Search Results - (Author, Cooperation:J. Haanen)
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1Latest Papers from Table of Contents or Articles in PressC. Sun ; L. Wang ; S. Huang ; G. J. Heynen ; A. Prahallad ; C. Robert ; J. Haanen ; C. Blank ; J. Wesseling ; S. M. Willems ; D. Zecchin ; S. Hobor ; P. K. Bajpe ; C. Lieftink ; C. Mateus ; S. Vagner ; W. Grernrum ; I. Hofland ; A. Schlicker ; L. F. Wessels ; R. L. Beijersbergen ; A. Bardelli ; F. Di Nicolantonio ; A. M. Eggermont ; R. Bernards
Nature Publishing Group (NPG)
Published 2014Staff ViewPublication Date: 2014-03-29Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Antineoplastic Agents/*administration & dosage/*pharmacology ; Cell Aging/drug effects ; Cell Proliferation/drug effects ; Drug Resistance, Neoplasm/drug effects/genetics ; Female ; Flow Cytometry ; Gene Expression Regulation, Neoplastic/drug effects ; Gene Library ; Humans ; Indoles/administration & dosage/pharmacology ; Melanoma/*drug therapy/enzymology/genetics/pathology ; Mice ; Mitogen-Activated Protein Kinase Kinases/antagonists & inhibitors/metabolism ; Protein Kinase Inhibitors/*administration & dosage/*pharmacology ; Proto-Oncogene Proteins B-raf/antagonists & inhibitors/*genetics/metabolism ; RNA, Small Interfering ; Receptor Protein-Tyrosine Kinases/biosynthesis/genetics/metabolism ; Receptor, Epidermal Growth Factor/biosynthesis/genetics/metabolism ; Receptor, Platelet-Derived Growth Factor beta/biosynthesis/genetics/metabolism ; SOXE Transcription Factors/deficiency/genetics ; Signal Transduction/drug effects ; Sulfonamides/administration & dosage/pharmacology ; Transforming Growth Factor beta/metabolism/pharmacologyPublished by: -
2Articles: DFG German National LicensesHAANEN, J. B. A. G. ; OTTENHOFF, T. H. M. ; VOORDOUW, A. ; ELFERINK, B. G. ; KLATSER, P. R. ; SPITS, H. ; VRIES, R. R. P.
Oxford, UK : Blackwell Publishing Ltd
Published 1986Staff ViewISSN: 1365-3083Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: This report describes an effective method for the cloning of Mycobacterium leprae reactive T lymphocytes with Epstein-Barr-virus transformed autologous B cells as antigen-presenting cells- The two advantages of this method are that it drastically reduces the number of autologous peripheral blood mononuclear cells I (〈107 cells) needed to obtain and propagate these T-cell clones (TLC). and that it enables us to expand individual TLC to large numbers of cells (〈108) Thus she major obstacles for the cloning of T lymphocytes-especially important with regard to patients-are bypassed. Thus far. TLC Srom three leprosy patients have been established. These TLC are HLA class H restricted in their M. leprae directed response. A marked enhancement in antigen responsiveness was observed after further expansion of several TLC. some of which turned from nonresponder into responder TLC, Four tested TLC display strikingly different antigen recognition patterns when tested against a number of other mycobacterial antigens: one T.LC so far recognizes only M leprae antigens.Type of Medium: Electronic ResourceURL: