Search Results - (Author, Cooperation:J. Kitzman)
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1Latest Papers from Table of Contents or Articles in PressM. Meyer ; M. Kircher ; M. T. Gansauge ; H. Li ; F. Racimo ; S. Mallick ; J. G. Schraiber ; F. Jay ; K. Prufer ; C. de Filippo ; P. H. Sudmant ; C. Alkan ; Q. Fu ; R. Do ; N. Rohland ; A. Tandon ; M. Siebauer ; R. E. Green ; K. Bryc ; A. W. Briggs ; U. Stenzel ; J. Dabney ; J. Shendure ; J. Kitzman ; M. F. Hammer ; M. V. Shunkov ; A. P. Derevianko ; N. Patterson ; A. M. Andres ; E. E. Eichler ; M. Slatkin ; D. Reich ; J. Kelso ; S. Paabo
American Association for the Advancement of Science (AAAS)
Published 2012Staff ViewPublication Date: 2012-09-01Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Alleles ; Animals ; Base Sequence ; Fossils ; Gene Flow ; Gene Library ; *Genetic Variation ; Genome, Human/*genetics ; *Heterozygote ; Humans ; Molecular Sequence Data ; Neanderthals/*genetics ; Sequence Analysis, DNAPublished by: -
2Articles: DFG German National LicensesKitzman, J. V. ; Holley, J. H. ; Huber, W. G. ; Koritz, G. D. ; Davis, L. E. ; Neff-Davis, C. A. ; Bevill, R. F. ; Short, C. R. ; Barker, S. A. ; Hsieh, L. C.
Springer
Published 1990Staff ViewISSN: 1573-7446Keywords: channel catfish ; fenbendazole ; metabolism ; pharmacokineticsSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract Fenbendazole (FBZ) was administered intravenously (1 mg/kg) and orally (5 mg/kg) to catheterized, confined channel catfish. Blood samples were collected for 72 h, and resulting FBZ plasma concentrations were pharmacokinetically modelled. Following intravenous administration t1/2α was 0.51 h, t1/2β was 16.8 h, body clearance (C1b) was 0.0598 L/kg/h, and Vd (area) was 1.45 L/kg. After oral administration the t1/2 (abs) was 1.47 h, the t1/2β was 20.1 h, and the tlag was 0.1 h. Following oral administration of 5 mg FBZ/kg body weight, the following tissues and body fluids were sampled for concentrations of FBZ, oxfendazole (FBZ-SO), sulphone metabolite (FBZ-SO2) and hydroxy metabolite (FBZ-OH): liver, posterior kidney, fat, muscle, bowel contents and urine. Fenbendazole was detected in the highest concentrations in abdominal fat, whereas oxfendazole was found primarily in the kidney, liver and abdominal fat. The sulphone metabolite was detected only in urine and bowel contents, while the hydroxy metabolite was found most often in the liver and abdominal fat samples.Type of Medium: Electronic ResourceURL: