Search Results - (Author, Cooperation:J. Hoffer)

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  1. 1
    Staff View
    Publication Date:
    2011-09-23
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Brain/metabolism/physiology ; Cell Cycle ; Cognition Disorders/*genetics ; Consanguinity ; DNA Mutational Analysis ; Exons/genetics ; Gene Regulatory Networks ; Genes, Essential/genetics ; Genes, Recessive/*genetics ; *High-Throughput Nucleotide Sequencing ; Homozygote ; Humans ; Intellectual Disability/*genetics ; Metabolic Networks and Pathways ; Mutation/genetics ; Organ Specificity ; Synapses/metabolism
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  2. 2
    Staff View
    Publication Date:
    2013-08-24
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Aging/*genetics/pathology ; Alleles ; Animals ; Brain/*abnormalities/growth & development/*metabolism ; Cell Nucleus/genetics ; DNA, Mitochondrial/*genetics ; Extrachromosomal Inheritance/*genetics ; Female ; Genome/genetics ; Heterozygote ; Litter Size ; Male ; Mice ; Mice, Inbred C57BL ; Mitochondria/*genetics ; Mutagenesis/genetics ; Mutation/*genetics ; Phenotype ; Reproduction/genetics/physiology ; Stochastic Processes
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  3. 3
    Cooke, D. W. ; Hoffer, J. K. ; Maez, M. ; Steyert, W. A. ; Heffner, R. H.

    [S.l.] : American Institute of Physics (AIP)
    Published 1986
    Staff View
    ISSN:
    1089-7623
    Source:
    AIP Digital Archive
    Topics:
    Physics
    Electrical Engineering, Measurement and Control Technology
    Notes:
    The design, construction, and operational characteristics of a continuous 3He–4He dilution refrigerator specifically built for use in muon spin relaxation ( μSR) measurements at LAMPF are described in this paper. The refrigerator is unique in that it makes an angle of 30° with respect to horizontal—a requirement imposed by the previously existing physical constraints of the μSR spectrometer. Additionally, the refrigerator and associated gas handling units are portable so as to facilitate ease of movement into and out of the muon beam. Typical parameters describing refrigerator performance are 60-mK base temperature with 22-μW cooling capacity at 100 mK.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1063/1.1138941

    Articles: DFG German National Licenses
  4. 4
    Obrist, Paul A. ; Light, Kathleen C. ; McCubbin, James A. ; Hutcheson, J. Stanford ; Hoffer, J. Lee

    Oxford, UK : Blackwell Publishing Ltd
    Published 1979
    Staff View
    ISSN:
    1469-8986
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Psychology
    Notes:
    The purpose of this research was to evaluate, in human subjects, the degree to which pulse transit time (PTT) covaries with systolic (SBP) and diastolic (DBP) blood pressure, and the degree to which PTT is sensitive to sympathetic influences on myocardial performance. Six studies were performed involving 118 young adult males. In all subjects, cardiovascular activity was assessed in both the resting state and during three stressors: the cold pressor, a pornographic movie and unsignaled shock avoidance reaction time task. The studies differed with respect to where on the arterial tree the pulse wave was transduced, whether blood pressure was measured invasively or noninvasively, and whether the myocardial sympathetic innervations were intact or not. It was observed that PTT covaried quite consistently with SBP but very inconsistently with DBP. The degree of covariation was influenced by the individual's reactivity and, with DBP, by the type of stress. PTT was appreciably influenced by myocardial sympathetic excitation and to a lesser degree by vascular processes. The use of PTT as an index of blood pressure and myocardial performance is discussed.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1111/j.1469-8986.1979.tb02993.x

    Articles: DFG German National Licenses
  5. 5
    Staff View
    ISSN:
    1573-7357
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Physics
    Notes:
    The constant-volume heat capacity of 4He has been measured at molar volumes from 20.45 to 29.71 cm3/mole in the temperature range from 0.3 to 4 K. The entropy has been obtained as a function of volume and temperature by extrapolation of the data to 0 K. The P-T equilibrium curves below 2 K were obtained from the volume dependence of the entropy in the two-phase regions. The V-T curves were obtained above 1.25 K by observation of heat capacity discontinuities at the phase boundaries and below 1.25 K from the equilibrium pressure-temperature data and the properties of the pure phases. The minimum in the melting pressure occurs at 0.774 K and is 8.04 × 10−3 atm below the 0 K value. The corresponding maxima in the molar volumes of the solid and liquid were also determined. In the bcc phase (∂S/∂V) T and (∂C v /∂V) T are everywhere positive. Both the temperature and volume dependence of the heat capacity are similar to those of bcc 3He, in the very limited ranges of volume and temperature in which the phase could be studied. An unexpected rise in heat capacity in the 20 mK interval below the melting temperature was observed.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF00117245

    Articles: DFG German National Licenses
  6. 6
    Staff View
    ISSN:
    1573-7357
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Physics
    Notes:
    Abstract The response of the superfluid film velocityv to varying driving force is measured from 1 to 2.12 K using gravitational film flow between bulk reservoirs. Data on the reservoir level vs. time are analyzed and compared with four intrinsic dissipation models and can be best fit, to within 0.5%, by the formdv/dt∝−ν(T) exp [−v b (T)/v], where ν(T) andv b (T) are phenomenological parameters. Previous intrinsic dissipation measurements are critically reviewed. New indirect evidence for kinetic thinning of the film is found in 0.5% distortions in the thermally damped oscillations of the reservoir levels. Topics in potential flow damping are discussed.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF00657166

    Articles: DFG German National Licenses
  7. 7
    Hoffer, J. A. ; Loeb, G. E.
    Springer
    Published 1980
    Staff View
    ISSN:
    1573-9686
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Technology
    Notes:
    Abstract The past ten years have witnessed the introduction of several new methods for chronic recording of electrical activity in peripheral nerves, single nerve fibers and muscles, and for monitoring mechanical events correlated with muscular action. Although these methods were developed as research tools in the study of movements of unrestrained, intact animals, such implantable interfaces with nerve and muscle also promise to be of value in clinical applications; some novel clinical efforts are already being pursued. A review is given of various new techniques that may be clinically applicable and the issues of surgical constraints, quality of signal isolation, and long-term reliability of implantable devices, which ultimately determine the usefulness of each method, are discussed. Experimental devices reviewed include nerve cuff electrodes, floating single-unit electrodes, EMG electrodes, length gauges, and force gauges. General considerations for potential clinical applications are then given.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF02363438

    Articles: DFG German National Licenses
  8. 8
    Hoffer, J. Lee ; Norfleet, Edward A.
    Springer
    Published 1996
    Staff View
    ISSN:
    1573-2614
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Computer Science
    Medicine
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF02078142

    Articles: DFG German National Licenses