Search Results - (Author, Cooperation:J. Kawaguchi)
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1Latest Papers from Table of Contents or Articles in PressA. Tsuchiyama ; M. Uesugi ; T. Matsushima ; T. Michikami ; T. Kadono ; T. Nakamura ; K. Uesugi ; T. Nakano ; S. A. Sandford ; R. Noguchi ; T. Matsumoto ; J. Matsuno ; T. Nagano ; Y. Imai ; A. Takeuchi ; Y. Suzuki ; T. Ogami ; J. Katagiri ; M. Ebihara ; T. R. Ireland ; F. Kitajima ; K. Nagao ; H. Naraoka ; T. Noguchi ; R. Okazaki ; H. Yurimoto ; M. E. Zolensky ; T. Mukai ; M. Abe ; T. Yada ; A. Fujimura ; M. Yoshikawa ; J. Kawaguchi
American Association for the Advancement of Science (AAAS)
Published 2011Staff ViewPublication Date: 2011-08-27Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsPublished by: -
2Latest Papers from Table of Contents or Articles in PressK. Nagao ; R. Okazaki ; T. Nakamura ; Y. N. Miura ; T. Osawa ; K. Bajo ; S. Matsuda ; M. Ebihara ; T. R. Ireland ; F. Kitajima ; H. Naraoka ; T. Noguchi ; A. Tsuchiyama ; H. Yurimoto ; M. E. Zolensky ; M. Uesugi ; K. Shirai ; M. Abe ; T. Yada ; Y. Ishibashi ; A. Fujimura ; T. Mukai ; M. Ueno ; T. Okada ; M. Yoshikawa ; J. Kawaguchi
American Association for the Advancement of Science (AAAS)
Published 2011Staff ViewPublication Date: 2011-08-27Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsPublished by: -
3Latest Papers from Table of Contents or Articles in PressT. Nakamura ; T. Noguchi ; M. Tanaka ; M. E. Zolensky ; M. Kimura ; A. Tsuchiyama ; A. Nakato ; T. Ogami ; H. Ishida ; M. Uesugi ; T. Yada ; K. Shirai ; A. Fujimura ; R. Okazaki ; S. A. Sandford ; Y. Ishibashi ; M. Abe ; T. Okada ; M. Ueno ; T. Mukai ; M. Yoshikawa ; J. Kawaguchi
American Association for the Advancement of Science (AAAS)
Published 2011Staff ViewPublication Date: 2011-08-27Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsPublished by: -
4Latest Papers from Table of Contents or Articles in PressH. Yurimoto ; K. Abe ; M. Abe ; M. Ebihara ; A. Fujimura ; M. Hashiguchi ; K. Hashizume ; T. R. Ireland ; S. Itoh ; J. Katayama ; C. Kato ; J. Kawaguchi ; N. Kawasaki ; F. Kitajima ; S. Kobayashi ; T. Meike ; T. Mukai ; K. Nagao ; T. Nakamura ; H. Naraoka ; T. Noguchi ; R. Okazaki ; C. Park ; N. Sakamoto ; Y. Seto ; M. Takei ; A. Tsuchiyama ; M. Uesugi ; S. Wakaki ; T. Yada ; K. Yamamoto ; M. Yoshikawa ; M. E. Zolensky
American Association for the Advancement of Science (AAAS)
Published 2011Staff ViewPublication Date: 2011-08-27Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsPublished by: -
5Articles: DFG German National LicensesTamura, Y. ; Kawaguchi, J. ; Serizawa, N. ; Hirahara, K. ; Shiraishi, A. ; Nigi, H. ; Taniguchi, Y. ; Toda, M. ; Inouye, S. ; Takemori, T. ; Sakaguchi, M.
Oxford, UK : Blackwell Science Ltd
Published 2003Staff ViewISSN: 1365-2222Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Background Japanese cedar (Cryptomeria japonica; CJ) pollinosis has been reported to occur naturally in Japanese monkeys (Macaca fuscata) as well as in humans. Most human patients and monkeys with pollinosis have specific IgE for Cry j 2, a major allergen of CJ pollen.Objective The main purpose of this study was to identify IgE B cell epitopes of Cry j 2 using a synthetic peptide in humans, monkeys and mice.Methods We synthesized 38 overlapping peptides that span the entire length of Cry j 2. We examined the B cell epitopes of Cry j 2 that are recognized by IgE in the sera of human patients and monkeys with pollinosis and immunized mice using synthetic peptides of Cry j 2. We also examined the reaction of Cry j 2-specific mouse monoclonal IgG antibodies to the peptides. Furthermore, we conducted a histamine release assay with leucocytes from a pollinosis patient using human serum albumin (HSA) conjugated with the peptides as a B cell epitope.Results We found that 16 of the 20 pollinosis patients who had specific IgE to Cry j 2 also exhibited IgE reaction with some Cry j 2 peptides. Of these 16 patients, 10 exhibited IgE reaction with Cry j 2 peptide no. 13 (121GQCKWVNGREICNDRDRPTA140). Five of the seven monkeys with CJ pollinosis exhibited a reaction with peptide no. 13. Furthermore, IgE in mice immunized with Cry j 2 and two mouse monoclonal IgG antibodies reacted with peptide no. 13. Peptide no. 13-conjugated HSA showed the release of histamine from basophils. Furthermore, to determine the minimum epitope in peptide no. 13, we conducted an enzyme-linked immunosorbent assay inhibition test. The core of the epitope in humans, monkeys and mice was 124KWVNGREI131.Conclusion We found that 124KWVNGREI131 is an important B cell epitope recognized by IgE in humans, monkeys and mice.Type of Medium: Electronic ResourceURL: