Search Results - (Author, Cooperation:J. L. Chang)

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  1. 1
    Staff View
    Publication Date:
    2018-01-17
    Publisher:
    The American Association for Cancer Research (AACR)
    Print ISSN:
    1078-0432
    Electronic ISSN:
    1557-3265
    Topics:
    Medicine
    Published by:
    http://www.aacr.org/

    Latest Papers from Table of Contents or Articles in Press
  2. 2
    Staff View
    Publication Date:
    2014-08-30
    Publisher:
    American Association for the Advancement of Science (AAAS)
    Print ISSN:
    0036-8075
    Electronic ISSN:
    1095-9203
    Topics:
    Biology
    Chemistry and Pharmacology
    Computer Science
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Animals ; Animals, Domestic/anatomy & histology/*genetics/psychology ; Animals, Wild/anatomy & histology/*genetics/psychology ; Base Sequence ; Behavior, Animal ; Breeding ; Evolution, Molecular ; Gene Frequency ; Genetic Loci ; Genome/genetics ; Molecular Sequence Data ; Phenotype ; Polymorphism, Single Nucleotide ; Rabbits/anatomy & histology/*genetics/psychology ; Selection, Genetic ; Sequence Analysis, DNA
    Published by:
    http://www.aaas.org/

    Latest Papers from Table of Contents or Articles in Press
  3. 3
    Staff View
    Publication Date:
    2013-08-10
    Publisher:
    American Association for the Advancement of Science (AAAS)
    Print ISSN:
    0036-8075
    Electronic ISSN:
    1095-9203
    Topics:
    Biology
    Chemistry and Pharmacology
    Computer Science
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Administration, Intravenous ; Adult ; Animals ; Cytokines/immunology ; Female ; Humans ; Immunity, Cellular ; Malaria Vaccines/*administration & dosage/adverse effects/*immunology ; Malaria, Falciparum/*prevention & control ; Male ; Mice ; Plasmodium falciparum/*immunology ; Sporozoites/immunology ; T-Lymphocytes/immunology ; Vaccination/adverse effects/methods
    Published by:
    http://www.aaas.org/

    Latest Papers from Table of Contents or Articles in Press
  4. 4
    Plisch, M. J. ; Chang, J. L. ; Silcox, J. ; Buhrman, R. A.

    Woodbury, NY : American Institute of Physics (AIP)
    Published 2001
    Staff View
    ISSN:
    1077-3118
    Source:
    AIP Digital Archive
    Topics:
    Physics
    Notes:
    Analytical electron microscopy has been employed to characterize the localized physical and electronic structure of a Co/AlOx/Co magnetic tunnel junction. The tunnel barrier is amorphous alumina with an extensive conduction band tail due to disorder. Both barrier edges are Al terminated and an Al-rich layer exists at the bottom Co/AlOx interface. sp-d hybridization between interfacial Co and Al atoms is observed and it is likely that the interfacial Al is metallic. All of these features are expected to be important to the magnetoresistance behavior of the junction. © 2001 American Institute of Physics.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1063/1.1383569

    Articles: DFG German National Licenses
  5. 5
    Staff View
    ISSN:
    1432-8798
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Summary.  Previously, we found that the E5 protein can be expressed in HPV-16 infected precancerous lesions and cervical cancer [4]. In this study, we investigated the presence of sequence variants of E5 in HPV-16 infected tissues. Toward this end, we amplified the E5 gene by polymerase chain reaction from 29 HPV-16 infected tissues including eight normal tissues, seven high grade neoplastic tissues (high grade squamous intraepithelial lesions (HSIL) and 14 cervical cancer tissues. Sequence analysis demonstrated that there were three mutational hot spots at positions 3979, 4042, and 4077 of the HPV-16 DNA; these and other mutations resulted in six variants in the E5 sequence. This resulted in four E5 protein mutants, named WTE5 [wild type E5 protein], 14E5, 21E5 and 56E5. Functional analysis of these four mutant proteins revealed that the transforming activities of 14E5, 21E5 and 56E5 were 0.95, 0.59, and 0.89 fold of WTE5, respectively. Although E5 was expressed in all of the HSIL and cervical cancer tissues, but in only one of the eight normal tissues tested, only WT E5 protein was found in HSIL while in cervical cancer tissues both WT and mutant E5 proteins were detected. Since these E5 proteins exhibited the same in vitro transforming activity, these data suggest that expression of E5 is important in development and progression toward malignancy but mutation of E5 does not affect the transformation process.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/s007050070020

    Articles: DFG German National Licenses
  6. 6
    Annen, F. ; Chang, J.-L. ; Paterson, A. H. ; Stockhaus, J.
    Springer
    Published 1998
    Staff View
    ISSN:
    1617-4623
    Keywords:
    Key words C4 photosynthesis ; Mesophyll specific ; Protein kinase ; Signal transduction ; Sorghum bicolor
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Biology
    Notes:
    Abstract C4 photosynthesis is functionally dependent on metabolic interactions between mesophyll- and bundle-sheath cells. Although the C4 cycle is biochemically well understood, many aspects of the regulation of enzyme activities, gene expression and cell differentiation are elusive. Protein kinases are likely involved in these regulatory processes, providing links to hormonal, metabolic and developmental signal-transduction pathways. Here we describe the cloning and characterization of 14 different putative protein kinase leaf cDNA clones from the C4 plant Sorghum bicolor. These genes belong to three different protein kinase subfamilies: ribosomal protein S6 kinases, SNF1-like protein kinases, and receptor-like protein kinases. We report the partial cDNA sequences, mesophyll/bundle-sheath steady-state mRNA ratios, mesophyll/etiolated leaf steady-state mRNA ratios, and the positions of 14 protein kinase genes on the genetic map of S. bicolor. Only three of the protein kinase genes described here are expressed preferentially in mesophyll cells as compared with the bundle-sheath.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/s004380050795

    Articles: DFG German National Licenses
  7. 7
    Chang, J. L. C. ; Kwak, D. ; Rogers, S. E. ; Yang, R.-J.

    Chichester : Wiley-Blackwell
    Published 1988
    Staff View
    ISSN:
    0271-2091
    Keywords:
    Incompressible flow ; Navier-Stokes equations ; Finite differences ; Engineering ; Engineering General
    Source:
    Wiley InterScience Backfile Collection 1832-2000
    Topics:
    Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes:
    This paper discusses incompressible Navier-Stokes solution methods with an emphasis on the pseudocompressibility method. A steady-state flow solver based on the pseudocompressibility approach is then described. This flow solver code has been used to analyse the internal flow in the Space Shuttle main engine hot-gas manifold. Salient features associated with this three-dimensional realistic flow simulation are discussed. Numerical solutions relevant to the current engine analysis and the redesign effort are discussed along with experimental results. This example demonstrates the potential of computational fluid dynamics as a design tool for aerospace applications.
    Additional Material:
    14 Ill.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1002/fld.1650081011

    Articles: DFG German National Licenses