wave linear stability do not explain the observed transport near the axis in plasmas with or without additional electron heating, and there are probably other processes controling transport in this region. © 1999 American Institute of Physics.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1063/1.873494

    Articles: DFG German National Licenses
  6. 6
    Ikezi, H. ; Moeller, C. P. ; Doane, J. L. ; DiMartino, M. ; Lohr, J. ; Ponce, D. ; Callis, R. W.

    [S.l.] : American Institute of Physics (AIP)
    Published 1999
    Staff View
    ISSN:
    1089-7623
    Source:
    AIP Digital Archive
    Topics:
    Physics
    Electrical Engineering, Measurement and Control Technology
    Notes:
    We have built a millimeter wave polarimeter which measures wave polarization parameters: the polarization angle, and the ellipticity including field spin direction in an evacuated high-power system. The polarimeter was applied to diagnose the 1 MW level electron-cyclotron plasma heating system at 110 GHz for the DIII-D tokamak. We have observed the time-dependent behavior of the gyrotrons and have characterized and calibrated the high-power transmission system which consists of grooved mirror polarizers, miter bends, switches, and corrugated wave guides. This article describes the principle of operation and the design method of the polarimeter and the examples of measurements. © 1999 American Institute of Physics.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1063/1.1149701

    Articles: DFG German National Licenses
  7. 7
    LOHR, J.

    Oxford, UK : Blackwell Publishing Ltd
    Published 1969
    Staff View
    ISSN:
    1365-2478
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Geosciences
    Physics
    Notes:
    According to a study of seismic velocities in the Alpine Foreland of Eastern Switzerland, the initial velocity is rather high in comparison with other Tertiary basins and shows an exceptionally high increase rate. When analysing the average and the interval velocities, especially of Tertiary strata, and when comparing them with velocities of strata of the same age and a very similar facies of the Northern Rheintalgraben, it has been found that the increase of velocity is closely related to the distance to the Subalpine Molasse. The conclusion is that the velocity of the Tertiary strata is strongly influenced by the folding pressure of the Subalpine Molasse or of the Alps. The same method has been applied to a relatively large number of wells in the area of the “German Molasse”. Not only the results in Eastern Switzerland have been confirmed, but also it has been proved that the diagenesis of the Tertiary strata and, hence, their velocities are influenced only partially by the specific depth of the basin. Velocities increase towards the Folded Molasse or the Alps. Consequently they depend on lateral folding pressure, which decreases from west to east with the increasing width of the basin. The tertiary strata of the basin have been affected by lateral folding pressurefrom south to north. However, structures with lateral compression have not been discovered yet in the German Alpine Foreland.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1111/j.1365-2478.1969.tb02075.x

    Articles: DFG German National Licenses
  8. 8
    Staff View
    ISSN:
    0920-9964
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Medicine
    Type of Medium:
    Electronic Resource
    URL:
    http://linkinghub.elsevier.com/retrieve/pii/0920-9964(91)90348-U

    Articles: DFG German National Licenses
  9. 9
    Lohr, J. ; Klein, J. ; Webster, S.G. ; Dircksen, H.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    0305-0491
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Biology
    Chemistry and Pharmacology
    Type of Medium:
    Electronic Resource
    URL:
    http://linkinghub.elsevier.com/retrieve/pii/0305-0491(93)90200-O

    Articles: DFG German National Licenses
  10. 10
    Gentry, R. R. ; Rust, R. S. ; Lohr, J. A. ; Alford, B. A.
    Springer
    Published 1983
    Staff View
    ISSN:
    1432-1998
    Keywords:
    Infantile cortical hyperostosis ; Caffey's disease ; Periosteal proliferation
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Abstract Infantile cortical hyperostosis (ICH), or Caffey's disease, first reported by Caffey and Silverman in 1945, is a benign condition characterized radiographically by corticoperiosteal thickening of bone with subperiosteal new bone formation. Sites of occurrence vary, with the mandible being involved in 75%–80% of cases. The following is a case report of ICH limited to four contiguous ribs with no evidence of mandibular involvement.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF00973165

