Search Results - (Author, Cooperation:J. Finke)

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  1. 1
    M. Ackermann ; M. Ajello ; K. Asano ; W. B. Atwood ; M. Axelsson ; L. Baldini ; J. Ballet ; G. Barbiellini ; M. G. Baring ; D. Bastieri ; K. Bechtol ; R. Bellazzini ; E. Bissaldi ; E. Bonamente ; J. Bregeon ; M. Brigida ; P. Bruel ; R. Buehler ; J. M. Burgess ; S. Buson ; G. A. Caliandro ; R. A. Cameron ; P. A. Caraveo ; C. Cecchi ; V. Chaplin ; E. Charles ; A. Chekhtman ; C. C. Cheung ; J. Chiang ; G. Chiaro ; S. Ciprini ; R. Claus ; W. Cleveland ; J. Cohen-Tanugi ; A. Collazzi ; L. R. Cominsky ; V. Connaughton ; J. Conrad ; S. Cutini ; F. D'Ammando ; A. de Angelis ; M. DeKlotz ; F. de Palma ; C. D. Dermer ; R. Desiante ; A. Diekmann ; L. Di Venere ; P. S. Drell ; A. Drlica-Wagner ; C. Favuzzi ; S. J. Fegan ; E. C. Ferrara ; J. Finke ; G. Fitzpatrick ; W. B. Focke ; A. Franckowiak ; Y. Fukazawa ; S. Funk ; P. Fusco ; F. Gargano ; N. Gehrels ; S. Germani ; M. Gibby ; N. Giglietto ; M. Giles ; F. Giordano ; M. Giroletti ; G. Godfrey ; J. Granot ; I. A. Grenier ; J. E. Grove ; D. Gruber ; S. Guiriec ; D. Hadasch ; Y. Hanabata ; A. K. Harding ; M. Hayashida ; E. Hays ; D. Horan ; R. E. Hughes ; Y. Inoue ; T. Jogler ; G. Johannesson ; W. N. Johnson ; T. Kawano ; J. Knodlseder ; D. Kocevski ; M. Kuss ; J. Lande ; S. Larsson ; L. Latronico ; F. Longo ; F. Loparco ; M. N. Lovellette ; P. Lubrano ; M. Mayer ; M. N. Mazziotta ; J. E. McEnery ; P. F. Michelson ; T. Mizuno ; A. A. Moiseev ; M. E. Monzani ; E. Moretti ; A. Morselli ; I. V. Moskalenko ; S. Murgia ; R. Nemmen ; E. Nuss ; M. Ohno ; T. Ohsugi ; A. Okumura ; N. Omodei ; M. Orienti ; D. Paneque ; V. Pelassa ; J. S. Perkins ; M. Pesce-Rollins ; V. Petrosian ; F. Piron ; G. Pivato ; T. A. Porter ; J. L. Racusin ; S. Raino ; R. Rando ; M. Razzano ; S. Razzaque ; A. Reimer ; O. Reimer ; S. Ritz ; M. Roth ; F. Ryde ; A. Sartori ; P. M. Parkinson ; J. D. Scargle ; A. Schulz ; C. Sgro ; E. J. Siskind ; E. Sonbas ; G. Spandre ; P. Spinelli ; H. Tajima ; H. Takahashi ; J. G. Thayer ; J. B. Thayer ; D. J. Thompson ; L. Tibaldo ; M. Tinivella ; D. F. Torres ; G. Tosti ; E. Troja ; T. L. Usher ; J. Vandenbroucke ; V. Vasileiou ; G. Vianello ; V. Vitale ; B. L. Winer ; K. S. Wood ; R. Yamazaki ; G. Younes ; H. F. Yu ; S. J. Zhu ; P. N. Bhat ; M. S. Briggs ; D. Byrne ; S. Foley ; A. Goldstein ; P. Jenke ; R. M. Kippen ; C. Kouveliotou ; S. McBreen ; C. Meegan ; W. S. Paciesas ; R. Preece ; A. Rau ; D. Tierney ; A. J. van der Horst ; A. von Kienlin ; C. Wilson-Hodge ; S. Xiong ; G. Cusumano ; V. La Parola ; J. R. Cummings
    American Association for the Advancement of Science (AAAS)
    Published 2013
    Staff View
    Publication Date:
    2013-11-23
    Publisher:
    American Association for the Advancement of Science (AAAS)
    Print ISSN:
    0036-8075
    Electronic ISSN:
    1095-9203
    Topics:
    Biology
    Chemistry and Pharmacology
    Computer Science
    Medicine
    Natural Sciences in General
    Physics
    Published by:
    http://www.aaas.org/

    Latest Papers from Table of Contents or Articles in Press
  2. 2
    FINKE, J. H. ; TUBBS, R. ; CONNELLY, B. ; PONTES, E. ; MONTIE, J.

    Oxford, UK : Blackwell Publishing Ltd
    Published 1988
    Staff View
    ISSN:
    1749-6632
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Natural Sciences in General
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1111/j.1749-6632.1988.tb36356.x

    Articles: DFG German National Licenses
  3. 3
    FINKE, J. H. ; OROSZ, C. G. ; BATTISTO, J. R.

    [s.l.] : Nature Publishing Group
    Published 1977
    Staff View
    ISSN:
    1476-4687
    Source:
    Nature Archives 1869 - 2009
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Notes:
    [Auszug] To illustrate the simplicity by which killer cells may be generated using this method, C57BL/6 spleen cells (107) were co-cultured, for sensitisation purposes, with allogeneic stimulator cells (107, CBA/H X-irradiated with 2,000 rad) derived from spleen and thymus. Supernatant fluids were added to ...
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1038/267353a0

    Articles: DFG German National Licenses
  4. 4
    Lange, W. ; Daskalakis, M. ; Finke, J. ; Dolken, G.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    0014-5793
    Keywords:
    BCR/ABL ; Chronic myelogenous leukemia ; Ribozyme
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Biology
    Chemistry and Pharmacology
    Physics
    Type of Medium:
    Electronic Resource
    URL:
    http://linkinghub.elsevier.com/retrieve/pii/0014-5793(94)80359-5

    Articles: DFG German National Licenses
  5. 5
    Staff View
    ISSN:
    1279-8509
    Keywords:
    Autologous bone marrow transplantation ; Autologous peripheral blood stem cell transplantation ; High-dose chemotherapy ; Second primary neoplasms
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Abstract We treated 500 patients with high-dose chemotherapy and autologous bone marrow or autologous peripheral blood stem cell transplantation. Treated conditions included leukemia, lymphoma, breast cancer, lung cancer, germ-cell carcinoma, and other solid tumors. 10/500 (2%) of patients were treated for a second malignancy diagnosed 12 months to 25 years after their initial neoplasm. Four of these ten patients are in complete remission (CR) of both malignancies at a median follow-up of 29+ months after high-dose chemotherapy and autotransplantation. None of these patients would have been eligible for high-dose chemotherapy and autotransplantation by conventional selection criteria which usually exclude patients with a history of prior malignancies. Conclusion. Conventional exclusion criteria for high-dose chemotherapy and autotransplantation may not adequately reflect the prognosis of patients with second or secondary malignancies treated with this therapeutic modality. High-dose chemotherapy and autologous hematopoietic stem cell transplantation may be of true benfit in selected cases of secondary malignancies.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/s00282-997-0079-3

    Articles: DFG German National Licenses
  6. 6
    Staff View
    ISSN:
    1569-8041
    Keywords:
    bone marrow scintigraphy ; immunoscintigraphy ; malignant lymphoma ; Tc-99m labelled anti-NCA-95
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Abstract Background: The purpose of this study was to elucidate the clinical reliability of immunoscintigraphy (IS) to detect infiltration of the bone marrow in patients with malignant lymphoma. Patients and methods: Whole body IS was performed in 103 patients with Hodgkin's disease (HD) or non-Hodgkin's lymphoma (NHL) using Tc-99m labelled anti-NCA-95 which allows visualization of the granulopoietic bone marrow. Of these, 52% were studied prior to any therapy. Findings were compared to posterior iliac crest biopsy as well as MRI and/or follow-up examination. Criteria of marrow infiltration were a positive biopsy, positive follow-up, or positive results of MRI. Results: Comparison of IS and biopsy revealed concordant findings in 69 and discordant findings in 34 of 103 patients. Of the 34 patients with discordant results, IS showed lesions suspicious of bone marrow infiltration in 29 patients despite normal biopsy findings. When follow-up and additional examinations were taken into consideration, 10 patients remained with probably false positive and five with false negative IS findings. IS proved to be highly sensitive and specific in patients with HD (100% and 84%, respectively) and high-grade NHL (93% and 84%, respectively). Moderate sensitivity (60%) was found in low-grade NHL. This was possibly due to false negative IS in three to five patients with chemotherapy in contrast to one of five false negative results in patients without chemotherapy. Conclusion: Bone marrow scintigraphy using antigranulocyte antibodies is highly sensitive in HD and high-grade NHL. Positive findings in IS subsequent to a negative biopsy should be followed by guided re-biopsy or MRI.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1023/A:1008356910239

    Articles: DFG German National Licenses
  7. 7
    Finke, J. ; Schuppener, H. J.
    Springer
    Published 1958
    Staff View
    ISSN:
    1432-069X
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Zusammenfassung Bei zwei Patienten (einer davon wurde bereits früher von uns beschrieben und jetzt nachuntersucht) konnten wir folgendes Syndrom beobachten: Im Alter von 14 bzw. 17 Jahren trat erstmalig im Dermatom D 1 eine sehr lästige, umschriebene Hyperhidrose auf, die durch körperliche Anstrengungen, Wärme und Emotionen auslösbar ist, jedoch nicht durch Geschmacksreize. Auf der Seite der Hyperhidrose besteht ein Horner-Syndrom als Hinweis auf eine Sympathicusschädigung, für welche die bei beiden Patienten vorhandenen Halsrippen verantwortlich sein können. Ob darüberhinaus besondere Verlaufseigentümlichkeiten der sympathischen Fasern vorliegen, wird erwogen. Fragen der somatotopischen Gliederung des Sympathicus sowie einer evtl. antagonistischen Innervation der Schweißdrüsen werden erörtert; möglicherweise kommt es durch partielle Lähmung des Sympathicus zur Enthemmung des Parasympathicus im betroffenen Areal. Vielleicht handelt es sich bei der beobachteten Trias (Hyperhidrose im Dermatom D 1, Horner, Halsrippen) um eine konstante Symptomengruppierung, die nicht allzu selten ist und die vor allem vom Dermatologen hin und wieder beobachtet werden kann, da derartige Patienten wahrscheinlich gerade seine Sprechstunde aufsuchen werden. — Durch Röntgentiefenbestrahlung des Halssympathicus wurde bei beiden Patienten die Hyperhidrose für einige Zeit zum Verschwinden gebracht und im ganzen auf ein erträgliches Maß vermindert.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF00482771

    Articles: DFG German National Licenses
  8. 8
    Staff View
    ISSN:
    1432-0851
    Keywords:
    Key words TCR/CD3 ; Lymphocytes ; Cytokines ; Lymphomas ; Signal transduction
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Abstract  T cells infiltrating (T-TIL) B cell non-Hodgkin’s lymphomas (NHL) are thought to represent a local host response to the tumor. However, tumor progression in the presence of this T cell infiltrate suggests that the T-TIL may be functionally impaired. To address this issue we determined whether response to stimulation of T-TIL from 25 patients with NHL through the T cell receptor (TCR/CD3) and the interleukin-2 (IL-2) receptor (IL-2R) was intact, since activation of these receptors is important for proliferation and cytokine production. Our results demonstrate defects in response to stimulation via TCR/CD3 and the IL-2R in T-TIL cells from patients with NHL that were not observed with T cells from the peripheral blood. T-TIL showed minimal proliferation to anti-CD3 and only modest proliferation to IL-2 alone or when combined with anti-CD3. Moreover, cytokine production in T-TIL was impaired since stimulation through the TCR/CD3 complex did not induce mRNA for interferon γ (IFNγ), IL-2, IL-4 or IL-10. The functional unresponsiveness of these cells may be linked to altered signalling through the TCR/CD3 since an abnormal tyrosine phosphorylation pattern was detected in T-TIL after stimulation with anti-CD3.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF01521344

    Articles: DFG German National Licenses
  9. 9
    Sommerkamp, H. ; Finke, J.
    Springer
    Published 1998
    Staff View
    ISSN:
    1433-0563
    Keywords:
    Key words Hemorrhagic cystitis • Chemotherapy • ; Cyclophosphamide-treatment ; Schlüsselwörter Hämorrhagische Zystitis • Chemotherapie • Cyclophosphamidtherapie
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Description / Table of Contents:
    Zusammenfassung Die hämorrhagische Urozystitis als Folge der Urotoxizität von Cyclophosphamid ist eine bekannte und nicht selten lebensbedrohliche Komplikation der Hochdosischemotherapie. Sie wird gehäuft nach allogener Knochenmarktransplantation beobachtet. Die hämorrhagisch-ulzerösen Veränderungen des Blasenurothels gehen ohne Prophylaxe mit Mikro-/Makrohämaturie, Koagelbildung und meist schwer stillbarer Blutung in bis zu 70 % der Patienten einher. Durch prophylaktische Maßnahmen läßt sich die Inzidenz reduzieren, jedoch nicht zuverlässig verhindern. Therapeutisch sind die meisten Fälle mit forcierter Diurese oder Dauerspülung der Blase unter Kontrolle zu bringen. Bei persistierender Blutung ist nach einem Stufenplan vorzugehen, der zunächst endoskopische Eingriffe und danach den Einsatz hämostyptischer Instillate vorsieht. Invasive Verfahren, wie Embolisation oder offen chirurgische Intervention bilden die Ausnahme, sind unter vitaler Indikation jedoch zu erwägen.
    Notes:
    Summary Hemorrhagic cystitis is a well known toxic and often life-threatening complication from high-dose chemotherapy with cyclophosphamide. The incidence is particularly high after allogeneic bone marrow transplantation. The morphologic bladder wall changes are associated with gross hematuria, clot formation in the bladder and problems to control the bleeding in up to 70 % without preventive measures. Prevention is routinely done and can reduce but not obviate the incidence of hemorrhagic cystitis. Treatment is initiated by forced diuresis and continous bladder irrigation. When necessary endoscopic cauterisation of bleeding mucosal areas is combined with the instillation of hemostyptic agents. Embolisation of the pelvic vessels or open surgery to control the bleeding is indicated in selected cases in a life-threatening situation.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/s001200050211

    Articles: DFG German National Licenses
  10. 10
    Staff View
    ISSN:
    1432-0584
    Keywords:
    Chronic myelogenous leukemia ; Allogeneic bone marrow transplantation ; Minimal residual disease ; BCR/ABL mRNA
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Summary A modified two-step polymerase chain reaction (PCR) was used for the amplification of BCR/ABL mRNA in 16 patients with Philadelphia chromosomepositive (Ph+) chronic myelogenous leukemia (CML) following allogeneic bone marrow transplantation (BMT). At different intervals after BMT, patient cells were assessed for the presence of BCR/ABL mRNA by two subsequent rounds of PCR amplification; this procedure increased the sensitivity for the detection of one Ph+ cell in 104–5 to one cell in 105–6. Eight of 16 patients were negative by two-step PCR 1–39 months after BMT, suggesting an elimination of Ph-positive cells or a decrease below the threshold of detection. Although five patients showed negative results by the one-step PCR only, they were tested positive when nested primers were used, indicating a substantial decrease in the amount of BCR/ABL target mRNA compared with earlier pre- or post-transplant analyses. One patient who was still PCR positive 27 months after BMT became negative 12 months later. Persistence of BCR/ABL mRNA-expressing cells correlated with subsequent clinical relapse only when the transplantation was performed during blast crisis. All patients who underwent transplantation in chronic phase, including those with BCR rearrangement by PCR, are in clinical and hematological remission between 24 and 95 months after BMT. We conclude that aggressive chemotherapy combined with total body irradiation is unable to completely eradicate the malignant clone in all CML patients, and it might be speculated that other mechanisms (e.g., graft versus host reaction [GVHD] or graft versus leukemia effect [GVL]) may effectively eliminate residual leukemic cells.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF01703441

    Articles: DFG German National Licenses
  11. 11
    Staff View
    ISSN:
    1432-0584
    Keywords:
    Key words Autologous bone marrow transplantation ; Autologous peripheral blood stem cell transplantation ; High-dose chemotherapy ; Second and secondary primary neoplasms
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Abstract  We treated 500 patients with high-dose chemotherapy (HDC) and autologous bone marrow (ABMT) or autologous peripheral blood stem cell transplantation (PBSCT). Treated conditions included leukemia, lymphomas, breast cancer, lung cancer, germ-cell carcinomas, and other solid tumors. In order to assess relapse of primary malignancy or occurrence of new neoplasms, routine screening after ABMT or PBPCT was performed at regular and close intervals. With a total follow-up of 1358 person-years and a median follow-up of 34 months (range 9–91), 10/500 (2%) patients developed second malignancies after PBSCT or ABMT; i.e., one new cancer occurred every 136 person-years. All malignancies were detected at routine follow-up examinations; and 7/10 diagnoses were made in an asymptomatic phase; 6/10 neoplasms were amenable to complete surgical resection, five of which remain in CR at a median of 23+ months after autotransplantation. We conclude that regular and close follow-up examination of patients after autologous hematopoietic stem cell transplantation may be beneficial, since successful treatment of second malignancies is possible in selected cases after early detection.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/s002770050260

    Articles: DFG German National Licenses
  12. 12
    Finke, J. ; Kunzmann, R. ; Lange, W.
    Springer
    Published 1994
    Staff View
    ISSN:
    1432-0584
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Summary Translocations involving chromosome band 11q23 are associated with acute lymphocytic and myelomonocytic leukemias with poor clinical prognosis. Pulsed-field gel electrophoresis (PFGE) was used to characterize the breakpoint region that has been mapped within a 300-kb fragment between the genes CD3G and PBGD. Using CD3G as a marker onSfuI-restricted DNA separated by PFGE, we detected a rearrangement involving 11q23 in the cell line B1 with a t(4; 11) and in the leukemic cells of two patients, one with a t(2; 11) and one with a t(11; 19). In comparison, lymphoblastoid cell lines established from normal peripheral blood lymphocytes of these two patients had a normal karyotype and showed germline configuration, thus excluding RFL polymorphisms. Digestion of DNA withBssHII orSalI showed heterogeneity of 11q23 involving breakpoints. A rearrangement in the t(4; 11) containing lymphoma cell line Karpas422 was seen only with the chromosome 4 probe KIT onSalI-digested DNA. PFGE is a reliable method for the mapping and detection of complex breakpoint regions. The break-points on 11q23 involve different introns of the highly spliced HRX/ALL-1/MLL gene.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF01727417

    Articles: DFG German National Licenses
  13. 13
    Staff View
    ISSN:
    1432-0584
    Keywords:
    Key words Aspergillosis ; Fungal infection ; Acute myeloid leukemia
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Abstract  Systemic aspergillosis is a well-recognized complication of chemotherapy-induced neutropenia. In this report a patient with acute myeloid leukemia is described in whom a chronic aspergillosis with systemic involvement developed after recovery from neutropenia following intensive chemotherapy and allogeneic bone marrow transplantation. The clinical features of a chronic course of systemic aspergillosis suggest a distinct clinical entity comparable to chronic systemic candidiasis.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/s002770050383

    Articles: DFG German National Licenses
  14. 14
    Staff View
    ISSN:
    1432-0584
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Description / Table of Contents:
    Summary Within a few months we observed four patients withZieve's-Syndrome. All were young men with upper abdominal pain, vomiting, weith loss, and alcoholism. The laboratory data were correlated to the significant diagnostic criteria of liver disease, hemolysis, hyperlipemia, and spontaneous improvement after the patients obstained from alcohol. The results and the etiological problems are discussed.
    Notes:
    Zusammenfassung Innerhalb weniger Monate wurden in der poliklinischen Ambulanz vier Patienten mit einemZieve-Syndrom beobachtet. In allen Fällen handelte es sich um junge Männer mit Oberbauchbeschwerden, Erbrechen und Gewichtsverlust bei Alkoholabusus. Die Labordaten werden nach den entscheidenden diagnostischen Kriterien Leberschaden, Hämolyse, Hyperlipämie und Spontanbesserung nach Alkoholkarenz dargestellt. Die Ergebnisse werden diskutiert und die ätiologischen Probleme referiert.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF01632248

    Articles: DFG German National Licenses
  15. 15
    Staff View
    ISSN:
    1432-1009
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Energy, Environment Protection, Nuclear Power Engineering
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF01866558

    Articles: DFG German National Licenses
  16. 16
    Staff View
    ISSN:
    1432-1440
    Keywords:
    Acute leucaemia ; Cytochemistry ; Akute Leukämie ; Cytochemie
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Description / Table of Contents:
    Zusammenfassung Bei 47 Patienten mit akuter Leukämie wurden die Ergebnisse einer voneinander unabhängigen Klassifizierung aufgrund der panoptischen Färbung einerseits und dem Ausfall cytochemischer Reaktionen andererseits (Peroxydase, PAS-Reaktion, Naphthol-AS-Acetat-Esterase) sowie das Ansprechen auf eine adäquate Induktionstherapie in den cytologisch und cytochemisch definierten Gruppen miteinander verglichen. In 42 Fällen stimmte die cytologische und cytochemische Differenzierung miteinander überein. Hinsichtlich des Ansprechens auf Therapie ergeben sich keine signifikanten Unterschiede, gleichgültig, ob man die AL nach cytologischen oder cytochemischen Kriterien gruppiert. Eine Ausnahme bildet der bei undifferenzierten AL cytochemisch charakterisierbare PAS-Typ, bei dem ein besseres Ansprechen auf Therapie als bei den Fällen ohne diagnostisch verwendbare cytochemische Aktivität wie auch bei den granulocytär differenzierten AL gefunden wurde. Hinsichtlich des Ansprechens auf Therapie verhalten sich die Erwachsenen mit PAS-Typ ähnlich günstig wie die Kinder.
    Notes:
    Summary The leukaemic blast cells of 47 cases of acute leukaemia have been independently subclassified on the basis of panoptic stains on the one side and cytochemical reactions (peroxydase, PAS, naphthol-AS-acetate-esterase) on the other. In 42 cases the results of the cytochemistry were concordant to those of the panoptic stains. The percentage of responders to adaequate inductive chemotherapy failed to show any differences between the groups defined according to the different criteria. However, within the group of acute leukaemias which on the basis of panoptical staining could not be attributed to one of the normal cell lines, patients with PAS-positive leukaemic cells seem to have a better response than all other cases. This may be true for adults as well as for children.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF01487293

    Articles: DFG German National Licenses
  17. 17
    Staff View
    ISSN:
    1432-1440
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Description / Table of Contents:
    Summary The57Co-vitamin B12-binding capacity of glycoproteins excreted with the urine during a 24 hrs. collecting period was determined in some cases of several blood diseases and in multiple sclerosis. Extremely high values were found in chronic myelogenous leukemia, approximately normal values in acute leukemias, and significantly diminished average values were observed in multiple sclerosis similarly as in a few cases of pernicious anemia.
    Notes:
    Zusammenfassung Bei einigen Fällen von chronischer myeloischer Leukämie fand sich eine exzessiv erhöhte57Co-Vitamin B12-Bindungskapazität der Uroglykoproteine, während die Werte bei akuten Leukosen normal waren. Unbehandelte Fälle von multipler Sklerose hatten ähnlich stark erniedrigte Bindungswerte aufzuweisen wie unbehandelte perniziöse Anämien.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF01711505

    Articles: DFG German National Licenses
  18. 18
    Turba, F. ; Büscher, H. ; Fasold, H. ; Finke, J. ; Gerlach, J.
    Springer
    Published 1966
    Staff View
    ISSN:
    1591-9528
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Description / Table of Contents:
    Summary The isolation of a membrane fraction from rat brain homogenates by density gradient centrifugation is described. It contains a Mg++-dependent adenosine triphosphatase activated by Na+ and K+, beside a lesser amount of an enzyme activated by Mg++ only. After electrical impulses the enzymatic activity was significantly enhanced.
    Notes:
    Zusammenfassung Die Abtrennung einer Membranfraktion aus Rattenhirnhomogenaten mittels Dichtegradienten-Zentrifugation wird beschrieben. Sie enthält eine durch Na+ und K+ aktivierbare, Mg++-abhängige Adenosintriphosphatase neben einer geringeren Menge einer nur durch Mg++ aktivierbaren Adenosintriphosphatase. Nach elektrischer Reizung der Versuchstiere war die enzymatische Aktivität gegenüber Kontrollversuchen signifikant erhöht.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF02043322

    Articles: DFG German National Licenses
  19. 19
    Hägele, E. ; Finke, J. ; Lehmann, P. ; Graßl, M.
    Springer
    Published 1982
    Staff View
    ISSN:
    1618-2650
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Chemistry and Pharmacology
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF00481784

    Articles: DFG German National Licenses
  20. 20
    Finke, J. ; Hägele, E. O.
    Springer
    Published 1986
    Staff View
    ISSN:
    1618-2650
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Chemistry and Pharmacology
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF00487959

    Articles: DFG German National Licenses