Search Results - (Author, Cooperation:J. H. Tobias)

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  1. 1
    H. F. Zheng ; V. Forgetta ; Y. H. Hsu ; K. Estrada ; A. Rosello-Diez ; P. J. Leo ; C. L. Dahia ; K. H. Park-Min ; J. H. Tobias ; C. Kooperberg ; A. Kleinman ; U. Styrkarsdottir ; C. T. Liu ; C. Uggla ; D. S. Evans ; C. M. Nielson ; K. Walter ; U. Pettersson-Kymmer ; S. McCarthy ; J. Eriksson ; T. Kwan ; M. Jhamai ; K. Trajanoska ; Y. Memari ; J. Min ; J. Huang ; P. Danecek ; B. Wilmot ; R. Li ; W. C. Chou ; L. E. Mokry ; A. Moayyeri ; M. Claussnitzer ; C. H. Cheng ; W. Cheung ; C. Medina-Gomez ; B. Ge ; S. H. Chen ; K. Choi ; L. Oei ; J. Fraser ; R. Kraaij ; M. A. Hibbs ; C. L. Gregson ; D. Paquette ; A. Hofman ; C. Wibom ; G. J. Tranah ; M. Marshall ; B. B. Gardiner ; K. Cremin ; P. Auer ; L. Hsu ; S. Ring ; J. Y. Tung ; G. Thorleifsson ; A. W. Enneman ; N. M. van Schoor ; L. C. de Groot ; N. van der Velde ; B. Melin ; J. P. Kemp ; C. Christiansen ; A. Sayers ; Y. Zhou ; S. Calderari ; J. van Rooij ; C. Carlson ; U. Peters ; S. Berlivet ; J. Dostie ; A. G. Uitterlinden ; S. R. Williams ; C. Farber ; D. Grinberg ; A. Z. LaCroix ; J. Haessler ; D. I. Chasman ; F. Giulianini ; L. M. Rose ; P. M. Ridker ; J. A. Eisman ; T. V. Nguyen ; J. R. Center ; X. Nogues ; N. Garcia-Giralt ; L. L. Launer ; V. Gudnason ; D. Mellstrom ; L. Vandenput ; N. Amin ; C. M. van Duijn ; M. K. Karlsson ; O. Ljunggren ; O. Svensson ; G. Hallmans ; F. Rousseau ; S. Giroux ; J. Bussiere ; P. P. Arp ; F. Koromani ; R. L. Prince ; J. R. Lewis ; B. L. Langdahl ; A. P. Hermann ; J. E. Jensen ; S. Kaptoge ; K. T. Khaw ; J. Reeve ; M. M. Formosa ; A. Xuereb-Anastasi ; K. Akesson ; F. E. McGuigan ; G. Garg ; J. M. Olmos ; M. T. Zarrabeitia ; J. A. Riancho ; S. H. Ralston ; N. Alonso ; X. Jiang ; D. Goltzman ; T. Pastinen ; E. Grundberg ; D. Gauguier ; E. S. Orwoll ; D. Karasik ; G. Davey-Smith ; A. V. Smith ; K. Siggeirsdottir ; T. B. Harris ; M. C. Zillikens ; J. B. van Meurs ; U. Thorsteinsdottir ; M. T. Maurano ; N. J. Timpson ; N. Soranzo ; R. Durbin ; S. G. Wilson ; E. E. Ntzani ; M. A. Brown ; K. Stefansson ; D. A. Hinds ; T. Spector ; L. A. Cupples ; C. Ohlsson ; C. M. Greenwood ; R. D. Jackson ; D. W. Rowe ; C. A. Loomis ; D. M. Evans ; C. L. Ackert-Bicknell ; A. L. Joyner ; E. L. Duncan ; D. P. Kiel ; F. Rivadeneira ; J. B. Richards
    Nature Publishing Group (NPG)
    Published 2015
    Staff View
    Publication Date:
    2015-09-15
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Animals ; Bone Density/*genetics ; Bone and Bones/metabolism ; Disease Models, Animal ; Europe/ethnology ; European Continental Ancestry Group/genetics ; Exome/genetics ; Female ; Fractures, Bone/*genetics ; Gene Frequency/genetics ; Genetic Predisposition to Disease/genetics ; Genetic Variation/genetics ; Genome, Human/*genetics ; Genomics ; Genotype ; Homeodomain Proteins/*genetics ; Humans ; Mice ; Sequence Analysis, DNA ; Wnt Proteins/genetics
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  2. 2
    N. D. Loh ; C. Y. Hampton ; A. V. Martin ; D. Starodub ; R. G. Sierra ; A. Barty ; A. Aquila ; J. Schulz ; L. Lomb ; J. Steinbrener ; R. L. Shoeman ; S. Kassemeyer ; C. Bostedt ; J. Bozek ; S. W. Epp ; B. Erk ; R. Hartmann ; D. Rolles ; A. Rudenko ; B. Rudek ; L. Foucar ; N. Kimmel ; G. Weidenspointner ; G. Hauser ; P. Holl ; E. Pedersoli ; M. Liang ; M. S. Hunter ; L. Gumprecht ; N. Coppola ; C. Wunderer ; H. Graafsma ; F. R. Maia ; T. Ekeberg ; M. Hantke ; H. Fleckenstein ; H. Hirsemann ; K. Nass ; T. A. White ; H. J. Tobias ; G. R. Farquar ; W. H. Benner ; S. P. Hau-Riege ; C. Reich ; A. Hartmann ; H. Soltau ; S. Marchesini ; S. Bajt ; M. Barthelmess ; P. Bucksbaum ; K. O. Hodgson ; L. Struder ; J. Ullrich ; M. Frank ; I. Schlichting ; H. N. Chapman ; M. J. Bogan
    Nature Publishing Group (NPG)
    Published 2012
    Staff View
    Publication Date:
    2012-06-29
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Aerosols/*analysis/*chemistry ; Amino Acids/chemistry ; Electrons ; *Fractals ; Lasers ; *Mass Spectrometry ; *Motion ; Nanoparticles ; Particle Size ; Proteins/chemistry ; Solvents/chemistry ; Soot/*analysis/*chemistry ; Vibration ; X-Ray Diffraction
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  3. 3
    Tobias, J. H. ; Sasi, M. R. ; Greenwood, R. ; Probert, C. S. J.

    Oxford, UK : Blackwell Science Ltd
    Published 2004
    Staff View
    ISSN:
    1365-2036
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Notes:
    Background : Uncertainty over whether corticosteroids cause bone loss in patients with Crohn's disease may reflect their short, intermittent use.Aim : We investigated whether a 2-month course of prednisolone is associated with detectable bone loss.Methods : Fifteen patients with active Crohn's disease and 19 controls with inactive Crohn's disease were recruited. Bone mineral density of the lumbar spine and hip was measured at baseline and 2 and 8 months.Results : At 2 months, significant bone loss was found in patients with active disease (femoral neck −2.7%, P 〈 0.002; Ward's triangle −3.9%, P 〈 0.01). Although bone mineral density was still lower at 8 months, these differences were no longer significant (−1.3% and −3.4%, femoral neck and Ward's triangle, respectively). No significant change in hip bone mineral density was observed in controls. Previous corticosteroid use was not significantly associated with baseline bone mineral density, although significant independent associations were observed between weight, site of disease and lumbar spine bone mineral density, and between dietary calcium deficiency and femoral neck and Ward's triangle bone mineral density.Conclusion : Significant bone loss at the hip can be detected in patients receiving corticosteroid treatment for 2 months for active Crohn's disease ; however, it remains unclear whether this is because of disease activity or its treatment. This rapid bone loss may represent a risk factor for fracture and justify bone protective therapy.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1111/j.1365-2036.2004.02207.x

    Articles: DFG German National Licenses
  4. 4
    Tobias, J. H. ; Laversuch, C. V. ; Wilson, N. ; Robins, S. P.
    Springer
    Published 1996
    Staff View
    ISSN:
    1432-0827
    Keywords:
    Key Words: Neridronate, Bisphosphonate, Deoxpyridinoline, Collagen Crosslink
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Biology
    Medicine
    Physics
    Notes:
    SUMMARY ELISAs for measuring the urinary excretion of collagen crosslinks and related peptides appear to show marked differences in sensitivity to anti-resorptive therapy. This presumably reflects variations in specificity of the anylate being detected in these assays, and the way in which they respond to treatment. To clarify these points, we used HPLC analysis to assess the effect of four weeks treatment with the amino-bisphosponate, neridronate, on free and peptide-bound fractions of the collagen cross-links deoxypyridinoline (Dpd) and pyridinoline (Pyd). Six postmenopausal women, in whom two hour morning urine samples were obtained at baseline (x2), and one, two and four weeks after commencing treatment, were included. We found that neridronate had relatively little effect on peptide-bound or free urinary Pyd, but markedly reduced peptide-bound urinary Dpd. However, urinary excretion of free Dpd was not significantly affected. As a consequence of these differential effects on collagen cross-link excretion, neridronate led to a striking increase in the free/total Dpd ratio, and in the peptide-bound Pyd/Dpd ratio. We conclude that neridronate, and presumably other bisphosphonates, selectively suppresses peptide-bound Dpd excretion, possibly reflecting altered processing of collagen crosslinks released during bone resorption.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/s002239900148

    Articles: DFG German National Licenses