Search Results - (Author, Cooperation:J. Gorman)
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1Dylan J Gorman, Boerge Hemmerling, Eli Megidish, Soenke A. Moeller, Philipp Schindler, Mohan Sarovar, and Hartmut Haeffner
American Physical Society (APS)
Published 2018Staff ViewPublication Date: 2018-03-09Publisher: American Physical Society (APS)Electronic ISSN: 2160-3308Topics: PhysicsPublished by: -
2J. B. Munro ; J. Gorman ; X. Ma ; Z. Zhou ; J. Arthos ; D. R. Burton ; W. C. Koff ; J. R. Courter ; A. B. Smith, 3rd ; P. D. Kwong ; S. C. Blanchard ; W. Mothes
American Association for the Advancement of Science (AAAS)
Published 2014Staff ViewPublication Date: 2014-10-10Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Antibodies, Neutralizing/immunology ; Antigens, CD4/immunology ; Fluorescence Resonance Energy Transfer/methods ; HIV Envelope Protein gp120/*chemistry/immunology ; HIV-1/*chemistry/immunology ; Humans ; *Immune Evasion ; Ligands ; Models, Chemical ; Molecular Imaging/methods ; Protein Multimerization ; Protein Structure, Tertiary ; Virion/*chemistry/immunologyPublished by: -
3R. Kong ; K. Xu ; T. Zhou ; P. Acharya ; T. Lemmin ; K. Liu ; G. Ozorowski ; C. Soto ; J. D. Taft ; R. T. Bailer ; E. M. Cale ; L. Chen ; C. W. Choi ; G. Y. Chuang ; N. A. Doria-Rose ; A. Druz ; I. S. Georgiev ; J. Gorman ; J. Huang ; M. G. Joyce ; M. K. Louder ; X. Ma ; K. McKee ; S. O'Dell ; M. Pancera ; Y. Yang ; S. C. Blanchard ; W. Mothes ; D. R. Burton ; W. C. Koff ; M. Connors ; A. B. Ward ; P. D. Kwong ; J. R. Mascola
American Association for the Advancement of Science (AAAS)
Published 2016Staff ViewPublication Date: 2016-05-14Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsPublished by: -
4J. S. McLellan ; M. Pancera ; C. Carrico ; J. Gorman ; J. P. Julien ; R. Khayat ; R. Louder ; R. Pejchal ; M. Sastry ; K. Dai ; S. O'Dell ; N. Patel ; S. Shahzad-ul-Hussan ; Y. Yang ; B. Zhang ; T. Zhou ; J. Zhu ; J. C. Boyington ; G. Y. Chuang ; D. Diwanji ; I. Georgiev ; Y. D. Kwon ; D. Lee ; M. K. Louder ; S. Moquin ; S. D. Schmidt ; Z. Y. Yang ; M. Bonsignori ; J. A. Crump ; S. H. Kapiga ; N. E. Sam ; B. F. Haynes ; D. R. Burton ; W. C. Koff ; L. M. Walker ; S. Phogat ; R. Wyatt ; J. Orwenyo ; L. X. Wang ; J. Arthos ; C. A. Bewley ; J. R. Mascola ; G. J. Nabel ; W. R. Schief ; A. B. Ward ; I. A. Wilson ; P. D. Kwong
Nature Publishing Group (NPG)
Published 2011Staff ViewPublication Date: 2011-11-25Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: AIDS Vaccines/chemistry/immunology ; Amino Acid Motifs ; Amino Acid Sequence ; Antibodies, Neutralizing/chemistry/*immunology ; Antibody Affinity/immunology ; Antibody Specificity/*immunology ; Antigen-Antibody Complex/chemistry/immunology ; Binding Sites, Antibody/immunology ; Conserved Sequence ; Crystallography, X-Ray ; Epitopes/chemistry/immunology ; Glycopeptides/chemistry/immunology ; Glycosylation ; HIV Antibodies/chemistry/*immunology ; HIV Envelope Protein gp120/*chemistry/*immunology ; HIV-1/*chemistry/*immunology ; Hydrogen Bonding ; Immune Evasion ; Models, Molecular ; Molecular Sequence Data ; Polysaccharides/chemistry/immunology ; Protein Structure, Quaternary ; Protein Structure, TertiaryPublished by: -
5M. Pancera ; T. Zhou ; A. Druz ; I. S. Georgiev ; C. Soto ; J. Gorman ; J. Huang ; P. Acharya ; G. Y. Chuang ; G. Ofek ; G. B. Stewart-Jones ; J. Stuckey ; R. T. Bailer ; M. G. Joyce ; M. K. Louder ; N. Tumba ; Y. Yang ; B. Zhang ; M. S. Cohen ; B. F. Haynes ; J. R. Mascola ; L. Morris ; J. B. Munro ; S. C. Blanchard ; W. Mothes ; M. Connors ; P. D. Kwong
Nature Publishing Group (NPG)
Published 2014Staff ViewPublication Date: 2014-10-09Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: AIDS Vaccines/chemistry/immunology ; Amino Acid Sequence ; Antibodies, Neutralizing/immunology ; Cohort Studies ; Crystallography, X-Ray ; Genetic Variation ; Glycosylation ; HIV Antibodies/immunology ; HIV Envelope Protein gp120/*chemistry/genetics/*immunology ; HIV Envelope Protein gp41/*chemistry/genetics/*immunology ; HIV Infections/immunology ; Humans ; Immune Evasion ; Membrane Fusion ; Models, Molecular ; Molecular Sequence Data ; Polysaccharides/chemistry/immunology ; Protein Multimerization ; Protein Structure, Quaternary ; Protein Subunits/chemistry/genetics/immunology ; Structural Homology, Protein ; Virus InternalizationPublished by: -