    Articles: DFG German National Licenses
  11. 11
    Staff View
    ISSN:
    1434-0879
    Keywords:
    Bacteriuria ; Urinary tract infection ; Neurogenic bladder
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Summary Bacteriuria and associated renal damage is common in children with a neurogenic bladder, but the pathogenesis of urinary tract infection (UTI) is undefined. We examined the association between periurethral bacterial colonization and the presence of urinary leukocytes in 76 catheter urine specimens from children with neurogenic bladders. Although all the children were asymptomatic, 38/76 (50%) of the urine cultures were positive. Periurethral colonization was significantly more common with positive than with negative urine cultures, suggesting a pathogenetic role for periurethral bacteria in infection of the neurogenic bladder. Urinary leukocytes were present in 24/38 (63%) with positive cultures, as against none (0/38) of those with negative urine cultures, and their presence represents a host response to bladder bacteriuria.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF00922749

    Articles: DFG German National Licenses
  12. 12
    Staff View
    ISSN:
    1432-2072
    Keywords:
    Key words Neuroleptic ; Antioxidant ; Cholinergic neurons ; Immunocytochemistry
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Abstract  Rationale: Investigators have postulated that neuroleptic medications may affect the motor system through the creation of free radicals. Also, structural brain changes related to oxidative damage may disrupt normal striatal function. Objective: The goals of this study were to examine whether an antioxidant diet reduced the abnormal movements caused by long-term neuroleptic exposure and to examine structural effects within specific striatal regions in rats. Methods: Rats were given a basal diet or a diet high in antioxidants for 4 months, and treated with 10 mg/kg fluphenazine decanoate or sesame seed oil IM every 2 weeks. At baseline and after treatment, head movements were quantified by accelerometry, and immunocytochemically stained cholinergic neurons in the ventrolateral, mediodorsal, and ventromedial regions of the striatum were quantified. Results: Rats treated with fluphenazine had significantly lower neuron densities than those that did not receive antioxidants. Rats exposed to a diet consisting of antioxidants had significantly higher neuron densities than those that did not receive antioxidants in each of the three regions tested. Rats treated with fluphenazine had a greater increase in the number of accelerometric peaks recorded per minute compared with untreated animals. The increase in the number of accelerometric peaks recorded per minute was lower for animals exposed to antioxidant diets compared with unexposed animals. Lastly, there was a significant correlation between the accelerometric peak change score and cholinergic neuron density in all three regions. Conclusions: Our results suggest that long-term neuroleptic treatment is associated with an increase in head movements and a reduction in ChAT-stained striatal cholinergic neurons and that these abnormalities are reduced by antioxidants.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/s002130050039

    Articles: DFG German National Licenses
  13. 13
    Wagner, P. K. ; Lohr, J. ; Rothmund, M.
    Springer
    Published 1984
    Staff View
    ISSN:
    1435-2451
    Keywords:
    Short-term antibiotic prophylaxis ; Single-dose ; Multiple-dose ; Elective colorectal surgery ; Cefotaxime ; Antibioticakurzzeitprophylaxe ; Einfachgabe ; Mehrfachgabe ; Elektive colorectale Eingriffe ; Cefotaxim
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Description / Table of Contents:
    Zusammenfassung In einer randomisierten Studie an 60 Patienten mit elektiven colorectalen Eingriffen wurde die Wirksamkeit der intravenösen Antibioticakurzzeitprophylaxe untersucht. Verglichen wurden Einmalgabe mit einer Mehrfachgabe innerhalb von 24 h, Testsubstanz war Cefotaxim. Die Wundinfektionsrate war in beiden Gruppen vergleichbar (16,6 bzw. 13,3%). Auch hinsichtlich der postoperativen Harnwegsinfekte war kein Unterschied nachweisbar (33,3 bzw. 23,3%). Die Ergebnisse dieser Studie zeigen, daß sich postoperative Infektionen nach elektiven colorectalen Eingriffen durch eine single-dose-Prophylaxe in demselben Ausmaß wie durch eine perioperative Mehrfachgabe von Antibiotica reduzieren lassen.
    Notes:
    Summary In a randomized trial in 60 patients undergoing elective colorectal surgery, the efficiency of intravenous short-term antibiotic prophylaxis was determined. We compared single-dose application with multiple-dose prophylaxis for 24 h. The substance used was cefotaxime. The rate of wound infections was comparable in both groups (16.6% vs 13.3%) as was the rate of postoperative infections of the urinary tract (33.3% vs 23.3%). The results of the study suggest that single-dose prophylaxis is as efficient as multiple-dose application to reduce postoperative infections in elective colorectal surgery.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF01823277

    Articles: DFG German National Licenses