6J. J. Mintzes ; A. Canas ; J. Coffey ; J. Gorman ; L. Gurley ; R. Hoffman ; S. Y. McGuire ; N. Miller ; B. Moon ; J. Trifone ; J. H. Wandersee
American Association for the Advancement of Science (AAAS)
Published 2011Staff ViewPublication Date: 2011-10-29Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Biological Science Disciplines/*education ; Humans ; *Learning ; *MemoryPublished by: -
7M. R. Gardner ; L. M. Kattenhorn ; H. R. Kondur ; M. von Schaewen ; T. Dorfman ; J. J. Chiang ; K. G. Haworth ; J. M. Decker ; M. D. Alpert ; C. C. Bailey ; E. S. Neale, Jr. ; C. H. Fellinger ; V. R. Joshi ; S. P. Fuchs ; J. M. Martinez-Navio ; B. D. Quinlan ; A. Y. Yao ; H. Mouquet ; J. Gorman ; B. Zhang ; P. Poignard ; M. C. Nussenzweig ; D. R. Burton ; P. D. Kwong ; M. Piatak, Jr. ; J. D. Lifson ; G. Gao ; R. C. Desrosiers ; D. T. Evans ; B. H. Hahn ; A. Ploss ; P. M. Cannon ; M. S. Seaman ; M. Farzan
Nature Publishing Group (NPG)
Published 2015Staff ViewPublication Date: 2015-02-25Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: AIDS Vaccines/genetics/immunology ; Animals ; Antibodies, Neutralizing/immunology ; Antigens, CD4/genetics/*immunology ; CCR5 Receptor Antagonists/immunology ; Dependovirus/*genetics ; Female ; Genetic Therapy ; HIV Antibodies/immunology ; HIV-1/immunology ; HIV-2/immunology ; Immunoglobulins/genetics/*immunology ; Macaca mulatta ; Male ; Neutralization Tests ; Receptors, CCR5/metabolism ; Simian Acquired Immunodeficiency Syndrome/*immunology/*prevention & ; control/virology ; Simian Immunodeficiency Virus/*immunology ; *Virus InternalizationPublished by: -
8N. A. Doria-Rose ; C. A. Schramm ; J. Gorman ; P. L. Moore ; J. N. Bhiman ; B. J. DeKosky ; M. J. Ernandes ; I. S. Georgiev ; H. J. Kim ; M. Pancera ; R. P. Staupe ; H. R. Altae-Tran ; R. T. Bailer ; E. T. Crooks ; A. Cupo ; A. Druz ; N. J. Garrett ; K. H. Hoi ; R. Kong ; M. K. Louder ; N. S. Longo ; K. McKee ; M. Nonyane ; S. O'Dell ; R. S. Roark ; R. S. Rudicell ; S. D. Schmidt ; D. J. Sheward ; C. Soto ; C. K. Wibmer ; Y. Yang ; Z. Zhang ; J. C. Mullikin ; J. M. Binley ; R. W. Sanders ; I. A. Wilson ; J. P. Moore ; A. B. Ward ; G. Georgiou ; C. Williamson ; S. S. Abdool Karim ; L. Morris ; P. D. Kwong ; L. Shapiro ; J. R. Mascola
Nature Publishing Group (NPG)
Published 2014Staff ViewPublication Date: 2014-03-05Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: AIDS Vaccines/chemistry/immunology ; Amino Acid Sequence ; Antibodies, Neutralizing/chemistry/genetics/*immunology/isolation & purification ; Antibody Affinity/genetics/immunology ; Antigens, CD4/immunology/metabolism ; B-Lymphocytes/cytology/immunology/metabolism ; Binding Sites/immunology ; Cell Lineage ; Complementarity Determining Regions/chemistry/genetics/immunology ; Epitope Mapping ; Epitopes, B-Lymphocyte/chemistry/immunology ; Evolution, Molecular ; HIV Antibodies/chemistry/genetics/*immunology/isolation & purification ; HIV Envelope Protein gp160/*chemistry/*immunology ; HIV Infections/immunology ; HIV-1/chemistry/immunology ; Humans ; Models, Molecular ; Molecular Sequence Data ; Neutralization Tests ; Protein Structure, Tertiary ; Somatic Hypermutation, Immunoglobulin/geneticsPublished by: -
9Staff View
ISSN: 1573-2630Keywords: blindness prevention ; ocular hypertension control ; primary open angle glaucoma ; cost-benefit analysis ; epidemiologySource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract From a case-control study we have quantified the effect (relative risk) of presenting intraocular pressure on visual field loss in primary open angle glaucoma. We found this effect to be modified by both age and sex. Using these effect values we have estimated the potential for prevention of glaucomatous blindness in clinical and community settings. The clinical, public health, and research implications of these findings and estimates are discussed.Type of Medium: Electronic ResourceURL: -
10Staff View
ISSN: 1573-2630Keywords: epidemiology ; primary open angle glaucoma ; decision making ; computerised clinical records ; sensitivity-specificity trade off curveSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract We have described the epidemiological analysis of one aspect of the King's College Hospital computerised data base; namely initial intraocular pressure as an indicator of visual field loss. The methods involved the use of the four-fold table to determine sensitivity and specificity at different pressure levels. From these results (1) the changes in the pre and post test probability of field loss are calculated and (2) a ‘sensitivity/specificity trade off curve’ or ‘decision curve’ is constructed. In this way the optimal ‘cut-off level’ or ‘operating point’ for a population of specific type and composition can be determined. The factors concerned in decision making are always complex but such an approach allows a rational and quantifiable alternative to reliance on clinical impression and intuition. The results have significance in relation to decisions on the management of patients and on population screening programmes for glaucoma.Type of Medium: Electronic ResourceURL: -
11Kugel, H. W. ; Gorman, J. ; Kaita, R. ; Munsat, T.
[S.l.] : American Institute of Physics (AIP)
Published 1999Staff ViewISSN: 1089-7623Source: AIP Digital ArchiveTopics: PhysicsElectrical Engineering, Measurement and Control TechnologyNotes: A simple low velocity boron micro-pellet injector has been under development for Current Drive Experiment Upgrade (CDX-U) spherical torus edge and core impurity transport measurements, and wall conditioning. The injector consists of 16 barrels on a rotatable turret. Each barrel can be loaded with boron powder particles of diameters ranging from 1 to 40 μm diameter in amounts ranging from less than 0.25 mg to more than 2 mg. A selected barrel is manually rotated into firing position using a vacuum precision rotary/linear motion feedthrough. A piezoelectric valve gas feed system triggered by CDX-U discharge timing is used to control H2 or D2 propellant gas at a cylinder pressure of 5.8×10−3 Pa (40 psi) or less. The injector barrel-to-CDX-U plasma edge distance is 0.47 m. Initial low mass injections of neutral boron beams were performed into CDX-U plasmas at a velocity of 23 m/s. Measurements were obtained with a filtered gated charge coupled device TV camera, bolometry, visible spectroscopy, and ultrasoft x-ray diagnostics. This work is in support of the present CDX-U research program and possible applications on National Spherical Torus Experiment. © 1999 American Institute of Physics.Type of Medium: Electronic ResourceURL: -
12Hsuan, H. ; Bitter, M. ; Ayers, W. M. ; Gorman, J. ; Hill, K. W. ; Manos, D. ; Schwarzmann, J. D. ; Smith, A. ; Timberlake, J.
[S.l.] : American Institute of Physics (AIP)
Published 1995Staff ViewISSN: 1089-7623Source: AIP Digital ArchiveTopics: PhysicsElectrical Engineering, Measurement and Control TechnologyNotes: Reduction of indigenous metal impurities in tokamak plasmas and impurity requirements for the x-ray diagnosis of central plasma parameters necessitates artificial introduction of metal atoms. A new inexpensive method is described using ferrocene, Fe(C5H5)2, a substance which sublimes. A prototype device was tested at the Atomic-Beam Facility at PPPL. Ferrocene was injected into a pulsed helium plasma with an electron density of 2×1013 cm−3 and an electron temperature of 5 eV. The injected amount of ferrocene was controlled by varying the sublimation temperature in the range from 70 to 150 °C and adjusting the pulse length of a solenoid valve; the resulting iron atom concentration in the plasma was determined by monitoring the intensity of the Fe line at 5269 A(ring). The device and the test results are presented. © 1995 American Institute of Physics.Type of Medium: Electronic ResourceURL: -
13SLOAN, R. P. ; SHAPIRO, P. A. ; BAGIELLA, E. ; GORMAN, J. M. ; BIGGER, J. T.
Oxford, UK : Blackwell Publishing Ltd
Published 1995Staff ViewISSN: 1469-8986Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicinePsychologyNotes: Central to the psychophysiologic reactivity hypothesis of the etiology of coronary artery disease is the assumption that reactivity is an individual characteristic that is stable over time. Although heart rate (HR) and blood pressure reactivity appear to meet this criterion, temporal stability of cardiac autonomic control as measured by analysis of heart period variability (HPV) has not been assessed. In this study, we tested the stability of HPV, measured in both the time and frequency domain, during a quiet, resting baseline and in response to 5-min mental arithmetic and reaction time tasks, in 20 normal subjects measured in three testing sessions during a 9-month period. Stability, assessed by the intraclass correlation coefficient (ICC), was excellent for resting baseline measures of HR and HPV, with ICCs of 0.68–0.86. However, HR and HPV reactivity to either arithmetic or reaction time tasks generally was less stable, with ICCs of 0.17–0.73, in contrast to results of previous studies demonstrating long-term Stability of HR responses to psychological challenge. Stability of aggregated reactivity scores was only slightly improved. Whether for individual tasks or aggregated measures, reactivity of total and low-frequency measures of HPV was moderately stable but stability of high-frequency HPV reactivity was poor.Type of Medium: Electronic ResourceURL: -
14SLOAN, R. P. ; SHAPIRO, P. A. ; BAGIELLA, E. ; FISHKIN, P. E. ; GORMAN, J. M. ; MYERS, M. M.
Oxford, UK : Blackwell Publishing Ltd
Published 1995Staff ViewISSN: 1469-8986Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicinePsychologyNotes: Theories that psychophysiological reactivity constitutes a risk factor for coronary artery disease assume that reactivity is a consistent individual characteristic. We tested this assumption by measuring reactivity to three psychologically challenging tasks performed by 22 healthy subjects across different autonomic contexts produced by positional change. Dependent variables included heart rate (HR), low-frequency (LF; 0.04–0.15 Hz) and high-frequency (HF; 0.15–0.50Hz) heart period variability, and the LF/HF ratio. HR (r= .44, p 〈 .05) and LF/HF ratio (r= .48, p= .03) reactivity were modestly correlated across the different autonomic contexts, but HF and LF power reactivity were not. These findings suggest that HR reactivity to psychological challenge is a modestly consistent characteristic of individuals, despite differences in autonomic context. Although the same is true of cardiac sympathovagal balance, reactivity of HF and LF power were less consistent.Type of Medium: Electronic ResourceURL: -
15Staff View
ISSN: 1467-9248Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: Political ScienceType of Medium: Electronic ResourceURL: -
16Staff View
ISSN: 1750-3841Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, NutritionProcess Engineering, Biotechnology, Nutrition TechnologyNotes: The thermodynamic stability constants for ferric and ferrous ascorbate complexes, change in net redox potential with pH, and efficacy of bathophenanthroline as an iron reagent in the presence of ascorbate were determined. The stability constants for the ferric and ferrous ascorbate complexes were found to be in the range 1.90 × 103 to 2.61 × 104 and 7.69 × 10-3 to 6.95 × 10-2, respectively. The stability of ferric ascorbate over a wide range of pH values suggests its potential use as an iron additive in foods. Redox potential decreased with an increase in pH. Bathophenanthroline analysis of these solutions for free iron proved to have limitations in the presence of ascorbate.Type of Medium: Electronic ResourceURL: -
17Staff View
ISSN: 0006-291XSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyPhysicsType of Medium: Electronic ResourceURL: -
18Staff View
ISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] IN considerations of polymorphisms in man, a pre-eminent role has frequently been invoked for infectious diseases, and in this regard malaria has featured prominently. Increased resistance to Plasmodium falciparum infection was shown by Allison1 in 1954 to be conveyed by the sickle-cell trait, and ...Type of Medium: Electronic ResourceURL: -
19Staff View
ISSN: 1061-7361Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyType of Medium: Electronic ResourceURL: -
20Kaufmann, C.A. ; Young, G.S. ; Malaspina, D. ; Monto, A. ; Speer, M. ; Ott, J. ; Bruder, G. ; Chan, S. ; Whitaker, A. ; Strauss, D.H. ; Gorman, J. ; Latov, N.
Amsterdam : ElsevierStaff ViewISSN: 0920-9964Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: MedicineType of Medium: Electronic ResourceURL: